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Study on the mechanism of vascular injury by novel species of advanced glycation endoproducts

Research Project

Project/Area Number 14580645
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional biochemistry
Research InstitutionKANAZAWA UNIVERSITY

Principal Investigator

WATANABE Takuo  Kanazawa University, Graduate School of Medical Science, Associated Professor, 医学系研究科, 助教授 (40303268)

Co-Investigator(Kenkyū-buntansha) TAKEUCHI Masayoshi  Kanazawa University, Department of Parmacology, Instructor, 薬学部, 講師 (20154982)
YAMAMOTO Yasuhiko  Kanazawa University, Graduate School of Medical Science, Instructor, 医学系研究科, 助手 (20313637)
YONEKURA Hideto  Kanazawa University, Graduate School of Medical Science, Associated Professor, 医学系研究科, 助教授 (80240373)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2003: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2002: ¥2,600,000 (Direct Cost: ¥2,600,000)
Keywordsadvanced glycation endproducts / AGE / RAGE / diabetic angiopath / MAP kinase / VCAM-1 / esRAGE / life-style related diseases / RAGE knockout
Research Abstract

In this research, we revealed that the novel species of advance glycation endproducts (AGE), whose level in serum is elevated in diabetic patients, do bind to their cellular receptor RAGE and induce intracellular signals.We also identified a novel splicing variant of RAGE-endogenous secretory RAGE (esRAGE)-and found that this variant has protective effect against vascular injury induced by the novel AGE species. Moreover, we found the significant coirelation between serwn esRAGE level and susceptibility of some life-style related diseases.
(1) We demonstrated that the novel AGE species, which is generated by incubating bovine serum albumin with glyceraldehyde or glycolaldehyde, strongly binds to cellular RAGE at comparable dissociation constants calculated by the suiface plasmon resonance method.
(2) We mapped the binding region of the novel AGEs on RAGE at an inununoglobulin V-domain-like region on its N-terminal end.
(3) We demonstrated that the interaction of the new AGEs to RAGE activated MAP kinase signaling pathway and induced V CAM-i expression in cultured human endothelialcells.
(4) We created RAGE knockout mice and demonstrated that the development of diabetic nephropa thy was dramatically suppressed in the absence of RAGE..
(5) We isolated a novel splicing variant of RAGE from human endothelial cells that lacks transmembrane domain and is secreted from cells, and termed this novel variant esRAGE (~ndogenous secretory RAGE).
(6) Furthennore we found that esRAGE has a protective effect against the vascular injuly induced by the novel AGEs, by extracellular capture of the RAGE lingads.
(7) We established esRAGE ELISA system and analyzed serum level of esRAGE in patients with life-style related deseases. Then we found significant correlation between serum esRAGE level and susceptibility of some life-style related diseases, suggesting that. the serum esRAGE level could be a useful risk marker for some life-style related deseases.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (126 results)

All Other

All Publications (126 results)

