転倒予防に向けた高齢者の安全な障害物跨ぎ越し動作を阻害する認知的要因の解明

• Project/Area Number: 14J07168
• Research Category: Grant-in-Aid for JSPS Fellows
• Allocation Type: Single-year Grants
• Section: 国内
• Research Field: Applied health science (A)
• Research Institution: Waseda University
• Principal Investigator: 桜井 良太 早稲田大学, スポーツ科学学術院, 特別研究員(PD)
• Project Period (FY): 2014-04-25 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 運動イメージ / 2重課題 / 歩行機能 / 海馬 / 高齢者 / 歩行 / 認知的負荷 / 介入

Outline of Annual Research Achievements

本年度の研究では、高齢者における運動イメージ能力低下と2重課題歩行時の歩行機能低下の関連の背後にある神経活動変化について明らかにすることを目的とした。
41名（平均年齢74歳、女性19名）の地域在住高齢者が実験参加に同意し、歩行機能測定、運動イメージ能力測定、脳容量解析のためのMRI検査を受けた。歩行機能の測定には、6mのマット式の歩容解析機器を用いた。歩行時には、通常歩行に加えて、100から1ずつ減算する課題と100から7ずつ減算する課題を2重課題として行った。解析には歩行速度、歩幅、1歩行周期当たりの時間に加えて、歩幅と1歩行周期時間の変動係数を用いた。運動イメージの測定には、Timed Up & Go test（イスから立ち上がり3m先の指標を回り、再びイスに座るまでの時間を測定、以後TUGテスト）を用いた運動時間予測課題を用いた。MRI撮像には3テスラMRIを用い、VBM（Voxel Based Morphometry）を用いて脳容量とそれぞれの変数との関連性について解析を行った。実験の結果、これまでの研究結果同様、運動イメージ能力と2重課題時の歩行能力の間に有意な関連が認められた。これらの成績と脳容量の関連を調べたところ、運動イメージ能力と有意に相関する脳部位は認められなかった。他方、2重課題時の歩行能力と海馬容量との有意な相関関係が認められ、2重課題時に歩行速度が低下する、もしくは歩幅・1歩行周期時間の変動係数が高くなる者ほど海馬の容量が小さいことが明らかとなった。しかしながら、運動イメージ能力を共変量として投入するとこれらの有意な相関関係は消失した。以上の結果は、2重課題時の歩行能力低下は海馬萎縮の前駆症状であり、その関連には運動イメージ能力が強く関与している可能性を示唆している。

