糖尿病発症予測ツールに基づく全県レベルでの予防介入効果の検討

• Project/Area Number: 14J30007
• Research Category: Grant-in-Aid for JSPS Fellows
• Allocation Type: Single-year Grants
• Section: 国内
• Research Field: Metabolomics
• Research Institution: Niigata University
• Principal Investigator: 平安座 依子 新潟大学, 医歯学系, 特別研究員(PD)
• Project Period (FY): 2014-04-25 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 糖尿病 / 栄養 / 遺伝子多形 / 肥満 / 2型糖尿病 / 発症予防 / 発症予測 / スクリーニング / 2型糖尿病発症予防 / リスクスコア / 食事調査 / 身体活動 / 運動

Outline of Annual Research Achievements

2型糖尿病発症予防についての臨床エビデンスの構築とリスク診断ツールの一般応用可能性を検討するため、臨床疫学研究と介入研究を融合した研究を行った。昨年度に引き続き、遺伝子多型と栄養食事介入（栄養摂取状況）の交互作用が臨床代謝指標に与える影響について解析をし、米国糖尿病学会やその他の国際学術集会において口頭発表をした。また、共同研究者らとも検討結果やプロジェクトについての打ち合わせを行った。
研究結果を英文原著論文をDiabetes Careに発表し、さらに特に炭水化物代謝の遺伝多形についての研究を発展させ、炭水化物代謝機能と関連する遺伝子多形と体重変化の関連について研究した。研究結果については現在糖尿病専門分野の学術雑誌であるDiabetesに投稿し、リバイス改定中である。採用最終年である本年度も、糖尿病分野の英文雑誌に筆頭論文が掲載されるなど、糖尿病発症予測に役立つ研究成果を報告することができた。また、血中アミノ酸と糖尿病関連遺伝子多形の交互作用が耐糖能異常に関連するかについて検討し、研究成果を第66回米国人類遺伝学会 (ASHG 2016）にて発表した。また、腸内細菌代謝産物であるTrimethylamine N-oxide、メタボロミクス関連指標（血中アミノ酸等）のデータを測定し、現在それらの耐糖能異常発症予測能についての解析結果をまとめているところである。
その他、Nutrition in the Prevention and Treatment of Disease　4th Edition書籍Book Chapter 30: Genetics and Diabetes（糖尿病と遺伝）の章を担当し、遺伝と糖尿病学について執筆した。これまでゲノムワイド関連解析により明らかとなってきた遺伝子多形は数多く存在することから、糖尿病発症予測リスクツールの応用可能性を検討するにあたり、遺伝子多形を考慮する意義についてもさらに検討が必要である。

Research Progress Status

28年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

28年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Gene-Diet Interaction and Precision Nutrition in Obesity (2017)
  • Author(s): Heianza Y, Qi L.
  • Journal Title: International Journal of Molecular Sciences Volume: 18 Issue: 4 Pages: 787-787
  • DOI: 10.3390/ijms18040787
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] PCSK9 variant, long-chain n-3 PUFAs, and risk of nonfatal myocardial infarction in Costa Rican Hispanics. (2017)
  • Author(s): Yu Z, Huang T, Zheng Y, Wang T, Heianza Y, Sun D, Campos H, Qi L.
  • Journal Title: The American journal of clinical nutrition Volume: 印刷中 Issue: 5 Pages: 1198-1203
  • DOI: 10.3945/ajcn.116.148106
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Genetic Variations of Circulating Adiponectin Levels Modulate Changes in Appetite in Response to Weight-Loss Diets. (2017)
  • Author(s): Ma W, Huang T, Heianza Y, Wang T, Sun D, Tong J, Williamson DA, Bray GA, Sacks FM, Qi L.
  • Journal Title: The Journal of clinical endocrinology and metabolism Volume: 102 Pages: 316-325
  • DOI: 10.1210/jc.2016-2909
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Impact of individual components and their combinations within a family history of hypertension on the incidence of hypertension: Toranomon hospital health management center study 22 (2016)
  • Author(s): Igarashi R, Furukawa K, Heianza Y, Ishizawa M, Kodama S, Saito K, Hara S, Hanyu O, Honda R, Tsuji H, Arase Y, Sone H
  • Journal Title: Medicine Volume: 95(38):e4564 Issue: 38 Pages: e4564-e4564
  • DOI: 10.1097/md.0000000000004564
  • Peer Reviewed / Open Access
• [Journal Article] Zinc-Associated Variant in SLC30A8 Gene Interacts With Gestational Weight Gain on Postpartum Glycemic Changes: A Longitudinal Study in Women With Prior Gestational Diabetes Mellitus. (2016)
  • Author(s): Wang T, Liu H, Wang L, Huang T, Li W, Zheng Y, Heianza Y, Sun D, Leng J, Zhang S, Li N, Hu G, Qi L.
