Experimental studies of pharyngeal dilating reflex and airway patency in rabbits
| Project/Area Number |
14571928
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka Dental University |
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Principal Investigator |
KOTANI Junichiro Osaka Dental University, Anesthesiology, Professor, 歯学部, 教授 (40109327)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIOKA Shingo Osaka Dental University, Department of Anesthesiology, Assistant Professor, 歯学部, 助手 (90278573)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2003: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2002: ¥3,100,000 (Direct Cost: ¥3,100,000)
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| Keywords | upper airway / rabbit / surface anesthesia / pharyngeal dilating reflex / 咽頭腔圧 / 筋電図 / オトガイ舌筋 / CO_2 / negative pressure airway reflex / セボフルラン / 反射 |
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| Research Abstract |
Background : Upper airway reflexes include a reflex protecting the airway as well as another dilating the airway. The latter reflex, the pharyngeal dilator reflex to negative airway pressure (NPAR), plays an important role in maintaining airway patency, although the peripheral receptors involved in NPAR have not been specified.
Methods : The effects of surface anesthesia of the pharyngeal mucous membrane on NPAR were evaluated by observing activity of the musculus genioglossus (GG) in rabbits. Following anesthesia with thiopental, two incisions were made on the trachea of each rabbit. Through these incisions, a tube connected to the anesthetic circuit was inserted into the lung and another tube connected to an aspirator into the pharynx. Effects of negative pressure on the myelogram of the GG were recorded with and without surface anesthesia with 1% lidocaine.
Results : Electric discharge from the GG was increased in the sessions with exposure to negative pressure without surface anesthesia, but was significantly decreased in those with surface anesthesia.
Conclusion : These findings suggest that the peripheral receptors of NPAR are located in the pharyngeal mucous membrane.
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Report
(3 results)
Research Products
(5 results)
