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Effect of several drugs on disruption of blood-aqueous barrier

Research Project

Project/Area Number 14571661
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionUniversity of Toyama (2005)
Toyama Medical and Pharmaceutical University (2002-2004)

Principal Investigator

HAYASAKA Seiji  Univ of Toyama, Dept Ophthalmology, Professor, 医学部, 教授 (00004961)

Co-Investigator(Kenkyū-buntansha) ZHANG Xue-Yun  Univ of Toyama, Dept Ophthalmology, Assistant, 医学部, 助手 (40324040)
HAYASAKA Yoriko  Univ of Toyama, Dept Ophthalmology, Assistant, 医学部, 助手 (90334739)
Project Period (FY) 2002 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2005: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2004: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2003: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywordsblood-aqueous barrier / aqueous flare / aqueous proteir / uvitis / corticosteroid / NSAID / cyclooxygenase / betaxolol / S100A8 / S100A9 / N-アセチル-システイン / ロリプラム / COX-1 / COX-2 / レーザー虹彩切開術 / 抗緑内障薬 / 抗炎症薬 / エピネフリン / 非ステロイド剤
Research Abstract

Disruption of blood-aqueous barrier elevates protein and flare in the anterior chamber. PGE2,PGE2 receptor antagonist, and isopropyl unoprostone (PG-related antiglaucoma agent) disrupted the blood -aqueous barrier in pigmented rabbits. Betaxolol (antiglaucoma agent having calcium blocking activity), apraclonidine (α 2 agonist), epinephrine (β 2 antagonist), diviyefrin (β 2 antagonist), betamethasone (corticosteroid), fluorometholone (corticosteroid), diclofenac (non-steroidal anti-inflammatory drug), pranoprofen (non-steroidal anti-inflammatory drug), baicalein (a component isolated from medicinal herb), baicalin (a component isolated from medicinal herb), tramazoline (vasoconstructor), FR122047 (COX-1 inhibitor), and FR188582(COX-2 inhibitor) suppressed PGE2-induced aqueous, flare elevation in pigmented rabbits. Postoperative aqueous flare elevation was inhibited by Kakkon-to in cataract patients or by betaxolol in glaucoma patients. It is possible that these agents may be useful in treatment for uveitis.

Report

(5 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (29 results)

All 2004 2003 2002 Other

All Journal Article (21 results) Publications (8 results)

  • [Journal Article] Effects of rolipram, a selective inhibitor of type 4 phosphodiesterase, on lipopolysaccharide-induced uveitis in rats2004

    • Author(s)
      Z.L.Chi, S.Hayasaka, X.Y.Zhang, Y.Hayasaka, H.S.Cui
    • Journal Title

      Investigative Ophthalmology and Visual Science 45

      Pages: 2497-2502

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of topical botaxolol on acute elevation of aqueous flare after argon laser iridotomy2004

    • Author(s)
      Y.Hayasaka, S.Hayasaka, Y.Nagaki, X.Y.Zhang
    • Journal Title

      Annals of Ophthalmology 36

      Pages: 98-102

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Elects of Intravenous administration of FR122047 (a selective cyclooxygenase-1 inhibitor) and FR188582 (a selective cyclooxysenase-2 inhibitor) on prostaglandin E2-induced aqueous flare elevation in pigmented rabbits2004

    • Author(s)
      T.Abe, T.Hayasaka, X.Y.Zhang, S.Hayasaka
    • Journal Title

      Ophthalmic Research 36

      Pages: 321-326

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of rolipram, a selective inhibitor of type 4 phosphodiesterase, on lipopolysaccharide-induced uveitis in rats.2004

    • Author(s)
      Z.L.Chi, S.Hayasaka, X.Y.Zhang, Y.Hayasaka, H.S.Cui
    • Journal Title

      Investigative Ophthalmology and Visual Science 45

      Pages: 2497-2502

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effects of topical betaxolol on acute elevation of aqueous flare after argon laser iridotomy.2004

    • Author(s)
      Y.Hayasaka, S.Hayasaka, Y.Nagaki, X.Y.Zhang
    • Journal Title

      Annals of Ophthalmology 36

      Pages: 98-102

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effects of intravenous administration of FR122047(a selective cyclooxygenase-1 inhibitor) and FR188582(a selective cyclooxygenase-2 inhibitor) on prostaglandin E2-induced aqueous flare elevation in pigmented rabbits.2004

    • Author(s)
      T.Abe, Y.Hayasaka, Z.Y.Zhang, S.Hayasaka
    • Journal Title

      Ophthalmic Research 36

      Pages: 321-326

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effects of topical instillation of traditional herbal medicines, herbal extracts, and their components on prostaglandin E2-induced aqueous flare elevation in pigmented rabbits2003

    • Author(s)
      Y.Nagaki, S.Hayasaka, X.Y.Zhang, Y.Hayasaka, N.Nakanura, K.Terasawa
    • Journal Title

      Japanese Journal of Ophthalmology 47

      Pages: 249-254

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of topical mydriatics and vasoconstrictors on prostaglandin E2-induced aqueous flare elevation in pigmented rabbits2003

    • Author(s)
      Y.Hayasaka, S.Hayasaka, X.Y.Zhang, Y.Nagaki
    • Journal Title

      Ophthalmic Research 35

      Pages: 256-260

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of topical corticosteroids and nonsteroidal anti-inflammatory drugs on prostaglandin E2-induced aqueous flare elevation in pigmented rabbits2003

    • Author(s)
      Y.Hayasaka, S.Hayasaka, X.Y.Zhang, Y.Nagaki
    • Journal Title

      Ophthalmic Research 35

      Pages: 341-344

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of oral administration of Gardeniae fructus extract and intravenous injection of crocetin on lipopolysaccharide-and prostaglandin E2-induced elevation of aqueous flare in pigmented rabbits2003

    • Author(s)
      Y.Nagaki, S.Hayasaka, T.Abe, X.Y.Zhang, Y.Hayasaka, K.Terasawa
    • Journal Title

      American Journal of Chinese Medicine 31

      Pages: 729-738

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of topical instillation of traditional herbal medicines, herbal extracts, and their components on prostaglandin E2-induced aqueous flare elevation in pigmented rabbits2003

    • Author(s)
      Y.Nagaki, S.Hayasaka, X.Y.Zhang, Y.Hayasaka, N.Nakamura, K.Terasawa
    • Journal Title

      Japanese Journal of Ophthalmology 47

      Pages: 249-254

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of topical betaxolol on acute rise of aqueous flare induced by highly selective agonists for prostaglandin E2 receptor subtypes in pigmented rabbits2002

    • Author(s)
      S.Yanagisawa, S.Hayasaka, X.Y.Zhang, Y.Hayasaka, K.Kitagawa
    • Journal Title

      Ophthalmic Research 34

      Pages: 48-50

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of isopropyl unoprostone, latanoprost, and prostaglandin E2 on acute elevation of aqueous flare in pigmented rabbits2002

    • Author(s)
      Y.Zhang, S.Hayasaka, Y.Hayasaka, S.Yanagisawa, Y.Nagaki
    • Journal Title

      Ophthalmic Research 34

      Pages: 90-93

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of topical antiglaucoma eyedrops on prostaglandin E2-induced aqueous flare elevation in pigmented rabbits2002

    • Author(s)
      Y.Hayasaka, S.Hayasaka, S.Hayasaka, Y.Nagaki
    • Journal Title

      Investigative Ophthalmology and Visual Science 43

      Pages: 1142-1145

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Efects of topical anti-inflammatory and antiallergic eyedrops on prostaglandin E2-induced aqueous flare elevation in pigmented rabbits2002

    • Author(s)
      Y.Hayasaka, S.Hayasaka, S.Hayasaka, Y.Nagaki
    • Journal Title

      Archives of Ophthalmology 120

      Pages: 950-953

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of Kakkon-to and Sairei-to, traditional of herbal medicines, on aqueous flare elevation after surgery complicated cataract2002

    • Author(s)
      N.Ikeda, S.Hayasaka, Y.Nagaki, Y.Hayasaka, C.Kadoi, M.Matsumoto
    • Journal Title

      American Journal of Chinese Medicine 30

      Pages: 347-353

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of Orengedoku-to and Scutellariae radix extract on aqueous flare elevation induced by intravitreal interleukin-1 alpha in pigmented rabbits2002

