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糖尿病発症予測ツールに基づく全県レベルでの予防介入効果の検討

Research Project

Project/Area Number 14J30007
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeSingle-year Grants
Section国内
Research Field Metabolomics
Research InstitutionNiigata University

Principal Investigator

平安座 依子  新潟大学, 医歯学系, 特別研究員(PD)

Project Period (FY) 2014-04-25 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords糖尿病 / 栄養 / 遺伝子多形 / 肥満 / 2型糖尿病 / 発症予防 / 発症予測 / スクリーニング / 2型糖尿病発症予防 / リスクスコア / 食事調査 / 身体活動 / 運動
Outline of Annual Research Achievements

2型糖尿病発症予防についての臨床エビデンスの構築とリスク診断ツールの一般応用可能性を検討するため、臨床疫学研究と介入研究を融合した研究を行った。昨年度に引き続き、遺伝子多型と栄養食事介入(栄養摂取状況)の交互作用が臨床代謝指標に与える影響について解析をし、米国糖尿病学会やその他の国際学術集会において口頭発表をした。また、共同研究者らとも検討結果やプロジェクトについての打ち合わせを行った。
研究結果を英文原著論文をDiabetes Careに発表し、さらに特に炭水化物代謝の遺伝多形についての研究を発展させ、炭水化物代謝機能と関連する遺伝子多形と体重変化の関連について研究した。研究結果については現在糖尿病専門分野の学術雑誌であるDiabetesに投稿し、リバイス改定中である。採用最終年である本年度も、糖尿病分野の英文雑誌に筆頭論文が掲載されるなど、糖尿病発症予測に役立つ研究成果を報告することができた。また、血中アミノ酸と糖尿病関連遺伝子多形の交互作用が耐糖能異常に関連するかについて検討し、研究成果を第66回米国人類遺伝学会 (ASHG 2016)にて発表した。また、腸内細菌代謝産物であるTrimethylamine N-oxide、メタボロミクス関連指標(血中アミノ酸等)のデータを測定し、現在それらの耐糖能異常発症予測能についての解析結果をまとめているところである。
その他、Nutrition in the Prevention and Treatment of Disease 4th Edition書籍Book Chapter 30: Genetics and Diabetes(糖尿病と遺伝)の章を担当し、遺伝と糖尿病学について執筆した。これまでゲノムワイド関連解析により明らかとなってきた遺伝子多形は数多く存在することから、糖尿病発症予測リスクツールの応用可能性を検討するにあたり、遺伝子多形を考慮する意義についてもさらに検討が必要である。

Research Progress Status

28年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

28年度が最終年度であるため、記入しない。

Report

(3 results)
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (68 results)

All 2017 2016 2015 2014 Other

All Journal Article (27 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 27 results,  Open Access: 13 results,  Acknowledgement Compliant: 18 results) Presentation (33 results) (of which Int'l Joint Research: 10 results) Book (5 results) Remarks (3 results)

  • [Journal Article] Gene-Diet Interaction and Precision Nutrition in Obesity2017

    • Author(s)
      Heianza Y, Qi L.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 18 Issue: 4 Pages: 787-787

    • DOI

      10.3390/ijms18040787

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] PCSK9 variant, long-chain n-3 PUFAs, and risk of nonfatal myocardial infarction in Costa Rican Hispanics.2017

    • Author(s)
      Yu Z, Huang T, Zheng Y, Wang T, Heianza Y, Sun D, Campos H, Qi L.
    • Journal Title

      The American journal of clinical nutrition

      Volume: 印刷中 Issue: 5 Pages: 1198-1203

    • DOI

      10.3945/ajcn.116.148106

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genetic Variations of Circulating Adiponectin Levels Modulate Changes in Appetite in Response to Weight-Loss Diets.2017

    • Author(s)
      Ma W, Huang T, Heianza Y, Wang T, Sun D, Tong J, Williamson DA, Bray GA, Sacks FM, Qi L.
    • Journal Title

      The Journal of clinical endocrinology and metabolism

      Volume: 102 Pages: 316-325

    • DOI

      10.1210/jc.2016-2909

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Impact of individual components and their combinations within a family history of hypertension on the incidence of hypertension: Toranomon hospital health management center study 222016

    • Author(s)
      Igarashi R, Furukawa K, Heianza Y, Ishizawa M, Kodama S, Saito K, Hara S, Hanyu O, Honda R, Tsuji H, Arase Y, Sone H
    • Journal Title

      Medicine

      Volume: 95(38):e4564 Issue: 38 Pages: e4564-e4564

    • DOI

      10.1097/md.0000000000004564

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Zinc-Associated Variant in SLC30A8 Gene Interacts With Gestational Weight Gain on Postpartum Glycemic Changes: A Longitudinal Study in Women With Prior Gestational Diabetes Mellitus.2016

    • Author(s)
      Wang T, Liu H, Wang L, Huang T, Li W, Zheng Y, Heianza Y, Sun D, Leng J, Zhang S, Li N, Hu G, Qi L.
    • Journal Title

      Diabetes

      Volume: 65 Issue: 12 Pages: 3786-3793

    • DOI

      10.2337/db16-0730

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials.2016

    • Author(s)
      Livingstone KM,Celis-Morales C,Papandonatos GD,Erar B, Florez J.C, Jablonski KA, Razquin C, Marti A, Heianza Y, Huang T, Sacks FM, Svendstrup M, Sui X, Church TS, Jaaskelainen T, Lindstrom J, Tuomilehto J, Uusitupa M, Rankinen T, Saris WH, Hansen T, Pedersen O, Astrup A, Sorensen TI, Qi L, et al.
    • Journal Title

      BMJ.

      Volume: 354 Pages: i4707-i4707

    • DOI

      10.1136/bmj.i4707

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Associations of Bowel Movement Frequency with Risk of Cardiovascular Disease and Mortality among US Women.2016

    • Author(s)
      Ma W, Li Y, Heianza Y, Staller KD, Chan AT, Rimm EB, Rexrode KM, Qi L.
    • Journal Title

      Scientific reports

      Volume: 6 Issue: 1 Pages: 33005-33005

    • DOI

      10.1038/srep33005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Macronutrient Intake-Associated FGF21 Genotype Modifies Effects of Weight-Loss Diets on 2-Year Changes of Central Adiposity and Body Composition: The POUNDS Lost Trial.2016

    • Author(s)
      Heianza Y, Ma W, Huang T, Wang T, Zheng Y, Smith SR, Bray GA, Sacks FM, Qi L.
    • Journal Title

      Diabetes Care

      Volume: 39 Issue: 11 Pages: 1909-1914

    • DOI

      10.2337/dc16-1111

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Plasma Taurine, Diabetes Genetic Predisposition, and Changes of Insulin Sensitivity in Response to Weight-Loss Diets.2016

    • Author(s)
      Zheng Y, Ceglarek U, Huang T, Wang T, Heianza Y, Ma W, Bray GA, Thiery J, Sacks FM, Qi L.
    • Journal Title

      The Journal of clinical endocrinology and metabolism

      Volume: 101 Issue: 10 Pages: 3820-3826

    • DOI

      10.1210/jc.2016-1760

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Two-year changes in circulating adiponectin, ectopic fat distribution and body composition in response to weight-loss diets: the POUNDS Lost Trial.2016

    • Author(s)
      Ma W, Huang T, Wang M, Zheng Y, Wang T, Heianza Y, Sun D, Smith SR, Bray GA, Sacks FM, Qi L.
    • Journal Title

      International journal of obesity

      Volume: 40 Issue: 11 Pages: 1723-1729

    • DOI

      10.1038/ijo.2016.128

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Assessment of kidney dysfunction with cystatin C- and creatinine-based estimated glomerular filtration rate and predicting type 2 diabetes: Toranomon Hospital Health Management Center Study 212016

    • Author(s)
      Heianza Y, Hara S, Saito K, Tsuji H, Tanaka S, Kodama S, Kobayashi T, Arase Y, Sone H.
    • Journal Title

      Diabetes Res Clin Pract

      Volume: 113 Pages: 60-68

    • DOI

      10.1016/j.diabres.2016.01.026

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Comparison of clinical characteristics in patients with type 2 diabetes among whom different antihyperglycemic agents were prescribed as monotherapy or combination therapy by diabetes specialists.2016

    • Author(s)
      Fujihara K, Hanyu O, Heianza Y, Suzuki A, Yamada T, Yokoyama H, Tanaka S, Yagyu H, Shimano H, Kashiwagi A, Yamazaki K, Kawai K, Sone H.
    • Journal Title

      J Diabetes Investig

      Volume: 7 Issue: 2 Pages: 260-9

    • DOI

      10.1111/jdi.12387

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Trajectory of body mass index before the development of type 2 diabetes in Japanese men: Toranomon Hospital Health Management Center Study 152015

    • Author(s)
      Heianza Y, Arase Y, Kodama S, Tsuji H, Tanaka S, Saito K, Hara S, Sone H.
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 6 Issue: 3 Pages: 289-294

    • DOI

      10.1111/jdi.12308

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Simple self-reported behavioral or psychological characteristics as risk factors for future type 2 diabetes in Japanese individuals: Toranomon Hospital Health Management Center Study 142015

    • Author(s)
      Heianza Y, Arase Y, Kodama S, Tsuji H, Fujihara K, Saito K, Hara S, Sone H.
    • Journal Title

      Journal of diabetes investigation

      Volume: 6 Issue: 2 Pages: 236-241

    • DOI

      10.1111/jdi.12274

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Risk of the Development of Type 2 Diabetes in Relation to Overall Obesity, Abdominal Obesity and the Clustering of Metabolic Abnormalities in Japanese Individuals - Does Metabolically Healthy Overweight Really Exist?: Niigata Wellness Study2015

    • Author(s)
      Heianza Y, Kato K, Kodama S, Ohara N, Suzuki A, Tanaka S, Hanyu O, Sato K, Sone H
    • Journal Title

      Diabet Med

      Volume: 32 Issue: 5 Pages: 665-72

    • DOI

      10.1111/dme.12646

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Fasting glucose and HbA1c levels as risk factors for the development of hypertension in Japanese individuals: Toranomon hospital health management center study 16 (TOPICS 16)2015

    • Author(s)
      Heianza Y, Arase Y, Kodama S, Hsieh S. D, Tsuji H, Saito K, Hara S, Sone H
    • Journal Title

      Journal of human hypertension

      Volume: 29 Issue: 4 Pages: 254-259

    • DOI

      10.1038/jhh.2014.77

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Circulating Malondialdehyde-Modified LDL-Related Variables and Coronary Artery Stenosis in Asymptomatic Patients with Type 2 Diabetes2015

    • Author(s)
      Fujihara K, Suzuki H, Sato A, Kodama S, Heianza Y, Saito K, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Yagyu H, Sone H, Shimano H.
    • Journal Title

      Journal of diabetes research

      Volume: 印刷中 Pages: 507245-507245

    • DOI

      10.1155/2015/507245

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Impact of population aging on trends in diabetes prevalence: A meta-regression analysis of 160,000 Japanese adults2015

    • Author(s)
      Charvat H, Goto A, Goto M, Inoue M, Heianza Y, Arase Y, Sone H, Nakagami T, Song X, Qiao Q, Tuomilehto J, Tsugane S, Noda M, Inoue M.
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 印刷中 Issue: 5 Pages: 533-542

    • DOI

      10.1111/jdi.12333

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Metabolically healthy obesity, presence or absence of fatty liver, and risk of type 2 diabetes in Japanese individuals: Toranomon Hospital Health Management Center Study 20 (TOPICS 20)2014

    • Author(s)
      Heianza Y, Arase Y, Tsuji H, Fujihara K, Saito K, Hsieh SD, Tanaka S, Kodama S, Hara S, Sone H.
    • Journal Title

      The Journal of clinical endocrinology and metabolism

      Volume: 99 Issue: 8 Pages: 2952-2960

    • DOI

      10.1210/jc.2013-4427

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Role of body mass index history in predicting risk of the development of hypertension in Japanese individuals: Toranomon Hospital Health Management Center Study 18 (TOPICS 18).2014

    • Author(s)
      Heianza Y, Kodama S, Arase Y, Hsieh SD, Yoshizawa S, Tsuji H, Saito K, Tanaka S, Hara S, Sone H.
    • Journal Title

      Hypertension

      Volume: 64 Issue: 2 Pages: 247-252

    • DOI

      10.1161/hypertensionaha.113.02918

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Impact on short-term glycaemic control of initiating diabetes care versus leaving diabetes untreated among individuals with newly screening-detected diabetes in Japan2014

    • Author(s)
      Heianza Y, Suzuki A, Fujihara K, Tanaka S, Kodama S, Hanyu O, Sone H.
    • Journal Title

      Journal of epidemiology and community health

      Volume: 68 Issue: 12 Pages: 1189-1195

    • DOI

      10.1136/jech-2014-204054

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Response to comment on Heianza et al. Effect of postmenopausal status and age at menopause on type 2 diabetes and prediabetes in Japanese individuals: Toranomon Hospital Health Management Center Study 17 (TOPICS 17). Diabetes Care 2013;36:4007-40142014

    • Author(s)
      Heianza Y, Sone H.
    • Journal Title

      Diabetes Care

      Volume: 37 Issue: 7 Pages: e165-e166

    • DOI

      10.2337/dc14-0745

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of sleep duration as a risk factor for Type 2 diabetes among adults of different ages in Japan: the Niigata Wellness Study2014

    • Author(s)
      Heianza Y, Kato, K, Fujihara, K, Tanaka, S, Kodama, S, Hanyu O, Sato K, Sone H.
    • Journal Title

      Diabetic Medicine

      Volume: 31 Issue: 11 Pages: 1363-1367

    • DOI

      10.1111/dme.12555

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Stability and changes in metabolically healthy overweight or obesity and risk of future diabetes: Niigata wellness study2014

    • Author(s)
      Heianza Y, Kato K, Kodama S, Suzuki A, Tanaka S, Hanyu O, Sato K, Sone H.
    • Journal Title

      Obesity (Silver Spring)

      Volume: 22 Issue: 11 Pages: 2420-2425

    • DOI

      10.1002/oby.20855

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Comparison of different aspects of BMI history to identify undiagnosed diabetes in Japanese men and women: Toranomon Hospital Health Management Center Study 12 (TOPICS 12)2014

    • Author(s)
      Yoshizawa S, Heianza Y, Arase Y, Saito K, Hsieh SD, Tsuji H, Hanyu O, Suzuki A, Tanaka S, Kodama S, Shimano H, Hara S, Sone H.
    • Journal Title

      Diabetic Medicine

      Volume: 31 Issue: 11 Pages: 1378-1386

    • DOI

      10.1111/dme.12471

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Utility of the Triglyceride Level for Predicting Incident Diabetes Mellitus According to the Fasting Status and Body Mass Index Category: The Ibaraki Prefectural Health Study2014

    • Author(s)
      Fujihara K, Sugawara A, Heianza Y, Sairenchi T, Irie F, Iso H, Doi M, Shimano H, Watanabe H, Sone H, Ota H
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 21 Issue: 11 Pages: 1152-1169

    • DOI

      10.5551/jat.22913

    • NAID

      130004704369

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Comparison of the Framingham Risk Score, UK Prospective Diabetes Study (UKPDS) Risk Engine, Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) and Maximum Carotid Intima-Media Thickness for Predicting Coronary Artery Stenosis in Patients with Asymptomatic Type 2 Diabetes2014

    • Author(s)
      Fujihara K, Suzuki H, Sato A, Ishizu T, Kodama S, Heianza Y, Saito K, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Sone H, Shimano H
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 21 Issue: 8 Pages: 799-815

    • DOI

      10.5551/jat.20487

    • NAID

      130004845472

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Gut-microbiota-derived Trimethylamine-N-oxide levels and Risk of Major Adverse Cardiovascular Events: A Systematic Review and Meta-analysis of Prospective Cohort Studies2016

    • Author(s)
      Yoriko Heianza, Wenjie Ma, Lu Qi
    • Organizer
      American Heart Association (AHA) Scientific Sessions 2016
    • Place of Presentation
      ニューオーリンズ (米国)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Circulating aromatic amino acids modify the GCKR genotype on changes of glucose metabolism in response to weight-loss diets: The POUNDS Lost trial.2016

    • Author(s)
      Yoriko Heianza, Wenjie Ma, Yan Zheng, George Bray, Frank Sacks, Lu Qi
    • Organizer
      American Society of Human Genetics 66th Annual Meeting
    • Place of Presentation
      バンクーバー(カナダ)
    • Year and Date
      2016-10-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genetic variant close to FGF21 is associated with dietary macronutrient intake and modifies effects of a weight-loss diet on 2-year changes of body composition and fat distribution: The POUNDS Lost Trial2016

    • Author(s)
      Yoriko Heianza, Tao Huang, Tiange Wang, Dianjianyi Sun, Steven R. Smith, George A. Bray, Frank M. Sacks, Lu Qi
    • Organizer
      第76回米国糖尿病学会
    • Place of Presentation
      ニューオーリンズ (米国)
    • Year and Date
      2016-06-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Plasma taurine, genetic predisposition, and changes of insulin sensitivity in response to weight-loss diets: The POUNDS lost2016

    • Author(s)
      Yoriko Heianza, Lu Qi
    • Organizer
      5th International Conference and Exhibition on Metabolomics
    • Place of Presentation
      Hyatt Regency (大阪府、大阪市)
    • Year and Date
      2016-05-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Risk of development of dysglycemia according to the combination of obesity and degrees of metabolic abnormalities.2015

    • Author(s)
      Yoriko Heianza, Kiminori Kato, Satoru Kodama, Minoru Tashiro, Osamu Hanyu, Koji Sato, Hirohito Sone.
    • Organizer
      国際糖尿病連合(IDF)世界会議2015
    • Place of Presentation
      バンクーバー(カナダ)
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Separate and combined associations of obesity and fatty liver with insulin resistance and beta-cell dysfunction.2015

    • Author(s)
      Yoriko Heianza, Yasuji Arase, Kazumi Saito, Hiroshi Tsuji, Satoru Kodama, Ritsuko Honda, Tetsuro Kobayashi, Shigeko Hara, Hirohito Sone.
    • Organizer
      国際糖尿病連合(IDF)世界会議2015
    • Place of Presentation
      バンクーバー(カナダ)
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Metabolic health, obesity and the risk of developing chronic kidney disease among Japanese individuals.2015

    • Author(s)
      Yoriko Heianza, Kiminori Kato, Satoru Kodama, Minoru Tashiro, Osamu Hanyu, Koji Sato, Hirohito Sone
    • Organizer
      国際糖尿病連合(IDF)世界会議2015
    • Place of Presentation
      バンクーバー(カナダ)
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Longitudinal trajectories of insulin sensitivity and beta cell function before the development of type 2 diabetes in Japanese individuals.2015

    • Author(s)
      Yoriko Heianza, Yasuji Arase, Satoru Kodama, Hiroshi Tsuji, Shiro Tanaka, Tetsuro Kobayashi, Shigeko Hara, Hirohito Sone.
    • Organizer
      第51回欧州糖尿病連合EASD学術集会
    • Place of Presentation
      ストックホルム(スウェーデン)
    • Year and Date
      2015-09-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 健康的肥満 (Metabolically Healthy Obesity) と慢性腎臓病 (CKD) 発症に関する大規模縦断的検討:Niigata Wellness Study2015

    • Author(s)
      平安座 依子, 加藤 公則, 児玉 暁, 田代 稔, 羽入 修, 佐藤 幸示, 曽根 博仁.
    • Organizer
      第56回日本人間ドック学会学術大会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2015-07-31
    • Related Report
      2015 Annual Research Report
  • [Presentation] 健康的肥満 (Metabolically Healthy Obesity) と慢性腎臓病 (CKD) 発症に関する大規模縦断的検討: Niigata Wellness Study2015

    • Author(s)
      平安座 依子, 加藤 公則, 児玉 暁, 田代 稔, 羽入 修, 佐藤 幸示, 曽根 博仁
    • Organizer
      第56回日本人間ドック学会学術大会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2015-07-31
    • Related Report
      2015 Annual Research Report
  • [Presentation] Role of body mass index history in predicting the risk of developing type 2 diabetes: Toranomon Hospital Health Management Center Study2015

    • Author(s)
      Yoriko Heianza, Yasuji Arase, Kazumi Saito, Hiroshi Tsuji, Shiro Tanaka, Satoru Kodama,Tetsuro Kobayashi, Shigeko Hara, Hirohito Sone.
    • Organizer
      第56回日本人間ドック学会学術大会(国際セッション)
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2015-07-31
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肥満と肝臓脂肪沈着がインスリン分泌動態とインスリン抵抗性・β細胞機能に与える影響の検討.2015

    • Author(s)
      平安座 依子, 荒瀬 康司, 原 茂子, 児玉 暁, 齋藤 和美, 辻 裕之, 小林 哲郎, 曽根 博仁.
    • Organizer
      第56回日本人間ドック学会学術大会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2015-07-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Longitudinal Trajectories of Glucose, Insulin Sensitivity, and Insulin Secretion during Development of Type 2 Diabetes in Japanese: Toranomon Hospital Health Management Center Study2015

    • Author(s)
      Yoriko Heianza, Kazuya Fujihara, Shigeko Hara, Osamu Hanyu, Kazumi Saito, Shiro Tanaka, Satoru Kodama, Tetsuro Kobayashi, Yasuji Arase, Hirohito Sone.
    • Organizer
      第75回米国糖尿病学会
    • Place of Presentation
      ボストン(米国)
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Assessment of Kidney Dysfunction with Cystatin C- and Creatinine-based Estimated Glomerular Filtration Rate and Predicting Future Type 2 Diabetes among Japanese: Toranomon Hospital Health Management Center Study2015

    • Author(s)
      Yoriko Heianza, Shigeko Hara, Satoru Kodama, Kazumi Saito, Shiro Tanaka, Osamu Hanyu, Tetsuro Kobayashi, Yasuji Arase, Hirohito Sone.
    • Organizer
      第75回米国糖尿病学会
    • Place of Presentation
      ボストン(米国)
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 血中シスタチンC, クレアチニンを用いた腎機能評価と2型糖尿病発症リスク: Toranomon Hospital Health Management Center Study.2015

    • Author(s)
      平安座 依子,原 茂子,児玉 暁,齋藤 和美,藤原 和哉,五十嵐 理沙,鈴木 亜希子, 羽入 修, 辻 裕之, 森 保道,小林 哲郎, 荒瀬 康司,曽根 博仁.
    • Organizer
      第58回 日本糖尿病学会年次学術集会
    • Place of Presentation
      東京第一ホテル下関 (山口県、下関市)
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Risk of Developing Diabetes in Relation to Overall Obesity, Abdominal Obesity and Clustering of Metabolic Abnormalities2015

    • Author(s)
      Heianza Y, Kato K, Kodama S, Ohara N, Sato K, Sone H.
    • Organizer
      第25回日本疫学会学術総会
    • Place of Presentation
      愛知県産業労働センター (名古屋市)
    • Year and Date
      2015-01-21 – 2015-01-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 加齢による睡眠時間の影響と将来の2型糖尿病発症リスク: Niigata Wellness Study2015

    • Author(s)
      平安座 依子, 加藤 公則, 児玉 暁, 田代 稔, 佐藤幸示,曽根博仁
    • Organizer
      第18回日本病態栄養学会年次学術集会
    • Place of Presentation
      国立京都国際会館 (京都府)
    • Year and Date
      2015-01-10 – 2015-01-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 体格的肥満・腹部肥満と代謝異常の程度の組み合わせが2型糖尿病発症リスクに与える影響2015

    • Author(s)
      平安座 依子, 加藤 公則, 児玉 暁, 田代 稔, 五十嵐 理沙, 由澤 咲子, 小原 伸雅, 羽入 修, 佐藤 幸示, 曽根 博仁
    • Organizer
      第18回日本病態栄養学会年次学術集会
    • Place of Presentation
      国立京都国際会館 (京都府)
    • Year and Date
      2015-01-10 – 2015-01-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Characteristics of patients with type 2 diabetes who achieved better glycaemic control through resistance training: a meta-analysis2014

    • Author(s)
      Ishiguro H, Kodama S, Matsunaga S, Horikawa C, Heianza Y, Ohara N, Yamada T, Suzuki A, Hanyu O, Sone H.
    • Organizer
      50th EASD Annual Meeting
    • Place of Presentation
      ウィーン(オーストリア)
    • Year and Date
      2014-09-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Metabolically healthy obesity, presence or absence of fatty liver, and risk of type 2 diabetes in Japanese individuals.2014

    • Author(s)
      Heianza Y, Arase Y, Fujihara K, Hsieh SD, Saito K, Hanyu O, Kodama S, Hara S, Sone H.
    • Organizer
      50th EASD Annual Meeting
    • Place of Presentation
      ウィーン(オーストリア)
    • Year and Date
      2014-09-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 尿蛋白測定試験紙(±)症例における腎機能低下に関連する因子についての検討2014

    • Author(s)
      番場一成、平安座依子、笠井真由美、大野 義将、清水不二雄、上村 由紀、山本 晃、松浦 恵子、曽根 博仁、村山 実
    • Organizer
      第55回日本人間ドック学会学術大会
    • Place of Presentation
      福岡国際会議場 (福岡県)
    • Year and Date
      2014-09-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Resistance Exercise Was Effective in Improving Glycemic Control but Inferior to Aerobic Exercise for Patients with Type 2 Diabetes Mellitus―A Meta-analysis.2014

    • Author(s)
      Ishiguro H, Kodama S, Horikawa C, Suzuki H, Matsunaga S, Heianza Y, Yamada T, Suzuki A, Hanyu O, Sone H.
    • Organizer
      74th American Diabetes Association Scientific Sessions
    • Place of Presentation
      サンフランシスコ (米国)
    • Year and Date
      2014-06-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Risk of Development of Type 2 Diabetes by Overall Obesity, Abdominal Obesity, and Metabolic Abnormalities-Does Metabolically Healthy Obesity Really Exist?2014

    • Author(s)
      Heianza Y, Kato K, Suzuki A, Horikawa C, Matsunaga S, Yoshizawa S, Hanyu O, Kodama S, Sato K, Sone H.
    • Organizer
      74th American Diabetes Association Scientific Sessions
    • Place of Presentation
      サンフランシスコ (米国)
    • Year and Date
      2014-06-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] Diabetes Risk Related to Carrying 1 Risk Allele of a Diabetes-Susceptible Gene Is Comparable to That Related to 1 Unit of Increased Body Mass Index: A Meta-analysis.2014

    • Author(s)
      Horikawa C, Kodama S, Matsunaga S, Yoshizawa S, Heianza Y, Yachi Y, Ohara N, Suzuki A, Hanyu O, Sone H.
    • Organizer
      74th American Diabetes Association Scientific Sessions
    • Place of Presentation
      サンフランシスコ (米国)
    • Year and Date
      2014-06-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] High Serum Uric Acid Level Is More Predictive of Risk of Future Type 2 Diabetes in Nonobese Than in Overweight/Obese People: The Niigata Wellness Study.2014

    • Author(s)
      Matsunaga S, Heianza Y, Suzuki T, Kitazawa M, Minagawa S, Yamada T, Suzuki A, Hanyu O, Kato K, Sato K, Sone H.
    • Organizer
      74th American Diabetes Association Scientific Sessions
    • Place of Presentation
      サンフランシスコ (米国)
    • Year and Date
      2014-06-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] Predictive Value of Combined Single Nucleotide Polymorphisms for Diabetes Mellitus―A Meta-analysis.2014

    • Author(s)
      Kodama S, Horikawa C, Matsunaga S, Fujihara K, Heianza Y, Hirose A, Yamada T, Suzuki A, Hanyu O, Sone H.
    • Organizer
      74th American Diabetes Association Scientific Sessions
    • Place of Presentation
      サンフランシスコ (米国)
    • Year and Date
      2014-06-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] Magnitude of Risk of Diabetes Mellitus in Relation to Carrying Risk Alleles of Diabetes-Susceptible Genes Was Not Influenced by Covariates: A Meta-analysis.2014

    • Author(s)
      Ishiguro H, Kodama S, Horikawa C, Furukawa K, Suzuki H, Fujihara K, Heianza Y, Suzuki A, Hanyu O, Sone H.
    • Organizer
      74th American Diabetes Association Scientific Sessions
    • Place of Presentation
      サンフランシスコ (米国)
    • Year and Date
      2014-06-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] Stability and Changes in the Metabolically Healthy Overweight or Obese State and the Risk of Development of Future Type 2 Diabete2014

    • Author(s)
      Heianza Y, Suzuki A, Kato K, Fujihara K, Yamada T, Hanyu O, Kodama S, Sato K, Sone H.
    • Organizer
      74th American Diabetes Association Scientific Sessions
    • Place of Presentation
      サンフランシスコ (米国)
    • Year and Date
      2014-06-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] レセプトデータを利用した新規糖尿病治療薬処方状況の検討2014

    • Author(s)
      鈴木 亜希子、平安座 依子、羽入 修、鈴木 達郎、北澤 勝、阿部 孝洋、植村 靖行、皆川 真一、山田 貴穂、曽根 博仁
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪府
    • Year and Date
      2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 健康的肥満(Metabolically Healthy Obesity)と2型糖尿病発症に関する大規模前向き研究:TOPICS2014

    • Author(s)
      平安座 依子、児玉 暁、原 茂子、謝 勲東、森 保道、辻 裕之、齋藤 和美、藤原 和哉、島野 仁、羽入 修、鈴木 亜希子、荒瀬 康司、曽根 博仁
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪府
    • Year and Date
      2014-05-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 尿酸の糖尿病発症への影響は非肥満者で強い2014

    • Author(s)
      松永 佐澄志、平安座 依子、皆川 真一、鈴木 亜希子、山田 貴穂、羽入 修、田代 稔、大塚 政人、佐藤 幸示、加藤 公則、曽根 博仁
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪府
    • Year and Date
      2014-05-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満と臨床代謝指標の変化がその後の糖尿病発症に与える影響についての大規模縦断的検討:the Niigata Wellness Study2014

    • Author(s)
      羽入 修、平安座 依子、加藤 公則、松永 佐澄志、田代 稔、児玉 暁、藤原 和哉、鈴木 亜希子、佐藤 幸示、曽根 博仁
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪府
    • Year and Date
      2014-05-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 糖尿病スクリーニング後の早期治療と未治療放置が短期間の血糖コントロールに与える影響の大規模疫学的検討2014

    • Author(s)
      五十嵐 理沙、平安座 依子、児玉 暁、由澤 咲子、山田 貴穂、藤原 和哉、鈴木 亜希子、羽入 修、曽根 博仁
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪府
    • Year and Date
      2014-05-22
    • Related Report
      2014 Annual Research Report
  • [Book] Nutrition in the Prevention and Treatment of Disease 4th Edition (Chapter 29. Genetics and Diabetes)2017

    • Author(s)
      Heianza Y, Qi L. 他
    • Total Pages
      1072
    • Publisher
      Elsevier
    • Related Report
      2016 Annual Research Report
  • [Book] プラクティス 第32巻第5号2016

    • Author(s)
      平安座 依子・荒瀬 康司・曽根 博仁
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2015 Annual Research Report
  • [Book] Diabetes Frontier 2015年12月号 特集 日本人糖尿病の大規模臨床2015

    • Author(s)
      平安座 依子、荒瀬 康司、曽根 博仁
    • Publisher
      メディカルレビュー社
    • Related Report
      2015 Annual Research Report
  • [Book] 月刊糖尿病 健診データを活かした糖尿病早期診断と発症予測2014

    • Author(s)
      平安座 依子、曽根 博仁
    • Total Pages
      96
    • Publisher
      医学出版
    • Related Report
      2014 Annual Research Report
  • [Book] 最新肥満症学2014

    • Author(s)
      小原 伸雅, 平安座 依子, 曽根 博仁
    • Publisher
      日本臨牀社
    • Related Report
      2014 Annual Research Report
  • [Remarks] Tulane University Obesity Research Center

    • URL

      https://sph.tulane.edu/tulane-university-obesity-research-center

    • Related Report
      2016 Annual Research Report
  • [Remarks] 新潟大学医学部・大学院医歯学総合研究科 血液・内分泌・代謝内科学分野

    • URL

      http://www.med.niigata-u.ac.jp/emh/outline.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 新潟大学医学部・大学院医歯学総合研究科血液・内分泌・代謝内科学分野>大規模臨床研究について

    • URL

      http://www.med.niigata-u.ac.jp/emh/research.html

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2015-01-22   Modified: 2024-03-26  

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