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THERAPY FOR MACULAR EDEMA AND RETINAL DETACHMENT BY USING WATER CHANNEL PROTEIN AQUAPORIN.

Research Project

Project/Area Number 14571678
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionNagasaki University

Principal Investigator

KITAOKA Takashi  Nagasaki University, GRADUATE SCHOOL OF BIOMEDICAL SCIENCES, Assistant Professor, 大学院・医歯薬学総合研究科, 教授 (80234235)

Co-Investigator(Kenkyū-buntansha) OGAWA Tsukihiko  Nagasaki University, GRADUATE SCHOOL OF BIOMEDICAL SCIENCES, Associate Professor, 大学院・医歯薬学総合研究科, 助教授 (50346962)
MIYAMURA Noritake  Nagasaki University, Hospital, Assistant Professor, 医学部・歯学部附属病院, 講師 (20343345)
雨宮 次生  長崎大学, 大学院・医歯薬学総合研究科, 教授 (60026862)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2002: ¥2,400,000 (Direct Cost: ¥2,400,000)
KeywordsAquaporin / retina / macula / internal limiting membrane / diabetes mellitus / vitrectomy / analysis / electron microscopy / 黄斑部 / 内境界膜 / 黄斑円孔 / 黄斑浮腫 / 免疫組織化 / ミュラー細胞
Research Abstract

Aquaporin (AQP) is a water channel protein which has been preserved through animals, plants, and microorganelles. In ophthalmological field, the eye and AQP have important relationship,such as that AQP exists in ciliary body, and that AQP 4 and 5 are related to the production and secretion of tear film. It was also reported that AQP 4 exists in the plasma membrane of Mueller cells. We reported that AQP exists in the internal limiting membrane which excised during vitrectomy. We discovered that AQP is more expressed in the internal limiting membrane of diabetic patient than that of non-diabetic patient. This may indicate that AQP is increasing to absorb edema or that AOP increase edema.
On the other hand, it is well known that visual field defect occur after vitrectomy and we reported that hyperbaric oxygenation therapy decreased this visual field defect. This may indicate the expression of AQP is affected by oxygen. After that, we reported that the wall between vitreous pocket and Cloquet's canal may cause several diseases such as vitreo-retinal traction syndrome and retinal edema by using Triamcinolone acetonide. Finally, we used ion microscope to detect the ion and organic which showed the possibility to observe the distribution of AQP.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Kuroki AM, Kitaoka T.Taniguchi H, Amemiya T.: "Hyperbaric oxygen therapy reduces visual field defect after macular hole surgery."Ophthalmic Surg Lasers. 33. 200-206 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 芦忠陽, 岸川泰宏, 津田恭央, 北岡隆, 雨宮次生: "黄斑部内境界膜の微細構造とその元素分析"臨眼. 57. 281-284 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 北岡隆, 宮村紀毅, 隈上武志, 雨宮次生: "硝子体ポケット・クローケ管の立体関係と網膜硝子体界面症候群における役割の可能性"臨眼. 57. 333-335 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 北岡隆: "特発性黄斑円孔に対する内境界膜切除"あたらしい眼科. 19. 705-708 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kitaoka T, Taniguchi H, Miyamura N, Amemiya T: "Aquaporin expression of internal limiting membrane in diabetic macular edema and idiopathic macular hole cases."Invest Ophthalmol Vis Sci. 44. E-abstract 372 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kuroki AM, Kitaoka T, Taniguchi H, Amemiya T.: "Hyperbaric oxygen therapy reduces visual field defect after macular hole surgery."Opthalmic Surg Lasers. 33. 200-206 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Zong-Yang Lu, Kishikawa Y,.Tsuda Y., Kitaoka T, Amemiya T.: "Macular internal limiting membrane : ultrastructure and trace elements"Rinsho Ganka (Jpn J Clin Ophthalmol). 57(3). 281-284 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kitaoka T, Miyamura N, Kumagami T, Amemiya T.: "Anatomical relationship between witreous pocket and Cloquet's canal and its possible role in vitreoretinal interface syndrome"Rinsho Ganka (Jpn J Clin Ophthalmol). 57(3). 333-335 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kitaoka T.: "Removal of Internal Limiting Membrane for Idiopathic Macular Hole"Atarashii Ganka (J.Eye). 19(6). 705-708 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kitaoka T, Taniguchi H, Miyamura N, Amemiya T.: "Aquaporin expression of internal limiting membrane in diabetic macular edema."Invest Ophthalmol Vis Sci. 44. E-abstract372 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kuroki AM, Kitaoka T, Taniguchi H, Amemiya T: "Hyperbaric oxygen therapy reduces visual field defect after macular hole surgery"Ophthalmic Surg Lasers. 33. 200-206 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] 芦忠陽, 岸川泰宏, 津田恭央, 北岡隆, 雨宮次生: "黄斑部内境界膜の微細構造とその元素分析"臨眼. 57. 281-284 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 北岡隆, 宮村紀毅, 隈上武志, 雨宮次生: "硝子体ポケット・クローケ管の立体関係と網膜硝子体界面症候群における役割の可能性"臨眼. 57. 333-335 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 北岡隆: "特発性黄斑円孔に対する内境界膜切除"あたらしい眼科. 19. 705-708 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kitaoka, Taniguchi N, Miyamura N, Amemiya T: "Aquaporin expression of internal limiting membrane in diabetic macular edema and idiopathic macular hole cases"Invest Ophthalmol Vis Sci. 44. E-abstract 372 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 北岡 隆: "特発性黄斑円孔に対する内境界膜切除"あたらしい眼科. 19. 705-708 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kurok AM, Kitaoka T, Taniguchi H, Amemiya T: "Hyperbaric oxygen therapy reduces visual field defect after macular holesurgery"Ophthalmic Surg Lasers. 33. 200-203 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kitaoka T, Taniguchi H, Miya, ura N,, Amemiya T: "Aquaporin expression of internal limiting membrane in diabetic macular edema and idiopathic macular hole cases"Invest Ophthalmol Vis Sci (Suppl). (in press).

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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