  • [Publications] Petrova, G.R.: "Advanced glycation endproduct-induced calcium handling impairment in mouse cardiac myocytes."J.Mol.Cell.Cardiol.. 34(10). 1425-1431 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamagishi, S.: "Advanced glycation end products-induced apoptosis and overexpression of vascular endothelial growth factor in bovine retinal pericytes."Biochem.Biophys.Res.Commun.. 290(3). 973-982 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamamoto, Y.: "The role of AGE-RAGE system in the development of diabetic nephropathy in vivo."Excerpta Medica International Congress Series. 1245. 45-50 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yonekura, H.: "RAGE engagement and vascular cell derangement by short chain sugar-derived advanced glycation endproducts."Excerpta Medica International Congress Series. 1245. 129-135 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakurai, S.: "Identification of a novel AGE-capturable soluble variant of the receptor for AGE in human sera."Excerpta Medica International Congress Series. 1245. 163-167 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Okamoto, T.: "Angiogenesis induced by advanced glycation end products and its prevention by cerivastatin."FASEB J.. 16. 1928-1930 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamagishi, S.: "Beraprost sodium, a prostaglandin I_2 analogue, protects against, advanced glycation endproducts-induced injury in cultured retinal pericytes."Mol.Med.. 8. 546-550 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamagishi, S.: "Pigment epithelium-derived factor protects cultured retinal pericytes from advanced glycation end product-induced injury through its anti-oxidative properties."Biochem.Biophys.Res.Commun.. 296. 877-882 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Okamoto, T.: "Incadronate disodium inhibits advanced glycation end products-induced angiogenesis in vitro."Biochem.Biophys.Res.Commun.. 297. 419-424 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Miyoshi, H.: "Aminoguanidine pyridoxal adduct is superior to aminoguanidine for preventing diabetic nephropathy in mice."Horm.Metab.Res.. 34. 371-377 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kikuchi, S.: "Detection of N epsilon-(carboxymethyl)lysine (CML) and non-CML advanced glycationend -products in the anterior horn of amyotrophic lateral sclerosis spinal cord."Amyotroph.Lateral Scler.Other Motor Neuron Disord.. 3. 63-68 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sasaki, N.: "Advanced glycation end products (AGE) and their receptor (RAGE) in the brain of patients with Creutzfeldt-Jakob disease with prion plagues."Neurosci.Lett.. 326. 117-120 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamagishi, S.: "Advanced glycation end product-induced apoptosis and overexpression of vascular endothelial growth factor and monocyte chemoattractant protein-1 in human cultured mesangial cells."J.Biol.Chem.. 277. 20309-20315 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yonekura, H.: "Novel splice variants of the receptor for advanced glycation endproducts (RAGE) expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury."Biochem.J.. 370(3). 1097-1109 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Miura, J.: "Serum levels of non-carboxymethyllysine advanced glycation endproducts are correlated to severity of microvascular complications in patients with Type 1 diabetes."J.Diabetes Complications. 17(1). 16-21 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Watanabe, T.: "Preparation and characterization of recombinant protein phosphatase 1."Methods Enzymol.. 366. 321-338 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kim, Y.M.: "PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit : Characterization of itsPP1-and RNA-binding domains and regulation by phosphorylation."J.Biol.Chem.. 278(16). 13819-13828 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakurai, S.: "The AGE-RAGE system and diabetic nephropathy."J.Am.Soc.Nephrol.. 14(suppl.3). S259-S263 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Unoki, H.: "Up-regulation of cyr61 in vascular smooth muscle cells of spontaneously hypertensive rats."Lab.Invest.. 83(7). 973-982 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yonemura, Y.: "REG gene expression is associated with the infiltrating growth of gastric carcinoma."Cancer. 98(7). 1394-1400 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kikuchi, S.: "Glycation-a sweet tempter for neuronal death."Brain Res.Brain Res.Rev.. 41. 