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DEVELOPMENT AND ITS APPLICATION OF NON-INVASIVE MEASUREMENT OF BIOTRACE

Research Project

Project/Area Number 14572099
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 医薬分子機能学
Research InstitutionSHOWA PHARMACEUTICAL UNIVERSITY

Principal Investigator

ENDO Kazutoyo  SHOWA PHARMACEUTICAL UNIVERSITY, DEPARTMENT OF PHARMACY, PROFESSOR, 薬学部, 教授 (50106598)

Co-Investigator(Kenkyū-buntansha) ENOMOTO Shuichi  SHOWA PHARMACEUTICAL UNIVERSITY, THE INSTITUTE OF PHYSICAL AND CHEMICAL RESEARCH, RESEARCH FELLOW, 加速器基盤研究室, 研究員 (10271553)
MATSUMOTO Ken-ichiro  SHOWA PHARMACEUTICAL UNIVERSITY, FELLOW OF NIH, USA, POST DR., 博士研究員 (10297046)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2002: ¥2,800,000 (Direct Cost: ¥2,800,000)
KeywordsNON-INVASIVE MEASUREMENT / BIOTRACE ELEMENTS / INDEX OF OXIDATIVE STRESS / MINERAL BALANCE / SIMALUTANIUS ANALYSIS / IN VIVO MEASUREMENT / MULTI-TRACER / 肝細胞と微量元素 / 生体内微量元素の非侵襲測定 / 肝細胞画分と微量元素
Research Abstract

Non-invasive and simultaneous measurement for distribution of 14 biotrace elements (^7Be, ^<46>Sc, ^<48>V, ^<54>Mn, ^<59>Fe, ^<58>Co, ^<65>Zn, ^<74>As, ^<75>Se, ^<83>Rb, ^<85>Sr, ^<88>Y, ^<88>Zr, and ^<103>Ru) in a living rat was developed and the dynamics for the biotrace elements was estimated. Computer simulations and practical measurements examined the efficiency of the detector settings for the in vivo multitracer analysis. The possibility of the technique as a diagnostic tool for examining the biological/physiological functions in living rats was discussed. ^<74>AS is mainly taken into the red blood cell, and ^<83>Rb was present in the blood but not in the plasma. The ^<103>Ru was present in the plasma and blood content was almost half of plasma, and the distribution amount of the ^<83>Rb can give information of the volumes of intracellular fluid. The ratio of ^<74>As to ^<83>Rb of the in vivo relative uptake rates at a particular time point was principally affected by the ratio of blood to tissue volume. Therefore, decrease for the ^<74>As/^<83>Rb ratio can be an index for ischemia. Although the case of ^<103>Ru distribution in plasma is not completely specific as ^<74>As showed in rat red blood cell, the ratio of ^<103>Ru/^<83>Rb at a particular time point may also be affected by the ratio of blood to tissue volume. The possibility of functional estimation of tissue blood volume and/or ischemia was proposed using ^<74>As and ^<83>Rb and ^<103>Ru.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Matsumoto, K, Yamazaki, M., Satoh, K, Ushio, F, Endo, K.: "Measurement of contents in organs of selenium- or vitamin E-deficient rat using instrumental neutron activation analysis"Yakugaku Zasshi. 122(4). 283-290 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Matsumoto, K, Nagashima, H, Sitogaku, N., Hirunuma, R, Enomoto, S., Endo, K: "In vivo assessment of dynamics of various elements in living rat by using multitracer"Journal of Radioanalytical and Nuclear Chemistry. 255. 143-147 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Matsumoto, K, U, Satoh, K, Tobe, T, Ushio, F, Endo, K: "Evaluation of oxidative damage in the liver of selenium-deficient rats"Redox Report. 7. 351-354 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Matsumoto, K., Nagashima, H., Sotagaku, N, Enomoto, S., Endo, K.: "Affinity of various bio-trace elements to lipid membrane : In vivo and in vitro study using multitracer"Journal of Radioanalytical and Nuclear chemistry. 255. 489-493 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Matsumoto, Ken-ichiro, Yamazaki, Megumi, Satoli, Kazue, Ushio, Fusao, Endo, Kazutoyo: "Measurement of contents in organs of seleniumor vitamin E-deficient rat using instrumental neutron activation analysis"Yakugaku Zasshi. 122(4). 283-290 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Matsumoto, K, Nagashima, H, Sitogaku, N., Hirunuma, R, Enomoto, S., Endo, K.: "In vivo assissment of dynamics of various elements in living rat by using multitracer"Journal of Radioanalytical and Nuclear Chemistry. 255(1). 143-147 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Matsumoto, Ken-ichiro, Ui, Ion, Satoh, Kazue: "Evaluation of oxidative damage in the liver of selenium-deficient rats"Redox Report. 7(5). 351-354 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Matsumoto, K., Nagashima, H., Sotagaku, N., Enomoto, S., Endo, K.: "Affinity of various bio-trace elements to lipid membrane: In vivo and in vitro study using multitracer"Journal of Radioanalytical and Nuclear Chemistry. 255(3). 489-493 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Matsumoto, K, et al.: "Relation of bile hydrogen peroxide level and liver super oxidedismutase activity in selenium-deficient rats"Yakugaku Zasshi. 122(6). 407-411 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Matsumoto, K, et al.: "Evaluation of oxidative damage in the liver of selenium-deficient rats"Redox Report. 7(5). 351-354 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Matsumoto, K, et al.: "In vivo assessment of dynamics of various elements in living rat by using a multitracer"Journal of Radioanalytical and Nuclear Chemistry. 255(1). 143-147 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Matsumoto K., Ui I., Hirunuma R., Enomoto S., Endo, K.: "In vivo assessment of dynamics of various elements in living rat by using a multitracer"J.Radioanal.Nucl.Chem.. 225・1. 143-147 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Matsumoto K., Ui I., Satoh K., Tobe T., Ushio F., Endo K.: "Evaluation of oxidative damage in the liver of selenium-deficient rats"Redox Report. 7・5. 351-354 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Matsumoto K., Ui I., Mochida T., Sakamoto R., Endo K.: "Relation of bile hydrogen peroxide level and liver super oxidedismutase activity in selenium-deficient rats"Yakugaku Zasshi. 122・6. 407-411 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Matsumoto, K., Yamazaki, M., Satoh, K., Ushio, F., Endo, K.: "Measurement of contents in organs of selenium-or vitamin E-deficient rat using instrumental neutron activation analysis"Yakuagaku Zasshi. 122・4. 283-290 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ishiwata, K., Ogi, N., Hayakawa, N., Umegaki, Nagaoka, T., Endo, K.: "Positron emission tomography and ex vivo and in vitro autoradiography studies on dopamine D2-like receptor degeneration in the quinolinic acid-lesioned rat striatum : comparison of [11C]raclopride, [11C]nemonapride"Nucl.Med.Biol.. 29・3. 307-316 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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