  • Journal Title: Diabetes Volume: 65 Issue: 12 Pages: 3786-3793
  • DOI: 10.2337/db16-0730
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials. (2016)
  • Author(s): Livingstone KM,Celis-Morales C,Papandonatos GD,Erar B, Florez J.C, Jablonski KA, Razquin C, Marti A, Heianza Y, Huang T, Sacks FM, Svendstrup M, Sui X, Church TS, Jaaskelainen T, Lindstrom J, Tuomilehto J, Uusitupa M, Rankinen T, Saris WH, Hansen T, Pedersen O, Astrup A, Sorensen TI, Qi L, et al.
  • Journal Title: BMJ. Volume: 354 Pages: i4707-i4707
  • DOI: 10.1136/bmj.i4707
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Associations of Bowel Movement Frequency with Risk of Cardiovascular Disease and Mortality among US Women. (2016)
  • Author(s): Ma W, Li Y, Heianza Y, Staller KD, Chan AT, Rimm EB, Rexrode KM, Qi L.
  • Journal Title: Scientific reports Volume: 6 Issue: 1 Pages: 33005-33005
  • DOI: 10.1038/srep33005
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Macronutrient Intake-Associated FGF21 Genotype Modifies Effects of Weight-Loss Diets on 2-Year Changes of Central Adiposity and Body Composition: The POUNDS Lost Trial. (2016)
  • Author(s): Heianza Y, Ma W, Huang T, Wang T, Zheng Y, Smith SR, Bray GA, Sacks FM, Qi L.
  • Journal Title: Diabetes Care Volume: 39 Issue: 11 Pages: 1909-1914
  • DOI: 10.2337/dc16-1111
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Plasma Taurine, Diabetes Genetic Predisposition, and Changes of Insulin Sensitivity in Response to Weight-Loss Diets. (2016)
  • Author(s): Zheng Y, Ceglarek U, Huang T, Wang T, Heianza Y, Ma W, Bray GA, Thiery J, Sacks FM, Qi L.
  • Journal Title: The Journal of clinical endocrinology and metabolism Volume: 101 Issue: 10 Pages: 3820-3826
  • DOI: 10.1210/jc.2016-1760
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Two-year changes in circulating adiponectin, ectopic fat distribution and body composition in response to weight-loss diets: the POUNDS Lost Trial. (2016)
  • Author(s): Ma W, Huang T, Wang M, Zheng Y, Wang T, Heianza Y, Sun D, Smith SR, Bray GA, Sacks FM, Qi L.
  • Journal Title: International journal of obesity Volume: 40 Issue: 11 Pages: 1723-1729
  • DOI: 10.1038/ijo.2016.128
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Assessment of kidney dysfunction with cystatin C- and creatinine-based estimated glomerular filtration rate and predicting type 2 diabetes: Toranomon Hospital Health Management Center Study 21 (2016)
  • Author(s): Heianza Y, Hara S, Saito K, Tsuji H, Tanaka S, Kodama S, Kobayashi T, Arase Y, Sone H.
  • Journal Title: Diabetes Res Clin Pract Volume: 113 Pages: 60-68
  • DOI: 10.1016/j.diabres.2016.01.026
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Comparison of clinical characteristics in patients with type 2 diabetes among whom different antihyperglycemic agents were prescribed as monotherapy or combination therapy by diabetes specialists. (2016)
  • Author(s): Fujihara K, Hanyu O, Heianza Y, Suzuki A, Yamada T, Yokoyama H, Tanaka S, Yagyu H, Shimano H, Kashiwagi A, Yamazaki K, Kawai K, Sone H.
  • Journal Title: J Diabetes Investig Volume: 7 Issue: 2 Pages: 260-9
  • DOI: 10.1111/jdi.12387
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Trajectory of body mass index before the development of type 2 diabetes in Japanese men: Toranomon Hospital Health Management Center Study 15 (2015)
  • Author(s): Heianza Y, Arase Y, Kodama S, Tsuji H, Tanaka S, Saito K, Hara S, Sone H.
