Elucidation of mechanism of MCDK and optimal treatment of obstructive uropathy in the Fetal Lamb
| Project/Area Number |
14571709
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | St.Marianna University School of Medicine |
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Principal Investigator |
KITAGAWA Hiroaki St.Marianna Univ., Pediatric Surgery, Associate Professor, 医学部, 助教授 (80153097)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Yuriko St.Marianna Univ., Pediatric Surgery, Lecturer, 医学部, 助手 (80318948)
WAKISAKA Munechika St.Marianna Univ., Pediatric Surgery, Assistant Professor, 医学部, 講師 (30267596)
KOIKE Jyunki St.Marianna Univ., Department of Pathology, Lecturer, 医学部, 助手 (40308440)
KAWASE Hirokazu St.Marianna Univ., Pediatric Surgery, Assistant Professor, 医学部, 講師 (90214650)
NAKADA Koonosuke St.Marianna Univ., Pediatric Surgery, Professor, 医学部, 教授 (70081734)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2002: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | Dysplastic Kidney / Potter Syndrome / Obstructive Uropathy / Ftal Surgery / 水腎症 / 胎児手術 / 多嚢胞性異型性腎(MCDK) / 胎児水腎症 / Potter症候群 |
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| Research Abstract |
Purpose : It is still unclear how urinary tract obstruction alters normal nephrogenesis ad leads to renal dysplasia. We created an obstructive uropathy model in fetal lambs ad reviewed the pathology of the obstructed kidney to determine the optimal timing for decompression of the obstruction.
Methods : A obstructive uropathy was created in fetal lambs at 60 days gestation by ligating the urethra and urachus. They were delivered 20-31 days later by caesarian section. The kidneys were processed for histological examination.
Results : Thirty four 60-day lambs were operated upon. Dysplastic changes were noted in 25 fetuses and 24 fetuses had cysts in the nephrogenic zone. The cystic components in multicystic dysplastic kidneys (MCDK) are mainly in the proximal tubules. Conclusions : In utero urinary tract obstruction causes reduction of numbers of functioning nephrons and produces cysts in the nephrogenic zone, and in the deeper cortex. These cysts and dilated proximal tubules suppress new nephron formation. Twenty days after obstruction there were early features of dysplasia but the nephrogenic zones were still present. We conclude that early shunting may salvage renal function.
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Report
(3 results)
Research Products
(7 results)
