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Pathogenesis and Treatment for Eosinophilic Inflammation in the Upper Respiratory Tract.

Research Project

Project/Area Number 14571635
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionTeikyo University

Principal Investigator

IINO Yukiko  TEIKYO UNIVERSITY, School of Medicine, Professor, 医学部, 教授 (30108534)

Co-Investigator(Kenkyū-buntansha) KAKIZAKI Keiko  TEIKYO UNIVERSITY, School of Medicine, Assistant, 医学部, 助手 (90297143)
KATANO Hiroaki  TEIKYO UNIVERSITY, School of Medicine, Assistant, 医学部, 助手 (70297141)
瀬端 宏  帝京大学, 医学部, 助手
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2002: ¥2,700,000 (Direct Cost: ¥2,700,000)
Keywordseosinophilic sinusitis / eosinophilic otitis media / viscous effusion / ntractable / IL-5 / ecalectin / patulous eustachian tube / 好酸球 / 中耳炎 / 副鼻腔炎 / 好酸球遊走因子 / RANTES / EG2
Research Abstract

Eosinophilic sinusitis and eosinophilic otitis media (EOM) are very intractable conditions that are resistant to conventional conservative or surgical treatments. To clarify the pathogenesis of accumulation of eosinophils in the upper respiratory tracts, we measured the concentration of eosinophil chemoattractants in the effusion and carried out immunohistochemical studies on the mucosa specimens to demonstrate the expression of eosinophil chemoattractants. In the nasal polyps, ecalectin-positive cells were observed in the subepithelial layer where many EG2-positive cells were present. The number of ecalectin-positive cells was significantly correlated with the number of EG2-positive cells in the nasal polyp from each patient. Many ecalectin mRNA-positive cells were also observed in the nasal polyps with accumulation of EG2-positive cells. In EOM, significantly higher concentrations of ECP and IL-5 were detected in MEE than in serum, and ECP, IL-5 and eotaxin concentrations in MEE were higher in the EOM patients than in the controls. Immunohistochemically, the numbers of cells positive for EG2 and ecalectin were significantly higher in EOM patients than in the controls. In addition, the presence of a patulous eustachian tube may be a major cause of EOM in the bronchial asthmatic patients. Locally produced chemoattractants may play a crucial role in the accumulation and activation of eosinophils in the mucosa of the upper respiratory tracts. The topical administration of the glucocorticoid induces apoptosis of not only eosinophils but also eosinophil chemoattractant-producing cells, thereby improving the eosinophilic inflammation.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (28 results)

All 2005 2004 2003 2002 Other

All Journal Article (22 results) Publications (6 results)

  • [Journal Article] 耳限局型Wegener肉芽腫の1症例2005

    • Author(s)
      伊藤茂彦, 飯野ゆき子, 余田敬子, 松浦栄作
    • Journal Title

      耳喉頭頸 77

      Pages: 90-91

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 騒音性難聴2症例の側頭骨病理所見2005

    • Author(s)
      中本吉紀, 飯野ゆき子, 小寺一興
    • Journal Title

      日耳鼻 108

      Pages: 172-181

    • NAID

      10015568469

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 長期間無症状に経過した頚部ガラス異物の一症例2005

    • Author(s)
      若山禎, 中本吉紀, 飯野ゆき子, 小寺一興
    • Journal Title

      耳鼻臨床 98

      Pages: 239-243

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 中耳炎の内耳波及と考えられた症例の側頭骨病理2005

    • Author(s)
      片野宏明, 飯野ゆき子, 伊藤茂彦, 村上嘉彦, 小寺一興
    • Journal Title

      日耳鼻 108(in press)

    • NAID

      10016674025

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Macrolide therapy is effective for otitis media with effusion in children.2004

    • Author(s)
      Iino Y
    • Journal Title

      Laryngoscope 114

      Pages: 1318-1318

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Macrolide theapy is effective for otitis media with effusion in children.2004

    • Author(s)
      Iino Y.
    • Journal Title

      Laryngoscope 114

      Pages: 1318-1318

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 再発を繰り返した中耳腺腫症例2004

    • Author(s)
      白居芳幸, 柿崎景子, 飯野ゆき子, 小寺一興
    • Journal Title

      日耳鼻 107

      Pages: 756-759

    • NAID

      10013516950

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Cochleosaccular degenerationxを呈した高度難聴耳の側頭骨病理2004

    • Author(s)
      三枝華子, 飯野ゆき子, 中本吉紀, 宮澤哲夫, 村上嘉彦, 小寺一興
    • Journal Title

      日耳鼻 107

      Pages: 195-198

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Acoustic trauma : temporal bone study2003

