| Project/Area Number |
14571695
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
KANNO Sanae Hyogo College of Medicine, Faculty of Medicine, Assistant Professor, 医学部, 講師 (10289069)
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| Co-Investigator(Kenkyū-buntansha) |
OKAMURA Haruki Hyogo College of Medicine, Faculty of Medicine, Professor, 医学部, 教授 (60111043)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2003: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2002: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | herpetic keratitis / Th-1,Th-2 / IFN-γ / IL-18 / mouse / animal / Th1 / Th2バランス |
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| Research Abstract |
Experimental herpetic keratitis is effected by Th-1 and Th-2 balance in cornea. In early stage of keratitis, Th-1 cytokine is dominant, in later Th-2 is dominant.
IL-18 is potential IFN-γ producing factor and modulator of inflammation. We are interested in the function on cornea and herpetic keratitis.
B6 mouse(Th-1 dominant mouse) is heavier inflammation on the cornea. Balb/c mouse(Th-2 dominant) is not serious on the cornea but become encephalitis and die. IL-4,IL-10 and IL-12 is measured in cornea on herpetic keratitis both B6 mouse and Balb/c mouse.
All cytokine in serum is same pattern both B6 mouse and Balb/c mouse on early and later stage of herpetic keratitis, so we concluded no significant chane Th-1/Th-2 balance.
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