306-323 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takeuchi, M.: "Neurotoxicity of acetaldehyde-derived advanced glycation end-products for cultured cortical neurons."J.Neuropathol.Exp.Neurol.. 62. 486-496 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamagishi, S.: "Advanced glycation end products inhibit de novo protein synthesis and induce TGF-β overexpression in proximal tubular cells."Kidney Int.. 63. 464-473 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Inagaki, Y.: "Pigment epithelium-derived factor prevents advanced glycation end products-induced monocyte chemoattractant protein-1 production in microvascular endothelial cells by suppressing intracellular reactive oxygen species generation."Diabetologia. 46. 284-287 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Miura, J.: "AGE down-regulation of monocyte RAGE expression and its association with diabetic complications in type 1 diabetes."J.Diabetes Complications. 18(1). 53-59 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Abe, R.: "Overexpression of pigment epithelium-derived factor decreases angiogenesis and inhibits the growth of human malignant melanoma cells in vivo."Am.J.Pathol.. 164. 1225-1232 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takeuchi, M: "Involvement of advanced glycation end-products (AGEs) in Alzheimer's disease."Curr.Alzheimer Res.. 1. 39-46 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Abe, R.: "Regulation of human malignant melanoma growth and metastasis by AGE-AGE receptor Interactions."J.Invest.Dermatol.. 122. 461-467 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohashi, S.: "Advanced glycation end products increase collagen-specific chaperone protein in mouse diabetic nephropathy."J.Biol.Chem.. (In press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Li, H.: "Possible participation of pICln in the regulation of angiogenesis through alternative splicing of VEGF receptor mRNAs."Endothelium. (In press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamamoto, Y.: "Nurture vs.nature in diabetic vasculopathy : roles of advanced glycation endproducts and the receptor for them."International Congress Series. (In press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 米倉 秀人: "新しい機能性遺伝子スクリーニング法-アンチセンスディスプレイ法-の開発と新規遺伝子探索への適用"バイオサイエンスとインダストリー((財)バイオインダストリー協会). 60(7). 36-37 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 山本 靖彦: "Development and prevention of advanced diabetic nepropathy in RAGE-overexpressing mice."ゲノムニュース(文部科学省 科学研究費特定領域研究C「ゲノム」 4領域広報委員会). 1(1). 32-33 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 山本 靖彦: "AGE-RAGE系を標的とした糖尿病血管障害抑制の可能性"日本薬理学会誌. 121(1). 49-56 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 山本 博: "高血糖による酸化ストレスと血管障害機構"Medical Tribune. 36(49). 18-19 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 山本 靖彦: "AGE-RAGE"内科. 91(6). 1419-1420 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 渡邉琢夫: "糖尿病血管症の分子機構"生化学. 75(10). 1361-1370 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 竹内正義: "高血糖とAGE:新しい治療戦略"Bio Clinica. 18(7). 47-51 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 李慧: "血管新生系制御"血管医学. 4(2). 41-46 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 徐 成金: "糖尿病血管合併症の環境因子と遺伝子"Diabetes Journal. 31(1). 1-6 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 山本 靖彦: "糖尿病学2002"診断と治療社. 4 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 大澤 真里: "Annual Review 2003 腎臓"中外医学社. 5 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 山本 博: "医学のための基礎分子細胞生物学"南山堂. 12(2-3, 34-39, 86-87, 90-91) (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 米倉秀人: "医学のための基礎分子細胞生物学"南山堂. 4(6-7, 82-83) (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 渡邉琢夫: "医学のための基礎分子細胞生物学"南山堂. 4(92-93, 102-103) (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 山本靖彦: "医学のための基礎分子細胞生物学"南山堂. 2(54-55) (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 山本 博: "医学大辞典"医学書院. 5(84, 92, 809, 1111, 1213) (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 米倉秀人: "医学大辞典"医学書院. 2(1799, 2285) (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 山本靖彦: "医学大辞典"医学書院. 2(2292, 2302) (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 山田 外史: "生体と電磁界"学会出版センター. 25(51-75) (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hatakeyma, H.: "The Encyclopedia of Endocrinology and Endocrine Diseases"Academic Press, San Diego(In press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Petrova, G.R.: "Advanced glycation endproduct-induced calcium handling impairment in mouse cardiac myocytes."J.Mol.Cell.Cardiol.. 34(10). 1425-1431 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamagishi, S.: "Advanced glycation end products-induced apoptosis and overexpression of vascular endothelial growth factor in bovine retinal pericytes."Biochein.Biophys.Res.Commnun.. 