| Project/Area Number |
14571652
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
YOSHIDA Akitoshi Asahikawa Medical College, Department of Ophthalmology, Professor, 医学部, 教授 (70125417)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Fumihiko Asahikawa Medical College, Department of Ophthalmology, Assistant Professor, 医学部, 講師 (90322916)
HIKICHI Taiichi Asahikawa Medical College, Department of Ophthalmology, Assistant Professor, 医学部, 講師 (50198983)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2002: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | Diabetes / losrtan / AT II receptor antagonist / SLO / OCT / Choroidal circulation |
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| Research Abstract |
Background : The effectiveness of losartan for the treatment of leukocyte entrapment in the retinal microcirculation of diabetic rats was evaluated quantitatively.
Methods : After diabetes was induced by injection of streptozotocin(STZ), the rats were divided into two subgroups. The first subgroup(n=6), received no medications ; the second subgroup(n=6) was given fresh drinking water supplemented with losartan(5mg/kg/day) for 4 weeks. Six rats that were not injected with STZ or given medications served as controls. 4 weeks after intervention leukocyte dynamics in the retina were observed using acridme orange digital fluorography. Leukocyte entrapment in the retina was compared among the three groups.
Results : In the untreated diabetic rats, the number of trapped leukocytes(6.1(SD1.4)cells/mm2) increased significantly compared with control rats(2.8(1.2) cells/mm2;p=0.005) and diabetic rats treated with losartan(3.1(0.9)cells/mm2;p=0.0002).
Conclusions : Losartan, an AT1 angiotensin II receptor antagonist, inhibited increased leukocyte entrapment in the diabetic retina. The authors demonstrated that losartan may have therapeutic efficacy in preventing development of diabetic retinopathy. Futher clinical studies of the effect of the angiotensin receptor antagonist on preventin development of diabetic retinopathy are needed.
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