| Project/Area Number |
14572121
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Yamanashi Institute of Environmental Sciences |
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Principal Investigator |
HASEGAWA Tatsuya Yamanashi Institute of Environmental Sciences, Division of Environmental Health Siences, Researcher, 環境健康研究部, 研究員 (90208489)
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| Co-Investigator(Kenkyū-buntansha) |
SEKO Yoshiyuki Yamanashi Institute of Environmental Sciences, Division of Environmental Health Siences, Research Manager, 環境健康研究部, 研究管理幹 (60133360)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2002: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | Vanadium / Trace Elements / Diabetes / Groundwater / Mt.Fuji / Animal Experiments / Pharmacotherapy / Interaction |
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| Research Abstract |
Groundwater from Mt.Fuji is utilized as souse of tap water and commercial bottle water. As quality of drinking water could affect human health, we are investigated the groundwater around Mt.Fuji. It has already been reported by many investigators that the groundwater from Mt.Fuji contain relatively high concentration of trace element vanadium. As vanadium compounds have several good effects on diabetic patients and animals, the effects of intake of Mt.Fuji groundwater are concern of many ordinary people. In this study showed that the effect of vanadium on diabetic mice treated with oral diabetic medicine. Diabetic KK-Ay mice were caged with 1 mg/L vanadium solution as drinking water for 3 weeks. Other KK-Ay mice were given the ion-exchanged water as control animal group. The diabetic mice were orally administered with glibenclamide or buformine. The glibenclamide is one of sulfonyl urea drugs, the buformine is one of biguanide drugs. Blood glucose, hemoglobin A1c (HbA1c), total cholesterol and triglyceride were analyzed in the diabetic mice. These parameters were no difference between vanadium solution-drink animal group and ion-exchanged water-drink animal group. These results suggest that vanadium is not enhanced activity of oral diabetic medicine on KK-Ay mice.
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