  • Journal Title: Journal of Diabetes Investigation Volume: 6 Issue: 3 Pages: 289-294
  • DOI: 10.1111/jdi.12308
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Simple self-reported behavioral or psychological characteristics as risk factors for future type 2 diabetes in Japanese individuals: Toranomon Hospital Health Management Center Study 14 (2015)
  • Author(s): Heianza Y, Arase Y, Kodama S, Tsuji H, Fujihara K, Saito K, Hara S, Sone H.
  • Journal Title: Journal of diabetes investigation Volume: 6 Issue: 2 Pages: 236-241
  • DOI: 10.1111/jdi.12274
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Risk of the Development of Type 2 Diabetes in Relation to Overall Obesity, Abdominal Obesity and the Clustering of Metabolic Abnormalities in Japanese Individuals - Does Metabolically Healthy Overweight Really Exist?: Niigata Wellness Study (2015)
  • Author(s): Heianza Y, Kato K, Kodama S, Ohara N, Suzuki A, Tanaka S, Hanyu O, Sato K, Sone H
  • Journal Title: Diabet Med Volume: 32 Issue: 5 Pages: 665-72
  • DOI: 10.1111/dme.12646
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Fasting glucose and HbA1c levels as risk factors for the development of hypertension in Japanese individuals: Toranomon hospital health management center study 16 (TOPICS 16) (2015)
  • Author(s): Heianza Y, Arase Y, Kodama S, Hsieh S. D, Tsuji H, Saito K, Hara S, Sone H
  • Journal Title: Journal of human hypertension Volume: 29 Issue: 4 Pages: 254-259
  • DOI: 10.1038/jhh.2014.77
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Circulating Malondialdehyde-Modified LDL-Related Variables and Coronary Artery Stenosis in Asymptomatic Patients with Type 2 Diabetes (2015)
  • Author(s): Fujihara K, Suzuki H, Sato A, Kodama S, Heianza Y, Saito K, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Yagyu H, Sone H, Shimano H.
  • Journal Title: Journal of diabetes research Volume: 印刷中 Pages: 507245-507245
  • DOI: 10.1155/2015/507245
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Impact of population aging on trends in diabetes prevalence: A meta-regression analysis of 160,000 Japanese adults (2015)
  • Author(s): Charvat H, Goto A, Goto M, Inoue M, Heianza Y, Arase Y, Sone H, Nakagami T, Song X, Qiao Q, Tuomilehto J, Tsugane S, Noda M, Inoue M.
  • Journal Title: Journal of Diabetes Investigation Volume: 印刷中 Issue: 5 Pages: 533-542
  • DOI: 10.1111/jdi.12333
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Metabolically healthy obesity, presence or absence of fatty liver, and risk of type 2 diabetes in Japanese individuals: Toranomon Hospital Health Management Center Study 20 (TOPICS 20) (2014)
  • Author(s): Heianza Y, Arase Y, Tsuji H, Fujihara K, Saito K, Hsieh SD, Tanaka S, Kodama S, Hara S, Sone H.
  • Journal Title: The Journal of clinical endocrinology and metabolism Volume: 99 Issue: 8 Pages: 2952-2960
  • DOI: 10.1210/jc.2013-4427
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Role of body mass index history in predicting risk of the development of hypertension in Japanese individuals: Toranomon Hospital Health Management Center Study 18 (TOPICS 18). (2014)
  • Author(s): Heianza Y, Kodama S, Arase Y, Hsieh SD, Yoshizawa S, Tsuji H, Saito K, Tanaka S, Hara S, Sone H.
  • Journal Title: Hypertension Volume: 64 Issue: 2 Pages: 247-252
  • DOI: 10.1161/hypertensionaha.113.02918
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Impact on short-term glycaemic control of initiating diabetes care versus leaving diabetes untreated among individuals with newly screening-detected diabetes in Japan (2014)
  • Author(s): Heianza Y, Suzuki A, Fujihara K, Tanaka S, Kodama S, Hanyu O, Sone H.
