| Project/Area Number |
14571933
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
矯正・小児・社会系歯学
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| Research Institution | Hokkaido University |
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Principal Investigator |
MITOME masato Hokkaido Univ., Grad.Sch.of Dent.Med., Instr., 大学院・歯学研究科, 助手 (50261318)
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| Co-Investigator(Kenkyū-buntansha) |
KIKUIRI Takashi Hokkaido Univ., Grad.Sch.of Dent.Med., Instr., 大学院・歯学研究科, 助手 (10322819)
YOSHIMURA Yoshitaka Hokkaido Univ., Grad.Sch.of Dent.Med., Instr., 大学院・歯学研究科, 助手 (30230816)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2003: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2002: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | Root resorption / periodontal cell / Macrophage migration inhibitory factor / Osteoclast differentiation / ヒト乳歯 / TRAP陽性多核細胞 / 遺伝子解析 |
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| Research Abstract |
We have been analyzed the periodontal cells, in order to clarify the mechanism of the root resorption. As part of this study, some genes specifically discovered in the periodontal cell were identified. The macrophage inhibit migration factor (MIF) is one of the genes which identified.
MIF has been characterized as a pro-inflammatory cytokine. MIF not only plays its role in immune system but is also involved in cell proliferation and differentiation in a variety of organs. There is no report demonstrating the effect of MIF on osteoclast formation. We investigated the regulatory effects of macrophage migration inhibitory factor (MIF) on osteoclast formation. In this study, MIF inhibits formation of mature osteoclasts by preventing the multinucleation process.
These results suggested that MIF would control the root resorption efficiently.
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