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Formation of the integrated insulin secretion system and its failure

Research Project

Project/Area Number 15002002
Research Category

Grant-in-Aid for Specially Promoted Research

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKobe University

Principal Investigator

SEINO Susumu  Kobe University, Graduate School of Medicine, Professor (80236067)

Co-Investigator(Kenkyū-buntansha) YOKOI Norihide  Kobe University, Graduate School of Medicine, Associate Professor (70311610)
SHIBASAKI Tadao  Kobe University, Graduate School of Medicine, Assistant Professor (00323436)
IWANAGA Toshihiko  Hokkaido University, Graduate School of Medicine, Professor (10160128)
Project Period (FY) 2003 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥594,100,000 (Direct Cost: ¥457,000,000、Indirect Cost: ¥137,100,000)
Fiscal Year 2007: ¥96,200,000 (Direct Cost: ¥74,000,000、Indirect Cost: ¥22,200,000)
Fiscal Year 2006: ¥96,200,000 (Direct Cost: ¥74,000,000、Indirect Cost: ¥22,200,000)
Fiscal Year 2005: ¥111,800,000 (Direct Cost: ¥86,000,000、Indirect Cost: ¥25,800,000)
Fiscal Year 2004: ¥137,800,000 (Direct Cost: ¥106,000,000、Indirect Cost: ¥31,800,000)
Fiscal Year 2003: ¥152,100,000 (Direct Cost: ¥117,000,000、Indirect Cost: ¥35,100,000)
KeywordsDiabetes / Cell signaling / Development&Differentiation / Bioimaging / Insulin secretion / Gene / バイオイメージング / 発生分化 / バイイメージング / プロテオーム / インスリン / 分泌 / 再生医学
Research Abstract

1) How is insulin secretory function acquired during β-cell differentiation? (1) We have demonstrated directly by cell lineage tracing that pancreatic acinar cells can transdifferentiate into insulin-secreting cells in vitro. Destruction and remodeling of cadherin-mediated cell-cell adhesion was found to be important for the transdifferentiation, and activation of PI3-kinase was required for these processes. (2) We have shown that pancreatic β-cells of Kir6.2G132S transgenic mice were spontaneously regenerated, and that intraislet DBA-labeled cells may represent progenitors for the β-cells. (3) We have identified a novel transcriptional factor, Mgx-1 (Isx), which is expressed specifically in gut. Isx inactivation is required for the gut-derived cell to express Pdx1 and Insulin2.
2) How are the signaling components in insulin secretion spatially and temporally integrated in β-cells? (1) Both 1st and 2nd phases of glucose-induced fusion event involved mostly granules that are newly recrui … More ted and immediately fused to the plasma membrane without docking (restless newcomer). (2) Activation of cAMP signaling clearly potentiated both phases of glucose-induced fusion events. All granules responsible for this potentiation were restless newcomer. We have found that Epac2/Rap1 signaling is essential in the potentiation of insulin granule exocytosis by cAMP, primarily in the first phase of cAMP-potentiated exocytosis, by increasing the number of restless newcomer. (3) We have proposed that Epac2-containing cAMP compartment is distinct from PKA-containing compartment.
3) How do B-cells interact functionally with other organs such as the brain and gastrointestine? (1) Although K_<ATP> channel-deficient mice lack glucose-induced insulin secretion, we found that gastrointestinal hormone incretin (such as GLP-1 and GIP) is released by food ingestion and endows Kir6.2^<-/-> β-cells with glucose responsiveness. (2) By studying the mice deficient in an exocytosis-related molecule Noc2, we found that Noc2 elicits an inhibitory effect on G_<i/o> mediated suppression of insulin secretion.
4) Pathophysiology due to defects in the system (1) We have generated mice deficient in transcription factor Otx3 (Dmbxl), which we previously identified in insulinoma cell lines. By cross-breeding with agouti yellow (Ay) mice, a hereditary mouse model of obesity and diabetes, we found that Dmbx1 is essential for developing obesity and diabetes of Ay mice. (2) Type 1 diabetes was reconstituted on a non-KDP genetic background with the two major susceptibility genes, MHC-RT1u and Cblb mutation, in the rat. By association study of variants involved in pancreatic β-cell function in Japanese type 2 diabetes, a significant association of a variant in SUR1(ABCC8) was found. Less

