• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

耐凍タンパク等の遺伝子導入による卵巣凍結保存法の創出

Research Project

Project/Area Number 14656104
Research Category

Grant-in-Aid for Exploratory Research

Allocation TypeSingle-year Grants
Research Field Applied animal science
Research InstitutionKyoto University

Principal Investigator

宮本 元  京都大学, 農学研究科, 教授 (00026618)

Co-Investigator(Kenkyū-buntansha) 眞鍋 昇  京都大学, 農学研究科, 助教授 (80243070)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2003: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2002: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywords卵巣 / 凍結保存 / 遺伝子導入 / 哺乳類 / 耐凍タンパク質 / 凍結傷害 / 卵母細胞 / 授精能
Research Abstract

哺乳類の卵巣の凍結保存を実現すべく、凍結前に卵巣組織を薄切して急速に冷却・凍結しようとする手法が試みられたが、受精能をもつ卵母細胞(厳密には、哺乳類では二次卵母細胞に精子が侵入して授精が成立するので、卵子は存在しない)をほとんど得られていない。あらかじめ卵巣を摘出する前に動脈から耐凍剤を灌流した後摘出し、組織を薄切して凍結する方法が考案されたが、満足な成績が得られていない。凍結保存法が確立している精子や受精卵などの遊離細胞より格段に巨大で血管系、神経系、結合組織などに富む卵巣の凍結保存を実現するためにはブレークスルー的技術革新が必要である。極地に生息する動物の体液氷点を低下させたり氷晶表面に結合して結晶の成長を抑えて細胞破砕を阻止する耐凍タンパクの遺伝子(耐凍タンパクには化学構造の違うI、II、III型とN型糖鎖をもつタンパクがあり、IおよびIII型がクローニング済)と申請者らが見いだした細胞内アポトーシス阻止因子(cFLIP)の遺伝子クローニングベクターに組み込んで、卵巣細胞に導入し、凍害保護や細胞死阻害を実現し、雌性生殖器官の凍結保存を実現しようとしている。卵巣に耐凍性タンパク、新規アポトーシス阻害因子cFLIPと既知アポトーシス阻害因子p53を特異的に発現させる遺伝子導入法の最適化を培養細胞レベルで進めた。導入効率は高いのだがゲノムDNAに入り込む可能性の高いウイルス遺伝子を含むウイルスベクター法と併行して、ゲノムDNAに導入遺伝子が組み込まれてしまう心配のないex vivo遺伝子導入のためのリポソーム作製法の確立も進めた。

Report

(2 results)
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (61 results)

All Other

All Publications (61 results)

