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Molecular investigation on prognostic factors and development of an tailor-made therapy for Hunt syndrome.

Research Project

Project/Area Number 14571602
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

FURUTA Yasushi  Hokkaido Univ., Grad.School of Med., Asso.Prof., 大学院・医学研究科, 助教授 (60261301)

Co-Investigator(Kenkyū-buntansha) SAWA Hirofumi  Hokkaido Univ., Grad.School of Med., Asso.Prof., 大学院・医学研究科, 助教授 (30292006)
FUKUDA Satoshi  Hokkaido Univ., Grad.School of Med., Prof., 大学院・医学研究科, 教授 (20125347)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2003: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2002: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsVaricella-zoster virus / VZV DNA / Real-time PCR / Anti-VZV antibody / Ramsay Hunt syndrome / Bell's palsy / Zoster sine herpete / 水痘帯状庖疹ウイルス / VAV DNA量
Research Abstract

1.Varicella-zoster virus DNA level and facial paralysis in Ramsay Hunt syndrome
We have investigated whether the copy number of varicella-zoster virus (VZV) in saliva correlates with the clinical symptoms in patients with Ramsay Hunt syndrome (RHS). Patients with oropharyngeal zoster showed worse recovery of facial function than those without. It seems that the VZV DNA level in saliva reflects the kinetics of viral reactivation in the facial nerve as well as in the oropharyngeal epithelium in RHS patients.
2.Patterns of varicella-zoster virus reactivation in Ramsay Hunt syndrome
We analyzed the relationship between VZV load and onset of facial paralysis in 42 RHS patients. The results indicate that facial paralysis in RHS can occur at various times between the early and the regression phase of VZV reactivation, suggesting that there are variable patterns of development of facial nerve dysfunction caused by VZV reactivation and the progression of neuritis.
3.Serological diagnosis of varicel … More la-zoster virus reactivation in patients with acute peripheral facial paralysis
We focused on the determination of an anti-VZV IgG antibody liter in sero-diagnosis by using an enzyme immunoassay (EIA) and investigated the diagnostic criteria for VZV reactivation by EIA. It was considered appropriate to give a diagnosis of VZV reactivation for those cases exhibiting a double-fold increasd in the VZV IgG EIA antibody titer.
4. Analysis of varicella-zoster virus load and cochleovestibular symptoms in patients with Ramsay Hunt syndrome
The present study analyzed the relationship between VZV load and the onset of the cochleovestibular symptoms. The results indicate that cochleovestibular symptoms can occur in various timing from the early phase to the regression phase of VZV reactivation, suggesting that there are various patterns in the development of the eighth cranial nerve dysfunction caused by VZV reactivation and progression of neuritis.
5.Varicella-zoster virus reactivation is the major cause of acute peripheral facial paralysis m children
This study analyzed the causes of acute peripheral facial paralysis in children by serological assays and PCR using paired sera and saliva samples. The results indicate that VZV reactivation is the major cause of acute peripheral facial paralysis in children, especially in ages between 6 and 15. In contrast, our data suggest that HSV-1 reactivation is not the major pathogenesis of Bell's palsy in children.
6.Analysis of patients with Bell's palsy who showed incomplete recovery
This study analyzed the causes of clinically diagnosed Bell's palsy who showed incomplete recovery of facial movement. The results indicate that VZV or HSV-1 reactivation is the major cause of Bell's palsy with poor prognosis. Less

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (45 results)

All Other

All Publications (45 results)