  • Journal Title: Journal of epidemiology and community health Volume: 68 Issue: 12 Pages: 1189-1195
  • DOI: 10.1136/jech-2014-204054
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Response to comment on Heianza et al. Effect of postmenopausal status and age at menopause on type 2 diabetes and prediabetes in Japanese individuals: Toranomon Hospital Health Management Center Study 17 (TOPICS 17). Diabetes Care 2013;36:4007-4014 (2014)
  • Author(s): Heianza Y, Sone H.
  • Journal Title: Diabetes Care Volume: 37 Issue: 7 Pages: e165-e166
  • DOI: 10.2337/dc14-0745
  • Peer Reviewed
• [Journal Article] Role of sleep duration as a risk factor for Type 2 diabetes among adults of different ages in Japan: the Niigata Wellness Study (2014)
  • Author(s): Heianza Y, Kato, K, Fujihara, K, Tanaka, S, Kodama, S, Hanyu O, Sato K, Sone H.
  • Journal Title: Diabetic Medicine Volume: 31 Issue: 11 Pages: 1363-1367
  • DOI: 10.1111/dme.12555
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Stability and changes in metabolically healthy overweight or obesity and risk of future diabetes: Niigata wellness study (2014)
  • Author(s): Heianza Y, Kato K, Kodama S, Suzuki A, Tanaka S, Hanyu O, Sato K, Sone H.
  • Journal Title: Obesity (Silver Spring) Volume: 22 Issue: 11 Pages: 2420-2425
  • DOI: 10.1002/oby.20855
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Comparison of different aspects of BMI history to identify undiagnosed diabetes in Japanese men and women: Toranomon Hospital Health Management Center Study 12 (TOPICS 12) (2014)
  • Author(s): Yoshizawa S, Heianza Y, Arase Y, Saito K, Hsieh SD, Tsuji H, Hanyu O, Suzuki A, Tanaka S, Kodama S, Shimano H, Hara S, Sone H.
  • Journal Title: Diabetic Medicine Volume: 31 Issue: 11 Pages: 1378-1386
  • DOI: 10.1111/dme.12471
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Utility of the Triglyceride Level for Predicting Incident Diabetes Mellitus According to the Fasting Status and Body Mass Index Category: The Ibaraki Prefectural Health Study (2014)
  • Author(s): Fujihara K, Sugawara A, Heianza Y, Sairenchi T, Irie F, Iso H, Doi M, Shimano H, Watanabe H, Sone H, Ota H
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 21 Issue: 11 Pages: 1152-1169
  • DOI: 10.5551/jat.22913
  • NAID: 130004704369
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Comparison of the Framingham Risk Score, UK Prospective Diabetes Study (UKPDS) Risk Engine, Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) and Maximum Carotid Intima-Media Thickness for Predicting Coronary Artery Stenosis in Patients with Asymptomatic Type 2 Diabetes (2014)
  • Author(s): Fujihara K, Suzuki H, Sato A, Ishizu T, Kodama S, Heianza Y, Saito K, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Sone H, Shimano H
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 21 Issue: 8 Pages: 799-815
  • DOI: 10.5551/jat.20487
  • NAID: 130004845472
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Gut-microbiota-derived Trimethylamine-N-oxide levels and Risk of Major Adverse Cardiovascular Events: A Systematic Review and Meta-analysis of Prospective Cohort Studies (2016)
  • Author(s): Yoriko Heianza, Wenjie Ma, Lu Qi
  • Organizer: American Heart Association (AHA) Scientific Sessions 2016
  • Place of Presentation: ニューオーリンズ （米国）
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Circulating aromatic amino acids modify the GCKR genotype on changes of glucose metabolism in response to weight-loss diets: The POUNDS Lost trial. (2016)
  • Author(s): Yoriko Heianza, Wenjie Ma, Yan Zheng, George Bray, Frank Sacks, Lu Qi
  • Organizer: American Society of Human Genetics 66th Annual Meeting
  • Place of Presentation: バンクーバー（カナダ）
  • Year and Date: 2016-10-18
  • Int'l Joint Research
• [Presentation] Genetic variant close to FGF21 is associated with dietary macronutrient intake and modifies effects of a weight-loss diet on 2-year changes of body composition and fat distribution: The POUNDS Lost Trial (2016)
  • Author(s): Yoriko Heianza, Tao Huang, Tiange Wang, Dianjianyi Sun, Steven R. Smith, George A. Bray, Frank M. Sacks, Lu Qi
  • Organizer: 第76回米国糖尿病学会
  • Place of Presentation: ニューオーリンズ （米国）
  • Year and Date: 2016-06-10
  • Int'l Joint Research
• [Presentation] Plasma taurine, genetic predisposition, and changes of insulin sensitivity in response to weight-loss diets: The POUNDS lost (2016)
  • Author(s): Yoriko Heianza, Lu Qi
  • Organizer: 5th International Conference and Exhibition on Metabolomics
  • Place of Presentation: Hyatt Regency （大阪府、大阪市）
  • Year and Date: 2016-05-16
  • Int'l Joint Research
• [Presentation] Risk of development of dysglycemia according to the combination of obesity and degrees of metabolic abnormalities. (2015)
  • Author(s): Yoriko Heianza, Kiminori Kato, Satoru Kodama, Minoru Tashiro, Osamu Hanyu, Koji Sato, Hirohito Sone.
