Suppression of angiogenesis in oral cancer by cyclooxygenase inhibitors
| Project/Area Number |
14571893
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | HIROSHIMA UNIVERSITY |
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Principal Investigator |
KOIZUMI Koichi Hiroshima University, Medical and Dental Hospital, Research Associate, 医学部・歯学部附属病院, 助手 (30335682)
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Tetsuji Hiroshima University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 (00169153)
HAYASHIDO Yasutaka Hiroshima University, Medical and Dental Hospital, Assistant Professor, 医学部・歯学部附属病院, 講師 (70243251)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2002: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | VEGF / oral cancer / NSAIDs / COX-2 |
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| Research Abstract |
It is well known that cyclooxygenase-2(COX-2) induces prostaglandin E2 (PGE2) synthesis and facilitates angiogenesis. Because synthesis of vascular endothelial growth factor (VEGF) is regulated by PGE2, COX-2 also might induce VEGF synthesis. We have investigated the expression of COX-2 mRNA in oral squamous cell carcinoma (SCC) cells, KA, NA, NI, KO and UE, and adenocarcinoma cells of salivary grand, HSG and HSY by RT-PCR. Any cells except UE expressed COX-2 mRNA. Nonsteroidal anti inflammatory drugs (NSAIDs), which inhibit cyclooxygenase enzyme activity, suppressed the growth of oral SCC cells expressing COX-2 mRNA. However, NSAIDs showed no effect on the growth UE cells lacking the expression of COX-2 mRNA. These findings suggest that NSAIDS, COX-2-Inhibitor inhibits angiogenesis by suppression of VEGF synthesis as well as proliferation
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Report
(3 results)
Research Products
(4 results)