290(3). 973-982 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamamoto, Y.: "The role of AGE-RAGE system in the development of diabetic nephiopathy in vivo."Excerpta Medica International Congress Series 1245, The Maillard Reaction in Food Chemistry and Medical Science : Update for The Postgenomic Era(Horiuchi S, et al., eds), (Elsevier Science B.V., Amsterdam). 45-50 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yonekura, H.: "RAGE engagement and vascular cell derangement by short chain sugar-derived advanced glycation endproducts."Excerpta Medica International Congress Series 1245, The Maillard Reaction in Food Chemistry and Medical Science : Update for The Postgenomic Era(Horiuchi S, et al., eds), (Elsevier Science B.V., Amsterdam). 129-135 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakurai, S.: "Identification of a novel AGE-capturable soluble variant of the receptor for AGE in human sera."Excerpta Medica International Congress Series 1245, The Maillard Reaction in Food Chemistry and Medical Science : Update for The Postgenomic Era(Horiuchi S, et al., eds), (Elsevier Science B.V., Amsterdam). 129-135 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Okamoto, T.: "Angiogenesis induced by advanced glycation end products and its prevention by cerivastatin."FASEB J.. 16. 1928-1930 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamagishi, S.: "Beraprost sodium, a prostaglandin I_2 analogue, protects against advanced glycation endproducts-induced injury in cultured retinal pericytes."Mol.Med.. 8. 546-550 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamagishi, S.: "Pigment epithelium-derived factor protects cultured retinal pericytes from advanced glycation.end product-induced injury through its anti-oxidative properties."Biochem.Biophys.Res.Commun.. 296. 877-882 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Okamoto, T.: "Incadronate disodium inhibits advanced glycation end products-induced angiogenesis in vitro."Biochein.Biophys.Res.Commun.. 297. 419-424 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Miyoshi, H.: "Aminoguanidine pyridoxal adduct is superior to aminoguanidine for preventing diabetic nephropathy in mice."Horm.Metab.Res.. 34. 371-377 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kikuchi, S.: "Detection of N epsilon-(carboxymethyl)lysine(CML)and non-CML advanced glycationend -products in the anterior horn of amyotrophic lateral sclerosis spinal cord."Amyotroph.Lateral Scler.Other Motor Neuron Disord.. 3. 63-68 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sasaki, N.: "Advanced glycation end products(AGE)and their receptor(RAGE)in the brain of patients with Creutzfeldt-Jakob disease with prion plaques."Neurosci.Lett.. 326. 117-120 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamagishi, S.: "Novel splice variants of the receptor for advanced glycation endproducts(RAGE)expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury."J.Biol.Chem.. 277. 1097-1109 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yonekura, H.: "Novel splice variants of the receptor for advanced glycation endproducts(RAGE)expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury."Biochem.J.. 370(3). 1097-1109 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Miura, J.: "Serum levels of non-carboxymethyllysine advanced glycation endproducts are correlated to severity of microvascular complications in patients with Type 1 diabetes."J.Diabetes Complications. 17(1). 16-21 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Watanabe, T.: "Preparation and characterization of recombinant protein phosphatase 1."Methods Enzymol.. 366. 321-338 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kim, Y.M.: "PNUTS, a protein phosphatase 1(PP 1)nuclear targeting subunit : Characterization of itsPP1-and RNA-binding domains and regulation by phosphorylation."J.Biol.Chem.. 278(16). 13819-13828 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakurai, S.: "The AGE-RAGE system and diabetic nephropathy."J.Am.Soc.Nephrol.. 14(suppl.3). S259-S263 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Unoki, H.: "Up-regulation of cyr61 in vascular smooth muscle cells of spontaneously hypertensive rats."Lab.Invest.. 83(7). 973-982 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yonemura, Y.: "REG gene expression is associated with the infiltrating growth of gastric carcinoma."Cancer. 98(7). 1394-1400 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kikuchi, S.: "Glycation-a sweet tempter for neuronal death."Brain Res.Brain Res.Rev.. 41. 306-323 (2003)