  • [Publications] Mizuho Nakayama, Noboru Manabe, Naoko Inoue, Toshikatsu Matsui, Hajime Miyamoto: "Changes in the expression of tumor necrosis factor (TNF)a, TNFa Receptor (TNFR) 2 and TNFR-associated factor 2 in granulosa cells during atresia in pig ovaries."Biology of Reproduction. 68(2). 530-535 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kohji Komatsu, Noboru Manabe, Minako Kiso, Munetake Shimabe, Hajime Miyamoto: "Changes in localization of immune cells and cytokines in corpora lutea during luteolysis in murine ovaries."Journal of Experimental Zoology. 296(1). 152-159 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kohji Komatsu, Noboru Manabe, Minako Kiso, Munetake Shimabe, Hajime Miyamoto: "Soluble Fas (FasB) regulates luteal cell apoptosis during luteolysis in murine ovaries."Molecular Reproduction and Development. 65. 345-352 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Toshikatsu Matsui, Noboru Manabe, Yasufumi Goto, Mizuho Nakayama, Naoko Inoue, Susumu Nishihara, Hajime Miyamoto: "Changes in the expression and activity of caspase-9 and Apaf1 in granulosa cells during follicular atresia in pig ovaries."Reproduction. 126. 113-120 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Istvan Egerszegi, Falk Schneider, Jozsef Ratky, Ferenc Soos, Laszlo Solti, Noboru Manabe, Klaus-Peter Brussow: "Comparison of luteinizing hormone and steroid hormone secretion during the peri- and post-ovulatory periods in mangalica and landrace gifts."Journal of Reproduction and Devevelopment. 49(4). 291-296 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Naoko Inoue, Noboru Manabe, Toshikatsu Matsui, Akihisa Maeda, Shynsuke Nakagawa, Satoko Wada, Hajime Miyamoto: "roles of tumor necrosis factor-related apoptosis-inducing ligand signaling pathway in granulosa cell apoptosis during atresia in pig ovaries."Journal of Reproduction and Devevelopment. 49(4). 313-321 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Satoshi Imanishi, Noboru Manabe, Hanako Nishizawa, Maki Morita, Miki Sugimoto, Mineko Iwahori, Hajime Miyamoto: "Effects of oral exposure of bisphenol A on mRNA expression of nuclear receptors in murine placentae assessed by DNA microarray."Journal of Reproduction and Devevelopment. 49(4). 329-336 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Minako Kiso, Noboru Manabe, Kohji Komatsu, Munetake Shimabe, Hajime Miyamoto: "Abnormal structural luteolysis in ovaries of the senescence accelerated mouse (SAM) : expression of Fas Ligand/Fas-mediated apoptosis signaling molecules in luteal cells."Journal of Reproduction and Devevelopment. 49(6). 457-463 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hanako Nishizawa, Noboru Manabe, Maki Morita, Miki Sugimoto, Satoshi Imanishi, Hajime Miyamoto: "Effects of in utero exposure of bisphenol A on expression of RARα and RXRα mRNAs in murine embryos."Journal of Reproduction and Devevelopment. 49(6). 539-545 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kozue Uchio-Yamada, Noboru Manabe, Misuzu Yamaguchi-Yamada, Yasufumi Goto, Yoshie Yamamoto, Atsuo Ogura, Hajime Miyamoto: "Changes in the localization of type I, III and IV collagen mRNAs in the kidneys of hereditary nephritic (ICGN) mice with renal fibrosis."The Journal of Veterinary Medical Science. 66(2). 123-128 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yasufumi Goto, Noboru Manabe, Kozue Uchio, Misuzu Yamaguchi-Yamada, Naoko Inoue, Yoshie Yamamoto, Atsuo Ogura, Nobuo Nagano, Hajime Miyamoto: "Myofibroblastic differentiation in tubulointerstitial cells is provoked by augmented cytoplasmic Smad4 protein in hereditary nephrotic ICGN mice with chronic renal fibrosis."Cell and Tissue Research. 315. 209-221 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Miki Sugimoto, Noboru Manabe, Hajime Miyamoto: "Cryopreservation of ovarian tissue."Igakuno Ayumi. 204(13). 921-925 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Noboru Manabe, Naoko Inoue, Chiemi Tajima, Toshikatsu Matsui, Shinsuke Nakagawa, Akihisa Maeda, Hajime Miyamoto: "Monoclonal antibodis recognize novel cell death receptors of granulosa cells in pig ovaries."Biology of Reproduction. 67. 234 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Naoko Inoue, Noboru Manabe, Toshikatsu Matsui, Shinsuke Nakagawa, Akihisa Maeda, Hajime Miyamoto: "Changes in expression of fas-dependent apoptotic signaling molecules in granulosa cells during folliclar atresia in pig ovaries."Biology of Reproduction. 67. 234 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Satoshi Imanishi, Noboru Manabe, Miki Sugimoto, Hajime Miyamoto: "Changes in mRNA expression of GPRC5B/RAIG2, a novel orphan receptor, in mouse placenta during late gestation."Biology of Reproduction. 