  • Organizer: 国際糖尿病連合（IDF）世界会議2015
  • Place of Presentation: バンクーバー（カナダ）
  • Year and Date: 2015-12-03
  • Int'l Joint Research
• [Presentation] Separate and combined associations of obesity and fatty liver with insulin resistance and beta-cell dysfunction. (2015)
  • Author(s): Yoriko Heianza, Yasuji Arase, Kazumi Saito, Hiroshi Tsuji, Satoru Kodama, Ritsuko Honda, Tetsuro Kobayashi, Shigeko Hara, Hirohito Sone.
  • Organizer: 国際糖尿病連合（IDF）世界会議2015
  • Place of Presentation: バンクーバー（カナダ）
  • Year and Date: 2015-12-03
  • Int'l Joint Research
• [Presentation] Metabolic health, obesity and the risk of developing chronic kidney disease among Japanese individuals. (2015)
  • Author(s): Yoriko Heianza, Kiminori Kato, Satoru Kodama, Minoru Tashiro, Osamu Hanyu, Koji Sato, Hirohito Sone
  • Organizer: 国際糖尿病連合（IDF）世界会議2015
  • Place of Presentation: バンクーバー（カナダ）
  • Year and Date: 2015-12-03
  • Int'l Joint Research
• [Presentation] Longitudinal trajectories of insulin sensitivity and beta cell function before the development of type 2 diabetes in Japanese individuals. (2015)
  • Author(s): Yoriko Heianza, Yasuji Arase, Satoru Kodama, Hiroshi Tsuji, Shiro Tanaka, Tetsuro Kobayashi, Shigeko Hara, Hirohito Sone.
  • Organizer: 第51回欧州糖尿病連合EASD学術集会
  • Place of Presentation: ストックホルム（スウェーデン）
  • Year and Date: 2015-09-05
  • Int'l Joint Research
• [Presentation] 健康的肥満 (Metabolically Healthy Obesity) と慢性腎臓病 (CKD) 発症に関する大規模縦断的検討:Niigata Wellness Study (2015)
  • Author(s): 平安座 依子, 加藤 公則, 児玉 暁, 田代 稔, 羽入 修, 佐藤 幸示, 曽根 博仁.
  • Organizer: 第56回日本人間ドック学会学術大会
  • Place of Presentation: パシフィコ横浜（神奈川県、横浜市）
  • Year and Date: 2015-07-31
• [Presentation] 健康的肥満 (Metabolically Healthy Obesity) と慢性腎臓病 (CKD) 発症に関する大規模縦断的検討: Niigata Wellness Study (2015)
  • Author(s): 平安座 依子, 加藤 公則, 児玉 暁, 田代 稔, 羽入 修, 佐藤 幸示, 曽根 博仁
  • Organizer: 第56回日本人間ドック学会学術大会
  • Place of Presentation: パシフィコ横浜（神奈川県、横浜市）
  • Year and Date: 2015-07-31
• [Presentation] Role of body mass index history in predicting the risk of developing type 2 diabetes: Toranomon Hospital Health Management Center Study (2015)
  • Author(s): Yoriko Heianza, Yasuji Arase, Kazumi Saito, Hiroshi Tsuji, Shiro Tanaka, Satoru Kodama,Tetsuro Kobayashi, Shigeko Hara, Hirohito Sone.