    • Author(s)
      N.Nakamura, Y.Nagaki, S.Hayasaka, K.Terasawa
    • Journal Title

      American Journal of Chinese Medicine 30

      Pages: 543-550

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of isopropyl unoprostone, latanoprost, and prostaglandin E2 on acute elevation of aqueous flare in pigmented rabbits2002

    • Author(s)
      X.Y.Zhang, S.Hayasaka, Y.Hayasaka, S.Yanagisawa, Y.Nagaki
    • Journal Title

      Ophthalmic Research 34

      Pages: 90-93

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of topical antiglaucoma eyedrops on prostaglandin E2-induced aqueous flare elevation in pigmented rabbits2002

    • Author(s)
      Y.Hayasaka, S.Hayasaka, X.Y.Zhang, Y.Nagaki
    • Journal Title

      Investigative Ophthalmology and Visual Science 43

      Pages: 1142-1145

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of topical anti-inflammatory and antiallergic eyedrops on prostaglandin E2-induced aqueous flare elevation in pigmented rabbits2002

    • Author(s)
      Y.Hayasaka, S.Hayasaka, X.Y.Zhang, Y.Nagaki
    • Journal Title

      Archives of Ophthalmology 120

      Pages: 950-953

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of Kakkon-to and Sairei-to, traditional herbal medicines, on aqueous flare elevation after surgery of complicated cataract2002

    • Author(s)
      N.Ikeda, S.Hayasaka, Y.Nagaki, Y.Hayasaka, C.Kadoi, M.Matsumoto
    • Journal Title

      American Journal of Chinese Medicine 30

      Pages: 347-353

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Publications] N.Nakamura, S.Hayasaka, X.Y.Zhang, Y.Nagaki, M.Matsumoto, Y.Hayasaka, K.Terasawa: "Effects of topical instillation of traditional herbal medicines, herbal extracts, and their components on prostaglanmdin E2-induced aqueous flare elevation in pigmented rabbits"Japanese Journal of Ophthalmology. 47. 249-254 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Hayasaka, S.Hayasaka, X.Y.Zhang, Y.Nagaki: "Effects of topical mydriatics and vasoconstrictors on prostaglandin E2-induoed aqueous flare elevation In pigmented rabbits"Ophthalmic Research. 35. 256-260 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Y.Hayasaka, S.Hayasaka, X.Y.Zhang, Y.Nagaki: "Effects of topical corticosteroids and nonsteroidal anti-inflammatory drugs on prostaglandin E2-induced aqueous flare elevation in pigmented rabbits"Ophthalmic Research. 35. 341-344 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] S.Yanagisawa, S.Hayasaka, X.Y.Zhang, Y.Hayasaka, K.Kitagawa: "Effect of topical betaxolol on acute rise of aqueous flare induced by highly selective agonists for prostaglandin E2 receptor subtypes in pigmented rabbits"Ophthalmic Research. 34. 48-50 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] X.Y.Zhang, S.Hayasaka, Y.Hayasaka, S.Yanagisawa, Y.Nagaki: "Effects of isopropyl unoprostone, latanoprost, and prostaglandin E2 on acute elevation of aqueous flare in pigmented rabbits"Ophthalmic Research. 34. 90-93 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Hayasaka, S.Hayasaka, X.Y.Zhang, Y.Nagaki: "Effects of topical antiglaucoma eyedrops on prostaglandin E2-induced aqueous flare elevation in pigmented rabbits"Investigative Ophthalmology and Visual Science. 43. 1142-1145 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Hayasaka, S.Harasaka, X.Y.Zhang, Y.Nagaki: "Effects of topical anti-inflammatory and antiallergic eyedrops on prostaglandin E2-induced aqueous flare elevation in pigmented rabbits"Archives of Ophthalmology. 120. 950-953 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] S.Yanagisawa, S.Hayasaka, X.Y.Zhang, Y.Hayasaka, Y.Nagaki: "Effects of topical iganidipine on experimental elevation on aqueous flare induced by rostaglandin E2 and EP agonists in pigmented rabbits"Ophthalmic Research. 34. 195-199 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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