67. 154 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Miki Sugimoto, Noboru Manabe, Maki Morita, Kei-Ichi Sezaki, Takako Tanaka, Satoshi Imanishi, Hanako Nishizawa, Mineko Iwahori, Hajime Miyamoto: "NMR spectroscopic assessment of effects of estrogenic compounds on male reproductive organs in mice."Biology of Reproduction. 67. 186 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Noboru Manabe, Naoko Inoue, Toshikatsu Matsui, Shinsuke Nakagawa, Akihisa Maeda, Takashi Miyano, Kazuhiro Sakamaki, Miki Sugimoto, Hajime Miyamoto: "Animal Frontier Science"Hokuto Pub.Co, Kyoto. 363 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Noboru Manabe, Satoko Wada, Naoko Inoue, Toshikatu Matsui, Shinsuke Nakagawa, Akihisa Maeda, Hajime Miyamoto: "Animal Frontier Science"Hokuto Pub.Co, Kyoto. 363 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Mizuho Nakayama, Noboru Manabe, Naoko Inoue, Toshikatsu Matsui, Shinsuke Nakagawa, Akihisa Maeda, Hajime Miyamoto: "Animal Frontier Science"Hokuto Pub.Co, Kyoto. 363 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Naoko Inoue, Noboru Manabe, Toshikatsu Matsui, Shinsuke Nakagawa, Hajime Miyamoto: "Animal Frontier Science"Hokuto Pub.Co, Kyoto. 363 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Toshikatu Matsui, Noboru Manabe, Yasufumi Goto, Naoko Inoue, Shinsuke Nakagawa, Akihisa Maeda, Susumu Nishihara, Hajime Miyamoto: "Animal Frontier Science"Hokuto Pub.Co, Kyoto. 363 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Misuzu Yamaguchi-Yamada, Noboru Manabe, Kozue Uchio-Yamada, Naotsugu Akashi, Yasufumi Gotoh, Masaya Nagao, Yoshie Yamamoto, Atsuo Ogura, Hajime Miyamoto: "Animal Frontier Science"Hokuto Pub.Co, Kyoto. 363 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Minako Kiso, Noboru Manabe, Kohji Komatsu, Munetake Shimabe Hajime Miyamoto: "Animal Frontier Science"Hokuto Pub.Co, Kyoto. 363 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Noboru Manabe, Kozue Yamada-Uchio, Misuzu Yamada-Yamaguchi, Yasufumi Gotoh, Toshiharu Mori, Chinatsu Sakata, Yoshihiro Furuya, Hajime Miyamoto: "Animal Frontier Science"Hokuto Pub.Co, Kyoto. 363 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Maki Morita, Miki Sugimoto, Takako Tanaka, Satoshi Imanishi, Hanako Nishizawa, Kei-Ichi Sezaki, Mineko Iwahori, Noboru Manabe, Hajime Miyamoto: "Animal Frontier Science"Hokuto Pub.Co, Kyoto. 363 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Miki Sugimoto, Noboru Manabe, Maki Morita, Satoshi Imanishi, Hanako Nishizawa, Mineko Iwahori, Hajime Miyamoto: "Animal Frontier Science"Hokuto Pub.Co, Kyoto. 363 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Noboru Manabe, Yasuyoshi Azuma, Miki Sugimoto, Satoshi Imanishi, Hanako Nishizawa, Maki Morita, Hajime Miyamoto: "Animal Frontier Science"Hokuto Pub.Co, Kyoto. 363 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Noboru Manabe, Naoko Inoue, Takashi Miyano, Kazuhiro Sakamaki, Miki Sugimoto, Hajime Miyamoto: "The Ovary, 2^<nd> edition"Academic Press/Elsevier Science, Amsterdam, The Nederland. 664 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Noboru Manabe: "Veterinary Histology 3^<rd> edition"Gakusoshya Pub.Co, Tokyo, Japan. 315 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Noboru Manabe: "Biology of Reproduction 2^<nd> edition"Asakura Pub.Co, Tokyo, Japan. 315 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Noboru Manabe, Minako Kiso, Munetake Shimabe, Hajime Miyamoto: "The Senescence-Accelerated Mouse (SAM) : An Animal Model of Senescence"Elsevier Science Publishers B.V., Amsterdam, The Nederland. 448 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Munetake Shimabe, Minako Kiso, Kohji Komatsu, Noboru Manabe, Hajime Miyamoto: "The Senescence-Accelerated Mouse (SAM) : An Animal Model of Senescence"Elsevier Science Publishers B.V., Amsterdam, The Nederland. 448 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Minako Kiso, Munetake Shimabe, Kohji Komatsu, Noboru Manabe, Hajime Miyamoto: "The Senescence-Accelerated Mouse (SAM) : An Animal Model of Senescence"Elsevier Science Publishers B.V., Amsterdam, The Nederland. 448 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Morikawa Masahiro, Wakoto Matsuyama, Miki Sugimoto, Maki Morita, Aki Nakayama, Noboru Manabe, Shinsuke Morisawa: "Environmental Toxicity Evaluation and Risk Management"The Environment Risk Management Group of the JSPS-VCC Program on Environmental Science, Engineering and Ethics 2000-2009. Kyoto, Japan. 