| Project/Area Number |
14571958
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
矯正・小児・社会系歯学
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| Research Institution | Kagoshima University |
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Principal Investigator |
YOSHIHARA Toshihiro Kagoshirna University, University Hospital, Faculty of Medicine and Dentistry, Assistant Professor, 医学部・歯学部附属病院, 講師 (60261319)
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| Project Period (FY) |
2002 – 2003
|
| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2003: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2002: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | occlusal disharmony / locomotor activity / restrsleeping / hypothalamus / corticosterone / stress |
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| Research Abstract |
Few neuroendocrinological studies have examined the relationship between occiusal disharmony and stress. To determine the effect of occiusal disharmony on the central nervous system, we measured plasma corticosterone and extracellular noradrenaline in the vicinity of the hypothalamic paraventricular nucleus in rats with and without incisal caps.
After setting the caps, plasma corticosterone and extracellular noradrenaline levels gradually increased, reaching a peak at 8.5 and at 6.5 hours respectively, after which they decreased.Furthermore, plasma corticosterone and extracellular noradrenaline levels increased in a circadian fashion around the onset of the dark phase in rats without caps, but not in rats with caps.
These results suggest that occiusal disharmony causes chronic stress in the rat.
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