Research Progress Status

28年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

28年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] University of Western Ontario/Robarts Research Institute(Canada)
• [Int'l Joint Research] University of Western Ontario/Robarts Research Institute(カナダ)
• [Journal Article] The neural substrate of gait and executive function relationship in elderly women: A PET study (2017)
  • Author(s): Sakurai R, Ishii K, Yasunaga M, Takeuchi R, Murayama H, Sakuma N, Sakata M, Oda K, Ishibashi K, Ishiwata K, Fujiwara Y, Montero-Odasso M
  • Journal Title: Geriatrics & Gerontology International Volume: 17 Issue: 11 Pages: 1873
  • DOI: 10.1111/ggi.12982
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Fear of falling, but not gait impairment, predicts subjective memory complaints in cognitively intact older adults. (2017)
  • Author(s): Sakurai R, Suzuki H, Ogawa S, Kawai H, Yoshida H, Hirano H, Ihara K, Obuchi S, Fujiwara Y
  • Journal Title: Geriatrics & Gerontology International Volume: 印刷中 Issue: 7 Pages: 1125-1131
  • DOI: 10.1111/ggi.12829
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Self-estimation of physical ability in stepping over an obstacle is not mediated by visual height perception: a comparison between young and older adults (2016)
  • Author(s): Sakurai, R., Fujiwara, Y., Ishihara, M., Yasunaga, M., Ogawa, S., Suzuki, Hi. & Imanaka, K.
  • Journal Title: Psychological Research Volume: 81 Issue: 4 Pages: 740
  • DOI: 10.1007/s00426-016-0779-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Parathyroid hormone but not vitamin D is associated with impaired gait in community-dwelling older adults. (2016)
  • Author(s): Montero-Odasso M, ○Sakurai R, Muir-Hunter S, Islam A, Doherty T, Duque G, Crilly R
  • Journal Title: Journal of American Geriatric Society Volume: 64 Issue: 12 Pages: 2606-2608
  • DOI: 10.1111/jgs.14501
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Neural correlates of older adults’ self-overestimation of stepping-over ability (2016)
  • Author(s): Ryota Sakurai, Yoshinori Fujiwara, Masashi Yasunaga, Hiroyuki Suzuki, Rumi Takeuchi, Yoh Murayama, Kazuyuki Kanosue, , Imanaka Kuniyasu, Kenji Ishii
  • Journal Title: AGE Volume: 38 Issue: 4 Pages: 351
  • DOI: 10.1007/s11357-016-9932-z
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Older adults with fear of falling show deficits in motor imagery of gait. (2016)
  • Author(s): Sakurai R, Fujiwara Y, Yasunaga M, Suzuki H, Sakuma N, Imanaka K, Montero-Odasso M.
  • Journal Title: J Nutr Health Aging. Volume: In press
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Fear of falling, but not gait impairment, predicts subjective memory complaints in cognitively intact older adults. (2016)
  • Author(s): Sakurai R, Suzuki H, Ogawa S, Kawai H, Yoshida H, Hirano H, Ihara K, Obuchi S, Fujiwara Y.
  • Journal Title: Geriatr Gerontol Int. Volume: In press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Neural basis for the relationship between frequency of going outdoors and depressive mood in older adults. (2016)
  • Author(s): Sakurai R, Suzuki H, Fujiwara Y, Yasunaga M, Takeuchi R, Murayama Y, Kobayashi K, Kanosue K, Ishii K.
  • Journal Title: Int J Geriatr Psychiatry. Volume: In press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Can You Ride a Bicycle? The Ability to Ride a Bicycle Prevents Reduced Social Function in Older Adults With Mobility Limitation (2016)
  • Author(s): Sakurai R, Kawai H, Yoshida H, Fukaya T, Suzuki H, Kim H, Hirano H, Ihara K, Obuchi S, Fujiwara Y.
  • Journal Title: Journal of Epidemiology Volume: 26 Issue: 6 Pages: 307-314
  • DOI: 10.2188/jea.JE20150017
  • NAID: 130005154810
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Multiple impacts of an intergenerational program in Japan: Evidence from the Research on Productivity through Intergenerational Sympathy Project (2016)
  • Author(s): Yasunaga M, Murayama Y, Takahashi T, Ohba H, Suzuki H, Nonaka K, Kuraoka M, Sakurai R, Nishi M, Sakuma N, Kobayashi E, Shinkai S, Fujiwara Y.
  • Journal Title: Geriatr Gerontol Int. Volume: 16 Issue: S1 Pages: 98
  • DOI: 10.1111/ggi.12770
  • URL: https://pure.teikyo.jp/en/publications/1409d124-3cfc-4db7-a293-e1ff7471280f
  • Peer Reviewed
• [Journal Article] Long-term effects of an intergenerational program on functional capacity in older adults: Results from a seven-year follow-up of the REPRINTS study. (2016)
  • Author(s): Sakurai R, Yasunaga M, Murayama Y, Ohba H, Nonaka K, Suzuki H, Sakuma N, Nishi M, Uchida H, Shinkai S, Rebok GW, Fujiwara Y.
  • Journal Title: Arch Gerontol Geriatr. Volume: 64 Pages: 13-24
  • DOI: 10.1016/j.archger.2015.12.005
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 地域在住高齢者における自転車関連事故発生率とその傷害率－潜在的傷害事故の把握に向けた検討. (2015)
  • Author(s): 桜井良太, 河合恒, 深谷太郎, 吉田英世, 金憲経, 平野浩彦, 鈴木宏幸, 大渕修一, 藤原佳典.
  • Journal Title: 公衆衛生学雑誌 Volume: 印刷中
  • NAID: 130005084361
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Influential factors affecting age-related self-overestimation of step-over ability: Focusing on frequency of going outdoors and executive function. (2014)
  • Author(s): Sakurai R, Fujiwara Y, Sakuma N, Suzuki H, Ishihara M, Higuchi T, Imanaka K
  • Journal Title: Arch Gerontol Geriatr. Volume: 59 Issue: 3 Pages: 577-83