  • Organizer: 第56回日本人間ドック学会学術大会（国際セッション）
  • Place of Presentation: パシフィコ横浜（神奈川県、横浜市）
  • Year and Date: 2015-07-31
• [Presentation] 肥満と肝臓脂肪沈着がインスリン分泌動態とインスリン抵抗性・β細胞機能に与える影響の検討. (2015)
  • Author(s): 平安座 依子, 荒瀬 康司, 原 茂子, 児玉 暁, 齋藤 和美, 辻 裕之, 小林 哲郎, 曽根 博仁.
  • Organizer: 第56回日本人間ドック学会学術大会
  • Place of Presentation: パシフィコ横浜（神奈川県、横浜市）
  • Year and Date: 2015-07-30
• [Presentation] Longitudinal Trajectories of Glucose, Insulin Sensitivity, and Insulin Secretion during Development of Type 2 Diabetes in Japanese: Toranomon Hospital Health Management Center Study (2015)
  • Author(s): Yoriko Heianza, Kazuya Fujihara, Shigeko Hara, Osamu Hanyu, Kazumi Saito, Shiro Tanaka, Satoru Kodama, Tetsuro Kobayashi, Yasuji Arase, Hirohito Sone.
  • Organizer: 第75回米国糖尿病学会
  • Place of Presentation: ボストン（米国）
  • Year and Date: 2015-06-05
  • Int'l Joint Research
• [Presentation] Assessment of Kidney Dysfunction with Cystatin C- and Creatinine-based Estimated Glomerular Filtration Rate and Predicting Future Type 2 Diabetes among Japanese: Toranomon Hospital Health Management Center Study (2015)
  • Author(s): Yoriko Heianza, Shigeko Hara, Satoru Kodama, Kazumi Saito, Shiro Tanaka, Osamu Hanyu, Tetsuro Kobayashi, Yasuji Arase, Hirohito Sone.
  • Organizer: 第75回米国糖尿病学会
  • Place of Presentation: ボストン（米国）
  • Year and Date: 2015-06-05
  • Int'l Joint Research
• [Presentation] 血中シスタチンC, クレアチニンを用いた腎機能評価と２型糖尿病発症リスク: Toranomon Hospital Health Management Center Study. (2015)
  • Author(s): 平安座 依子,原 茂子,児玉 暁,齋藤 和美,藤原 和哉,五十嵐 理沙,鈴木 亜希子, 羽入 修, 辻 裕之, 森 保道,小林 哲郎, 荒瀬 康司,曽根 博仁.
  • Organizer: 第58回 日本糖尿病学会年次学術集会
  • Place of Presentation: 東京第一ホテル下関 （山口県、下関市）
  • Year and Date: 2015-05-21
• [Presentation] Risk of Developing Diabetes in Relation to Overall Obesity, Abdominal Obesity and Clustering of Metabolic Abnormalities (2015)
  • Author(s): Heianza Y, Kato K, Kodama S, Ohara N, Sato K, Sone H.
  • Organizer: 第25回日本疫学会学術総会
  • Place of Presentation: 愛知県産業労働センター (名古屋市）
  • Year and Date: 2015-01-21 – 2015-01-23
• [Presentation] 加齢による睡眠時間の影響と将来の２型糖尿病発症リスク: Niigata Wellness Study (2015)
  • Author(s): 平安座 依子, 加藤 公則, 児玉 暁, 田代 稔, 佐藤幸示,曽根博仁
  • Organizer: 第18回日本病態栄養学会年次学術集会
  • Place of Presentation: 国立京都国際会館 (京都府)
  • Year and Date: 2015-01-10 – 2015-01-11
• [Presentation] 体格的肥満・腹部肥満と代謝異常の程度の組み合わせが２型糖尿病発症リスクに与える影響 (2015)
  • Author(s): 平安座 依子, 加藤 公則, 児玉 暁, 田代 稔, 五十嵐 理沙, 由澤 咲子, 小原 伸雅, 羽入 修, 佐藤 幸示, 曽根 博仁
  • Organizer: 第18回日本病態栄養学会年次学術集会
  • Place of Presentation: 国立京都国際会館 (京都府)
  • Year and Date: 2015-01-10 – 2015-01-11
• [Presentation] Characteristics of patients with type 2 diabetes who achieved better glycaemic control through resistance training: a meta-analysis (2014)
  • Author(s): Ishiguro H, Kodama S, Matsunaga S, Horikawa C, Heianza Y, Ohara N, Yamada T, Suzuki A, Hanyu O, Sone H.
