| Project/Area Number |
14572024
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kobe Gakuin University |
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Principal Investigator |
KAWASAKI Koichi Kobe Gakuin University, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (40068242)
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Mitsuko Kobe Gakuin University, Faculty of Pharmaceutical Sciences, Senior Assistant, 薬学部, 助手 (90131531)
HOJO Keiko Kobe Gakuin University, Faculty of Pharmaceutical Sciences, Research Assistant, 薬学部, 実験助手 (20289028)
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| Project Period (FY) |
2002 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2004: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2003: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | solid phase synthesis / peptide synthesis / green chemistry / Leu-enkephalin / water-soluble protecting group / water / 水中合成 / 2-(4-sulfophenyl)ethoxycarbonyl group / 水中固相合成 / エンケファリン / 水溶性保護アミノ酸 / 水系固相法合成 / 2-[phenyl(methyl)sulfonio]eyhoxycarbonyl基 |
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| Research Abstract |
Solid phase peptide synthesis (SPPS) is a well-established technique for the facile and rapid preparation of peptides, but it requires large amounts of organic solvents. Since the safe disposal of organic solvents is an important environmental issue, the ability to synthesize peptides in an aqueous medium would be preferable. In order to do so, water-soluble N-protected amino acids are necessary. We have successfully used the water-soluble N-protecting groups, 2-[phenyl(methyl)sulfonio]ethoxycarbonyl (Pms), ethanesulfonylethoxycarbonyl (Esc) and 2-(4-sulfophenylsulfonyl)ethoxycarbonyl (Sps), for the SPPS of Leu-enkephalin amide in water.
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