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STUDY OF HEALTH RISK ASSESSMENT OF ENVIRONMENTAL NANO PARTICULATE MATTER BASEDE ON PHYSICAL AND CHEMICAL CARACTERISTICS.

Research Project

Project/Area Number 14580574
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 環境影響評価(含放射線生物学)
Research InstitutionTOKYO WOMEN'S MEDICAL UNIVERSITY

Principal Investigator

ISHIHARA Yoko  TOKYO WOMEN'S MEDICAL UNIVERSITY, SCHOOL OF MEDICINE, ASSOCIATE PROFESSOR, 医学部, 助教授 (50203021)

Co-Investigator(Kenkyū-buntansha) NAKAJIMA Toru  JAPAN AUTOMOBIL RESEARCH INSTITUTE, THE CHIEF EDITOR, 主幹
TOMITA Sachiko  TOKYO WOMEN'S MEDICAL UNIVERSITY, SCHOOL OF MEDICINE, ASSISTANT, 医学部, 助手 (40231451)
HAGIWARA Hiromi  TOKYO INSTITUTE OF TECHNOLOGY, GRADUATE SCHOOL BIOMEDICAL RESEARCH SUPPORT CENTER, ASSOCIATE PROFESSOR, 大学院・バイオ研究基盤支援センター, 助教授 (90189465)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2003: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2002: ¥2,600,000 (Direct Cost: ¥2,600,000)
KeywordsNANO PARTICLES / RISK ASSESSMENT / HEALTH EFFECTS / PARTICULATE MATTER / ULTRAFINE PARTICULATE MATTER / CARDIOPULMONARY DISEASES / PARTICLE DOSIMETRY / 環境衛生 / 超微粒子 / 生体内動態
Research Abstract