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      「研究成果報告書概要(欧文)」より
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  • [Publications] Takeuchi, M.: "Neurotoxicity of acetaldehyde-derived advanced glycation end-products for cultured cortical neurons."J.Neuropathol.Exp.Neurol.. 62. 486-496 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Yamagishi, S.: "Advanced glycation end products inhibit de novo protein synthesis and induce TGF-β overexpression in proximal tubular cells."Kidney Int.. 63. 464-473 (2003)

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      「研究成果報告書概要(欧文)」より
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  • [Publications] Inagaki, Y.: "Pigment epithelium-derived factor prevents advanced glycation end products-induced monocyte chemoattractant protein-1 production in microvascular endothelial cells by suppressing intracellular reactive oxygen species generation."Diabetologia. 46. 284-287 (2003)

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      「研究成果報告書概要(欧文)」より
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  • [Publications] Yamamoto, Y.: "Possible participation of advanced glycation endproducts and their receptor system in the development of diabetic vascular complications"Nippon Yakugaku Zasshi. 121(1). 49-45 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Watanabe, T.: "Molecular mechanism of diabetic angiopathy"Seikagaku. 75(10). 1361-1370 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Miura, J.: "AGE down-regulation of monocyte RAGE expression and its association with diabetic complications in type 1 diabetes."J.Diabetes Complications. 18(1). 53-59 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Abe R.: "Overexpression of pigment epithelium-derived factor decreases angiogenesis and inhibits the growth of human malignant melanoma cells in vivo."Am.J.Pathol.. 164. 1225-1232 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Abe, R.: "Regulation of human malignant melanoma growth and metastasis by AGE-AGE receptor Interactions."J.Invest.Dermatol.. 122. 461-467 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Takeuchi, M.: "Involvement of advanced glycation end-products(AGEs)in Alzheimer's disease."Curr.Alzheirner Res.. 1. 39-46 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Ohashi, S.: "Advanced glycation end products increase collagen-specific chaperone protein in mouse diabetic nephropathy."J.Biol.Chem.. (In press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Li, H.: "Possible participation of plCln in the regulation of angiogenesis through alternative splicing of VEGF receptor mRNAs."Endothelium. (In press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Yamamoto, Y.: "Nurture vs. nature in diabetic vasculopathy : roles of advanced glycation endproducts and the receptor for them."International Congress Series. (In press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Yonekura, H.: "Novel splice variants of the receptor for advanced glycation endproducts (RAGE) expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury"Biochem.J.. 370(3). 1097-1109 (2003)

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  • [Publications] Watanabe, T.: "Preparation and characterization of recombinant protein phosphatase 1"Methods Enzymol.. 366. 321-338 (2003)

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  • [Publications] Young-Mi Kim: "PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit"J.Biol.Chem.. 278(16). 13819-13828 (2003)

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  • [Publications] Miura, J.: "Serum levels of non-carboxymethyllysine advanced glycation endproducts are correlated to severity of microvascular complications in patients with Type 1 diabetes"J Diabetes Complications. 17(1). 16-21 (2003)

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  • [Publications] Sakurai, S.: "The AGE-RAGE system and diabetic nephropathy"J.Am.Soc.Nephrol.. 14(suppl.3). S259-S263 (2003)

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  • [Publications] Unoki, H.: "Up-regulation of cyr61 in vascular smooth muscle cells of spontaneously hypertensive rats"Lab.Invest. 83(7). 973-982 (2003)

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  • [Publications] Yonemura, Y.: "REG gene expression is associated with the infiltrating growth of gastric carcinoma"Cancer. 98(7). 1394-1400 (2003)

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  • [Publications] Miura, J.: "AGE down-regulation of monocyte RAGE expression and its association with diabetic complications in type 1 diabetes"J Diabetes Complications. 18(1). 53-59 (2004)

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  • [Publications] Ohashi, S.: "Advanced glycation end products increase collagen-specific chaperone protein in mouse diabetic nephropathy"J.Biol.Chem.. (In press). (2004)

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  • [Publications] Li, H.: "Possible participation of pICln in the regulation of angiogenesis through alternative splicing of VEGF receptor mRNAs"Endothelium. (In press). (2004)

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  • [Publications] Yamamoto, Y.: "Nurture vs. nature in diabetic vasculopathy : roles of advanced glycation endproducts and the receptor for them"International Congress Series. (In press). (2004)

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  • [Publications] 山本 博: "高血糖による酸化ストレスと血管障害機構"Medical Tribune. 36(49). 18-19 (2003)

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  • [Publications] 山本 靖彦: "AGE-RAGE"内科. 91(6). 1419-1420 (2003)

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  • [Publications] 渡邉琢夫: "糖尿病血管症の分子機構"生化学. 75(10). 1361-1370 (2003)

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  • [Publications] 竹内正義: "高血糖とAGE:新しい治療戦略"Bio Clinica. 18(7). 47-51 (2003)

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  • [Publications] 李 慧: "血管新生系制御"血管医学. 4(2). 41-46 (2003)

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  • [Publications] 徐 成金: "糖尿病血管合併症の環境因子と遺伝子"Diabetes Journal. 31(1). 1-6 (2003)

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  • [Publications] 山本 博: "医学のための基礎分子細胞生物学(pp2-3,pp34-39,pp86-87,pp90-91)"南山堂. 12 (2003)

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  • [Publications] 米倉秀人: "医学のための基礎分子細胞生物学(pp6-7,pp82-83)"南山堂. 4 (2003)

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  • [Publications] 渡邉琢夫: "医学のための基礎分子細胞生物学(pp92-93,pp102-103)"南山堂. 4 (2003)

