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Development of Comprehensive Electrophysiological Heart Simulator for In-Silico Study

Research Project

Project/Area Number 14580843
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

NAKAZAWA Kazuo  National Cardiovascular Center Research Institute, Laboratory of Development and Evaluation of Biomedical Instruments and Systems, Laboratory Chie, 研究機器管理室, 室長 (50198058)

Co-Investigator(Kenkyū-buntansha) IKEDA Takanori  Kyorin University Hospital, 医学部附属病院, 講師 (80256734)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2003: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2002: ¥900,000 (Direct Cost: ¥900,000)
KeywordsFatal Arrhythmia / Computer Simulation / Spiral Reentry / Luo-Rudy Model / Bidomain Model / R-on-T
Research Abstract

So far the ventricle morphology data in our simulator were based on the polygon data for the computer graphics. But we have to carry out simulation with a patient's individual ventricle morphology in order to estimate fatal arrhythmia as correct as possible. So we extracted myocardial region manually from MRI images and reconstructed 4-dimensional (3D space + time) heart morphology during one heart-beat. First, we obtained 24 cross-sectional short-axis images that cover the whole heart at each of 17 phases by True FISP sequences. Second, we developed an editor tool to put points manually at the myocardial boundary on each image, and extracted the region. We also developed a 3-dimensional editor tool to link these points between consecutive sections, and reconstructed heart morphological polygon data. To improve the shape and to use it as a simulation model, we performed several processes such as correction of different heart position between MRI images, smoothing of heart polygons, conversion to volume data and so on.
On the other hand, we developed the 2-dimensional bidomain model to clarify the electrical defibrillation mechanism. The model was consisted of a homogeneous and an isotropic bidomain myocardial sheet. Membrane kinetics was represented by a modified version of the Luo-Rudy-1 model and myocardial fibers were considered. Possibilities of the electrical stimulation to control spiral wave reentry were investigated under the effects of stimulus induced virtual electrode polarization. As a result, a set of localized stimulations during spiral wave reentry caused spiral wave shift or capture, which provided insight into mechanistic basis of spiral wave control leading to the new electrical defibrillation mechanism.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] T.Ashihara, T.Namba, M.Ito, T.Ikeda, K.Nakazawa et al.: "Spiral Wave Control by a Localized Stimulus : A Bidomain Model Study"Journal of Cardiovascular Electrophysiology. Vol.15, No.2. 226-233 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Ashihara, T.Namba, T.Ikeda, M.Ito, K.Nakazawa et al.: "Mechanisms of Myocardial Capture and Temporal Excitable Gap During Spiral Wave Reentry in a Bidomain Model"Circulation. Vol.109. 920-925 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 中沢一雄, 原口亮: "仮想心臓による不整脈現象のシミュレーションと可視化"最新医学. 第58巻・第8号. 38-45 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 芦原貴司, 中沢一雄: "不整脈モデル"分子心血管病. Vol.4, No.5. 51-62 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Ashihara, T.Namba, M.Ito, T.Ikeda, K.Nakazawa et al.: "Spiral Wave Control by a Localized Stimulus : A Bidomain Model Study"Journal of Cardiovascular Electrophysiology. Vol.15-No.2. 226-233 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Ashihara, T.Namba, T.Ikeda, M.Ito., K.Nakazawa et al.: "Mechanisims of Myocardial Capture and Temporal Excitable Gap During Spiral Wave reentry in a Bidomain Model"Circlation. Vol.109. 920-925 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Nakazawa, R.Haraguchi: "Simulation and Visualization of Arrhythmic Phenomena using by Virtual Heart"The Medical Frontline. Vol.58-NO.8. 38-45 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Ashihara, K.Nakazawa: "Simulation Model for Arrhythmia"Molecular Cardiovascular Medicine. Vol.4-No.5. 51-62 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Ashihara, T.Namba, M.Ito, T.Ikeda, K.Nakazawa et al.: "Spiral Wave Control by a Localized Stimulus : A Bidomain Model Study"Journal of Cardiovascular Electrophysiology. Vol.15,No.2. 226-233 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Ashihara, T.Namba, T.Ikeda, M.Ito, Kazuo Nakazawa et al.: "Mechanisms of Myocardial Capture and Temporal Excitable Gap During Spiral Wave Reentry in a Bidomain Model"Circulation. Vol.109. 920-925 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 中沢一雄, 原口亮: "仮想心臓による不整脈現象のシミュレーションと可視化"最新医学. 第58巻・第8号. 38-45 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 芦原貴司, 中沢一雄: "不整脈モデル"分子心血管病. Vol.4,No.5. 51-62 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 八尾武憲, 池田隆徳, 中沢一雄ほか: "R-on-TとPacing-on-Tでは心室受攻期が異なる:コンピュータシミュレーションによる研究"不整脈. Vol.18,No.4. 496-503 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] A.Kawase, T.Ikeda, K.Nakazawa et al.: "Widening of Excitable Gap and Enlargement of the Core of Reentry During Atrial Fibrillation with a Pure Sodium Channel in Canine Atria"Circulation. Vol.107,No.6. 905-910 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 鈴木亨, 中沢一雄ほか: "MRI画像からの心臓形状の4D抽出"電子情報通信学会技術研究報告. Vol.102 No.387. 5-8 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 中沢一雄, 鈴木亨: "スーパーコンピュータによる不整脈現象の数値シミュレーション"現代医療. 第35巻,第3号. 110-116 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Ashihara, T.Ikeda, K.Nakazawa, et al.: "Vortex Cordis as a Mechanism of Postshock Activation : Arrhythmia Induction Study using a Bidomain Model"Journal of Cardiovascular Electrophysiology. Vol.14,No.3(in press). (2003)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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