| Project/Area Number |
14F04382
|
|---|
| Research Category |
Grant-in-Aid for JSPS Fellows
|
| Allocation Type | Single-year Grants |
|---|
| Section | 外国 |
|---|
| Research Field |
Genome biology
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
岩崎 渉 東京大学, 大学院理学系研究科(理学部), 准教授 (50545019)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SRISWASDI SIRA 東京大学, 大学院理学系研究科(理学部), 外国人特別研究員
SRISWASDI Sira 東京大学, 理学系研究科, 外国人特別研究員
|
|---|
| Project Period (FY) |
2014-04-25 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2016: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2015: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2014: ¥200,000 (Direct Cost: ¥200,000)
|
|---|
| Keywords | バイオインフォマティクス / ゲノム進化 / ゲノム / 進化 |
|---|
| Outline of Annual Research Achievements |
In this project, we aim to understand how neofunctionalization and subfunctionalization occur and whether they are driven by particular genetic elements or functions of nearby genes after genome polyploidization. Following the identification and characterization of genome polyploidization in newly sequenced fungal genomes, we investigated evolution rates among orthologs and paralogs, transcriptional orientation of newly formed adjacent genes, and conservations of stoichiometry for protein complexes and biological pathway components. In this year, we reported the discovery of two recent and independent genome hybridizations within a single clade of a fungal genus, Trichosporon. Comparative genomic analyses revealed that redundant genes are experiencing decelerations, not accelerations, of evolutionary rates. We identified a relationship between gene conversion and decelerated evolution suggesting that gene conversion may improve the genome stability of young hybrids by restricting gene functional divergences. Furthermore, we detected large-scale gene losses from transcriptional and translational machineries that indicate a global compensatory mechanism against increased gene dosages. Overall, our findings illustrate counteracting mechanisms during an early phase of post-genome hybridization and fill a critical gap in existing theories on genome evolution.
|
| Research Progress Status |
28年度が最終年度であるため、記入しない。
|
| Strategy for Future Research Activity |
28年度が最終年度であるため、記入しない。
|
