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Establishment of a Novel Marker for Atherosclerosis. -Measurement of Soluble FcγRIIIa^<M_Φ> Derived from Macrophages in Plasma-

Research Project

Project/Area Number 14572192
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionKansai Medical University

Principal Investigator

MASUDA Midori  Kansai Medical University, Faculty of Medicine, Associate Professor, 医学部, 講師 (50173753)

Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2003: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2002: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsAtherosclerosis / Macrophages / soluble FcγRIIIa^<M_Φ> / Coronary artery diseases / Hypertension / Diabetes / Hyperlipidemia / Carotid maximum intima-media thickness / 可溶性FcγRIIIa^<Mφ> / 可溶性FcγRII
Research Abstract

Macrophages play a major role in the development of vascular lesions in atherogenesis. The cells express FcγRIIIa(CD16) identical to that in NK cells, but with a cell type-specific glycosylation. The FcγRIIIa are released from the cell surface on activation, and these soluble forms (sFcγRIIIa) are present in plasma. We measured sFcγRIIIa^<M_Φ> derived from macrophages in plasma with Immuno-PCR with anti-FcγRIII mAb,MKGR14(mlgM), which recognizes FcγRIIIa^<M_Φ> specifically. In healthy volunteers, the level of sFcγRIIIa^<M_Φ> increased with ageing, and positively correlated with serum LDL-cholesterol to HDL-cholesterol ratios and LDL-cholesterol, but negatively with HDL-cholesterol. In addition, the sFcγRIIIa^<M_Φ> level was related to the number of risk factors for atherosclerosis and correlated with carotid maximum intima-media thickness(IMT) in subjects with annual medical checkup. In contrast, the level of sFcγRIIIa(sFcγRIIIa^<M_Φ> plus sFcγRIIIa^<NK>) correlated with the number of NK cells in peripheral blood, and the level of total sFcγRIII(sFcγRIIIa plus sFcγRIIIb) correlated with the number of neutrophils. In patients undergoing coronary angiography, the levels of these sFcγRIIIs were significantly increased in patients with coronary artery diseases(CAD) with atherosclerosis, but not in patients with vasospastic angina(VSA) or intact coronary artery, compared with age-matched healthy donors. The sFcγRIIIa^<M_Φ> level was related to the number of significant coronary artery stenoses, and positively correlated with LDL-cholesterol to HDL-cholesterol ratios and lipoprotein(a), but negatively with HDL-cholesterol. No correlation among the levels of three sFcγRIIIs was observed in CAD patients, as well as in healthy donors. These findings may show that the macrophages are activated during the incipient stage of atherosclerosis, and that sFcγRIIIa^<M_Φ> may serve as predictive marker for atherosclerosis.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] 桝田緑, 高橋伯夫: "動脈硬化症における司溶性FcγRIIIa^<Mφ>の増加"臨床検査. 46. 441-443 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 桝田緑, 高橋伯夫: "動脈硬化症におけるマクロファージ由来可溶性FcγRIIIa^<Mφ>の増加"臨床病理. 50. 502-505 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Midori Masuda, et al.: "Increse of soluble FcγRIIIa derived from NK cells and macrophages in plasma from patients with rheumatoid arthritis."J.Rheumatol.. 30. 1191-1197 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Midori Masuda, et al.: "Mcasuremont of soluble FcγRIIIa derived from macrophages in plasma : Increase in patients with rheumatoid arthritis."Clin.Exp.Immunol.. 132. 477-484 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 桝田緑, 高橋伯夫: "マクロファージ由来可溶性FcγRIIIa^<Mφ>."臨床病理. 51. 1102-1105 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Midori Masuda, Hakuo Takahashi: "Incresed soluble FcγRIIIa^<M_Φ> in plasma from patients with atherosclerosis."Rinsyou Kensa. 46(4). 441-443 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Midori Masuda, Hakuo Takahashi: "Incresed soluble FcγRIIIa^<M_Φ> derived from macrophages in plasma from patients with atherosclerosis."Rinsyo Byori. 50(5). 502-505 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Midori Masuda, et al.: "Increse of soluble FcγRIIIa derived from NK cells and macrophages in plasma from patients with rheumatoid arthritis."J.Rheumatol.. 30. 1191-1197 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Midori Masuda, et al.: "Measurement of soluble FcγRIIIa derived from macrophages in plasma : Increase in patients with rheumatoid arthritis."Clin.ExImmunol.. 132. 477-484 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Midori Masuda, Hakuo Takahashi: "Soluble FcγRIIIa^<M_Φ> derived from macrophages."Rinsyo Byori. 51(11). 1102-1105 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 桝田緑, 高橋伯夫: "動脈硬化症における可溶性FcγRIIIa^<Mφ>の増加"臨床検査. 46. 441-443 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] 桝田緑, 高橋伯夫: "動脈硬化症におけるマクロファージ由来可溶性FcγRIIIa^<Mφ>の増加"臨床病理. 50. 502-505 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Midori Masuda, et al.: "Increse of soluble FcγRIIIa derived from NK cells and macrophages in plasma from patients with rheumatoid arthritis."J.Rheumatol.. 30. 1191-1197 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Midori Masuda, et al.: "Measurement of soluble FcγRIIIa derived from macrophages in plasma : Increase in patients with rheumatoid arthritis."Clin.Exp.Immunol.. 132. 477-484 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 桝田緑, 高橋伯夫: "マクロファージ由来可溶性FcγRIIIa^<Mφ>"臨床病理. 51. 1102-1105 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Midori Masuda, et al.: "Measurement of soluble FcγRIIIa derived from macrophages in plasma : Increase in patients with rheumatoid arthritis"Clin. Exp. Immunol.. (印刷中).

    • Related Report
      2002 Annual Research Report
  • [Publications] Midori Masuda, et al.: "Increse of soluble FcγRIIIa derived from NK cells and macrophages in plasma from patients with rheumatoid arthritis"J. Rheumatol.. (印刷中).

    • Related Report
      2002 Annual Research Report
  • [Publications] 桝田緑, 他: "動脈硬化症におけるマクロファージ由来可溶性sFcγRIIIa^<Mφ>の増加"臨床病理. 50・5. 502-505 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 桝田緑, 他: "動脈硬化症における可溶性sFcγRIIIa^<Mφ>の増加"臨床検査. 411-443 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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