| Project/Area Number |
14571932
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
TANIGUCHI Shogo FUKUOKA DENTAL COLLEGE, DENTISTRY, PROFESSOR, 歯学部, 教授 (70179836)
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| Co-Investigator(Kenkyū-buntansha) |
TOMINAGA Shinji FUKUOKA DENTAL COLLEGE, DENTISTRY, INSTRUCTOR, 歯学部, 講師 (70269041)
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| Project Period (FY) |
2002 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2004: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2003: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2002: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | OXIDATION-REDUCTION POTENTIAL / OXIDATIVE STRESS / SURGERY / ELECTROLYTE SOLUTION / ASCORBIC ACID / ALKALI ION SOLUTION / 生体侵襲 / 血中乳酸値 / BE / 酸素ストレス / 還元剤 |
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| Research Abstract |
In this study we investigated the effectiveness of reduction of blood Oxidation- Reduction potential(ORP) on the oxidative stress during surgery. ORP of the various electrolyte solutions were measured, and all electrolyte solution showed lower ORP by addition of alkali ion solution and ascorbic acid. Addition of alkali ion solution and ascorbic acid for the blood samples showed same results. We also measured blood ORP of the patient during surgery and in severe shock state, and they elevated statistically in severe shock state.
From these results we administered electrolyte solutions, such as lactated Ringer's solution, acetated Ringer's solution, and acetated Ringer's solution with 1% glucose, that have lower ORP. As a result, we could decrease blood ORP and lactate concentration, and improve acidosis of the patient with surgical stress.
This result suggested that administration of more reduced solution would be useful for the patient with oxidative stress during surgery.
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