Report

(9 results)
  • 2013 Self-evaluation (Follow-up Assessment) ( PDF )   Comments (Follow-up Assessment) ( PDF )
  • 2012 Abstract(Follow-up Assessment) ( PDF )
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (304 results)

All 2008 2007 2006 2005 2004 2003 Other

All Journal Article (199 results) (of which Peer Reviewed: 69 results) Presentation (84 results) Book (10 results) Patent(Industrial Property Rights) (4 results) Publications (7 results)

  • [Journal Article] Identification and functional analysis of CBLB mutations in type l diabetes2008

    • Author(s)
      Yokoi N, et al.
    • Journal Title

      Biochem Biophys Res Commun 368

      Pages: 37-42

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Isx participates in the maintenance of vitamin A metabolism by regulation of β-carotene 15, 15'-monooxygenase (Bcmo1) expression2008

    • Author(s)
      Seino Y, et al.
    • Journal Title

      J Biol Chem 283

      Pages: 4905-4911

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] K_<ATP> channel-deficient pancreatic β-cells are streptozotocin resistant because of lower GLUT2 activity2008

    • Author(s)
      Xu J, et al.
    • Journal Title

      Am J Physiol 294

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Involvement of Exoc31, a protein structurally related to the exocyst subunit Sec6, in insulin secretion2008

    • Author(s)
      Saito T, et al.
    • Journal Title

      Biomed Res (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Role of cadherin-mediated cell-cell adhesion in pancreatic exocrine-to-endocrine transdifferentiation2008

    • Author(s)
      Minami K, et al.
    • Journal Title

      J Biol Chem 283

      Pages: 13753-13761

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Identification and functional analysis of CBLB mutations in type 1 diabetes.2008

    • Author(s)
      Yokoi N, Fujiwara Y, Wang HY, Kitao M, Hayashi C, Someya T, Kanamori M, Oiso Y, Tajima N, Yamada Y, Seino Y, Ikegami H, Seino S
    • Journal Title

      Biochem Biophys Res Commun 368

      Pages: 37-42

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Isx participates in the maintenance of vitamin A metabolism by regulation of β-carotene 15, 15'-monooxygenase (Bcmo1) expression.2008

    • Author(s)
      Seino Y, Miki T, Kiyonari H, Abe T, Fujimoto W, Kimura K, Takeuchi A, Takahashi Y, Oiso Y, Iwanaga T, Seino S
    • Journal Title

      J Biol Chem 283

      Pages: 4905-4911

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] K_<ATP> channel-deficient pancreatic β-cells are streptozotocin resistant because of lower GLUT2 activity.2008

    • Author(s)
      Xu J, Zhang L, Chou A, Allaby T, Belanger G, Radziuk J, Jasmin BJ, Miki T, Seino S, Renaud JM
    • Journal Title

      Am J Physiol 294

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Role of cadherin-mediated cell-cell adhesion in pancreatic exocrine-to-endocrine transdifferentiation.2008

    • Author(s)
      Minami K, Okano H, Okumachi A, Seino S
    • Journal Title

      Biol Chem 283

      Pages: 13753-13761

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] PKA-independent mechanism of cAMP in insulin secretion.2008

    • Author(s)
      Seino S, Miki T, Shibasaki T
    • Journal Title

      Pancreatic Beta Cell in Health and Disease.(Seino S and Bell GI (eds.). Springer)

      Pages: 133-146

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Role of cadherin-mediated cell-cell adhesion in pancreatic acinar-to-endocrine transdifferentiation.2008

    • Author(s)
      Minami, K, et. al.
    • Journal Title

      J Biol Chem (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pancreatic acinar-to-β cell transdifferenfiation in vitro.2008

    • Author(s)
      Minami, K, seino, S
    • Journal Title

      Front Biosci (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of Exoc31, a protein structurally Iclated to the exocyst subunit Sec6, in insulin secretion.2008

    • Author(s)
      Saito, T, et. al.
    • Journal Title

      Biomed Res (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isx participates in the maintenance of vitamin A metabolism by regulation of β-carotene 15,15-monooxygenase(Bcmo1)expression2008

