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Development of New Target-Based Anticancer Agents from Higher Plants

Research Project

Project/Area Number 14572013
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemical pharmacy
Research InstitutionTokyo University of Pharmacy and Life Sciences

Principal Investigator

MIKAMI Yoshihiro  Tokyo University of Pharmacy and Life Sciences, School of Pharmacy, Professor, 薬学部, 教授 (90229790)

Co-Investigator(Kenkyū-buntansha) KURODA Minpei  Tokyo University of Pharmacy and Life Sciences, School of Pharmacy, Lecturer, 薬学部, 講師 (80266890)
YOKOSUKA Akihito  Tokyo University of Pharmacy and Life Sciences, School of Pharmacy, Assistant Professor, 薬学部, 助手 (20318190)
Project Period (FY) 2002 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2005: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2004: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2003: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2002: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordstarget-based anticancer agent / apoptosis / panel-screening / phytoecdysone / cycloartane / sesquiterpene / 5β-spirostanol / higher plant / ステロイド配糖体 / Helleborus orientalis / HSC-2細胞 / フロスピロスタノールサポニン / 芳香精油 / HL-60細胞 / サンダルウッド / レモングラス / 仙茅 / Curculigo orchioides / HL-60白血病細胞 / ニトベギク / hispidulin / Tacca chantrieri / ステロイド / シクロラノスタン / β-ecdysone / アポトーシス誘導 / 分子標的 / 配糖体 / フェノール性物質 / フェニルアントラキノン / 分子標的薬剤 / 腫瘍選択性
Research Abstract

The objective of this research is to develop new target-based anticancer agents with apoptosis inducing activity from higher plants. The chemical constituents of Bulbinella floribunda (Liliaceae), Agave utahensis (Agavaceae), Tacca chantrieri (Taccaceae), Helleborus orientalis (Ranunculaceae), Helleborus niger (Ranunculaceae), Curculigo orchioides (Hypoxidaceae), and Tithonia diversifolia (Compositae) have been investigated. New phenylanthraquinone derivatives, new steroidal glycosides, cardeotonic glycosides, phytoecdysones, triterpenes with the cycloartane skeleton, and flavonoids and sesquiterpenoids were isolated from B.floribunda, A.utahensis, H.orientalis, H.niger, C.orchioides, and T.diversifolia, respectively, as cytotoxic and antitumor compounds, and their chemical structures were determined on the basis of the spectroscopic data and chemical evidence. Since the cytotoxic compounds isolated from the same plants are structurally related each other, the structure-activity relationships were established. In a panel-screening using a variety of cultured tumor cells, a phytoecdysone from H.niger, a cycloartane triterpene from C.orchioides, and a sesquiterpene from T.diversifolia showed differential cytotoxicity. Some 5β-spirostanol glycosides from A.utahensis caused the death of HL-60 cells through the apoptotic process.

Report

(5 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (18 results)

All 2005 2004 2003 2002 Other

All Journal Article (15 results) Book (1 results) Publications (2 results)

  • [Journal Article] New Glycosides of the Campesterol Derivative from the Rhizomes of Tacca chantrieri2005

    • Author(s)
      Yokosuka, A., Mimaki, Y., Sakuma, C., Sashida, Y.
    • Journal Title

      Setroids 70・4

      Pages: 257-265

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Four New Steroidal Saponins from the Rhizomes of Helleborus orientalis2005

    • Author(s)
      Watanabe, K., Sakagami, H., Mimaki, Y.
    • Journal Title

      Heterocycles 65・4

      Pages: 775-785

    • NAID

      40006693664

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Taccasterosides A-C, Novel C_<28>Sterol Oligoglucosides from the Rhizomes of Tacca chantrieri2004

    • Author(s)
      Yokosuka, A., Mimaki, Y., Sashida, Y.
    • Journal Title

      Chem. Pharm. Bull. 52・11

      Pages: 1396-1398

    • NAID

      110003665462

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Taccasterosides A-C, Novel C_<28> Sterol Oligoglucosides from the Rhizomes of Tacca chantrieri2004