    • Author(s)
      Kakizaki K, Iino Y, et al.
    • Journal Title

      Otol Neurotol 24

      Pages: 965-967

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Nasopharyngeal flora and drug susceptibility in children・・・2003

    • Author(s)
      Iino Y.et al.
    • Journal Title

      Laryngoscope 113

      Pages: 1780-1785

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Acoustic trauma : temporal bone study.2003

    • Author(s)
      Kakizaki K, Iino Y, Nakamoto Y, Murakami Y
    • Journal Title

      Otol Neurotol 24

      Pages: 965-967

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Nasopharyngeal flora and drug susceptibility in children with macrolide therapy.2003

    • Author(s)
      Iino Y, Sasaki Y, Miyazawa T, Kodera K
    • Journal Title

      Laryngoscope 113

      Pages: 1780-1785

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Temporal bone histopathological and quantitative analysis of mitochondrial DNA in MELAS.2003

    • Author(s)
      Takahashi K, Merchant SN, Miyazawa T, Yamaguchi T, McKenna MJ, Kouda H, Iino Y, Someya T, Tamagawa Y, Takiyama Y, Nakano I, Saito K, Boyer P, Kitamura K.
    • Journal Title

      Laryngoscope 113

      Pages: 1362-1368

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 中耳手術の聴力改善成績の判定基準をめぐって-中耳真珠腫-2003

    • Author(s)
      飯野ゆき子
    • Journal Title

      Otol Jpn 13

      Pages: 6-9

    • NAID

      10026920254

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 小児中耳真珠腫症における鼓室形成術後の再含気化について2003

    • Author(s)
      柿崎景子, 佐々木祐佳子, 飯野ゆき子, 小寺一興
    • Journal Title

      Otol Jpn 13

      Pages: 204-208

    • NAID

      10026920743

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Clinical characteristics of so called eosinophilic otitis meclia2002

    • Author(s)
      Nagamine H, Iino Y, et al.
    • Journal Title

      ANL 29

      Pages: 19-28

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Comparison of duration of deafness and tumor in vosion to the inner ear2002

    • Author(s)
      Nishimura S.et al.
    • Journal Title

      J.Laryngol Otol 116

      Pages: 256-260

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Posterior canal wall reconstruction tympanoplasty for operated ears2002

    • Author(s)
      Sasaki Y, Iino Y, et al.
    • Journal Title

      Acta Ctolaryngol 122

      Pages: 249-254

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Clinical characteristics of so called eosinophilic otitis media.2002

    • Author(s)
      Nagamine H, Iino Y, Kojima C, Miyazawa T, Iida T.
    • Journal Title

      Auris Nasus Larynx 29

      Pages: 19-28

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Comparison of duration of deafness and tumour invation to the inner ear from metastatic tumours of the internal auditory canal : human temporal bone pathology.2002

    • Author(s)
      Nishimura S, Kaga K, Tsuzuku T, Iino Y
    • Journal Title

      J Laryngol Otol 116

      Pages: 256-260

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Posterior canal wall reconstruction tympanoplasty for operated ears with open mastoid.2002

    • Author(s)
      Sasaki Y, Iino Y, Suzuki J
    • Journal Title

      Acta Otolaryngol 122

      Pages: 249-254

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Degeneration of type II collagen in the inner ear with relapsing polychondritis.

    • Author(s)
      Miyazawa T, Iino Y, Nakamoto Y, Ishii T, Murakami Y.
    • Journal Title

      Otolaryngol Head Neck Surg (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 飯野ゆき子, 他: "好酸球性中耳炎の中耳粘膜における好酸球遊走因子の発現"耳鼻咽喉科免疫アレルギー. 21巻・2号. 28-29 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takahashi K, Iino Y, et al.: "Temporal bone histopathology and quantitative analysis of mitochondrial DNA in MELAS"Laryngoscope. 113. 1362-1368 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Iino Y, et al.: "Nasopharyngeal flora and drug susceptibility in children with macrolide therapy"Larngoscope. 113. 1780-1785 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kakizaki K, Iino Y, et al.: "Acoustic trauma : temporal bone study"Otol Neurotol. 24・6. 965-966 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 飯野ゆき子他: "鼻茸における好酸球遊走因子エカレクチンの発現"耳鼻咽喉科免疫アレルギー. 20(2). 56-57 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nagamine H., Iino Y., et al.: "Clinical Characteristics of so called eosinophilic otitis media"Auris Nasus Larynx. 29. 19-28 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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