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Establishment of the new mouse model of Sjogren's syndrome and detection of their autoantigens.

Research Project

Project/Area Number 14571790
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 病態科学系歯学(含放射線系歯学)
Research InstitutionKyushu University

Principal Investigator

OHYAMA Yukiko  Kyushu University, Faculty of Dentistry, Research Associate, 大学院・歯学研究院, 助手 (70294957)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Seiji  Kyushu University, Faculty of Dentistry, Professor, 大学院・歯学研究院, 教授 (60189040)
YOSHIDA Hiroki  Saga University, Faculty of Medicine, Professor, 医学部, 教授 (40260715)
SHIRASUNA Kanemitsu  Kyushu University, Faculty of Dentistry, Professor, 大学院・歯学研究院, 教授 (30093420)
Project Period (FY) 2002 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2004: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2003: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2002: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsSjogren's syndrome / model mouse / autoantigens / 自己免疫疾患 / サイトメガロウイルス
Research Abstract

Sjogren's syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration and ductal destruction in salivary glands (SG) and lacrimal glands (LG). Its cause remains unknown although viral infection has been implicated to play an initiating role. NZM2328 mice, which are murine model of SLE, were inoculated intraperitoneally with MCMV and induced sialoadenitis at 100 days after inoculation despite the absence of detectable MCMV. Histological findings and the production of autoantibodies against Ro60, Ro52 and La were similar to SS. Anti-SG and anti-LG ductal antibodies were also detected and autoantibodies against exocrine glands were detected from their sera. 67kDa of proteins, which were DNAK type molecular chaperone and cytokeratin, were the candidates of one of the autoantigens. These results indicate that acute inflammation by MCMV infection trigger chronic sialoadenitis in autoimmune-prone mice with female predominance, establishing a new model useful to study the pathogenesis of SS regarding the initiation of autoimmunity by common pathogens and to find out their autoantigens are useful to treatment for the patients with SS.

Report

(4 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (8 results)

All 2005 2004 2003

All Journal Article (8 results)

  • [Journal Article] Evidence for multiple shared antigenic determinants within Ro60 and other lupus-related ribonucleoprotein autoantigens in human autoimmune responses.2005

    • Author(s)
      Pal R Pal R et al.
    • Journal Title

      J Immunol 175(11)

      Pages: 7669-77

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Multiple sialolithiasis in the parotid gland with Sjogren's syndrome and its sonographic findings--report of 3 cases.2005

    • Author(s)
      Shimizu M et al.
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod 99(1)

      Pages: 85-92

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Evidence for multiple shared antigenic determinants within Ro60 and other lupus-related ribonucleoprotein autoantigens in human autoimmune responses.2005

    • Author(s)
      R.Pal et al.
    • Journal Title

      J Immunol 175(11)

      Pages: 7669-7677

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Multiple sialolithiasis in the parotid gland with Sjogren's syndrome and its sonographic findings--report of 3 cases.2005

    • Author(s)
      M.Shimizu, et al.
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 99(1)

      Pages: 85-92

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] T-cell receptor Vbeta gene usage by T cells reactive with the tumor-rejection antigen SART-1 in oral squamous cell carcinoma.2004

    • Author(s)
      Kumamaru W et al.
    • Journal Title

      Int J Cancer 108(5)

      Pages: 686-95

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] T-cell receptor Vbeta gene usage by T cells reactive with the tumor-rejection antigen SART-1 in oral squamous cell carcinoma.2004

    • Author(s)
      W.Kumamaru et al.
    • Journal Title

      Int J Cancer. 108(5)

      Pages: 686-695

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Accumulation of oligoclonal T cells in the infiltrating lymphocytes in oral lichen planus.2003

    • Author(s)
      Kawamura E et al.
    • Journal Title

      J Oral Pathol Med 32(5)

      Pages: 282-9

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Accumulation of oligoclonal T cells in the infiltrating lymphocytes in oral lichen planus.2003

    • Author(s)
      E.Kawamura et al.
    • Journal Title

      J Oral Pathol Med. 32(5)

      Pages: 282-289

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary

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Published: 2002-04-01   Modified: 2016-04-21  

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