| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2003: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2002: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Research Abstract |
During perioperative period, tissue injury and/or inflammation results in a marked restructuring of body fluid composition. For example, tissue inflammation affects the integrity of cell membrane, and increased permeability contributes to interstitial edema. Such changes in body fluid composition also affect the postoperative recovery and we need a monitoring technique to establish a precise measurement of perioperative body fluid dynamics. Bio-impedance analysis (BIA), evaluated as an electrical impedance of the body in the multi-frequency range, allows us to non-invasively trace the changes in body fluid dynamics. We found this technique reflects the changes in the extracellular fluid volume and non-linear fitting to cell suspension model also indicates some possibilities to expand the technique to explore information's regarding the changes in tissue structure. This particular study was to re-evaluate the clinical usefulness of BIA in the patients receiving the open-heart surgery. By comparing with the measured fluid balance, it was found that correlation between extracellular fluid volume and trunk impedance was relatively high (r=0.61), but correlation to whole body resistance was poor (r=0.24). There were also wide variations in impedance data, and other confounding factors, such as fluid therapy, catecholamine administration and body temperature, made our interpretation difficult. We need further studies to clarify the usefulness of BIA in monitoring perioperative body fluid dynamics.
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