159 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Noboru Manabe, Minako Kiso, Munetake Shimabe, H.Miyamoto: "Proceedings of the 2^<nd> International Conference on Senescence : The SAM model"The Council for SAM Research, Sapporo, Japan. 120 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Munetake Shimabe, Minako Kiso, Noboru Manabe, Hajime Miyamoto: "Proceedings of the 2^<nd> International Conference on Senescence : The SAM model"The Council for SAM Research, Sapporo, Japan. 120 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Minako Kiso, Munetake Shimabe, Noboru Manabe, Hajime Miyamoto: "Proceedings of the 2^<nd> International Conference on Senescence : The SAM model"The Council for SAM Research, Sapporo, Japan. 120 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Mizuho Nakayama, Noboru Manabe, Naoko Inoue, Toshikatsu Matsui, Hajime Miyamoto: "Changes in the expression of tumor necrosis factor (TNF) a, TNFa Receptor (TNFR) 2 and TNFR-associated factor 2 in granulosa cells during atresia in pig ovaries"Biology of Reproduction. 68・2. 530-535 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Uchio K, Tuchweber B, Manabe Noboru, Gabbiani G, Rosenbaum J, Desmouliere A.: "Cellular retinol-binding protein-1 expression and modulation during in vivo and in vitro myofibroblastic differentiation of rat hepatic stellate cells and portal fibroblasts"Laboratory Investigation. 82・4. 619-628 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Chiemi Tajima, Noboru Manabe, Mizuho Nakayama, Naoko Inoue, Toshikatsu Matsui, Eiichi Hondo, Hajime Miyamoto: "Monoclonal antibody recognizes follicular granulosa cell antigens in porcine ovaries"Journal of Reproduction and Development. 48・4. 567-572 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Satoshi Imanishi, Noboru Manabe, Takako Tanaka, Reika Okamoto, Maki Morita, Miki Sugimoto, Hajime Miyamoto: "mRNA of GPCR5B/Raig2, a novel orphan receptor, expresses in murine placentae"Journal of Reproduction and Development. 48・4. 627-632 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Noboru Manabe: "Molecular mechanism of follicle selection in mammalian ovaries"Journal of Laboratory Animals (Kansai). 23・1. 71-78 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Noboru Manabe, Miki Sugimoto, Hajime Miyamoto: "In vivo noninvasive nuclear magnetic resonance (NMR) technique for assessment of teratogenicity induced by chemicals"Chemical Engineering. 47・2. 110-114 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Satoko Wada, Noboru Manabe, Naoko Inoue, Mizuho Nakayama, Toshikatsu Matsui, Hajime Miyamoto: "TRAIL-decoy receptor-1 disappears in granulosa cells of atretic follicles in porcine ovaries"Journal of Reproduction and Development. 48・1. 167-173 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Satoko Wada, Noboru Manabe, Naoko Inoue, Mizuho Nakayama, Toshikatsu Matsui, Hajime Miyamoto: "TRADD is involved in apoptosis induction in granulosa cells during atresia in pig ovaries"Journal of Reproduction and Development. 48・1. 175-181 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hideki Tonomura H, Miyake T, Taniguchi Y, Manabe Noboru, Kose H, Matsumoto K, Yamada T, Sasaki Y.: "Detection of quantitative trait locus for rat model useful for genetic analysis of intramascular fat accumulation using the OLETF rat"The Journal of Veterinary Medical Science. 64・1. 45-50 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Satoko Wada, Noboru Manabe, Mizuho Nakayama, Naoko Inoue, Tohikatsu Matsui, Hajime Miyamoto: "TRAIL-decoy receptor-1 plays inhibitory role in apoptosis of granulosa cells from pig ovarian follicules"The Journal of Veterinary Medical Science. 64・5. 435-439 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Miki Sugimoto, Noboru Manabe, Maki Morita, Takako Tanaka, Reika Okamoto, Satoshi Imanishi, Hajime Miyamoto: "NMR microscopic observation of mouse embryo malformations induced by maternal administration of retinoic acid"The Journal of Veterinary Medical Science. 64・5. 427-433 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Miki Sugimoto, Noboru Manabe, Hajime Miyamoto: "Cryopreservation techniques for ovarian tissues"Hormone Frontier in Gynecology. 9・1. 135-140 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Mizuho Nakayama, Noboru Manabe, Naoko Inoue, Toshikatsu Matsui, Shinsuke Nakagawa, Akihisa Maeda, Hajime Miyamoto Sakamaki, Miki Sugimoto, Hajime Miyamoto: "Animal Frontier Science (Sato E, Miyamoto H, Manabe Noboru eds.), Tumor necrosis factor-α acts as a survival factor in granulosa cells during follicular selection in porcine ovaries. PP. 143-149"Hokuto Publication Company, Kyoto, Japan. 