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  • [Publications] 山本靖彦: "医学のための基礎分子細胞生物学(pp54-55)"南山堂. 2 (2003)

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  • [Publications] 山本 博: "医学大辞典(p84,p92,p809,p1111,p1213)"医学書院. 5 (2003)

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  • [Publications] 米倉秀人: "医学大辞典(p1799,p2285)"医学書院. 2 (2003)

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  • [Publications] 山本靖彦: "医学大辞典(p2292,p2302)"医学書院. 2 (2003)

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  • [Publications] 山本 博: "生体と電磁界(pp.51-75)"学会出版センター. 25 (2003)

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  • [Publications] Petrova, G.R.: "Advanced glycation endproduct-induced calcium handling impairment in mouse cardiac myocytes"J. Mol. Cell. Cardiol.. 34・10. 1425-1431 (2002)

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  • [Publications] Yamagishi, S.: "Advanced glycation end products-induced apoptosis and overexpression of vascular endothelial growth factor in bovine retinal pericytes"Biochem. Biophys. Res. Commun.. 290・3. 973-982 (2002)

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  • [Publications] Yonekura, H.: "RAGE engagement and vascular cell derangement by short chain sugar-derived advanced glycation endproducts"The Maillard Reaction in Food Chemistry and Medical Science : Update for The Postgenomic Era. 1245. 129-135 (2002)

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  • [Publications] Yamamoto, Y.: "The role of AGE-RAGE system in the development of diabetic nephropathy in vivo"The Maillard Reaction in Food Chemistry and Medical Science : Update for The Postgenomic Era. 1245. 45-50 (2002)

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  • [Publications] Sakurai, S.: "Identification of a novel AGE-capturable soluble variant of the receptor for AGE in human sera"The Maillard Reaction in Food Chemistry and Medical Science : Update for The Postgenomic Era. 1245. 163-167 (2002)

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  • [Publications] Yonekura, H.: "Novel splice variants of the receptor for advanced glycation endproducts (RAGE) expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury"Biocherm. J.. 370・3. 1097-1109 (2003)

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  • [Publications] Miura, J.: "Serum levels of non-carboxymethyllysine advanced glycation endproducts are correlated to severity of microvascular complications in patients with Type 1 diabetes"J Diabetes Complications. 17・1. 16-21 (2003)

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  • [Publications] Miura, J.: "AGE downregulation of monocyte expression of RAGE mRNA and its association with diabetic complications in type 1 diabetes"J Diabetes Complications. (in press). (2003)

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  • [Publications] Unoki, H.: "Cyr61 upregulation in vascular smooth muscle cells of spontaneously hypertensive rats"Lab. invest.. (in press). (2003)

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  • [Publications] Kim, Y.M.: "PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit : Characterization of itsPPl-and RNA-binding domains and regulation by phosphorylation"J. Biol. Chem.. (in press). (2003)

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  • [Publications] 米倉 秀人: "新しい機能性遺伝子スクリーニング法-アンチセンスディスプレイ法ーの開発と新規遺伝子探索への適用"バイオサイエンスとインダストリー((財)バイオインダストリー協会). 60(7). 36-37 (2002)

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  • [Publications] 山本 靖彦: "Development and prevention of advanced diabetic nepropathy in RAGE-overexpressing mice"ゲノムニュース(文部科学省 科学研究費特定領域研究C「ゲノム」4領域広報委員会). 1(1). 32-33 (2002)

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  • [Publications] 山本 靖彦: "AGE-RAGE系を標的とした糖尿病血管障害抑制の可能性"日本薬理学会誌. 121(1). 49-56 (2003)

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  • [Publications] 李 慧: "生体諸システムの制御臓器としての血管内皮細胞:血管新生系制御"血管医学(メディカルレビュー社). (印刷中). (2003)

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  • [Publications] 山本 靖彦: "糖尿病学2002"診断と治療社. 4 (2002)

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  • [Publications] 大沢 真里: "Annual Review 2003腎臓"中外医学社. 5 (2003)

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  • [Publications] 渡辺 琢夫: "医学のための基礎分子細胞生物学(第3版)"南山堂(in press). (2003)

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Published: 2002-04-01   Modified: 2016-04-21  

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