  • DOI: 10.1016/j.archger.2014.07.017
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Cognitive intervention through a training program for picture book reading in community-dwelling older adults: A randomized controlled trial (2014)
  • Author(s): Suzuki H, Kuraoka M, Yasunaga M, Nonaka K, Sakurai R, Takeuchi R, Murayama Y, Ohba H, Fujiwara Y
  • Journal Title: BMC Geriatrics Volume: 14 Issue: 1 Pages: 14-14
  • DOI: 10.1186/1471-2318-14-122
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Regional cerebral glucose metabolism and gait speed in healthy community-dwelling older women (2014)
  • Author(s): Sakurai R, Fujiwara Y, Yasunaga M, Takeuchi R, Murayama Y, Ohba H, Sakuma N, Suzuki H, Oda K, Sakata M, Toyohara J, Ishiwata K, Shinkai S, Ishii K
  • Journal Title: J Gerontol A Biol Sci Med Sci Volume: 69 Issue: 12 Pages: 1519
  • DOI: 10.1093/gerona/glu093
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Reduced cerebral glucose metabolism in older adults with fear of falling: cross-sectional and longitudinal analyses. (2016)
  • Author(s): Sakurai R, Fujiwara Y, Yasunaga M, Murayama Y, Suzuki H, Montero-Odasso M, Ishii K
  • Organizer: The Gerontological Society of America 69th Annual Scientific Meeting
  • Place of Presentation: New Orleans
  • Year and Date: 2016-11-16
  • Int'l Joint Research
• [Presentation] 加齢に伴う海馬萎縮に対する世代間交流プログラムの抑制効果－REPRINTS study－. (2016)
  • Author(s): 桜井良太、佐久間尚子、安永正史、鈴木宏幸、村山陽、西真理子、内田勇人、新開省二、石井賢二、藤原佳典
  • Organizer: 第75回日本公衆衛生学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2016-10-26
• [Presentation] Apolipoprotein E genotype and longitudinal change in physical function among high-functioning older adults (2016)
  • Author(s): Sakurai R, Ishii K, Yasunaga M, Murayama Y, Suzuki H, Sakuma N, Fujiwara Y
  • Organizer: 10th European Congress of Biogerontology
  • Place of Presentation: Poland
  • Year and Date: 2016-09-23
  • Int'l Joint Research
• [Presentation] Longitudinal relationship between cerebral glucose metabolism and gait speed in older adults. (2015)
  • Author(s): Sakurai R, Montero-Odasso M, Yasunaga M, Murayama Y, Fujiwara Y, Ishii K.
  • Organizer: The Gerontological Society of America 68th Annual Scientific Meeting.
  • Place of Presentation: Orlando, USA.
  • Year and Date: 2015-11-18
  • Int'l Joint Research
• [Presentation] Age-related changes in self-estimation of step-over ability in older adults: A three-year follow-up study. (2015)
  • Author(s): Sakurai R, Higuchi T, Fujiwara Y, Imanaka K.
  • Organizer: 2015 ISPGR World Congress
  • Place of Presentation: Seville, Spain.
  • Year and Date: 2015-06-28
  • Int'l Joint Research
• [Presentation] Executive function, gait function, and cerebral glucose metabolism in healthy older women. (2015)
  • Author(s): Sakurai R, Ishii K, Fujiwara Y, Yasunaga M, Sakuma N, Shinkai S, Manuel Montero-Odasso Montero-Odasso M.
  • Organizer: The American Geriatric Society 2015 Annual Scientific Meeting.
  • Place of Presentation: Washington, D.C., USA.
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Presentation] Understanding the mechanism of the aging brain in healthy older adults. (2015)
  • Author(s): Sakurai R, Ishii K, Fujiwara Y, Yasunaga M, Montero-Odasso M.
  • Organizer: Department of Medicine Resident Research Day
  • Place of Presentation: London, Canada
  • Year and Date: 2015-05-07
  • Int'l Joint Research
• [Presentation] Understanding the mechanism underlying the relationship between gait and executive functions using regional cerebral glucose metabolism in healthy older women. (2015)
  • Author(s): Sakurai R, Ishii K, Fujiwara Y, Yasunaga M, Montero-Odasso M.
  • Organizer: 35th Canadian Geriatric Society Annual Scientific Meeting.
  • Place of Presentation: Montreal, Canada.
  • Year and Date: 2015-04-16
  • Int'l Joint Research
• [Presentation] Can you ride a bicycle? The ability to ride a bicycle in elderly with mobility limitation influences social function. (2015)
  • Author(s): Sakurai R, Kawai H, Yoshida H, Fukaya T, Suzuki H, Kim H, Hirano H, Ihara K, Obuchi S, Fujiwara Y.
  • Organizer: 第25回日本疫学会学術総会
  • Place of Presentation: 愛知
  • Year and Date: 2015-01-21 – 2015-01-23
• [Presentation] Gait speed, executive function, and cerebral glucose metabolism in older adults. (2014)
  • Author(s): Sakurai R, Fujiwara Y, Yasunaga M, Murayama Y, Sakuma N, Kobayashi K, Shinkai S, Ishii K.
  • Organizer: The Gerontological Society of America 67th Annual Scientific Meeting
  • Place of Presentation: Washington, DC., USA
  • Year and Date: 2014-11-05 – 2014-11-09
• [Presentation] 地域在住高齢者における抑うつ傾向と安静時脳糖代謝量の関連性―運動習慣の有無に着目した検討― (2014)
  • Author(s): 桜井良太, 彼末一之
  • Organizer: 第69回日本体力医学会
  • Place of Presentation: 長崎
  • Year and Date: 2014-09-19 – 2014-09-24
• [Presentation] 手指巧緻性と認知機能の関連に関与する安静時脳糖代謝変化 (2014)
  • Author(s): 桜井良太, 藤原佳典, 安永正史, 村山陽, 大場宏美, 鈴木宏幸, 新開省二, 石井賢二
  • Organizer: 第56回日本老年医学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2014-06-12 – 2014-06-14
• [Book] 第3章1節 高齢者の身体機能に関する特徴．『シニアボランティアを活かすコーディネーターマニュアル』． (2016)
  • Author(s): 桜井良太（藤原佳典，倉岡正高 編集）
  • Total Pages: 240
  • Publisher: 大修館書店
• [Book] シニア向けノルディックウォーキング・ポールウォーキングGUIDE BOOK (2015)
  • Author(s): 桜井良太 (ライフ出版編)
  • Total Pages: 212
  • Publisher: ライフ出版