  • Organizer: 50th EASD Annual Meeting
  • Place of Presentation: ウィーン（オーストリア）
  • Year and Date: 2014-09-18
• [Presentation] Metabolically healthy obesity, presence or absence of fatty liver, and risk of type 2 diabetes in Japanese individuals. (2014)
  • Author(s): Heianza Y, Arase Y, Fujihara K, Hsieh SD, Saito K, Hanyu O, Kodama S, Hara S, Sone H.
  • Organizer: 50th EASD Annual Meeting
  • Place of Presentation: ウィーン（オーストリア）
  • Year and Date: 2014-09-17
• [Presentation] 尿蛋白測定試験紙（±）症例における腎機能低下に関連する因子についての検討 (2014)
  • Author(s): 番場一成、平安座依子、笠井真由美、大野 義将、清水不二雄、上村 由紀、山本 晃、松浦 恵子、曽根 博仁、村山 実
  • Organizer: 第55回日本人間ドック学会学術大会
  • Place of Presentation: 福岡国際会議場 (福岡県)
  • Year and Date: 2014-09-04
• [Presentation] Resistance Exercise Was Effective in Improving Glycemic Control but Inferior to Aerobic Exercise for Patients with Type 2 Diabetes Mellitus―A Meta-analysis. (2014)
  • Author(s): Ishiguro H, Kodama S, Horikawa C, Suzuki H, Matsunaga S, Heianza Y, Yamada T, Suzuki A, Hanyu O, Sone H.
  • Organizer: 74th American Diabetes Association Scientific Sessions
  • Place of Presentation: サンフランシスコ (米国）
  • Year and Date: 2014-06-16
• [Presentation] Risk of Development of Type 2 Diabetes by Overall Obesity, Abdominal Obesity, and Metabolic Abnormalities-Does Metabolically Healthy Obesity Really Exist? (2014)
  • Author(s): Heianza Y, Kato K, Suzuki A, Horikawa C, Matsunaga S, Yoshizawa S, Hanyu O, Kodama S, Sato K, Sone H.
  • Organizer: 74th American Diabetes Association Scientific Sessions
  • Place of Presentation: サンフランシスコ (米国）
  • Year and Date: 2014-06-15
• [Presentation] Diabetes Risk Related to Carrying 1 Risk Allele of a Diabetes-Susceptible Gene Is Comparable to That Related to 1 Unit of Increased Body Mass Index: A Meta-analysis. (2014)
  • Author(s): Horikawa C, Kodama S, Matsunaga S, Yoshizawa S, Heianza Y, Yachi Y, Ohara N, Suzuki A, Hanyu O, Sone H.
  • Organizer: 74th American Diabetes Association Scientific Sessions
  • Place of Presentation: サンフランシスコ (米国）
  • Year and Date: 2014-06-15
• [Presentation] High Serum Uric Acid Level Is More Predictive of Risk of Future Type 2 Diabetes in Nonobese Than in Overweight/Obese People: The Niigata Wellness Study. (2014)
  • Author(s): Matsunaga S, Heianza Y, Suzuki T, Kitazawa M, Minagawa S, Yamada T, Suzuki A, Hanyu O, Kato K, Sato K, Sone H.
  • Organizer: 74th American Diabetes Association Scientific Sessions
  • Place of Presentation: サンフランシスコ (米国）
  • Year and Date: 2014-06-15
• [Presentation] Predictive Value of Combined Single Nucleotide Polymorphisms for Diabetes Mellitus―A Meta-analysis. (2014)
  • Author(s): Kodama S, Horikawa C, Matsunaga S, Fujihara K, Heianza Y, Hirose A, Yamada T, Suzuki A, Hanyu O, Sone H.
  • Organizer: 74th American Diabetes Association Scientific Sessions
  • Place of Presentation: サンフランシスコ (米国）
  • Year and Date: 2014-06-15
• [Presentation] Magnitude of Risk of Diabetes Mellitus in Relation to Carrying Risk Alleles of Diabetes-Susceptible Genes Was Not Influenced by Covariates: A Meta-analysis. (2014)
  • Author(s): Ishiguro H, Kodama S, Horikawa C, Furukawa K, Suzuki H, Fujihara K, Heianza Y, Suzuki A, Hanyu O, Sone H.
