ヒト褐色脂肪組織による糖代謝改善効果とそのメカニズムの解明

• Project/Area Number: 14J10103
• Research Category: Grant-in-Aid for JSPS Fellows
• Allocation Type: Single-year Grants
• Section: 国内
• Research Field: Endocrinology
• Research Institution: Hokkaido University
• Principal Investigator: 米代 武司 北海道大学, 獣医学研究科, 特別研究員(PD)
• Project Period (FY): 2014-04-25 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 脂肪細胞 / 糖代謝 / 肥満 / 骨髄 / BCAA / 褐色脂肪組織 / 糖尿病

Outline of Annual Research Achievements

白色脂肪組織（WAT）中に刺激応答性に出現するベージュ脂肪細胞はエネルギー消費に寄与する。本研究では、１）ベージュ脂肪組織の形成における骨髄由来幹細胞の関与、および２）ベージュ脂肪細胞の分岐差アミノ酸（BCAA）代謝能力の有無とその糖代謝への影響について検証した。
ベージュ脂肪細胞は、脂肪組織中の前駆細胞に由来すると考えられているが、骨髄由来幹細胞の寄与はよく知られていない。そこで、放射線照射により骨髄細胞を損傷させたC57BL/6JマウスにCAG-EGFPマウスの骨髄細胞を移植し、β3アドレナリン受容体作動薬（CL, 0.1mg/kg）を3日間投与してベージュ脂肪細胞を誘導した。その結果、マーカー分子であるUCP1を発現するベージュ脂肪細胞の一部にGFPの発現が確認された。CL誘導のベージュ脂肪組織の形成は、骨髄由来細胞がWATに供給され、分化することで達成されていることが判明した。
必須アミノ酸であるBCAAは、インスリン抵抗性を惹起する可能性が提唱されている。最近、白色脂肪細胞が高いBCAA代謝活性を有していることが報告されたが、ベージュ脂肪細胞については不明なままである。そこで、ヒトとマウスのベージュ脂肪細胞を培養し、1-14C バリン酸化量を評価した。ノルエピネフリン（NE）を投与して熱産生を活性化させると、バリン酸化量が上昇した。バリン存在下と非存在下でNEを投与し、酸素消費量を測定したところ、バリン存在下の方がNE誘導酸素消費量が高かった。13C-バリンを用いたメタボローム解析を行ったところ、バリン代謝物はTCA回路に入り、グルコースの効率的な利用を支持することが示唆された。以上から、BCAAはベージュ脂肪細胞の熱産生活性、および効率的なグルコース消費に重要な役割を担っていることが明らかになった。

Research Progress Status

28年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

28年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Tea catechin activates and recruits brown adipose tissue in humans (2017)
  • Author(s): Yoneshiro T, Matsushita M, Hibi M, Tone H, Takeshita M, Yasunaga K, Katsuragi Y, Kameya T, Sugie H, Saito M
  • Journal Title: Am J Clin Nutr Volume: Epub ahead of print Issue: 4 Pages: 873-881
  • DOI: 10.3945/ajcn.116.144972
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Royal jelly ameliorates diet-induced obesity and glucose intolerance by promoting brown adipose tissue thermogenesis in mice (2017)
  • Author(s): Yoneshiro T, Kaede R, Nagaya K, Aoyama J, Saito M, Izawa S, Okamatsu-Ogura Y, Kimura K, Terao A
  • Journal Title: Obe Res Clin Pract Volume: Epub ahead of print Issue: 1 Pages: 127-137
  • DOI: 10.1016/j.orcp.2016.12.006
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Brown adipose tissue is involved in the seasonal variation of cold-induced thermogenesis in humans. (2016)
  • Author(s): Yoneshiro T, Matsushita M, Nakae S, Kameya T, Sugie H, Tanaka S, Saito M
  • Journal Title: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology Volume: Epub ahead of print Issue: 10 Pages: 999-1009
  • DOI: 10.1152/ajpregu.00057.2015
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Brown adipose tissue is involved in diet-induced thermogenesis and whole-body fat utilization in healthy humans (2016)
  • Author(s): Hibi H, Oishi S, Matsushita M, Yoneshiro T, Yamaguchi T, Usui C, Yasunaga K, Katsuragi Y, Kubota K, Tanaka S, Saito M
  • Journal Title: Int J Obes Volume: 40 Issue: 11 Pages: 1655-1661
  • DOI: 10.1038/ijo.2016.124
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Near-infrared time resolved spectroscopy assessment of changes in human brown adipose tissue density during repeated capsiate intake and intake cessation (2016)
  • Author(s): Nirengi S, Homma T, Inoue N, Sato H, Yoneshiro T, Tsuzaki K, Saito M, Sakane N, Kurosawa Y, Hamaoka T
  • Journal Title: J Biomed Opt Volume: 21 Issue: 9 Pages: 091305-091305
  • DOI: 10.1117/1.jbo.21.9.091305
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Daily ingestion of catechin-rich beverage increases brown adipose tissue density and decreases extramyocellular lipids in healthy young women (2016)
  • Author(s): Nirengi S, Amagasa S, Homma T, Yoneshiro T, Matsumiya S, Kurosawa Y, Sakane N, Ebi K, Saito M, Hamaoka T
  • Journal Title: SplingerPlus Volume: 5 Issue: 1 Pages: 1363-1363
  • DOI: 10.1186/s40064-016-3029-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] ヒト褐色脂肪組織の活性化・増量－その評価法と肥満対策への応用 (2016)
  • Author(s): 斉藤昌之, 松下真美, 米代武司
  • Journal Title: 実験医学 Volume: 34 Pages: 197-202
  • Peer Reviewed
• [Journal Article] Activation and recruitment of brown adipose tissue by cold exposure and food ingredients in humans (2016)
  • Author(s): Saito M, Yoneshiro T, Matsushita M
  • Journal Title: Best Practice & Research Clinical Endocrinology & Metabolism Volume: Epub ahead of print
  • Peer Reviewed
• [Journal Article] Activation and recruitment of brown adipose tissue as anti-obesity regimens in humans. (2015)
  • Author(s): Takeshi Yoneshiro, Masayuki Saito.
  • Journal Title: Annals of Medicine Volume: 47 Issue: 2 Pages: 133-141
  • DOI: 10.3109/07853890.2014.911595
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Food ingredients as anti-obesity agents (2015)
  • Author(s): Saito M, Takeshi Yoneshiro T, and Matsushita M
  • Journal Title: Trends in Endocrinology and Metabolism Volume: 26（11） Issue: 11 Pages: 585-587
  • DOI: 10.1016/j.tem.2015.08.009
  • Peer Reviewed / Open Access
• [Journal Article] <i>Kaempferia parviflora</i> Extract Increases Whole-Body Energy Expenditure in Humans: Roles of Brown Adipose Tissue (2015)
  • Author(s): Matsushita M, Yoneshiro T, Aita S, Kamiya T, Kusaba N, Yamaguchi N, Takagaki K, Kameya T, Sugie H, Saito M.
  • Journal Title: Journal of Nutritional Science and Vitaminology Volume: 61 Issue: 1 Pages: 79-83
  • DOI: 10.3177/jnsv.61.79
  • NAID: 130005070826
  • ISSN: 0301-4800, 1881-7742
  • Peer Reviewed / Open Access
• [Journal Article] 寒冷適応と体脂肪制御における褐色脂肪組織の生理学的意義 (2015)
  • Author(s): 米代武司, 松下真美, 斉藤昌之
  • Journal Title: 日本生理人類学会誌 Volume: 20 Pages: 219-223
  • Peer Reviewed
• [Journal Article] Evaluation of brown adipose tissue using near-infrared time-resolved spectroscopy. (2015)
  • Author(s): Shinsuke Nirengi, Takeshi Yoneshiro, Takeshi Saiki, Sayuri Aita, Mami Matsushita, Hiroki Sugie, Masayuki Saito, Takafumi Hamaoka.
  • Journal Title: Advances in Experimental Medicine and Biology Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Kaempferia parviflora extract increases whole-body energy expenditure in humans: roles of brown adipose tissue. (2015)
  • Author(s): Mami Matsushita, Takeshi Yoneshiro, Sayuri Aita, Tomoyasu Kamiya, Nobutaka Kusaba, Kazuya Yamaguchi, Kinya Takagaki, Toshimitsu Kameya, Hiroki Sugie, Masayuki Saito.
  • Journal Title: Journal of Nutritional Science and Vitaminology Volume: 印刷中
  • Peer Reviewed
• [Journal Article] A novel simple method for detecting brown adipose tissue using near-infrared time-resolved spectroscopy. (2015)
  • Author(s): Shinsuke Nirengi, Takeshi Yoneshiro, Hiroki Sugie, Masayuki Saito, Takafumi Hamaoka.
  • Journal Title: Obesity (Silver Spring) Volume: 23 Issue: 5 Pages: 973-980
  • DOI: 10.1002/oby.21012
  • Peer Reviewed
• [Journal Article] Impact of brown adipose tissue on body fatness and glucose metabolism in healthy humans. (2014)
  • Author(s): Mami Matsushita, Takeshi Yoneshiro, Sayuri Aita, Toshimitsu Kameya, Hiroki Sugie, Masayuki Saito.
  • Journal Title: International Journal of Obesity Volume: 38 Issue: 6 Pages: 812-817
  • DOI: 10.1038/ijo.2013.206
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Daily ingestion of Grains of Paradise (Aframomum melegueta) extract increases whole-body energy expenditure and decreases visceral fat in humans. (2014)
  • Author(s): Jun Sugita, Takeshi Yoneshiro, Yuuki Sugishima, Takeshi Ikemoto, Hideyo Uchiwa, Toshihiko Iwanaga, Isao Suzuki, Masayuki Saito
  • Journal Title: Journal of Nutritional Science and Vitaminology Volume: 60 Pages: 22-27
  • Peer Reviewed
• [Journal Article] 褐色脂肪組織とエネルギー消費―肥満対策の視点から (2014)
  • Author(s): 米代武司
  • Journal Title: 臨床栄養 Volume: 120 Pages: 692-693
• [Journal Article] 肥満の医学－臨床と研究の最先端－抗肥満作用を有する食品成分 カプシノイド (2014)
  • Author(s): 米代武司, 斉藤昌之
  • Journal Title: 医学のあゆみ Volume: 250 Pages: 843-844
• [Journal Article] ヒト褐色脂肪のエネルギー消費機能と肥満 (2014)
  • Author(s): 米代武司, 斉藤昌之
  • Journal Title: The Lipid Volume: 25 Pages: 59-63
• [Presentation] Brown adipose tissue is involved in diet-induced thermogenesis and whole body fat utilization in healthy humans (2016)
  • Author(s): Tanaka S, Hibi M, Oishi S, Yamaguchi T, Yasunaga K, Yoneshiro T, Matsushita M, Usui C, Kubota K, Saito M
  • Organizer: 13th International Congress on Obesity
  • Place of Presentation: Vancouver Convention Centre, Vancouver, Canada
  • Year and Date: 2016-05-04
  • Int'l Joint Research
• [Presentation] 温度感受性TRPチャネル刺激活性を有する食品成分と褐色脂肪熱産生 (2016)
  • Author(s): 米代武司
  • Organizer: 第93回日本生理学会大会
  • Place of Presentation: 北海道札幌市, 札幌コンベンションセンター
  • Year and Date: 2016-03-22
  • Invited
• [Presentation] エネルギー代謝学と性差 (2016)
  • Author(s): 米代武司
  • Organizer: 第9回日本性差医学・医療学会学術集会
  • Place of Presentation: 北海道札幌市, ニューオータニイン札幌
  • Year and Date: 2016-01-30
  • Invited
• [Presentation] シンポジウム「脂肪細胞、アディポバイオロジーと肥満」食品成分によるTRPを介したヒトBAT活性化機構 (2016)
  • Author(s): 米代武司, 斉藤昌之
  • Organizer: 第59回日本糖尿病学会
  • Place of Presentation: 京都市（京都府）国立京都国際会館
  • Invited
• [Presentation] Tea catechin activates and recruits brown fat-dependent thermogenesis in men (2015)
  • Author(s): Saito M, Yoneshiro T, Matsushita M, Hibi M, Tone H, Takeshita M, Yasunaga K, Osaki N, Katsuragi Y
  • Organizer: 2015 International Congress on Obesity and Metabolic Syndrome
  • Place of Presentation: Sheraton-Seoul W-Walkerhill Hotel, Seoul, Korea
  • Year and Date: 2015-11-13
  • Int'l Joint Research
• [Presentation] 鎖骨上窩皮下組織温から見た褐色脂肪活性 (2015)
  • Author(s): 小林功嗣, 前田享史, 米代武司, 松下真美, 斉藤昌之
  • Organizer: 第23回衛生工学シンポジウム
  • Place of Presentation: 北海道札幌市, 北海道大学フロンティア応用科学研究棟
  • Year and Date: 2015-11-12
• [Presentation] Relationship between brown adipose tissue activity and subcutaneous tissue temperature of supraclavicular region during mild cold exposure (2015)
  • Author(s): Kobayashi K, Maeda T, Yoneshiro T, Matsushita M, Saito M
  • Organizer: 12th International Congress of Physiological Anthropology
  • Place of Presentation: 千葉県千葉市, 東京ベイ幕張ホール
  • Year and Date: 2015-10-30
  • Int'l Joint Research
• [Presentation] 緑茶カテキンのヒト褐色脂肪活性化・増量効果 (2015)
  • Author(s): 米代武司, 松下真美, 日比壮信, 刀禰寛, 竹下尚男, 安永浩一, 大崎紀子, 斉藤昌之
  • Organizer: 第36回日本肥満学会
  • Place of Presentation: 愛知県名古屋市, 名古屋国際会議場
  • Year and Date: 2015-10-03
• [Presentation] 長期カプシエイト類摂取および摂取終了後の褐色脂肪組織の変化 (2015)
  • Author(s): 二連木晋輔, 本間俊行, 米代武司, 井上尚彦, 佐藤斉, 津崎こころ, 斉藤昌之, 坂根直樹, 浜岡隆文
  • Organizer: 第36回日本肥満学会
  • Place of Presentation: 愛知県名古屋市, 名古屋国際会議場
  • Year and Date: 2015-10-03
• [Presentation] 褐色脂肪組織は日常生活中のエネルギー消費量増大に貢献するのか (2015)
  • Author(s): 中江悟司, 米代武司, 松下真美, 山田陽介, 高田和子, 斉藤昌之, 田中茂穂
  • Organizer: 第36回日本肥満学会
  • Place of Presentation: 愛知県名古屋市, 名古屋国際会議場
  • Year and Date: 2015-10-03
• [Presentation] 「肥満症と食品の標的分子」：食品成分によるTRPを介したヒトBAT活性化機構 (2015)
  • Author(s): 米代武司
  • Organizer: 第36回日本肥満学会
  • Place of Presentation: 名古屋市
  • Year and Date: 2015-10-02 – 2015-10-03
  • Invited
• [Presentation] シンポジウム「肥満症と食品の標的分子」食品成分によるTRPを介したヒトBAT活性化機構 (2015)
  • Author(s): 米代武司, 松下真美, 斉藤昌之
  • Organizer: 第36回日本肥満学会
  • Place of Presentation: 愛知県名古屋市, 名古屋国際会議場
  • Year and Date: 2015-10-02
• [Presentation] 黒ショウガエキス摂取によるヒト褐色脂肪組織の活性化と肥満予防 (2015)
  • Author(s): 松下真美, 米代武司
  • Organizer: 第62回日本栄養改善学会学術集会
  • Place of Presentation: 福岡県福岡市, 福岡国際会議場
  • Year and Date: 2015-09-26
• [Presentation] 褐色脂肪組織の適応的熱産生能と肥満予防 (2015)
  • Author(s): 米代武司, 松下真美, 斉藤昌之
  • Organizer: 日本生理人類学会第72回大会
  • Place of Presentation: 北海道札幌市, 北海道大学医学部学友会館
  • Year and Date: 2015-05-31
• [Presentation] 寒冷曝露時の鎖骨上窩皮下組織温と褐色脂肪活性の関係 (2015)
  • Author(s): 小林功嗣, 鷹野翔一, 高屋敷亮太, 前田享史, 米代武司, 松下真美, 斉藤昌之
  • Organizer: 日本生理人類学会第72回大会
  • Place of Presentation: 北海道札幌市, 北海道大学医学部学友会館
  • Year and Date: 2015-05-31
• [Presentation] 寒冷曝露時の鎖骨上窩皮下組織温と褐色脂肪活性の関係 (2015)
  • Author(s): 小林功嗣, 鷹野翔一, 高屋敷亮太, 前田享史, 米代武司, 松下真美, 斉藤昌之
  • Organizer: 日本生理人類学会第72回大会
  • Place of Presentation: 札幌市
  • Year and Date: 2015-05-30 – 2015-05-31
• [Presentation] 褐色脂肪組織の適応的熱産生能と肥満予防 (2015)
  • Author(s): 米代武司, 松下真美, 斉藤昌之
  • Organizer: 日本生理人類学会第72回大会
  • Place of Presentation: 札幌市
  • Year and Date: 2015-05-30 – 2015-05-31
  • Invited
• [Presentation] Food ingredients activating brown fat thermogenesis and reducing body fat in humans (2015)
  • Author(s): Yoneshiro T
  • Organizer: 12th Asian Congress of Nutrition
  • Place of Presentation: 神奈川県横浜市, パシフィコ横浜
  • Year and Date: 2015-05-17
  • Int'l Joint Research / Invited
• [Presentation] Food ingredients activating brown fat thermogenesis and reducing body fat in humans (2015)
  • Author(s): Takeshi Yoneshiro
  • Organizer: 12th Asian Congress of Nutrition
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2015-05-14 – 2015-05-18
  • Invited
• [Presentation] Green tee catechin increases brown fat-dependent thermogenesis (2015)
  • Author(s): Yoneshiro T, Matsushita M, Tone H, Hibi M, Takeshita M, Yasunaga K, Katsuragi Y, Saito M
  • Organizer: Keystone Symposia on Molecular and Cellular Biology -Beige and Brown Fat: Basic Biology and Novel Therapeutics
  • Place of Presentation: Snowbird Resort, Snowbird, Utah, USA
  • Year and Date: 2015-04-20
  • Int'l Joint Research
• [Presentation] Brown adipose tissue as a therapeutic target for human obesity (2015)
  • Author(s): Saito M, Yoneshiro T, Matsushita M
  • Organizer: Keystone Symposia on Molecular and Cellular Biology -Beige and Brown Fat: Basic Biology and Novel Therapeutics
  • Place of Presentation: Snowbird Resort, Snowbird, Utah, USA
  • Year and Date: 2015-04-20
  • Int'l Joint Research / Invited
• [Presentation] Effects of 12-week catechin-rich beverage intake on brown adipose tissue determined by novel near-infrared time-resolved spectroscopy and extramyocellular lipids in healthy young women (2015)
  • Author(s): Nirengi S, Amagasa S, Homma T, Yoneshiro T, Kurosawa Y, Saito M, Hamaoka T
  • Organizer: Keystone Symposia on Molecular and Cellular Biology -Beige and Brown Fat: Basic Biology and Novel Therapeutics
  • Place of Presentation: Snowbird Resort, Snowbird, Utah, USA
  • Year and Date: 2015-04-20
  • Int'l Joint Research
• [Presentation] Brown adipose tissue as a therapeutic target for human obesity (2015)
  • Author(s): Masayuki Saito, Takeshi Yoneshiro, Mami Matsushita
  • Organizer: Keystone Symposia on Molecular and Cellular Biology -Beige and Brown Fat: Basic Biology and Novel Therapeutics
  • Place of Presentation: Snowbird, USA
  • Year and Date: 2015-04-17 – 2015-04-22
  • Invited
• [Presentation] Effects of 12-week catechin-rich beverage intake on brown adipose tissue determined by novel near-infrared time-resolved spectroscopy and extramyocellular lipids in healthy young women (2015)
  • Author(s): Shinsuke Nirengi, Shiho Amagasa, Toshiyuki Homma, Takeshi Yoneshiro, Yuko Kurosawa, Masayuki Saito, Takafumi Hamaoka
  • Organizer: Keystone Symposia on Molecular and Cellular Biology -Beige and Brown Fat: Basic Biology and Novel Therapeutics
  • Place of Presentation: Snowbird, USA
  • Year and Date: 2015-04-17 – 2015-04-22
• [Presentation] Green tee catechin increases brown fat-dependent thermogenesis (2015)
  • Author(s): akeshi Yoneshiro, Mami Matsushita, Hiroshi Tone, Masanobu Hibi, Masao Takeshita, Koichi Yasunaga, Yoshihisa Katsuragi, Masayuki Saito
  • Organizer: Keystone Symposia on Molecular and Cellular Biology -Beige and Brown Fat: Basic Biology and Novel Therapeutics
  • Place of Presentation: Snowbird, USA
  • Year and Date: 2015-04-17 – 2015-04-22
• [Presentation] Roles of brown adipose tissue in seasonal variations of thermogenesis in men (2015)
  • Author(s): Masayuki Saito, Takeshi Yoneshiro, Mami Matsushita
  • Organizer: Experimental Biology 2015
  • Place of Presentation: Boston, USA
  • Year and Date: 2015-03-28 – 2015-04-01
• [Presentation] Verification of human brown adipose tissue evaluation using near-infrared time-resolved spectroscopy (2015)
  • Author(s): Shinsuke Nirengi, Shiho Amagasa, Toshiyuki Homma, Takeshi Yoneshiro, Yuko Kurosawa, Tomomi Iida, Motoki Oda, Yutaka Yamashita, Masayuki Saito, Takafumi Hamaoka
  • Organizer: International Symposium on Human Adaptation to Environment and Whole-body Coordination
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2015-03-14 – 2015-03-16
• [Presentation] The role of brown adipose tissue in thermoregulation and cold adaptation (2015)
  • Author(s): Takeshi Yoneshiro, Mami Matsushita, Masayuki Saito
  • Organizer: International Symposium on Human Adaptation to Environment and Whole-body Coordination
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2015-03-14 – 2015-03-16
  • Invited
• [Presentation] 褐色脂肪組織による非震え熱産生：寒冷応答と季節変動 (2014)
  • Author(s): 米代武司
  • Organizer: 日本生理人類学会体温調節研究部会
  • Place of Presentation: 札幌市
  • Year and Date: 2014-10-27
  • Invited
• [Presentation] 6週間のカプシノイド摂取による褐色脂肪増量と体脂肪量および内臓脂肪面積の減少 (2014)
  • Author(s): 二連木晋輔, 米代武司, 井上尚彦, 栢原孝志, 斉藤昌之, 浜岡隆文
  • Organizer: 第35回日本肥満学会
  • Place of Presentation: 宮崎市
  • Year and Date: 2014-10-24 – 2014-10-25
• [Presentation] ヒト褐色脂肪と2型甲状腺ホルモン脱ヨード化酵素（DIO2）の一塩基多型 (2014)
  • Author(s): 米代武司, 松下真美, 正保佳史, 常川勝彦, 村上正巳, 斉藤昌之