363 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Naoko Inoue, Noboru Manabe, Toshikatsu Matsui, Shinsuke Nakagawa, Akihisa Maeda, Hajime Miyamoto: "Animal Frontier Science (Sato E, Miyamoto H, Manabe Noboru eds.), Roles of Fas-ligand and TRAIL systems in granulosa cell apoptosis during follicular atresia in porcine ovaries. PP. 151-156"Hokuto Publication Company, Kyoto, Japan. 363 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Toshikatu Matsui, Noboru Manabe, Yasufumi Goto, Naoko Inoue, Shinsuke Nakagawa, Akihisa Maeda, Susumu Nishihara, Hajime Miyamoto: "Animal Frontier Science (Sato E, Miyamoto H, Manabe Noboru eds.), Roles of the mitochondria-dependent pathway in granulosa cell apoptosis during follicular atresia in pig ovaries. PP. 157-163"Hokuto Publication Company, Kyoto, Japan. 363 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yamaguchi-Yamada M, Noboru Manabe, Uchio-Yamada K, Akashi N, Gotoh Y, Nagao M, Yamamoto Y, Ogura A, Miyamoto H.: "Animal Frontier Science (Sato E, Miyamoto H, Manabe Noboru eds.), Anemia associated with renal failure in the ICR-derived glomerulonephritis (ICGN) mice. PP.281-285"Hokuto Publication Company, Kyoto, Japan. 363 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Minako Kiso, Noboru Manabe, Kohji Komatsu, Munetake Shimabe, Hajime Miyamoto: "Animal Frontier Science (Sato E, Miyamoto H, Manabe Noboru eds.), Abnormal structural luteolysis in ovaries of the senescence accelerated mouse (SAM) : expression of Fas mediated apoptosis signal in luteal bodies. PP. 287-294"Hokuto Publication Company, Kyoto, Japan. 363 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Noboru Manabe, Kozue Yamada-Uchio, Misuzu Yamada-Yamaguchi, Yasufumi Gotoh, Toshiharu Mori, Chinatsu Sakata, Yoshihiro Furuya, Hajime Miyamoto: "Animal Frontier Science (Sato E, Miyamoto H, Manabe Noboru eds.), Histochemical technique quantitatively estimates the physiological and pathological properties. PP.303-309"Hokuto Publication Company, Kyoto, Japan. 363 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Noboru Manabe, Naoko Inoue, Toshikatsu Matsui, Shinsuke Nakagawa, Akihisa Maeda, Takashi Miyano, Kazuhiro Sakamaki, Miki Sugimoto Hajime: "Animal Frontier Science (Sato E, Miyamoto H, Manabe Noboru eds.), Regulatory mechanisms of follicle selection in mammalian ovaries. PP. 117-132"Hokuto Publication Company, Kyoto, Japan. 363 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Noboru Manabe, Naoko Inoue, Toshikatsu Matsui, Shinsuke Nakagawa, Akihisa Maeda, Takashi Miyano, Kazuhiro Sakamaki, Miki Sugimoto, Hajime Miyamoto: "Animal Frontier Science (Sato E, Miyamoto H, Manabe Noboru eds.), Tumor necrosis factor-related apoptosis-inducing ligand and its receptors play crucial roles in apoptosis of granulosa cells during follicular atresia in pig ovaries. PP. 133-142"Hokuto Publication Company, Kyoto, Japan. 363 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Maki Morita, Miki Sugimoto, Noboru Manabe, Hajime Miyamoto: "Animal Frontier Science (Sato E, Miyamoto H, Manabe Noboru eds.), Morphological alterations in mammalian reproductive organ induced by exposure to diethylstilbestrol (DES). PP. 319-323"Hokuto Publication Company, Kyoto, Japan. 363 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Miki SUGIMOTO, Noboru MANABE, Maki MORITA, Hajime MIYAMOTO: "Animal Frontier Science (Sato E, Miyamoto H, Manabe Noboru eds.), Utilization of magnetic resonance microscope for studies in reproductive toxicology. PP. 325-330"Hokuto Publication Company, Kyoto, Japan. 363 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Noboru Manabe, Yasuyoshi Azuma, Miki Sugimoto, Kei-Ichi Sezaki, Mineko Iwahori, Satoshi Imanishi, Hanako Nishizawa, Takako Tanaka, Maki Morita, Hajime Miyamoto: "Animal Frontier Science (Sato E, Miyamoto H, Manabe Noboru eds.), In vivo and real time estimation of energy metabolism by ^<31>p-nuclear magnetic resonance. PP. 339-347"Hokuto Publication Company, Kyoto, Japan. 363 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Morikawa Masahiro, Wakoto Matsuyama, Yuko Kawamoto, Miki Sugimoto, Maki Morita, Aki Nakayama, Noboru Manabe, Minoru Yoneda, Shinsuke Morisawa: "Environmental Toxicity Evaluation and Risk Management Vol.1(Morisawa S eds.), Dynamic performance of bisphenol-A (BPA) in pregnant mouse and physiologically-based pharmacokinetic model development. PP. 60-74"The Environment Risk Management Group of The JSPS-VCC Program on Environmental Science, Engineering and Ethics 2000-2009. Kyoto, Japan. 159 (2002)

    • Related Report
      2002 Annual Research Report

URL: 

Published: 2002-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi