| Project/Area Number |
14571927
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Aichi-Gakuin University |
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Principal Investigator |
OGI Nobumi Aichi-Gakuin University, School of Dentistry, Assistant Professor, 歯学部, 講師 (90211127)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMOZATO Kazuo Aichi-Gakuin University, School of Dentistry, Professor, 歯学部, 教授 (00158966)
KURITA Kenichi Aichi-Gakuin University, School of Dentistry, Professor, 歯学部, 教授 (40133483)
加藤 勇 愛知学院大学, 歯学部, 助手 (50340154)
後藤 達之 愛知学院大学, 歯学部, 助手 (60340155)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2003: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2002: ¥500,000 (Direct Cost: ¥500,000)
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| Keywords | TMJ / disc / tendon / interpositional materials / rabbit |
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| Research Abstract |
The disc has important biomechanical functions for the temporomandibular joint. However, the pathologic disc has to be removed from painful refractory internally deranged or osteoarthritic temporomandibular joint. There are no ideal interpositional materials at present that can protect articular cartilage from degenerative arthritis following discectomy. The aim of this study is to evaluate the protective effect of disc replacement with stored tendon allograft after disc removal in the rabbit temporomandibular joint.
Thirty Japanese. white rabbits were divided into 3 surgical groups as follows : In group 1, unilateral discectomy alone was carried out. In group 2, glutaraldehyde(GA)treated allogenic tendon was grafted as an interpositional material after discectomy. In group 3, epoxy(E)treated allogenic tendon was grafted after discectomy. GA or E was used as a cross-linking agent for tendon collagen. The animals were killed at 3rd post-operative month. The TMJs were removed en bloc, histologically processed and stained with hematoxylin and eosin.
Disc replacement with E-treated tendon allografts seems to give promising short-term results following discectomy. GA-treated tendon allografts also have protective effects on condylar articular cartilage. However, in most series, the both GA-treated and Etreated tendon allografts were difficult to survive after disc removal in the temporomandibular joint. The risk of tendon-graft shrinkage or resorption was not prevented.
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