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ウシ小型ピロプラズマ病における貧血病態と発症機序の解明

Research Project

Project/Area Number 14F04087
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeSingle-year Grants
Section外国
Research Field Veterinary medical science
Research InstitutionObihiro University of Agriculture and Veterinary Medicine

Principal Investigator

横山 直明  帯広畜産大学, 原虫病研究センター, 教授 (80301802)

Co-Investigator(Kenkyū-buntansha) SIVAKUMAR THILLAIAMPALAM  帯広畜産大学, 原虫病研究センター, 外国人特別研究員
SIVAKUMAR Thillaiampalam  帯広畜産大学, 原虫病研究センター, 外国人特別研究員
Project Period (FY) 2014-04-25 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2015: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywords小型ピロプラズマ病 / 牛 / 貧血 / 発症 / 原虫 / タイレリア
Outline of Annual Research Achievements

最終年度では、以下の研究成果を得た。
1)小型ピロプラズマ感染による放牧牛の貧血病態は宿主免疫の異常バランスに起因する大球性高色素性貧血であることを解明した。
2)スリランカ、エジプト、ベトナム、モンゴル、及びタイにおける牛やマダニのピロプラズマ感染の実態を国際疫学調査によって明らかにした。
3)ピロプラズマ病の治療薬の候補を同定した。

Research Progress Status

27年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

27年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (19 results)

All 2016 2015 2014 Other

All Int'l Joint Research (5 results) Journal Article (10 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 10 results,  Open Access: 2 results,  Acknowledgement Compliant: 5 results) Presentation (3 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Int'l Joint Research] 獣医学研究所(スリランカ)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] モンゴル農業大学(モンゴル)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] フエ大学/フエ農林大学(ベトナム)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] サダト大学(エジプト)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] 国立動物科学研究所(タイ)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Type-specific PCR assays for Babesia bovis msa-1 genotypes in Asia: Revisiting the genetic diversity in Sri Lanka, Mongolia, and Vietnam.2016

    • Author(s)
      Liyanagunawardena N, Sivakumar T, Kothalawala H, Silva SS, Battsetseg B, Lan DT, Inoue N, Igarashi I, Yokoyama N.
    • Journal Title

      Infect Genet Evol.

      Volume: 37 Pages: 64-69

    • DOI

      10.1016/j.meegid.2015.10.029

    • NAID

      120006390924

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The PCR detection and phylogenetic characterization of Babesia microti in questing ticks in Mongolia.2015

    • Author(s)
      Tuvshintulga B, Sivakumar T, Battsetseg B, Narantsatsaral SO, Enkhtaivan B, Battur B, Hayashida K, Okubo K, Ishizaki T, Inoue N, Igarashi I, Yokoyama N.
    • Journal Title

      Parasitol Int.

      Volume: 64 Issue: 6 Pages: 527-532

    • DOI

      10.1016/j.parint.2015.07.007

    • NAID

      120006390873

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetic variations in merozoite surface antigen genes of Babesia bovis detected in Vietnamese cattle and water buffaloes.2015

    • Author(s)
      Yokoyama N, Sivakumar T, Tuvshintulga B, Hayashida K, Igarashi I, Inoue N, Long PT, Lan DT.
    • Journal Title

      Infect. Genet. Evol.

      Volume: 30 Pages: 288-295

    • DOI

      10.1016/j.meegid.2014.12.035

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Genetic diversity in Trypanosoma theileri from Sri Lankan cattle and water buffaloes.2015

    • Author(s)
      Yokoyama N, Sivakumar T, Fukushi S, Tattiyapong M, Tuvshintulga B, Kothalawala H, Silva SS, Igarashi I, Inoue N.
    • Journal Title

      Vet Parasitol.

      Volume: 207 Issue: 3-4 Pages: 335-41

    • DOI

      10.1016/j.vetpar.2014.12.006

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] An epidemiological survey of bovine Babesia and Theileria parasites in cattle, buffaloes, and sheep in Egypt.2015

    • Author(s)
      Elsify, A., Sivakumar, T., Nayel, M., Salama, A., Elkhtam, A., Rizk, M., Mosaab, O., Sultan, K., Elsayed, S., Igarashi, I., and Yokoyama, N.
    • Journal Title

      Parasitol. Int.

      Volume: 64 Issue: 1 Pages: 79-85

    • DOI

      10.1016/j.parint.2014.10.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Evaluation of inhibitory effect of methylene blue against Babesia and Theileria parasites.2015

    • Author(s)
      Tuvshintulga B, Sivakumar T, Salama AA, Yokoyama N, Igarashi I.
    • Journal Title

      J. Protozool. Res.

      Volume: 25 Pages: 18-28

    • NAID

      120006391034

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] First detection of Babesia venatorum (EU1) in Ixodes persulcatus ticks in Mongolia.2015

    • Author(s)
      Tuvshintulga B, Battsetseg B, Battur B, Myagmarsuren P, Narantsatsral S, Sivakumar T, Takemae H, Igarashi I, Inoue N, Yokoyama N.
    • Journal Title

      J. Protozool. Res.

      Volume: 25 Pages: 29-37

    • NAID

      120006391035

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Analysis of the genetic diversity of Babesia bovis msa-1 in Thailand using type-specific polymerase chain reaction.2015

    • Author(s)
      Tattiyapong M, Sivakumar T, Takemae H, Simking P, Jittapalapong S, Igarashi I, Yokoyama N.
    • Journal Title

      J. Protozool. Res.

      Volume: 25 Pages: 38-43

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Evolution and genetic diversity of Theileria.2014

    • Author(s)
      Sivakumar T, Hayashida K, Sugimoto C, Yokoyama N.
    • Journal Title

      Infect. Genet. Evol.

      Volume: 27 Pages: 250-263

    • DOI

      10.1016/j.meegid.2014.07.013

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Genetic characterization of Babesia and Theileria parasites in water buffaloes in Sri Lanka.2014

    • Author(s)
      Sivakumar T, Tattiyapong M, Fukushi S, Hayashida K, Kothalawala H, Silva SS, Vimalakumar SC, Kanagaratnam R, Meewewa AS, Suthaharan K, Puvirajan T, de Silva WK, Igarashi I, Yokoyama N.
    • Journal Title

      Vet. Parasitol.

      Volume: 200 Issue: 1-2 Pages: 24-30

    • DOI

      10.1016/j.vetpar.2013.11.029

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Type-specific PCR assays for Babesia bovis msa-1 genotypes in Asia: Revisiting the genetic diversity in Sri Lanka, Mongolia, and Vietnam.2015

    • Author(s)
      Sivakumar T, Inoue N, Igarashi I, Yokoyama N.
    • Organizer
      第56回日本熱帯医学会大会
    • Place of Presentation
      大阪大学(大阪府吹田市)
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] Molecular epidemiology of Babesia and Theileria, and Trypanosoma in cattle and water buffaloes in Sri Lanka.2015

    • Author(s)
      Sivakumar T, Kothalawala H, Silva SSP, Yokoyama N.
    • Organizer
      57th Annual Convention of the Sri Lanka Veterinary Association
    • Place of Presentation
      Oak-Ray and Earl's Regency (Kandy, Sri Lanka)
    • Year and Date
      2015-07-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genetic diversity of Theileria2014

    • Author(s)
      横山直明、Sivakumar Thillaiamapalam, 林田京子、杉本千尋
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2014-09-09 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Remarks] 帯広畜産大学・原虫病研究センター ホームページ

    • URL

      http://www.obihiro.ac.jp/~protozoa/index.html

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2015-01-22   Modified: 2024-03-26  

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