    • Author(s)
      Sino, Y, et. al.
    • Journal Title

      J Bio Chem 283

      Pages: 4905-4911

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] K_ATP channel-deficient pancreatic β-cells are streptozotocin resistant be ciluse of lower CLUT2 activity.2008

    • Author(s)
      Xu, J, et. al.
    • Journal Title

      Am J Physiol 294

      Pages: 326-335

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dmbxl is essential in agouti-related protein action2007

    • Author(s)
      Fujimoto W, et al.
    • Journal Title

      Proc Natl Acad Sci USA 104

      Pages: 15514-15519

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP2007

    • Author(s)
      Shibasaki T, et al.
    • Journal Title

      Proc Natl Acad Sci USA 104

      Pages: 19333-19338

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Generation of insulin-secreting cells from pancreatic acinar cells of animal models of type 1 diabetes2007

    • Author(s)
      Okuno M, et al.
    • Journal Title

      Am J Physiol 292

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Genetic reconstitution of autoimmune type l diabetes with two major susceptibility genes in the rat2007

    • Author(s)
      Yokoi N, et al.
    • Journal Title

      Diabetes 56

      Pages: 506-512

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Induction by NeuroD of the components required for regulated exocytosis2007

    • Author(s)
      Ishizuka N, et al.
    • Journal Title

      Biochem Biophys Res Commun 354

      Pages: 271-277

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cellular expression of Noc2, a Rab effector protein, in endocrine and exocrine tissues in the mouse2007

    • Author(s)
      Teramae H, et al.
    • Journal Title

      Histochem Cell Biol 127

      Pages: 1-11

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Disruption of Kir6.2-containing ATP-sensitive potassium channels impairs maintenance of hypoxic gasping in mice2007

    • Author(s)
      Miyake, et al.
    • Journal Title

      Eur J Neurosci 25

      Pages: 2349-2363

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] K_<ATP> channel knockout worsens myocardial calcium stress load in vivo and impairs recovery in stunned heart2007

    • Author(s)
      Gumina RJ, et al.
    • Journal Title

      Am J Physiol 292

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] K_<ATP> channel mutation confers risk for vein of Marshall adrenergic atrial fibrillation2007

    • Author(s)
      Olson TM, et al.
    • Journal Title

      Nat Clin Pract Cardiovasc Med 4

      Pages: 110-116

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] K_<ATP> channels confer survival advantage in cocaine overdose2007

    • Author(s)
      Reyes S, et al.
    • Journal Title

      Mol Psychiatry 12

      Pages: 1060-1061

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 膵β細胞研究と糖尿病2007

    • Author(s)
      清野 進(依頼執筆)
    • Journal Title

      日本眼科学会紀要 57

      Pages: 171-175

    • NAID

      10018327307

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 膵腺房細胞からインスリン分泌細胞への分化転換.2007

    • Author(s)
      南幸太郎, 他(依頼執筆)
    • Journal Title

      医学のあゆみ 220

      Pages: 1145-1148

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Dmbx1 is essential in agouti-related protein action.2007

    • Author(s)
      Fujimoto W, Shiuchi T, Miki T, Minokoshi Y, Takahashi Y, Takeuchi A, Kimura K, Saito M, Iwanaga T, Seino S
    • Journal Title

      Proc Natl Acad Sci USA 104

      Pages: 15514-15519

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP.2007

    • Author(s)
      Shibasaki T, Takahashi H, Miki T, Sunaga Y, Matsumura K, Yamanaka M, Zhang C, Tamamoto A, Satoh T, Miyazaki J, Seino S
    • Journal Title

      Proc Natl Acad Sci USA 104

      Pages: 19333-19338

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Generation of insulin-secreting cells from pancreatic acinar cells of animal models of type 1 diabetes.2007

    • Author(s)
      Okuno M, Minami K, Okumachi A, Miyawaki K, Yokoi N, Toyokuni S, Seino S
    • Journal Title

      Am J Physiol 292

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Geneticreconstitution of autoimmune type 1 diabetes with two major susceptibility genes in the rat.2007

    • Author(s)
      Yokoi N, Hayashi C, Fujiwara Y, Wang HY, Seino S
    • Journal Title

      Diabetes 56

      Pages: 506-512

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Induction by NeuroD of the components required for regulated exocytosis.2007

    • Author(s)
      Ishizuka N, Minami K, Okumachi A, Okuno M, Seino S
    • Journal Title

      Biochem Biophys Res Commun 354

      Pages: 271-277

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cellular expression of Noc2, a Rab effector protein, in endocrine and exocrine tissues in the mouse.2007

    • Author(s)
      Teramae H, Fujimoto W, Seino S, Iwanaga T
    • Journal Title

      Histochem Cell Biol 127

      Pages: 1-11

    • NAID

      120000969656

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Disruption of Kir6.2-containing ATP-sensitive potassium channels impairs maintenance of hypoxic gasping in mice.2007

    • Author(s)
      Miyake A, Yamada K, Kosaka T, Miki T, Seino S, Inagaki N
    • Journal Title

      Eur J Neurosci 25

      Pages: 2349-2363

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] K_<ATP> channel knockout worsens myocardial calcium stress load in vivo and impairs recovery in stunned heart.2007

    • Author(s)
      Gumina RJ, O'Cochlain DF, Kurtz CE, Bast P, Pucar D, Mishra P, Miki T, Seino S, Macura S, Terzic A
    • Journal Title

      Am J Physiol 292

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] K_<ATP> channel mutation confers risk for vein of Marshall adrenergic atrial fibrillation.2007

    • Author(s)
      Olson TM, Alekseev AE, Moreau C, Liu XK, Zingman LV, Miki T, Seino S, Asirvatham SJ, Jahangir A, Terzic A
    • Journal Title

      Nat Clin Pract Cardiovasc Med 4

      Pages: 110-116

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] K_<ATP> channels confer survival advantage in cocaine overdose.2007

    • Author(s)
      Reyes S, Kane GC, Miki T, Seino S, Terzic A
    • Journal Title

      Mol Psychiatry 12

      Pages: 1060-1061

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Sui β-saibou kenkyu to tounyoubyou2007

    • Author(s)
      Seino S
    • Journal Title

      Nippon gankagakkai kiyou 57

      Pages: 171-175

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Suisenbou saibou kara insulin bunpitsu saibou eno bunka tenkan.2007

    • Author(s)
      Minami K, Seino S
    • Journal Title

      Igaku no ayumi 220

      Pages: 1145-1148

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Shizen hassyou ichigata tounyoubyou doubutsu no genin idenshi.2007

    • Author(s)
      Yokoi N, Seino S
    • Journal Title

      Tounyoubyougaku kiso to rinsyou. (Nishimura Co., Ltd.)

      Pages: 291-293

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Suisenbou saibou no bunkan tenkan niyoru insulin bunpitsu saibou no sakusyutsu.2007

    • Author(s)
      Minami K, Okuno M, Miyawaki K, Seino S
    • Journal Title

      Tounyoubyougaku2007, (Shindan to Chiryou Co., LTD.)

      Pages: 84-97

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Suisenbou saibou no bunkan tenkan niyoru Sui β-saibou saisei no kanousei.2007

    • Author(s)
      Minami K, Seino S
    • Journal Title

      Bunshi tounyougaku no shinpo kiso kara rinsyou made-2007. (KANEHARA Co., LTD.)

      Pages: 22-26

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Essential role of epac2/rapl signaling in regulation of insulin granule dynamics by cAMp.2007

    • Author(s)
      Shibasaki, T, et. al.
    • Journal Title

      Proc Natl Acad Sci USA 104

      Pages: 19333-19338

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dmbxl is essential in agouti-related protein action.2007

    • Author(s)
      Fujimoto, W, et. al.
    • Journal Title

      Proc Nall Acad Sci USA 104

      Pages: 15514-15519

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] K_ATP channels confer survival advantage in cocaine overdose.2007

    • Author(s)
      Reyes, S, et. al.
    • Journal Title

      Mol Psychiatry 12

      Pages: 1060-1061

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disruption of Kir6.2-containing ATP-sensitive potassium channels impairs maintenance of hypoxic gasping in mice.2007

    • Author(s)
      Miyake, A, et. al.
    • Journal Title

      Eur J Neurosci 25

      Pages: 2349-2363

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] K_ATP channel knockout worsens myocardial calcjum stress load in vivo and impairs recovery in stunned heart.2007

    • Author(s)
      Gumina, Rj, et. al.
    • Journal Title

      Am J Physiol 292

      Pages: 1706-1713

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic reconstitution of autoimmune type 1 diabetes with two major susceptibility genes in the rat.2007

    • Author(s)
      Yokoi, N. et al.
    • Journal Title

      Diabetes 56

      Pages: 506-512

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Generation of insulin-secreting cells from pancreatic acinar cells of animal models of type 1 diabetes.2007

    • Author(s)
      Okuno, M. et al.
    • Journal Title

      Am J Physiol Endocrinol Metab 292

      Pages: 158-165

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Induction by NeuroD of the components required for regulated exocytosis.2007

    • Author(s)
      Ishizuka, N. et al.
    • Journal Title

      Biochem Biophys Res Commun 354

      Pages: 271-277

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cellular expression of Noc2, a Rab effector protein, in endocrine and exocrine tissues in the mouse.2007

    • Author(s)
      Teramae, H. et al.
    • Journal Title

      Histochem Cell Biol. 127

      Pages: 1-11

    • Related Report
      2006 Annual Research Report
  • [Journal Article] K_<ATP> channel mutation confers risk for vein of Marshall adrenergic atrial fibrillation2007

    • Author(s)
      Olson
    • Journal Title

      Nat Clin Pract Cardiovasc Med 4

      Pages: 110-116

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Essential role of ubiquitin-proteasome system in normal regulation of insulin secretion2006

    • Author(s)
      Kawaguchi M, et al.
    • Journal Title

      J Biol Chem 281

      Pages: 13015-13020

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Spontaneous recovery from hyperglycemia by regeneration of pancreatic β-cells in Kir6.2G132S transgenic mice2006

    • Author(s)
      Oyama K, et al.
    • Journal Title

      Diabetes 55

      Pages: 1930-1938

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Identification and characterization of a novel member of the ATP-sensitive K^+ channelsubunit family, Kir6.3, in zebrafish.2006

    • Author(s)
      Zhang C, et al.
    • Journal Title

      Physiol Genomics 24

      Pages: 290-297

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Association studies of variants in the genes involved in pancreatic beta-cell function intype 2 diabetes in Japanese subjects2006

    • Author(s)
      Yokoi N, et al.
    • Journal Title

      Diabetes 55

      Pages: 2379-2386

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Protection conferred by myocardial ATP-sensitive K^+ channels in pressure overload-induced congestive heart failure revealed in KCNJ11 Kir6.2-null mutant2006

    • Author(s)
      Yamada S, et al.
    • Journal Title

      J Physiol 577

      Pages: 1053-1065

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Enhanced neuronal damage after ischemic insults in mice lacking Kir6.2-containing ATP-sensitive K^+ channels2006

    • Author(s)
      Sun HS, et al.
    • Journal Title

      J Neurophysiol 95

      Pages: 2590-2601

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cerebral glucose transporters expression and spatial learning in the K-ATPKir6^<-/->knockout mice.2006

    • Author(s)
      Choeiri C, et al.
    • Journal Title

      Behav Brain Res 172

      Pages: 233-239

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Behavioral phenotyping of mice lacking the K_<ATP> channel subunit Kir6.22006

    • Author(s)
      Deacon RM, et al.
    • Journal Title

      Physiol Behav 87

      Pages: 723-733

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] KCNJ11 gene knockout of the Kir6.2 K_<ATP> channel causes maladaptive remodeling and heart failure in hypertension .2006

    • Author(s)
      Kane GC, et al.
    • Journal Title

      Hum Mol Genet 15

      Pages: 2285-2297

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Gene knockout of the KCNJ8-encoded Kir6.1 K_<ATP> channel imparts fatal susceptibility to endotoxemia2006

    • Author(s)
      Kane GC, et al.
    • Journal Title

      FASEB J 20

      Pages: 2271-2280

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] シグナル受容機構の解明が導く創薬・治療への躍進 : シグナル受容と疾患 膵β細胞からのインスリン分泌制御シグナルとその破綻2006

    • Author(s)
      三木隆司, 他(依頼執筆)
    • Journal Title

      実験医学 24

      Pages: 758-763

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] cAMPシグナルによるエキソサイトーシスの調節機構.2006