    • Author(s)
      Yokosuka, A., Mimaki, Y., Sashida, Y.
    • Journal Title

      Chem.Pharm.Bull. 52・11

      Pages: 1396-1398

    • NAID

      110003665462

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Taccasterosides A-C, novel C_<28> sterol oligoglucosides from the rhizomes of Tacca chantrieri2004

    • Author(s)
      Yokosuka A., Mimaki Y., Sashida Y.
    • Journal Title

      Chem.Pharm.Bull. 52・11

      Pages: 1396-1398

    • NAID

      110003665462

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Bufadienolide and Spirostanol Glycosides from the Rhizomes of Helleborus orientalis2003

    • Author(s)
      Watanabe, K., Mimaki, Y., Sakagami, H., Sashida, Y.
    • Journal Title

      J. Net. Prod. 66・2

      Pages: 236-241

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Chantriolides A nad B, Two New Withanlide Glucosides from the Rhizomes of Tacca chantrieri2003

    • Author(s)
      Yokosuka, A., Mimaki, Y., Sashida, Y.
    • Journal Title

      J. Net. Prod. 66・6

      Pages: 876-878

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Bulbinelonesides A-E, Phenylanthraquinone Glycosides from the Roots of Bulbinella floribunda2003

    • Author(s)
      Kuroda, M., Mimaki, Y., Sakagami, H., Sashida, Y.
    • Journal Title

      J. Nat. Prod. 66・6

      Pages: 894-897

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Bufadienolide and Spirostanol Glycosides from the Rhizomes of Helleborus orientails2003

    • Author(s)
      Watanabe, K., Mimaki, Y., Sakagami, H., Sashida, Y.
    • Journal Title

      J.Nat.Prod. 66・2

      Pages: 236-241

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Chantriolides A nad B, Two New Withanolide Glucosides from the Rhizomes of Tacca chantrieri2003

    • Author(s)
      Yokosuka, A., Mimaki, Y., Sashida, Y.
    • Journal Title

      J.Nat.Prod. 66・6

      Pages: 876-878

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Bulbinelonesides A-E, Phenylanthraquinone Glycosides from the Roots of Bulbinella floribunda2003

    • Author(s)
      Kuroda, M., Mimaki, Y., Sakagami, H., Sashida, Y.
    • Journal Title

      J.Nat.Prod. 66・6

      Pages: 894-897

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Spirostanol Saponins from the Rhizomes of Tacca chantrieri and Their Cytotoxic Activity2002

    • Author(s)
      Yokosuka, A., Mimaki, Y., Sashida, Y
    • Journal Title

      Phytochemistry 61・1

      Pages: 73-78

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Steroidal and Pregnane Glycosides from the Rhizomes of Tacca chantrieri2002

    • Author(s)
      Yokosuka, A., Mimaki, Y., Sashida, Y
    • Journal Title

      J. Nat. Prod. 65・9

      Pages: 1293-1298

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Spirostanol Saponins from the Rhizomes of Tacca chantrieri and Their Cytotoxic Activity2002

    • Author(s)
      Yokosuka, A., Mimaki, Y., Sashida, Y.
    • Journal Title

      Phytochemistry 61・1

      Pages: 73-78

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Steroidal and Pregnane Glycosides from the Rhizomes of Tacca chantrieri2002

    • Author(s)
      Yokosuka, A., Mimaki, Y., Sashida, Y.
    • Journal Title

      J.Nat.Prod. 65・9

      Pages: 1293-1298

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Functional Polyphenols and Carotenes with Antioxidative Action2005

    • Author(s)
      Hiroshi, S., Mimaki, Y., et al.
    • Total Pages
      43
    • Publisher
      Research Signpost
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Publications] Minpei Kuroda, Yoshihiro Mimaki, Hiroshi Sakagami, Yutaka Sashida: "Bulbinelonesides A-E, Phenylanthraquinone Glycosides from the Roots of Bulbinellafloribunda"Journal of Natural Products. 66・6. 894-897 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kazuki Watanabe, Yoshihiro Mimaki, Hiroshi Sakagami, Yutaka Sashida: "Bufadienolide and Spirostanol Glycosides from the Rhizomes of Helleborus orientalis"Journal of Natural Products. 66・2. 236-241 (2003)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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