• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Prostate cancer specific cell-mediated immunotherapy utilizing dendritic cells pulsed with prostate-specific antigen

Research Project

Project/Area Number 14571521
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionKEIO UNIVERSITY

Principal Investigator

HORIGUCHI Yutaka  Keio University, School of Medicine, instructor, 医学部, 助手 (60229234)

Co-Investigator(Kenkyū-buntansha) MURAI Masaru  Keio University, School of Medicine, Professor, 医学部, 教授 (90101956)
NAKASHIMA Jun  Keio University, School of Medicine, Assistant Processor, 医学部, 専任講師 (10167546)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2002: ¥2,500,000 (Direct Cost: ¥2,500,000)
Keywordsprostate cancer / immunotherapy / dendritic cell / prostate specific membrane antigen / cancer targeting therapy / peptide / CTL / HLA-A24 / 前立腺癌特異的膜抗原
Research Abstract

Prostate cancer is a significant and growing health problem in the Japanese population, and hormone-refractory disease is known to be highly resistant to the conventional radiotherapy and/or chemotherapy. Therefore, it is important to develop an alternative strategy to treat hormone-refractory prostate cancer patients. Prostate-specific membrane antigen (PSMA), which is a transmembrane glycoprotein predominantly expressed in prostate cancer, is an attractive target for tumor-specific immunotherapy. Because HLA-A24 is the most common MHC class 1 allele among Japanese population, it is of great interest to identify HLA-A24-restricted epitope peptides from PSMA for further application of the dendritic cells (DC)-based immunotherapy targeting of prostate cancer. To identify HLA-A24-restricted epitope peptides, several PSMA-encoded HLA-A24 binding peptides were designed and screened for their capabilities to elicit specific antitumor cytotoxic T-lymphocytes response. These epitopes would be utilized to further evaluate the clinical utility of DC-based immunotherapeutic strategies for treatment of hormone-refractory prostate cancers.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] Yutaka Horiguchi, et al.: "Screening of HLA-A24-restricted epitope peptides from prostate-specific membrane antigen that induce specific antitumor cytotoxic T lymphocytes"Clinical Cancer Research. 8(12). 3885-3892 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yutaka Horiguchi, et al.: "Screening of HLA-A24-restricted epitope peptides from prostate-specific membrane antigen that induce specific antitumor cytotoxic T lymphocytes."Clinical Cancer Research. 8(12). 3885-3892 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yutaka Horiguchi, et al.: "Screening of HLA-A24-restricted epitope peptides from prostate-specific membrane antigen that induce specific antitumor cytotoxic T lymphocytes"Clinical Cancer Research. 8(12). 3885-3892 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yutaka Horiguchi, et al.: "Screening of HLA-A24-restricted epitope peptides from prostate-specific membrane antigen that induce specific antitumor cytotoxic T lymphocytes"Clinical Cancer Research. 8(12). 3885-3892 (2002)

    • Related Report
      2002 Annual Research Report

URL: 

Published: 2002-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi