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Prevention of Blindness caused by High Myopia

Research Project

Project/Area Number 14571670
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionOSAKA UNIVERSITY

Principal Investigator

FUJIKADO Tokashi  Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (50243233)

Co-Investigator(Kenkyū-buntansha) IKUNO Yasushi  Osaka University, Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (50294096)
NISHIDA Kohji  Osaka University, Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (40244610)
MAEDA Naoyuki  Osaka University, Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (00273623)
OKADA Masaki  Osaka University, Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (90344457)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2003: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2002: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsHigh Myopia / Candidate Gene Approach / MMP Inhibitor / Macular Translocation Surgery / Reading Ability / Nuclear Cataract / Spherical Aberration / 球面収差 / 実験近視 / 経角膜電気刺激 / 単眼三重視
Research Abstract

1) Molecular Genetics of High-Myopia: Blood samples of 70 patients with high myopia (>-6D) and have family history of myopia were investigated. Positional candidate gene approach was undertaken against chromosome 18q and found a candidate gene, Titin. However, segregation study was incomplete and it was not verified as a meaningful mutation for high myopia.
2) The Effect of Matrix Metalloproteinase (MMP) inhibitor on Experimental Myopia: The solution of MMP2 inhibitor, N-biphenyl sulfonylphenylalanine hydroxiamic acid(BPHA) and MMP3 inhibitor, Anecortave acetate were applied in retrobulbar space before occlusion on chicks 6 days after hatching. Seven days after occlusion, ocular refraction of occluded eyes was compared with that of fellow untreated eyes. The results were that neither BPHA nor Anecortave' acetate prevented the axial elongation, suggesting that local MMP inhibitor treatment is not effective to prevent axial myopia.
3) Visual Function of High Myopia. Reading ability was investigated in high myopic eyes treated with macular translocation surgery. Both the reading speed and the critical print size improved after surgery, suggesting that macular translocation surgery is effective to improve reading ability in eyes with myopic neovascularization. The wavefront analysis of high-myopic eyes with nuclear cataract showed the increase of negative spherical aberration, showing visual degradation in high myopia with nuclear cataract.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] Takashi Fujikado: "Reading ability after foveal translocation surgery with 360° retinotomy."Am.J.Ophthalmol. 134. 849-856 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sayuri Ninomiya: "Ocular aberrations with static accommodation."Am.J.Ophthalmol. 134. 924-926 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Teruhito Kuroda: "Wavefront analysis in eyes with nuclear or cortical cataract."Am.J.Ophthalmol. 134. 1-9 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Teruhito Kuroda: "Wavefront analysis of higher-order aberrations in patients with cataract."J Cataract Refract Surg.. 28(3). 438-444 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takashi Fujikado: "Effect of Simultaneous Oblique Muscle Surgery in Foveal Translocation by 360° Retinotomy."Graefe's Arch Clin ExpOphthalmol. 240. 21-30 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fujikado T: "Wavefront analysis of monocular triplopia in the eye of nuclear cataract"Am J Ophthalmol. 037. 361-363 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ninomiya S, Fujikado T, Kuroda T, Maeda N, Tano Y, Oshika T, Hirohara Y, Mihashi T.: "Wavefront analysis in eyes with accommodative spasmus."AmJ Ophthalmol. 136. 1161-1163 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fujikado T, Kuroda T, Maeda N, Kim A, Tano Y, Oshika T, Hirohara Y, Mihashi T.: "Wavefront analysis of monocular triplopia in the eye of nuclear cataract."AmJ Ophthalmol. 137. 361-363 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ikuno Y, Sayanagi K, Oshima T, Gomi F, Kusaka S, Kamei M, Ohji M, Fujikado T, Tano Y.: "Optical coherence tomographic findings of macular holes and retinal detachment after vitrectomy in highly myopic eyes."AmJ Ophthalmol. 136. 477-481 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ninomiya S, Fujikado T, Kuroda T, Maeda N, Tano Y, Oshika T, Hirohara Y, Mihashi T.: "Chang~s of ocular aberration with accommodation."AmJ Ophthalmol. 134. 924-926 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fujikado T, Asonuma S, Ohji, M, Kusaka, S, Hayashi A, Kamei M, Oda K, Tano Y.: "Reading ability after foveal translocat ion surgery with 360°retinotomy."Am.J.Ophthalmol. 134. 849-856 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kuroda T, Fujikado T, Maeda N, Oshika T, Hirohara Y, Mihashi T: "Wavefront analysis in eyes with nuclear or cortical cataract."AmJ Ophthalmol. 134(1). 1-9 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fujikado T, Shimojyo H, Hosohata J, Tsujikawa K, Fukui T, Ohji M, Tano Y.: "Effect of Simultaneous Oblique Muscle Surgery in Foveal Translocation by 360°Retinotomy."Grafe's Arch Clin Exp Ophthalmol. 240. 21-30 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kuroda T, Fujikado T, Maeda N, Oshika T, Hirohara Y, Mihashi T: "Wavefront analysis of higher order aberrations in patients with cataracts."J Cat Ref Surg.. 28. 438-444 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ninomiya S, Maeda N, Kurocla T, Fujikado T, Tno Y: "Comparison of ocular higher-order aberrations and visual performance between photorefractive keratectomy and laser in situ keratomileusis for myopia."Semin Ophthalmol. 34. 18-29 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fujikado T: "The problems and treatment of High Myopia."Ganka Gakkaishi. 106. 381-382 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fujikado T, et al.: "Wavefront analysis of monocular triplopia in the eye of nuclear cataract"Am J Ophthalmol. 137. 361-363 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Fujikado T, et al.: "Light Scattering and Optical Aberrations as Objective Parameters to Predict Visual Deterioration in Eyes with Cataracts"J Cat Ref Surg. (in press).

    • Related Report
      2003 Annual Research Report
  • [Publications] Sawa M, Fujikado T, et al.: "Successful photodynamic therapy with verteporfin for recurrent choroidal neovascularization beneath the new fovea after macular translocation surgery with 360-degree retinotomy"Am J Ophthalmol. 136. 560-563 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ikuno Y, Fujikado T, et al.: "Optical coherence tomographic findings of macular holes and retinal detachment after vitrectomy in highly myopic eyes"Am J Ophthalmol. 136. 477-781 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sayanagi K, Fujikado T, et al.: "Chediak-Higashi syndrome with progressive visual loss"Jpn J Ophthalmol. 47. 304-306 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ninomiya S, Fujikado T, et al.: "Changes of ocular aberration with accommodation"Am J Ophthalmol. 134. 924-926 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takashi Fujikado: "Reading ability after foveal translocation surgery with 360° retinotomy"Am. J. Ophthalmol. 134. 849-856 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sayuri Ninomiya: "Ocular aberrations with static accommodation"Am. J. Ophthalmol. 134. 924-926 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Teruhito Kuroda: "Wavefront analysis in eyes with nuclea or cortical cataract"Am. J. Ophthalmol. 134. 1-9 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Teruhito Kuroda: "Wavefront analysis of higher-order aberrations in patients with cataract"J Cataract Refract Surg.. 28(3). 438-444 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takashi Fujikado: "Effect of Simultaneous Oblique Muscle Surgery in Foveal Translocation by 360° Retinotomy"Graefe's Arch Clin ExpOphthalmol. 240. 21-30 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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