  • Organizer: 74th American Diabetes Association Scientific Sessions
  • Place of Presentation: サンフランシスコ (米国）
  • Year and Date: 2014-06-15
• [Presentation] Stability and Changes in the Metabolically Healthy Overweight or Obese State and the Risk of Development of Future Type 2 Diabete (2014)
  • Author(s): Heianza Y, Suzuki A, Kato K, Fujihara K, Yamada T, Hanyu O, Kodama S, Sato K, Sone H.
  • Organizer: 74th American Diabetes Association Scientific Sessions
  • Place of Presentation: サンフランシスコ (米国）
  • Year and Date: 2014-06-14
• [Presentation] レセプトデータを利用した新規糖尿病治療薬処方状況の検討 (2014)
  • Author(s): 鈴木 亜希子、平安座 依子、羽入 修、鈴木 達郎、北澤 勝、阿部 孝洋、植村 靖行、皆川 真一、山田 貴穂、曽根 博仁
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪府
  • Year and Date: 2014-05-24
• [Presentation] 健康的肥満（Metabolically Healthy Obesity）と2型糖尿病発症に関する大規模前向き研究：TOPICS (2014)
  • Author(s): 平安座 依子、児玉 暁、原 茂子、謝 勲東、森 保道、辻 裕之、齋藤 和美、藤原 和哉、島野 仁、羽入 修、鈴木 亜希子、荒瀬 康司、曽根 博仁
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪府
  • Year and Date: 2014-05-23
• [Presentation] 尿酸の糖尿病発症への影響は非肥満者で強い (2014)
  • Author(s): 松永 佐澄志、平安座 依子、皆川 真一、鈴木 亜希子、山田 貴穂、羽入 修、田代 稔、大塚 政人、佐藤 幸示、加藤 公則、曽根 博仁
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪府
  • Year and Date: 2014-05-23
• [Presentation] 肥満と臨床代謝指標の変化がその後の糖尿病発症に与える影響についての大規模縦断的検討：the Niigata Wellness Study (2014)
  • Author(s): 羽入 修、平安座 依子、加藤 公則、松永 佐澄志、田代 稔、児玉 暁、藤原 和哉、鈴木 亜希子、佐藤 幸示、曽根 博仁
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪府
  • Year and Date: 2014-05-22
• [Presentation] 糖尿病スクリーニング後の早期治療と未治療放置が短期間の血糖コントロールに与える影響の大規模疫学的検討 (2014)
  • Author(s): 五十嵐 理沙、平安座 依子、児玉 暁、由澤 咲子、山田 貴穂、藤原 和哉、鈴木 亜希子、羽入 修、曽根 博仁
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪府
  • Year and Date: 2014-05-22
• [Book] Nutrition in the Prevention and Treatment of Disease 4th Edition (Chapter 29. Genetics and Diabetes) (2017)
  • Author(s): Heianza Y, Qi L. 他
  • Total Pages: 1072
  • Publisher: Elsevier
• [Book] プラクティス 第32巻第5号 (2016)
  • Author(s): 平安座 依子・荒瀬 康司・曽根 博仁
  • Publisher: 医歯薬出版株式会社
• [Book] Diabetes Frontier 2015年12月号 特集 日本人糖尿病の大規模臨床 (2015)
  • Author(s): 平安座 依子、荒瀬 康司、曽根 博仁
  • Publisher: メディカルレビュー社
• [Book] 月刊糖尿病 健診データを活かした糖尿病早期診断と発症予測 (2014)
  • Author(s): 平安座 依子、曽根 博仁
  • Total Pages: 96
  • Publisher: 医学出版
• [Book] 最新肥満症学 (2014)
  • Author(s): 小原 伸雅, 平安座 依子, 曽根 博仁
  • Publisher: 日本臨牀社
• [Remarks] Tulane University Obesity Research Center
  • URL: https://sph.tulane.edu/tulane-university-obesity-research-center
• [Remarks] 新潟大学医学部・大学院医歯学総合研究科 血液・内分泌・代謝内科学分野
  • URL: http://www.med.niigata-u.ac.jp/emh/outline.html
• [Remarks] 新潟大学医学部・大学院医歯学総合研究科血液・内分泌・代謝内科学分野＞大規模臨床研究について
  • URL: http://www.med.niigata-u.ac.jp/emh/research.html