STUDY OF GRANULYSIN AS A USEFUL PARAMETER FOR ASSESSING PATHOLOGICAL STATUS
| Project/Area Number |
14572196
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | LOUIS PASTEUR CENTER FOR MEDICAL RESEARCH |
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Principal Investigator |
KISHI Atsuko LOUIS PASTEUR CENTER FOR MEDICAL RESEARCH, BASIC RESEARCH, HEA, パストゥール医学研究センター・基礎研究部, 室長 (80260165)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2003: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2002: ¥2,600,000 (Direct Cost: ¥2,600,000)
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| Keywords | GRANULYSIN / NK CELL / CD8T CELL / CYTOLYTIC GRANULE / PATHOLOGICAL CONDITION / granulysin / perforin / 細胞障害性顆粒 / 癌 / 免疫機能 |
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| Research Abstract |
We set up a system using mAbs of detecting granulysin using ELISA method and revealed that granulysin can be detected from the supernatants of PBMC without any stimulation. Ganulysin production of healthy individuals is correlated with the number of NK cells, whereas some cancer patients do not show any correlation with NK cells due to the high production from CD8+ T cells.
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Report
(3 results)
Research Products
(1 results)