  • Organizer: 第35回日本肥満学会
  • Place of Presentation: 宮崎市
  • Year and Date: 2014-10-24 – 2014-10-25
• [Presentation] Noninvasive evaluation of human brown adipose tissue using quantitative near-infrared spectroscopy (2014)
  • Author(s): Takafumi Hamaoka, Shinsuke Nirengi, Takeshi Yoneshiro, Masayuki Saito
  • Organizer: 3rd International Conference on Recent Advances and Controversies in Measuring Energy Metabolism
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2014-10-10 – 2014-10-12
  • Invited
• [Presentation] A 12-week catechin-rich beverage intake increases brown adipose tissue and decreases extramyocellular lipids in healthy young women (2014)
  • Author(s): Shinsuke Nirengi, Shiho Amagasa Toshiyuki Homma, Takeshi Yoneshiro, Saori Matsumiya, Yuko Kurosawa, Kumiko Ebi, Masayuki Saito, Takafumi Hamaoka
  • Organizer: 3rd International Conference on Recent Advances and Controversies in Measuring Energy Metabolism
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2014-10-10 – 2014-10-12
• [Presentation] Recruitment of brown adipose tissue after daily ingestion of catechin in men (2014)
  • Author(s): Takeshi Yoneshiro, Mami Matsushita, Hiroshi Tone, Masanobu Hibi, Masao Takeshita, Koichi Yasunaga, Yoshihisa Katsuragi, Masayuki Saito
  • Organizer: 3rd International Conference on Recent Advances and Controversies in Measuring Energy Metabolism
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2014-10-10 – 2014-10-12
  • Invited
• [Presentation] Evaluation of brown adipose tissue using near-infrared time-resolved spectroscopy (2014)
  • Author(s): Shinsuke Nirengi, Takeshi Yoneshiro, Takeshi Saiki, Sayuri Aita, Mami Matsushita, Hiroki Sugie, Masayuki Saito, Takafumi Hamaoka
  • Organizer: 42nd Meeting of the International Society on Oxygen Transport to Tissue
  • Place of Presentation: London, UK
  • Year and Date: 2014-06-28 – 2014-07-03
• [Presentation] ヒトエネルギー代謝研究若手の会「エネルギー代謝の個人内・個人間変動と褐色脂肪組織との関係」 (2014)
  • Author(s): 米代武司
  • Organizer: 第68回 日本栄養・食糧学会大会
  • Place of Presentation: 札幌市
  • Year and Date: 2014-05-30 – 2014-06-01
  • Invited
• [Presentation] 適応性熱産生の季節変動とヒト褐色脂肪組織との関係 (2014)
  • Author(s): 中江悟司, 米代武司, 松下真美, 岩永敏彦, 田中茂穂, 斉藤昌之. 適応性熱産生の季節変動とヒト褐色脂肪組織との関係
  • Organizer: 第68回 日本栄養・食糧学会大会
  • Place of Presentation: 札幌市
  • Year and Date: 2014-05-30 – 2014-06-01
• [Presentation] 体脂肪と糖代謝に対する褐色脂肪組織の関与：ヒトでの横断的解析 (2014)
  • Author(s): 米代武司, 松下真美, 斉藤昌之
  • Organizer: 第68回 日本栄養・食糧学会大会
  • Place of Presentation: 札幌市
  • Year and Date: 2014-05-30 – 2014-06-01
• [Presentation] シンポジウム エネルギー代謝をターゲットとした抗肥満食品素材の探索・利用「ヒト褐色脂肪組織の評価法と肥満対策への応用」 (2014)
  • Author(s): 米代武司, 松下真美, 斉藤昌之
  • Organizer: 第68回 日本栄養・食糧学会大会
  • Place of Presentation: 札幌市
  • Year and Date: 2014-05-30 – 2014-06-01
  • Invited