We studied the particle dosimetry in mice with a single intratracheal injection of nano particulate matter. Particle deposition was observed in type I alveolar epithelial cells and alveolar macrophages in the lung on day 3 after treatment. On day 7, particles were detected in the type I alveolar epithelial cells, basement and blood vessels in the lung. On day 10, particles were detected in the type I cells and blood vessels in the lung, cooper cells in the liver and olfactory. The selection criteria for appropriate makers for the cardiopulmonary diseases-related risk assessment in nano particulate matter were studied in rats exposed with diesel exhaust. The R-R interval, systemic, arrhythmia were selected related to physiological, effects, gene expression of inflammation response-related cytokines, ANP and BNP were selected as for appropriate markers. However, these markers did not show marked correlation with heart failure.
Rats treated with particles from diesel exhaust devoid of organic, component showed significant increase of gene expression of inflammation-related cytokines compared with those in rats treated with whole diesel particles. This indicates that the number of nano particles is a major factor for the observed effects rather than their weight.
The health effect of organic component of diesel particles was studied in rats using telemetry system. Although inflammatory cells emerged immediately in alveolar spaces after single intratracheal injection of organic components, RR-interval, autonomic nerves system, systemic, and core-temperature did not change markedly for 4 days after treatment.
These data suggested that not only the lung where particles initially deposited but also other organs including liver, nerves and brain must be considered in the risk assessment of nano particulate matter. Additionally, physical and chemical characteristics of particles should be factored in the evaluation of health effects of nano particulate matter.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] Ishihara Y et al.: "Chronic diesel exhaust exposures of rats demonstrate concentration and time-dependent effects on pulmonary inflammation."Inhal Toxicol. 15. 473-492 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishihara Y et al.: "Dose-response assessment and effect of particles in guinea pigs exposed chronically to diesel exhaust : analysis of various biological markers in pulmonary alveolar lavage fluid and circulating blood."Inhal Toxicol. 14. 1049-1067 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishihara Y et al.: "Effects of surface characteristics of potassium titanate whisker samples on acute lung injury induced by a single intratracheal administration in rats"Inhal Toxicol. 14. 503-519 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishihara Y et al.: "Inflammatory responses and mucus secretion in rats with acute bronchiolitis induced by nickel chloride"Inhal Toxicol. 14. 101-114 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishihara Y et al.: "Expression and mutation of p53 gene in the lung of mice intratracheal injected with crystalline silica"Cancer Letters. 177. 125-128 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishihara Y et al.: "Comparison of Susceptibility of Immunological Response in Matured and Aged Mice with Acute Bronchiolities Exposed to Ozone"Int.Symp.Series. 91-102 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishihara Y, Kagawa J: "Chronic diesel exhaust exposures of rats demonstrate concentration and time dependent effects on pulmonary inflammation."Inhal Toxicol.. 15. 473-492 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishihara Y, Kagawa J: "Dose-response assessment and effect of particles in guinea pigs exposed chronically to diesel exhaust : Analysis of various biological markers in pulmonary alveolar lavage fluid and circulating blood."Inhal Toxicol.. 14. 1049-1067 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishihara Y, Kyono H, Kohyama N, Otaki N, Serita F, Toya T: "Effects of surface characteristics of potassium titanate whisker samples on acute lung injury induced by a single transtracheal administration in rats."Inhal Toxicol.. 14. 503-519 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishihara Y, Kyono H, Serita F, Toya T, Kawashima H, Miyasaka M: "Inflammatory responses and mucus secretion in rats with acute bronchiolitis induced by nickel chloride."Inhal Toxicol.. 14. 101-114 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishihara Y, Iijima H, Matsunaga K, Fukushima T, Nishikawa T, Takenoshita S: "Expression and mutation of p53 gene in the lung of mice intratracheal injected with crystalline silica."Cancer Letters. 177. 125-128 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishihara Y, Matsubara I, Nakagawa K, Nishikawa T, Kagawa J: "Comparison of susceptibility of immunological response in matured and aged mice with acute bronchiolitis exposed to ozone."International Inhalation Symposium Series, ILSI Press. 91-102 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 石原陽子: "大気中粒子状物質と肺がん"自動車研究. 24. 203-212 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishihara Y, Yasuhara T, Ishiyama S, Kawashima H, Miyasaka M, Miyazaki Y: "The role of leukocytes during acute phase inflammation in crystalline silica-induced lung injury."Exp Lung Res. 27. 589-603 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 石原陽子: "粒子状物質(PM)の生体内動態とその健康影響"自動車研究. 23. 503-517 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Adachi C, Naruse H, Ishihara Y, Tanabe A, Takagi S, Yoshimoto T, Naruse K, Kagawa J, Takano K.: "Effects of acute and chronic cigarette smoking on the expression of endothelin-1 mRNA of the cardiovascular tissues in rats."J Cardiovas Pharm. 36(suppl.). s198-s200 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishihara Y, Nishikawa T, Kagawa J: "Expression of cytokaines in the lungs of normal and sensitized mice single transtracheally injected with diesel exhaust particles or its organic solvent extracted particles."International Inhalation Symposium Series. ILSI Press. 393-396 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishihara Y, Kagawa J: "Chronic diesel exhaust exposures of rats demonstrate concentration and time-dependent effects on pulmonary inflammation"Inhal Toxicol. 15. 473-492 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ishihara Y, Kagawa J: "Dose-response assessment and effect of particles in guinea pigs exposed chronically to diesel exhaust: analysis of various biological markers in pulmonary alveolar lavage fluid and circulating blood."Inhal Toxicol. 14. 1049-1067 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ishihara Y, Kyono H, Kohyama N, et al.: "Effects of surface characteristics of potassium titanate whisker samples on acute lung injury induced by a single intratracheal administration in rats"Inhal Toxicol. 14. 503-519 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ishihara Y, Kyono H, Serita F, et al.: "Inflammatory responses and mucus secretion in rats with acute bronchiolitis induced by nickel chloride"Inhal Toxicol. 14. 101-114 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ishihara Ym Iijima H, Matsunaga K, et al.: "Expression and mutation of p53 gene in the lung of mice intratracheal injected with crystalline silica"Cancer Letters. 177. 125-128 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ishihara Y, Matsubara I, Nakagawa K, et al.: "Comparison of susceptibility of immunological response in matured and aged mice with acute bronchiolities exposed to ozone"International Inhalation Symposium Series. 91-102 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ishihara Y, Kagawa J: "Chronic diesel exhaust exposures of rats demonstrate concentration and time dependent effects on pulmonary inflammation"Inhal Toxicol. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ishihara Y, Kagawa J: "Dose-response assessment and effect of particles in guinea pigs exposed chronically to diesel exhaust"Inhal Toxicol. 14. 1049-1067 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ishihara Y, et al.: "EFFECTS OF SURFACE CHARACTERISTICS OF POTASSIUM TITANATE WHISKER SAMPLES ON ACUTE LUNG INJURY INDUCED BY A SINGLE INTRATRACHEAL ADMINISTRATION IN RATS"Inhal Toxicol. 14. 503-519 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ishihara Y, et al.: "Inflammatory responses and mucus secretion in rats with acute bronchiolitis induced by nickel chloride"Inhal Toxicol. 14. 101-114 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ishihara, et al.: "Expression and mutation of p53 gene in the lung of mice intratracheal injected with crystalline silica"Cancer Letters. 177. 125-128 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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