    • Author(s)
      柴崎忠雄, 他(依頼執筆)
    • Journal Title

      生体の科学 57

      Pages: 91-95

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 膵腺房細胞の分化転換によるインスリン分泌細胞の誘導2006

    • Author(s)
      南幸太郎, 他(依頼執筆)
    • Journal Title

      最新医学 61

      Pages: 1496-1501

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Essential role of ubiquitin-proteasome system in normal regulation of insulin secretion.2006

    • Author(s)
      Kawaguchi M, Minami K, Nagashima K, Seino S
    • Journal Title

      J Biol Chem 281

      Pages: 13015-13020

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Spontaneous recovery from hyperglycemia by regeneration of pancreatic β-cells in Kir6.2G132S transgenic mice.2006

    • Author(s)
      Oyama K, Minami K, Ishizaki K, Fuse M, Miki T, Seino S
    • Journal Title

      Diabetes 55

      Pages: 1930-1938

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Identification and characterization of a novel member of the ATP-sensitive K^+ channel subunit family, Kir6.3, in zebrafish.2006

    • Author(s)
      Zhang C, Miki T, Shibasaki T, Yokokura M, Saraya A, Seino S
    • Journal Title

      Physiol Genomics 24

      Pages: 290-297

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Association studies of variants in the genes involved in pancreatic β-cell function in type 2 diabetes in Japanese subjects.2006

    • Author(s)
      Yokoi N, Kanamori M, Horikawa Y, Takeda J, Sanke T, Furuta H, Nanjo K, Mori H, Kasuga M, Hara K, Kadowaki T, Tanizawa Y, Oka Y, Iwami Y, Ohgawara H, Yamada Y, Seino Y, Yano H, Cox NJ, Seino S
    • Journal Title

      Diabetes 55

      Pages: 2379-2386

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Protection conferred by myocardial ATP-sensitive K^+ channels in pressure overload-induced congestive heart failure revealed in KCNJ11 Kir6.2-null mutant.2006

    • Author(s)
      Yamada S, Kane GC, Behfar A, Liu XK, Dyer RB, Faustino RS, Miki T, Seino S, Terzic A
    • Journal Title

      J Physiol 577

      Pages: 1053-1065

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Enhanced neuronal damage after ischemic insults in mice lacking Kir6.2-containing ATP-sensitive K^+ channels.2006

    • Author(s)
      Sun HS, Feng ZP, Miki T, Seino S, French RJ
    • Journal Title

      J Neurophysiol 95

      Pages: 2590-2601

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cerebral glucose transporters expression and spatial learning in the K-ATP Kir6.2^<-/-> knockout mice.2006

    • Author(s)
      Choeiri C, Staines WA, Miki T, Seino S, Renaud JM, Teutenberg K, Messier C
    • Journal Title

      Behav Brain Res 172

      Pages: 233-239

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Behavioral phenotyping of mice lacking the K_<ATP> channel subunit Kir6.2.2006

    • Author(s)
      Deacon RM, Brook RC, Meyer D, Haeckel O, Ashcroft FM, Miki T, Seino S, Liss B
    • Journal Title

      Physiol Behav 87

      Pages: 723-733

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] KCNJ11 gene knockout of the Kir6.2 K_<ATP> channel causes maladaptive remodeling and heart failure in hypertension.2006

    • Author(s)
      Kane GC, Behfar A, Dyer RB, O'Cochlain DF, Liu XK, Hodgson DM, Reyes S, Miki T, Seino S, Terzic A
    • Journal Title

      Hum Mol Genet 15

      Pages: 2285-2297

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Gene knockout of the KCNJ8-encoded Kir6.1 K_<ATP> channel imparts fatal susceptibility to endotoxemia.2006

    • Author(s)
      Kane GC, Lam CF, O'Cochlain F, Hodgson DM, Reyes S, Liu XK, Miki T, Seino S, Katusic ZS, Terzic A
    • Journal Title

      FASEB J 20

      Pages: 2271-2280

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Shigunaru jyuyou kikou no kaimei ga michibiku souyaku chiryou eno tyouyaku : shigunaru jyuyou to shikkan Sui β-saibou karano insulin bunpitsu seigyo shigunaru to sono hatan.2006

    • Author(s)
      Miki T, Seino S
    • Journal Title

      Jikken igaku 24

      Pages: 758-763

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] cAMP shigunaru niyoru exocytosis no tyousetsu kikou2006

