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Investigation of Biologically Active Antioxidants from Food Plant Waste to Find New Source of Supplement and Medicine

Research Project

Project/Area Number 14580614
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Bioorganic chemistry
Research InstitutionNagoya City University

Principal Investigator

NAGATSU Akito  Nagoya City University, Graduate School of Pharmaceutical Sciences, Assistant Professor, 大学院・薬学研究科, 講師 (70244572)

Co-Investigator(Kenkyū-buntansha) INOUE Makoto  Nagoya City University, Graduate School of Pharmaceutical Sciences, Assistant Professor, 大学院・薬学研究科, 助教授 (50191888)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2002: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsPrunus yedoensis / Trapa japonica / Brassica campestris var. japonica HARA / antioxidative activity / Inhibition of NO production / antiinflamatory activity / フラボノイド / tetragalloyl glucose
Research Abstract

Antioxidative and antiinflamatory activities were found from the BuOH and AcOEt soluble material, respectively, of EtOH extract from petals of cherry (Prunus yedoencis). Separation of BuOH and AcOEt soluble material was carried out and glucose ester of caffeic acid and p-coumaric acid, rutin and quercetin 3-O-lathyroside were isolated from BuOH soluble material, and quercetin, kaempferol, and their 3-O-glucosides and galactosides were isolated from AcOEt soluble material.
From the pericarp of water chestnuts (Trapa japonica), 4 antioxidative compounds, gallic acid, 1,2,3,6-tetragalloylglucose, 2,3,6-trigalloylglucose, tellimagrandin II, were isolated. As 2,3,6-trigalloylglucose was the new compound. Gallic acid, and 1,2,3,6-tetragalloylglucose were included in large ratio in the pericarp, this is the possible source for antioxidative food additives or supplements.
The rape (Brassica campestris var. japonica HARA) seed oil cake was investigated and 6 compounds including new 1-methoxy-1-(3,5-dimethoxy-4-hydroxyphenyl )ethane was isolated as antioxidative principles.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (2 results)

All Other

All Publications (2 results)

  • [Publications] A.Nagatsu, T.Sugitani, H.Okuyama, H.Mizukami et al.: "Anitioxidants from rape (Brassica campestris var Japonica HARA) oil cake"Natural Products Research. 18(3). 231-240 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Akito Nagatsu, Tomochika Sugitani, Yoshiko Mori, Harumi Okuyama, Jinsaku Sakakibara, Hajime Mizukami: "Anitioxidants from rape (Brassica campestris var Japonica HARA) oil cake"Natural Products Research. 18-3. 231-240 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary

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Published: 2002-04-01   Modified: 2016-04-21  

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