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Elucidation of the role of fractalkine in chronic inflammatory diseases -An approach for its clinical application

Research Project

Project/Area Number 14571807
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 病態科学系歯学(含放射線系歯学)
Research InstitutionOsaka Dental University

Principal Investigator

NAGANO Yutaka  Osaka Dental University, Assistant Professor, 歯学部, 講師 (80228048)

Co-Investigator(Kenkyū-buntansha) UMEHARA Hisanori  Kyoto University, Associate Professor, 医学部, 助教授 (70247881)
DOMAE Naochika  Osaka Dental University, Professor, 歯学部, 教授 (60115889)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2002: ¥1,600,000 (Direct Cost: ¥1,600,000)
KeywordsFractalkine / Atherosclerosis / Periodontitis / Macrophage / Endothelial Cell / Chronic Inflammation / 内皮細胞
Research Abstract

Fractalkine is a chemokine that recruits monocytes or T lymphocytes to the site of inflammation. Since these are major types of cells seen in chronic inflammatory diseases, in this study, we investigated the distribution of fractalkine in two different types of chronic inflammatory diseases : atherosclerosis and periodontitis, and tried to elucidate its function during development of these lesions.
Fractalkine was not identified either normal aortic tissue or early stage of atherosclerotic lesion obtained from apo E knockout mice. Unexpectedly, fractalkine was not identified in endothelial layer of atheromatous lesion of aorta, either. However, it distributed in deeper layer of advanced atheromatous plaque of apo E knockout mice. CX_3CR1, a receptor for fractalkine, was also identified in advanced lesion, and its distribution was similar to that of fractalkine.
When human gingival tissue was investigated, fractalkine was identified in inflammatory gingiva. In addition, fractalkine was also expressed in gingiva without apparent periodontitis, although less strongly than that seen in periodontitis. Fractalkine distributed mostly in vascular endothelial layer of gingiva.
Thus, protein expression of fractalkine was confirmed in two different chronic inflammatory diseases. Together with its unexpected tissue distribution, the results suggest that fractalkine is involved not only in initiation but also in development of chronic inflammatory diseases.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] Tatematsu M, et al.: "Preoperative assessment scale for elderly Japanese patients (part I): basic study design and clinical trial"Geriatr Gerontol Internat. 2. 36-39 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nagano Y, et al.: "Molecules that regulate maturation of osteoclasts are expressed in atheromatous plaque."Atherosclerosis Supplements. 4(2). 322-322 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 長野 豊: "低HDLコレステロール血症"The Lipid. 14(2). 19-24 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Umehara H, et al.: "Fractalkine in vascular biology. -from basic research to clinical disease."Arterioscler thromb Vasc Biol. 24(1). 34-40 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 堂前 尚親, 他編: "歯科のための内科学 第2版 (第9章 代謝・栄養疾患)"南江堂. 403 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tatematsu M et al.: "Preoperative assessment scale for elderly Japanese patients (part I) : basic study design and clinical trial."Geriatr Gerontol Internat. 2. 36-39 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nagano Y et al.: "Molecules that regulate maturation of osteoclasts are expressed in atheromatous plaque."Atherosclerosis Supplements. 4(4). 322-322 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nagano Y.: "Hypo-HDLcholesterolemia."The Lipid. 14(2). 19-24 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Umehara H et al.: "Fractalkine in vascular biology. -from basic research to clinical disease."Arterioscler Thromb Vasc Biol. 24(1). 34-40 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nagano Y et al.: "Molecules that regulate maturation of osteoclasts are expressed in atheromatous plaque."Atherosclerosis Supplements. 4(2). 322-322 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoneda O et al.: "Membrane-bound form of fractalkine induces IFN-gamma production by NK cells."Eur J Immunol. 33(1). 53-58 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yakushiji K et al.: "Characterization of C2-ceramide-resistant HL-60 subline (HL-CR) : Involvement of PKC delta in C2-ceramide resistanve."Exp Cell Res. 286(2). 396-402 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 長野 豊: "低HDLコレステロール血症"The Lipid. 14(2). 19-24 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Iwai K et al.: "Ceramide increases oxidative damage due to inhibition of catalase by caspase-3-dependent proteolysis in HL-60 cell apoptosis."The Journal of Biological Chemistry. 278(11). 9813-9822 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Umehara H et al.: "Fractalkine in vascular biology. -from basic research to clinical disease."Arterioscler Thromb Vasc Biol. 24(1). 34-40 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 堂前 尚親 他 編: "歯科のための内科学 第2版 (第9章 代謝・栄養疾患)"南江堂. 403 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 長野 豊: "低HDLコレステロール血症"The Lipid. 14(2)(発表予定). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yoneda O: "Membrane-bound form of fractalkine induces IFN-gamma production by NK cells"Eur J Immunol. 33(1). 53-58 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Inoue H: "Lipid rafts as the signaling scaffold for NK cell activation : tyrosine phosphorylation and association of LAT with phosphatidylinositol 3-kinase and phospholipase C-gamma following CD2 stimulation"Eur J Immunol. 32(8). 2188-2198 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nishimura M: "Dual functions of fractalkine/CX_3C ligand 1 in trafficking of perforin+/grazyme B+ cytotoxic effector lymphocytes that are defined by CX_3CR1 expression"J Immunol. 168(12). 6173-6180 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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