  • [Publications] 古田 康 他: "唾液中VZV DNA量によるHunt症候群の予後判定"Facial Nerve Research. 22巻. 25-27 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 大谷 文雄 他: "Hunt症候群におけるVZV再活性化動態について"Facial Nerve Research. 22巻. 50-52 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 相澤 寛志 他: "末梢性顔面神経麻痺症例におけるVZV再活性化の血清診断"Facial Nerve Research. 22巻. 53-55 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takagi D, et al.: "Otologic manifestations of Wegener's granulomatosis"Laryngoscope. 112巻. 1684-1690 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 古田 康 他: "耳鼻咽喉科領域の皮膚・粘膜疾患 耳性帯状疱疹"耳喉頭頸. 75巻. 517-522 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 古田 康 他: "末梢性顔面神経麻痺における水痘帯状疱疹ウイルス再活性化動態の解析と治療への応用"耳喉頭頸. 75巻. 766-779 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 古田 康 他: "側頭骨内顔面神経手術における光学式ナビゲーションシステムの応用"Facial Nerve Research. 23巻. 114-116 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 大谷 文雄 他: "Hunt症候群における第8脳神経症状とVZV再活性化動態"Facial Nerve Research. 23巻. 92-94 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 相澤 寛志 他: "ステロイド療法による血清IgG値の低下は血清抗VZV IgG抗体の有意の変動をマスクする"Facial Nerve Research. 23巻. 95-98 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 黒田 徹 他: "多発脳神経障害と脊髄根炎を呈したRamsay Hunt症候群の1例"Facial Nerve Research. 23巻. 149-151 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakamaru Y, et al.: "Macrophage migration inhibitory factor in allergic rhinitis : It's identification in eosinophils at the site of inflammation"Ann Otol Rhinol Laryngol. 113巻. 205-209 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takagi D, et al.: "Clinical features of myeloperoxidase-antineutrophil cytoplasmic antibody-associated bilateral progressive hearing loss"Ann Otol Rhinol Laryngol. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Furuta Y, et al.: "Varicella-zoster virus DNA level and facial paralysis in Ramsay Hunt syndrome"Ann Otol Rhinol Laryngol. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 古田 康: "末梢性神経障害の病態と治療 ベル麻痺"医学と薬学. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 古田 康: "ベル麻痺,今日の耳鼻咽喉科・頭頸部外科治療指針(森山 寛, 岸本誠司, 小林俊光, 川内秀之編)"医学書院. 213-214 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Furuta Y: "Reactivation of Herpes Simplex Virus and Bell's palsy"Studahl M, Cinque P, Bergstrom T, Marcel Dekker, Inc(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Furuta Y.: "Prognostic evaluation of Hunt syndrome by VZV quantitation."Facial Nerve Research. 22. 25-27 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohtani F.: "Analysis of VZV load in patients with Hunt syndrome"Facial Nerve Research. 22. 50-52 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Aizawa H.: "Fluctuations in anti-VZV IgG antibody for serologic diagnosis of VZV reactivation in patients with acute peripheral facial palsy."Facial Nerve Research. 22. 53-55 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takagi D.: "Otologic manifestations of Wegener's granulomatosis."Laryngoscope. 112. 1684-1690 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Furuta Y.: "Herpes zoster oticus"Otolaryngol Head Neck Surg (Tokyo). 75. 517-522 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Furuta Y.: "Analysis of varicella-zoster virus reactivation in acute peripheral facial paralysis and its application to the treatment."Otolaryngol Head Neck Surg (Tokyo). 75. 766-779 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Furuta Y.: "Application of an opitcal-tracking navigation system to facial nerve surgery in the temporal bone."Facial Nerve Research. 23. 114-116 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohtani F.: "Analysis of varicella-zoster virus load and cochleovestibular symptoms in patients with Ramsay Hunt syndrome."Facial Nerve Research. 23. 92-94 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Aizawa H.: "A significant increase in anti-VZV IgG antibody is masked by decreases in serum IgG due to the steroid therapy."Facial Nerve Research. 23. 95-98 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kuroda T.: "A case of Ramsay Hunt syndrome presenting multiple cranial nerve dysfunctions and spinal radiculitis"Facial Nerve Research. 23. 149-151 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakamaru Y.: "Macrophage migiation inhibitory factor in allergic rhinitis : It's identification in eosinophils at the site of inflammation"Ann Otol Rhinol Laryngol. 113. 205-209 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takagi D.: "Clinical features of myeloperoxidase-antineutrophil cytoplasmic antibody-associated bilateral progressive hearing loss"Ann Otol Rhinol Laryngol. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Furuta Y.: "Varicella-zoster virus DNA level and facial paralysis in Ramsay Hunt syndrome"Ann Otol Rhinol Laryngol. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Furuta Y.: "Bell's palsy"Igaku to Yakugaku. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Furuta Y.: "Bell's palsy. Update therapy in ORL and H & N surgery(Moriyama H, Kishimoto S, Kobayashi T, Kawauchi H.)"Igaku-syoinn. 213-214 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Furuta Y.: "Reactivation of Herpes Simplex Virus and Bell's patsy(Studahl M, Cinque P, Bergstrom T)"Marcel Dekker, Inc(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 古田 康 他: "耳鼻咽喉科領域の皮膚・粘膜疾患 耳性帯状疱疹"耳喉頭頸. 75巻. 517-522 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 古田 康 他: "末梢性顔面神経麻痺における水痘帯状疱疹ウイルス再活性化動態の解析と治療への応用"耳喉頭頸. 75巻. 766-779 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 古田 康 他: "側頭骨内顔面神経手術における光学式ナビゲーションシステムの応用"Facial Nerve Research. 23巻. 114-116 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 大谷文雄 他: "Hunt症候群における第8脳神経症状とVZV再活性化動態"Facial Nerve Research. 23巻. 92-94 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Furuta Y, et al.: "Varicella-zoster virus DNA level and facial paralysis in Ramsay Hunt syndrome"Ann Otol Phinol Laryngol. (in press).

    • Related Report
      2003 Annual Research Report
  • [Publications] Takagi D, et al.: "features of myeloperoxidase-antineutrophil cytoplasmic antibody-associated bilateral progressive hearing"Ann Otol Rhinol Laryngol. (in press).

    • Related Report
      2003 Annual Research Report
  • [Publications] 古田 康: "ベル麻痺,今日の耳鼻咽喉科・頭頸部外科治療指針(森山 寛, 岸本誠司, 小林俊光, 川内秀之編)"医学書院. 213-214 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Furuta Y: "Reactivation of Herpes Simplex Virus and Bell's palsy"Studahl M, Cinque P, Bergstrom T, Marcel Dekker, Inc (印刷中).

    • Related Report
      2003 Annual Research Report
  • [Publications] 古田 康 他: "唾液中VZV DNA量によるHunt症候群の予後判定"Facial Nerve Research. 22巻. 25-27 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 大谷 文雄 他: "Hunt症候群におけるVZV再活性化動態について"Facial Nerve Research. 22巻. 50-52 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 相澤 寛志 他: "末梢性顔面神経麻痺症例におけるVZV再活性化の血清診断"Facial Nerve Research. 22巻. 53-55 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 古田 康 他: "耳鼻咽喉科領域の皮膚・粘膜疾患 耳性帯状疱疹"耳喉頭頸. (印刷中).

    • Related Report
      2002 Annual Research Report
  • [Publications] Furuta Y: "Reactivation of Herpes Simplex Virus and Bells palsy"Studahl M, Cinque P, Bergstrom T, Marcel Dekker, Inc(印刷中).

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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