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EFFECTS OF PHYSICAL TRAINING-INDUCED SKELETALMUSCLE TRANSCRIPTIONAL ACTIVAIONS ON GLUCOSE METABOLISM

Research Project

Project/Area Number 14580046
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 体育学
Research InstitutionNational Institute of Health and Nutrition

Principal Investigator

TABATA Izumi  National Institute of Health and Nutrition, Division of Health Promotion and Exercise, Division Chief, 健康増進研究部, 室長 (20188402)

Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2002: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsPGC-1 / Swimming exercise / Running exercise / AMPK / AICAR / Epitrochlearis / Soleus / ヒラメ筋 / PGC-1 / )走運動
Research Abstract

The purpose of this study was to elucidate the mechanisms underlying low-intensity-exercise-induced peroxisome proliferator-activated receptor γ coactivator-1 α (PGC-1 α) protein expression in rat skeletal muscles. Rats (5-6-week-old) swam without a load and ran on the treadmill at a speed of 13 m/min, respectively, in two 3-h sessions separated by 45 min of rest. PGC-1 α content in epitrochlearis muscle (EPI) was increased by 75 % and 95 %, immediately and 6-h post-swimming, respectively, with no increase in PGC-1 α content in the soleus (SOL). After running, PGC-1 α content in EPI was unchanged, while a 107 % increase in PGC- 1 α content was observed in SOL 6-h post-running. Furthermore, in EPI and SOL as well as other muscles (triceps, plantaris, red and white gastrocnemius), PGC-1 α expression was enhanced concomitant with reduced glycogen post-exercise, suggesting that expression of PGC-1 α occurs in skeletal muscle recruited during exercise.
Six-hour after in vitro electrical stimulation, mRNA of PGC-1 α increased in epitrochlearis muscle dissected from sedentary rat. PGC-1 α content in EPI was increased after 18-h in vitro incubation with 0.5 mM 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) and 4 mM caffeine. However, AICAR incubation did not affect PGC-1 α content in the SOL, while PGC-1 α content in the SOL was increased after caffeine incubation. These results suggest that exercise-induced PGC-1 α expression in skeletal muscle may mediated by at least two exercise-induced signaling factors : AMPK activation and Ca2+ elevation. The number of factors involved (both AMPK and Ca2+, or Ca2+ only) in exercise-induced PGC-1 α expression may differ among muscles.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (11 results)

All 2004 2003 2002 Other

All Journal Article (6 results) Publications (5 results)

  • [Journal Article] Effects of acute bouts of running and swimming exercise on PGC-1 a protein expression in rat epitrochlearis and soleus muscle2004

    • Author(s)
      Terada S, I Tabata
    • Journal Title

      American Journal of Physiology (Endocrinology and Metabolism) 286

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Effects of acute bouts of running and swimming exercise on PGC-1 α protein expression in rat epitrochlearis and soleus muscle2004

    • Author(s)
      Terada, S., I.Tabata
    • Journal Title

      American Journal of Physiology (Endocrinology and Metabolism) 286

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Changes in 〔Ca2+〕 i induced by several glucose transport-enhancing stimuli in rat epitrochlearis muscle2003

    • Author(s)
      Terada S, I Muraoka, I Tabata
    • Journal Title

      Journal of Applied Physiology 94

      Pages: 1813-1820

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Changes in intracellular [Ca^<2+>]i concentration induced by several glucose transport- enhancing stimuli in rat epitrochlearis muscle.2003

    • Author(s)
      Terada, S., I.Muraoka, I.Tabata
    • Journal Title

      Journal of Applied Physiology 94

      Pages: 1813-1820

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle2002

    • Author(s)
      Terada S, M Goto, M Kato, K Kawanaka, T Shimokawa, I Tabata
    • Journal Title

      Biochemical and Biophysical Research Communications 296

      Pages: 350-359

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscl2002

    • Author(s)
      Terada, S., M.Goto, M.Kato, K.Kawanaka, T.Shimokawa, I.Tabata
    • Journal Title

      Biochemical and Biophysical Research Communications 296

      Pages: 350-359

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Terada S, I Muraoka, I Tabata: "Changes in [Ca^<2+>]i, induced by several glucose transport-enhancing stimuli in rat epitrochlearis muscle"Journal of Applied Physiology. 94. 1813-1820 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Terada S, I Tabata: "Effects of acute bouts of running and swimming exercise on PGC-1 α protein expression in rat epitrochlearis and soleus muscle"American Journal of Physiology (Endocrinology and Metabolism. 286. E208-E216 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 田畑 泉: "トレーニングと糖・エネルギー代謝:トレーニングによる骨格筋のタンパク質発現を包括的に制御する可能性のあるPGC-1"体育の科学. 53. 576-581 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Terada S, M Goto, M Kato, K Kawanaka, T Shimokawa, I Tabata: "Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle"Biochemical and Biophysical Research Communications. 296. 350-354 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Terada S, I Muraoka, I Tabata: "Changes in 〔Ca^<2+>〕i induced by several glucose transport-enhancing stimuli in rat epitrochlearis muscle"Journal of Applied Physiology. 94. 1813-1820 (2003)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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