| Project/Area Number |
14571793
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
病態科学系歯学(含放射線系歯学)
|
|---|
| Research Institution | Nagasaki University |
|---|
Principal Investigator |
SUMI Misa Nagasaki University, HOSPITAL OF MEDICINE AND DENTISTRY, Assistant Professor, 医学部・歯学部附属病院, 講師 (90284702)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKAGI Yukinori Nagasaki University, Graduate School of Biochemical Sciences, Instructor, 大学院・医歯薬学総合研究科, 助手 (30295084)
YONETSU Koichi Nagasaki University, Graduate School of Biochemical Sciences, Associate Professor, 大学院・医歯薬学総合研究科, 助教授 (70167039)
NAKAMURA Takashi Nagasaki University, Graduate School of Biochemical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 (30172406)
KATAYAMA Ikuo NAGASAKI UNIVERSITY HOSPITAL OF MEDICINE AND DENTISTRY, Instructor, 医学部・歯学部附属病院, 助手 (80295089)
SATO Eida Nagasaki University, Graduate School of Biochemical Sciences, Instructor, 大学院・医歯薬学総合研究科, 助手 (80325662)
|
|---|
| Project Period (FY) |
2002 – 2003
|
| Project Status |
Completed (Fiscal Year 2003)
|
| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2002: ¥2,500,000 (Direct Cost: ¥2,500,000)
|
|---|
| Keywords | diffusion-weighted MR imaging / ADC / cervical lymphadenopathy / metastatic lymph node / lymphoma |
|---|
| Research Abstract |
We determined the apparent diffusion coefficients (ADCs) of 1) normal and dysfunctional salivary glands, and 2) cervical lymphadenopathy using diffusion-weighted echo planar MR imaging. The ADC was calculated using two b-factors (=500 and 1,000 sec/mm^2). Results. 1) The ADC was lower in the parotid glands than that of the submandibular glands. The ADC was increased in sialoadenitis, whereas it descreased with abscess formation. The ADCs of parotid glands in patients with Sjogren's syndrome correlated with the salivary flow rates and the severity of gland damage as assessed on T1WI. 2) The ADC was significantly greater in metastatic lymph nodes than in benign lymphadenopathy. Nodal lymphomas showed even lower levels of the apparent diffusion coefficient. We also showed that metastatic nodes from highly or moderately differentiated cancers were associated with a significantly greater apparent diffusion coefficient than those from poorly differentiated cancers. Conculusion : These findings suggest that diffusion-weighted imaging is useful in revealing diseased states of the salivary glands and discriminating metastatic nodes.
|
