Influence of prostaglandin E 1 which gives it to an antitumor effect of anticancer drug in oral cavity cancer animal model

• Project/Area Number: 14571884
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Gifu University
• Principal Investigator: FUJITSUKA Hideki Gifu University, Hospital, Lecturers, 医学部附属病院, 助手 (90262766)
• Co-Investigator(Kenkyū-buntansha): MAKITA Hiroki Gifu University, Hospital, Lecturer, 医学部附属病院, 助手 (50345790) ; KATO Yukihiro Gifu University, School of Medicine, Lecturer, 医学部, 助手 (30293567) ; TOIDA Makoto Gifu University, School of Medicine, Associate Professor, 医学部, 助教授 (90313890) ; TANAKA Takuji Kanazawa Medical University, Professor, 医学部, 教授 (40126743) ; SHIBATA Toshiyuki Gifu University, School of Medicine, Professor, 医学部, 教授 (50226172)
• Project Period (FY): 2002 – 2003
• Project Status: Completed (Fiscal Year 2003)
• Budget Amount: ¥3,000,000 (Direct Cost: ¥3,000,000); Fiscal Year 2003: ¥1,600,000 (Direct Cost: ¥1,600,000); Fiscal Year 2002: ¥1,400,000 (Direct Cost: ¥1,400,000)
• Keywords: VX2 / PGE1 / 血管新生 / プロスタグランジンE1

Research Abstract

We followed methods of Sotoyama. We transplantation 0.1ml (12×10^4/ml) for sterility from the left margin of tongue of a rabbit with VX2 cancer cell suspension (volume rate 50%) in about 5mm locus. We assumed it the experimental end after transplantation by the 20th day.
The evaluation measured a tumor volume (longer axis × minor axis × thickness), cell growth activity by BrdU-labeling index, the number of the miniature blood vessels in a tumor per a unit area from vascular endothelium dyed by CD 31.
As a result, we did not recognize significant difference in prostaglandin E1 administrated group and non-administration group in a tumor volume, cell growth activity, the number of the miniature blood vessels.
In addition, we did not accept influence about metastasis either.

Research Products

• [Publications] M.TOIDA, T.HASEGAWA, H.MAKITA, H.FUJITSUKA, K.KATO, T.SHIBATA: "Lobular capillary hemangioma of the oral mucosa : clinicopathological study of 43 cases"Pathology International. 53. 1-7 (2003)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] TOIDA M, HASEGAWA T, MAKITA H, FUJITSUKA H, KATO K, SHIBATA T: "Lobular capillary bemangioma of the oral mucosa : clinicopathlogical study of 43 cases with special reference to immunohistochemical characterization of the vascular elements"Pathology international. 53(1). 1-7 (2003)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Toida M, Hasegawa T, Watanabe F, Kato K, Makita H, Fujitsuka H, Kato Y, Miyamoto K, Shibata T, Shimokawa K: "Lobular capillary hemangioma of the oral mucosa : clinicopathological study of 43 cases with a special reference to immunohistochemical characterization of the vascular elements"Pathology International. 53(1). 1-7 (2003)
• [Publications] Takuji Tanaka, Hiroyuki Kohno, Eisaku Nomura, Hisaji Taniguchi, Takuo Tsuno, Hiroyuki Tsuda: "A novel geranylated derivative, ethyl 3(4'-geranyloxy-3'-methoxyphenyl)-2-propenoate, synthesized from ferulic acid suppresses carcinogenesis and iducible nitric oxide synthase in rat tongue"Oncology. 64. 166-175 (2003)
• [Publications] T.Shibata, D.Nakata, I.Chiba, T.Yamashita, Y.Abiko, T.Moriuchi: "Detection of TP53 mutation in ameloblastoma by the use of a yeast functional assay"J Oral Pathol Med. 31. 534-538 (2002)