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Properties of the masticatory muscle piimary afferents from the trigeminal ganglion in the rats

Research Project

Project/Area Number 14571731
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionOSAKA UNIVERSITY

Principal Investigator

MORITANI Masayuki  OSAKA UNIV., GRALDUATE SCHOOL OF DENTISTRY, ASSISTANT PROFESSOR, 大学院・歯学研究科, 講師 (80303981)

Co-Investigator(Kenkyū-buntansha) ATSUSHI Ypshida  OSAKA UNIV., GRALDUATE SCHOOL OF DENTISTRY, PROFESSOR, 大学院・歯学研究科, 教授 (90201855)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2003: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2002: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywordstrigeminal nerve / masticatory muscle / sensory / primary afferent nueron / trigeminal ganglion / pain / neuron tracer / neuro-transmitter
Research Abstract

The main findings of this research project are as follows:
(1) Rerogradely labeled muscle afferent neurons were significantly lager and fewer than retrogradely labeled cutaneous afferent neurons. (2) α-D-galactose specific lectin IB4 binding was found in 6% of muscle and 44% of cutaneous afferents indicating a target specific difference. (3) The experiments inducing muscle inflammation by injecting complete Freund's adjuvant (CFA) to masseter muscle indicate that the percentage of trigeminal ganglion muscle afferent neurons immunoreactive for CGRP or SP does not change significantly four days after inflammation. (4) Muscle inflammation resulted in increased number of CGRP and substance P positive trigeminal ganglion muscle afferent neurons 12 days after CFA injection. It is suggested that the increased number of peptidergic neurons following muscle inflammation is recruited equally from trigeminal group III and IV muscle afferents. (5) It is indicated that in trigeminal ganglia, P2X3 receptor is not exclusively expressed in IB4 neurons but includes larger neurons. Target specific differences exist in P2X3 and IB4 expression. Furthermore, it is suggested that deep tissue inflammation can modulate the number of neurons expressing the P2X3 receptor.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Bae, Y.C., et al.: "Synaptic Organization of Tooth Pulp Afferent Terminals in the Rat Trigeminalal Sensory Nuclei."Journal of Comparative Neurology. 463(1). 13-24 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ambalavanar, R., et al.: "Chemical phenotypes of muscle and cutaneous afferent neurons in the rat trigeminal ganglion."Journal of Comparative Neurology. 460(2). 167-179 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Moritani, M., et al.: "Quantitative analysis of the dendritic architectures of single jaw-closing and jaw-opening motoneurons in cats."Experimental Brain Research. 150(3). 265-275 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Zhang, W., et al.: "An involvement of trigeminal mesencephalic neurons in regulation of occlusal vertical dimension in the guinea pig."Journal of Dental Research. 82(7). 565-569 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Moritani M. et al.: "Quantitative analysis of the dendritic architectures of single jaw-closing and jaw-opening motoneurons in cats."Exp Brain Res.. 150(3). 265-275 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Zhang W. et al.: "An involvement of trigeminal mesencephalic neurons in regulation of occlusal vertical dimension in the guinea pig."J Dent Res.. 82(7). 565-569 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Bae YC.et al.: "Synaptic organization of tooth pulp afferent terminals in the rat trigeminal sensory nuclei."J Comp Neurol.. 463(1). 13-24 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ambalavanar R. et al.: "Chemical phenotypes of muscle and cutaneous afferent neurons in the rat trigeminal ganglion."J Comp Neurol.. 460(2). 167-179 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Bae YC.et al.: "Quantitative ultrastructural analysis of glycine-and gamma-aminobutyric acid-immunoreactive terminals on trigeminal alpha-and gamma-motoneuron somata in the rat."J Comp Neurol. 442(2). 308-319 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Bae, Y.C., et al.: "Synaptic Organization of Tooth Pulp Afferent Terminals in the Rat Trigeminal Sensory Nuclei"Journal of Comparative Neurology. 463(1). 13-24 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ambalavanar, R., et al.: "Chemical phenotypes of muscle and cutaneous afferent neurons in the rat trigeminal ganglion"Journal of Comparative Neurology. 460(2). 167-179 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Moritani, M., et al.: "Quantitative analysis of the dendritic architectures of single jaw-closing and jaw-opening motoneurons in cats"Experimental Brain Research. 150(3). 265-275 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Zhang, W., et al.: "An involvement of trigeminal mesencephalic neurons in regulation of occlusal vertical dimension in the guinea pig"Journal of Dental Research. 82(7). 565-569 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Bae, Y.C.: "Synaptic Organization of Tooth Pulp Afferent Terminals in the Rat Trigeminal Sensory Nuclei"Journal of Comparative Neurology. (In press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ambalavanar, R.: "Chemical phenotypes of muscle and cutaneous afferent neurons in the rat trigeminal ganglion"Journal of Comparative Neurology. (In press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Moritani, M.: "Quantitative analysis of the dendritic architectures of single jaw-closing and jaw-opening motoneurons in cats"Experimental Brain Research. (In press). (2003)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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