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Measurement of impedance in vivo in eye lids-development of examination of malignant lid tumors

Research Project

Project/Area Number 14571675
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionKochi University

Principal Investigator

FUKUSHIMA Atsuki (2004)  Kochi Universty, medical dwpartment associate, professor, 医学部, 助教授 (40281737)

渡邊 牧夫 (2002-2003)  高知大学, 医学部, 助教授 (00220921)

Co-Investigator(Kenkyū-buntansha) 安藤 元紀  高知大学, 医学部附属病院, 助手 (20222789)
福島 敦樹  高知大学, 医学部附属病院, 助手 (40281737)
Project Period (FY) 2002 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2004: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2003: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2002: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywordsimpedance / in vivo / cornea / lid tumor / bullous keratopathy / 生体インピーダンス / 誘電挙動
Research Abstract

Dr.Makio Watanabe (head investigator,2002,2003) has investigated measurement of impedance in many types of cells and tissues, and has demonstrated that measurement of impedance in vitro in ocular cells and tissues was possible. Next, he succeeded to measure impedance in vivo of cornea of experimental animals. However, it has not been examined to measure corneal impedance in vivo in humans. Therefore, in this study, we aimed to measure impedance in vivo of ocular tissues in humans. First, after obtaining approval of Kochi Medical School Ethical Committee, we tried to measure corneal impedance in vivo in humans, including healthy volunteers and patients with bullous keratopathy. By using the surface electrode and the impedance analyzer 4194A (Hewlett-Packard) under the control of personal computer, impedance of cornea was measured from 10 KHz to 100 MHz. Data demonstrated that the ratio of the dispersions between low frequency and high frequency differed between healthy volunteers and patients with bullous keratopathy. The ratio was around 1.5 in healthy volunteers, while about 0.5 in patients with bullous keratopathy. Furthermore, we found the trend that a correlation existed between the ratio and the number of corneal endothelial cells. Next, we tried to measure impedance of patients with lid tumor. However, although repeated improvements of the surface electrode, we were not able to measure impedance in vivo of patients with lid tumor.

Report

(4 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (4 results)

All 2005 2004

All Journal Article (4 results)

  • [Journal Article] インピーダンス法による角膜内皮機能検査2005

    • Author(s)
      渡邊牧夫 他
    • Journal Title

      第109回日本眼科学会抄録集

      Pages: 172-172

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Examination of corneal endothelial function by using impedance method2005

    • Author(s)
      Makio Watanabe et al.
    • Journal Title

      The 109^<th> Annual meeting of Japanese Ophthalmological Society

      Pages: 172-172

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] インピーダンス測定による角膜内皮機能検査2004

    • Author(s)
      渡邊牧夫 他
    • Journal Title

      第58回日本臨床眼科学会抄録集

      Pages: 115-115

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Evaluation of corneal endothelial function by measurement of impedance2004

    • Author(s)
      Makio Watanabe et al.
    • Journal Title

      The 58^<th> Congress of Clinical Ophthalmology of Japan

      Pages: 115-115

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary

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Published: 2002-04-01   Modified: 2016-04-21  

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