| Project/Area Number |
14571821
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
|
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| Research Institution | Meikai University |
|---|
Principal Investigator |
KIKUCHI Hirotaka Meikai University, School of dentistry, research associate, 歯学部, 助手 (70234193)
|
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| Co-Investigator(Kenkyū-buntansha) |
SAKAGAMI Hirosbi Meikai University, School of dentistry, professor, 歯学部, 教授 (50138484)
|
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| Project Period (FY) |
2002 – 2004
|
| Project Status |
Completed (Fiscal Year 2004)
|
| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2004: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2003: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2002: ¥1,400,000 (Direct Cost: ¥1,400,000)
|
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| Keywords | macrolides / apical periodontitis / endodontics |
|---|
| Research Abstract |
Macrolides are well-known antimicrobial agent and has been reported to possess immunomodulating properties. The aim of the present study was to investigate the efficacy of macrolides as an inhibitor of lipopolysaccharide (LPS)-induced bone resorption via CD14. The mouse calbaria-derived bone cells was used in this study. LPS-induced expression of IL-1 alpha mRNA and production of IL-l, and Lipid A-induced production of the factor were all completely inhibited by treatment with erythromycin. Interestingly, LPS-induced formation of osteoclasts and stimulation of bone resorption in mouse calvarial cell culture were also inhibited by erythromycin treatment. These results suggest that erythromycin is a potent inhibitor of LPS-induced bone resorption in the cells. Based on these observations, Macrolides may prove to be an effective anti-inflammatory agent against LPS-stimulated periodontal destruction in periapical and periodontal diseases.
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