    • Author(s)
      Shibasaki T, Seino S
    • Journal Title

      Seitai no kagaku 57

      Pages: 91-95

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Suisenbou saibou no bunka tenkan niyoru insulin bunpitsu saibou no yuudou.2006

    • Author(s)
      Minami K, Seino S
    • Journal Title

      Saishin igaku 61

      Pages: 1496-1501

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] cAMP compartment to insulin bunpitsu.2006

    • Author(s)
      Shibasaki T, Seino S
    • Journal Title

      Bunshi tounyougaku no shinpo kiso kara rinsyou made-2006. (KANEHARA Co., LTD.)

      Pages: 2-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Spontaneous recovery from hyperglycemia by regeneration of pancreatic β-cells in Kir6.2G132S transgenic mice.2006

    • Author(s)
      Oyama, K. et al.
    • Journal Title

      Diabetes 55

      Pages: 1930-1938

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Association studies of variants in the genes involved in pancreatic β-cell function in type 2 diabetes in Japanese subjects.2006

    • Author(s)
      Yokoi, N. et al.
    • Journal Title

      Diabetes 55

      Pages: 2379-2386

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Essential role of ubiquitin-proteasome system in normal regulation of insulin secretion.2006

    • Author(s)
      Kawaguchi, M. et al.
    • Journal Title

      J Biol Chem 281

      Pages: 13015-13020

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Enhanced neuronal damage after ischemic insults in mice lacking Kir6.2-containing ATP-sensitive K^+ channels.2006

    • Author(s)
      Sun, H.S.et al.
    • Journal Title

      J Neurophysiol 95

      Pages: 2590-2601

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Behavioral phenotyping of mice lacking the K_<ATP> channel subunit Kir6.2.2006

    • Author(s)
      Deacon, R.M. et al.
    • Journal Title

      Physiol Behav 87

      Pages: 723-733

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cerebral glucose transporters expression and spatial learning in the K-ATP Kir6.2^<-/-> knockout mice.2006

    • Author(s)
      Choeiri, C. et al.
    • Journal Title

      Behav Brain Res 172

      Pages: 233-239

    • Related Report
      2006 Annual Research Report
  • [Journal Article] KCNJ11 gene knockout of the Kir6.2 K_<ATP> channel causes maladaptive remodeling and heart failure in hypertension.2006

    • Author(s)
      Kane, G.C.et al.
    • Journal Title

      Hum Mol Genet. 15

      Pages: 2285-2297

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Gene knockout of the KCNJ8-encoded Kir6.1 K_<ATP> channel imparts fatal susceptibility to endotoxemia.2006

    • Author(s)
      Kane, G.C.et al.
    • Journal Title

      FASEB J. 20

      Pages: 2271-2280

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Protection conferred by myocardial ATP-sensitive K^+ channels in pressure overload-induced congestive heart failure revealed in KCNJ11 Kir6.2-null mutant.2006

    • Author(s)
      Yamada, S. et al.
    • Journal Title

      J Physiol. 577

      Pages: 1053-1065

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Behavioral phenotyping of mice lacking the K_<ATP> channel subunit Kir6.22006

    • Author(s)
      Deacon RM et al.
    • Journal Title

      Physiol Behav (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Enhanced Neuronal Damage after Ischemic Insults in Mice Lacking Kir6.2-containing ATP-sensitive K^+ channels2006

    • Author(s)
      Sun HS et al.
    • Journal Title

      J Neurophysiol (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Identification and characterization of a novel member of the ATP-sensitive K^+ channel subunit family, Kir6.3, in zebrafish2006

    • Author(s)
      Zhang C et al.
    • Journal Title

      Physiol Genomics 24・3

      Pages: 290-297

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells2005

    • Author(s)
      Minami K, et al.
    • Journal Title

      Proc Natl Acad Sci USA 102

      Pages: 15116-15121

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility2005

    • Author(s)
      Miki T, et al.
    • Journal Title

      Diabetes 54

      Pages: 1056-1063

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Direct inhibition of the interaction between a-interaction domain and β-interaction domain of voltage-dependent Ca^<2+> channels by Gem2005

