| Project/Area Number |
14571828
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
KITAJIMA Kayoko The Nippon Dental University, School of Dentistry at Niigata, Dept of Endodontics, Assistant Professor, 新潟歯学部, 講師 (00177841)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Tomonori The Nippon Dental University, School of Dentistry at Niigata, Dept of Endodontics, Assistant, 新潟歯学部, 助手 (30318547)
YOKOSUKA Takashi The Nippon Dental University, School of Dentistry at Niigata, Dept of Endodontics, Assistant Professor, 新潟歯学部, 講師 (10277600)
IGARASHI Masaru The Nippon Dental University, School of Dentistry at Niigata, Dept of Endodontics, Associate Professor, 新潟歯学部, 助教授 (90168104)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2003: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2002: ¥3,200,000 (Direct Cost: ¥3,200,000)
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| Keywords | root canal / calcification / narrowed canal / closed canal / root canal treatment / biological adhesive / cyanoacrylate |
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| Research Abstract |
As teeth are retained longer, the prevalence of narrow root canals is increasing. The objective of the present study was to investigate the usefulness of a novel root canal treatment utilizing a highly permeable fixative (biological adhesive cyanoacrylate : DC).
Over 20-year-old Rhesus monkeys were used in this study. Teeth were selected based on dental X-ray confirmation of canal narrowing or lack of alignment of the root canal. A cavity was prepared in each tooth so that the original pulp horn was visible as a pinpoint. Four experimental groups receiving the following respective treatments were established after alternate washing with 6% NaClO and 3% H_2O_2 and dryness:1) 0.2 μml of DC was instilled;2)It was treated with EDTA, rinsed with water and dried, and 0.2 μml of DC was then instilled;3)It was irradiated with 10 pps of the Nd-YAG laser for 1 second, after which 0.2 μml of DC was instilled ; and 4)It was treated with EDTA, rinsed with water, dried and irradiated with 10 pps of the Nd-YAG laser for 1 second, and then 0.2 μml of DC was instilled. At one week and three months after treatment, the teeth were fixed and embedded in resin. Vertical cross-sections including the root canal were prepared to analyze under a light microscope.
The results showed that cyanoacrylate penetrated deep into teeth with marked narrowing and no pathology was evident in the periapical and periodontal tissues. However, in two root canals of which we judged those root canals were marked narrowing with X-ray imaging, although these weren't narrowing histologically, cyanoacrylate leaked out of the apical foramen. More favorable results were obtained with laser irradiation. In the future, it will be necessary to investigate the safety, physical properties, and appropriate usage of, as well as the indications for, this biological adhesive.
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