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Molecular biology of calus formation after mandibular reconstruction using vasculized long bone

Research Project

Project/Area Number 14571887
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionKobe University

Principal Investigator

YOKOO Satoshi  Kobe University, Graduate School of Medicine, Lecturer, 医学部附属病院, 講師 (00322206)

Co-Investigator(Kenkyū-buntansha) TERASHI Hiroto  Kobe University, Graduate School of Medicine, Associate Professor, 医学部附属病院, 助教授 (80217421)
WATATANI Sanae  Kobe University, Graduate School of Medicine, Assistant Professor, 医学部附属病院, 助手 (50343265)
KOMORI Takahide  Kobe University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (50251294)
OJIMA Yasutaka  Kobe University, Graduate School of Medicine, Attending researcher, 医学部附属病院, 医員
UMEDA Masahiro  Kobe University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 (60301280)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2003: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2002: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywordsvascularized bone transplantation / long bone / menbranous bone / calus / immunohistochemistry / rat
Research Abstract

A new mandibular reconstruction model using the saphenous artery osteocutaneous flap is developed in the rat. The saphenous artery osteocutaneous flap in the rat was reported by Mutaf, et al in the Journal of Plastic and Reconstructive Surgery, 1994. This is a true osteocutaneous flap flap composed of a skin island from the medial aspect of the lower leg, the the gracilis and semitendinosus muscles, and a bone segment from the tibia based on the saphenous vascular pedicle. The mandibular defect was reconstructed by the vascularized tibia harvested in these technigue.
The process of membranous bone healing has not been clearly understood. The union of fibrous bone was assumed to be the only process in the healing of membranous bones. In the present study, cartilage formation associated with the bone healing process was observed. These findings are similar to early stage of endochondral (long) bone healing. It is concluded that cartilage tissue is formed in the process of membranous bone defect healing. In comparison with the long bone defect healing process, however, callus formation was limited.
We conclude that membranous bone periosteum is not main factor in the repair of bone defects, and that bone formation from membranous periosteum dose not itself completely heal the bone defect. The present observations indicated that the main sources of bone formation are the endosteum and bone marrow. We are of the union their investigation reveals the healing process of membranous bone defects to differ from that of endochondral ossification.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] Yokoo S, et al.: "Replantation of an avulsed bone as a freeze-preserved autologous graft"J Cranio-Maxillofac Surg. 31. 115-119 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yokoo S, et al.: "Indications for vascularized free rectus abdominis musculocutaneous flap in oromandibular region in terms of efficiency of anterior rectus sheath"Microsurgery. 23. 96-102 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yokoo S, et al.: "Therapeutic importance of vascularized free flap transplantation for oromandibular injury with infected and sever scar contracture"Br J Oral Maxillofac Surg. 41. 380-382 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yokoo S, et al.: "Three-dimensional reconstruction after oral oncologic surgery using single free radial forearm flaps or free rectus abdominis musculocutaneous flaps"J Oral Sci. 46. 65-70 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishii J, Yoshida T, Yokoo S, et al.: "Use of magnetic abutments for short endosseous implants following a fibula bone graft"J Oral Implantology. XXIX. 289-292 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ichinose A, Tahara S, Yokoo S, et al.: "Fail-safe drainage procedure in free radial forearm flap transplantation"J Reconstr Microsurg. 19. 371-376 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yokoo S, et al.: "Replantation of an avulsed bone as a freeze-preserved autologous graft"J Cranio-maxillofac Surg. 31. 115-119 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yokoo S, et al.: "Indications for vascularized free rectus abdominis musculocutaneous flap in oromandibular region interms of efficiency of anterior rectus sheath"Microsurgery. 29. 96-102 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yokoo S, et al.: "Therapeutic importance of vascularized free flap transplantation for oromandibular injury with infected and sever scar contracture"Br J Oral Maxillofac Surg. 41. 380-382 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yokoo S, et al.: "Three-dimensional reconstruction after oral oncologic surgery using single free radial forearm flaps or free rectus abdominis musculocutaneous flaps"J Oral Sci. 46. 65-69 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishii J, Yoshida T, Yokoo S, et al.: "Use of magnetic abutments for short endosseous implants following a fibula bone graft"J Oral Implantology. XXIX. 289-292 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ichinose A, Tahara S, Yokoo S, et al.: "Fail-safe drainage procedure in radial forearm flap transplantation"J Reconstr Microsurg. 19. 371-376 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yokoo S, et al.: "Replantation of an avulsed zygomatic bone as a freeze-preserved autologous graft"J Cranio-Maxillofac Surg. 31・2. 115-119 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yokoo S, et al.: "Indications for vascularized free rectus abdominis musculocutaneous flap in oromandibular region in terms of efficiency of anterior rectus sheath"Microsurgery. 23・2. 96-102 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yokoo S, et al.: "Therapeutic significance of vascularized free flap transplantation for oromandibular injury with infected and sever scar contracture"Br J Oral Maxillofac Surg. 41・6. 380-382 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yokoo S, et al.: "Three-dimensional reconstruction after oral oncologic surgery using single free radial forearm flaps or free rectus abdominis masculocutaneous flaps"J Oral Sci. 46・1(in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yokoo S, et al.: "Replantation of an avulsed zygomatic bone as a freeze-preserved autologous graft"J Cranio-Maxillofac Surg. 31・2. 115-119 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yokoo S, et al.: "Indications for vascularized free rectus abdominis musculocutaneous flap in oromandibular region of efficiency of anterior rectus sheath"Microsurgery. 23・2(in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yokoo S, et al.: "Therapeutic significance of vascularized free flap transplantation for oromandibular injury with infected and sever scar contracture"Br J Oral Maxillofac Surg. 41・6(in press). (2003)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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