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A study of a role for GLP-1 as a newly found neurotrophic factor and its beneficial effects on brain diseases

Research Project

Project/Area Number 14572074
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionTokyo University of Science

Principal Investigator

OKA Jun-ichiro  Tokyo University of Science, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (40134613)

Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2003: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2002: ¥2,200,000 (Direct Cost: ¥2,200,000)
KeywordsNeurotrophic factor / GLP-1 / BDNF / Hippocampus / Motoneuron / Concussive brain injury / Learnina & memory / GLP-2 / 頭部外傷 / 神経損傷 / アスピリン / 炎症 / 神経突起伸長 / 神経生存率 / 初代培養
Research Abstract

The final goal of the present study is to examine intracellular mechanisms of neurotrophic action of glucagon-like peptide-1(GLP-1)and its beneficial effects in brain diseases.First, we found that endogenous GLP-1 increased neurite length and branching of neurite without any effect on cell viability, indicating that it acts as a major neurotrophic factor in the brain of rat embryos in a manner similar to BDNF.Also we found that activation of cAMP and MAP kinase pathways may be involved in its effects.Second, we examined effects of exogenous GLP-1 and GLP-2 on brain dysfunction in model mice of the concussive brain injury.Our results demonstrated that GLP-1 or GLP-2 injected, icv.10 mm after the injury impaired memory impairment.Since aspirin but not indometacine injected s.c. alsof impaired memory impairment, inflammation may occur in the injured brain and, at least partially, cause memoryimpairment. G'LP-2 suppressed an increase in IL-1β.These results suggest that GLP-1 and GLP-2 have therapeutic effects on brain dysfunction induced with neuronal degeneration or brain injury.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Hashimoto, M., Hossain, Md.S., Shimada, T., Sugioka, K., Yamasaki, H., Fujii, Y., Ishibashi, Y., Oka J-I., Shido, O: "Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats."Journal of Neurochemistry. 81・5. 1084-1091 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nagai, Y., Tsugane, M., Oka, J.-I, Kimura, H.: "Hydrogen sulfide induces calcium waves in astrocytes"The FASEB Journal, express afticle published online January.20,2004. 10.1096/03-1052fje. 03-1052fje (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shimizu, S., Honda, M., Tanabe, M., Oka, J.-I., Ono, H.: "Endogenous GABA does not mediate the inhibitory efeects of gabapentin on spinal reflexes in rats"Journal of Pharmacological Sciences. 94・2. 137-143 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 岡 淳一郎: "薬の作用を考える〜抗痴呆薬の探索〜"科学フォーラム. 226. 13-17 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 岡 淳一郎: "脳の病気と治療薬(1)"科学フォーラム. 235. 12-16 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 岡 淳一郎: "脳の病気と治療薬(1)"科学フォーラム. 236. 17-21 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hashimoto, M., Hossain, Md.S., Shimada, T., Sugioka, K., Yamasaki, H., Fujii, Y., Ishibashi, Y., Oka, J.-I., Shido, 0.: "Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats."Journal of Neurochemistry. 81-5. 1084-1091 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nagai, Y., Tsugane, M., Oka, J.-I., Kimura, H.: "Hydrogen sulfide induces calcium waves in astrocytes."The FASEB Jounal, express afticle published online January.. 20. 10.1096-03-1052 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shimizu, S., Honda, M., Tanabe, M., Oka, J.-I., Ono, H.: "Endogenous GABA does not mediate the inhibitoiy efeects of gabapentin on spinal reflexes in rats."Journal of Pharmacological Sciences. 94-2. 137-143 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Oka, J.-I.: "Mechanisms of drug action : Development of antidementia-type drugs."Kagaku Forum. 226. 13-17 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Oka, J.-I.: "Neuropsychopharmacology(1)"Kagaku Forum(in Japanese). 235. 12-16 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Oka, J.-I.: "Neuropsychopharmacology(2)"Kagaku Forum(in Japanese). 236. 17-21 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nagai, Y., Tsugane, M., Oka, J.-I., Kimura, H.: "Hydrogen sulfide induces calcium waves in astrocytes"The FASEB Journal, express article. 10.1096(published online January. 20, 2004). 03-1052fje (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Shimizu, S., Honda, M., Tanabe, M., Oka, J.-I., Ono, H.: "Endogenous GABA does not mediate the inhibitory effects of gabapentin on spinal reflexes in rats"Journal of Pharmacological Sciences. 94・2. 137-143 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 岡 淳一郎: "薬の作用を考える〜抗痴呆薬の探索〜"科学フォーラム. 2003・4(通巻226号). 13-17 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 岡 淳一郎: "脳の病気と治療薬(1)"科学フォーラム. 2004・1(通巻235号). 12-16 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 岡 淳一郎: "脳の病気と治療薬(2)"科学フォーラム. 2004・2(通巻236号). 17-21 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hashimoto, M., Hossain, Md.S., Shimada, T., Sugioka, K., Yamasaki, H., Fujii, Y., Ishibashi, Y., Oka, J.-I., Shido, O: "Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats"Journal of Neurochemistry. 81・5. 1084-1091 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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