| Project/Area Number |
14572007
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
SUEMUNE Hiroshi Kyushu University, Graduate School of Pharmaceutical Sciences, Professor, 薬学研究院, 教授 (20095897)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2002: ¥2,600,000 (Direct Cost: ¥2,600,000)
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| Keywords | Hydroacylation / rhodium complex / catalytic reaction / double chelation / diene / asymmetric reaction / サリチルアルデヒド / タブルキレーション |
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| Research Abstract |
Intermolecular hydroacylation between salicylaldehyde and 1,4-penta-or 1,5-hexadienes by Rh-catalyst proceeded under mild reaction conditions to give a mixture of iso-and normal-hydroacylated products. In the hydroacylation reaction, chelation of both salicylaldehyde and diene to the Rh-complex play a crucial role. The ratio of iso-and normal-hydroacylated products could be regulated by the addition of salicylic acid or amines. The effects of various Rh-complexes, solvents, and additives were examined, and the plausible mechanisms of the catalytic cycle were proposed on the basis of the basis of the deuterium-labeling salicylaldehyde experiments.
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