    • Author(s)
      Sasaki T, et al.
    • Journal Title

      J Biol Chem 280

      Pages: 9308-9312

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Possible role of PEPTl in gastrointestinal hormone secretion2005

    • Author(s)
      Matsumura K, et al.
    • Journal Title

      Biochem Biophys Res Commun 336

      Pages: 1028-1032

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Functional analysis of transcriptional repressor Otx3/Dmbxl.2005

    • Author(s)
      Kimura K, et al.
    • Journal Title

      FEBS Lett 579

      Pages: 2926-2932

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons2005

    • Author(s)
      Liss B, et al.
    • Journal Title

      Nat Neurosci 8

      Pages: 1742-1751

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] PDX-1 protein is internalized by lipid raft-dependent macropinocytosis2005

    • Author(s)
      Noguchi H, et al.
    • Journal Title

      Cell Transplant 14

      Pages: 637-645

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Glucose transporter plasticity during memory processing2005

    • Author(s)
      Choeiri C, et al.
    • Journal Title

      Neuroscience 130

      Pages: 591-600

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Treadmill running causes significant fiber damage in skeletal muscle of K_<ATP> channel-deficient mice2005

    • Author(s)
      Thabet M, et al.
    • Journal Title

      Physiol Genomics 22

      Pages: 204-212

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Role of ATP-sensitive K^+ channels in electrophysiological alterations during myocardialischemia: a study using Kir6.2-null mice2005

    • Author(s)
      Saito T, et al.
    • Journal Title

      Am J Physiol 288

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Physical and functional interaction of noc2/rab3 in exocytosis2005

    • Author(s)
      Shibasaki T, Seino S
    • Journal Title

      Methods Enzymol 403

      Pages: 408-419

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels2005

    • Author(s)
      Kubo Y, et al.
    • Journal Title

      Pharmacol Rev 57

      Pages: 509-526

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis2005

    • Author(s)
      Seino S, Shibasaki T)
    • Journal Title

      Physiol Rev 85

      Pages: 1303-1342

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 膵β細胞におけるcAMPコンパートメント2005

    • Author(s)
      柴崎忠雄, 他(依頼執筆)
    • Journal Title

      最新医学 60

      Pages: 2649-2653

    • NAID

      40007040930

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells.2005

    • Author(s)
      Minami K, Okuno M, Miyawaki K, Okumachi A, Ishizaki K, Oyama K, Kawaguchi M, Ishizuka N, Iwanaga T, Seino S
    • Journal Title

      Proc Natl Acad Sci USA 102

      Pages: 15116-15121

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Distinct effects of glucosedependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility.2005

    • Author(s)
      Miki T, Minami K, Shinozaki H, Matsumura K, Saraya A, Ikeda H, Yamada Y, Holst JJ, Seino S
    • Journal Title

      Diabetes 54

      Pages: 1056-1063

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Direct inhibition of : the interaction between α-interaction domain and β-interaction domain of voltage-dependent Ca^<2+> channels by Gem.2005

    • Author(s)
      Sasaki T, Shibasaki T, Beguin P, Nagashima K, Miyazaki M, Seino S
    • Journal Title

      J Biol Chem 280

      Pages: 9308-9312

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Possible role of PEPT1 in gastrointestinal hormone secretion.2005

    • Author(s)
      Matsumura K, Miki T, Jhomori T, Gonoi T, Seino S
    • Journal Title

      Biochem Biophys Res Commun 336

      Pages: 1028-1032

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Functional analysis of transcriptional repressor Otx3/Dmbx1.2005

    • Author(s)
      Kimura K, Miki T, Shibasaki T, Zhang Y, Ogawa M, Saisho H, Okuno M, Iwanaga T, Seino S
    • Journal Title

      FEBS Lett 579

      Pages: 2926-2932

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons.2005

    • Author(s)
      Liss B, Haeckel O, Wildmann J, Miki T, Seino S, Roeper J
    • Journal Title

      Nat Neurosci 8

      Pages: 1742-1751

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] PDX-1 protein is internalized by lipid raft-dependent macropinocytosis.2005

    • Author(s)
      Noguchi H, Matsumoto S, Okitsu T, Iwanaga Y, Yonekawa Y, Nagata H, Matsushita M, Wei FY, Matsui H, Minami K, Seino S, Masui Y, Futaki S, Tanaka K
    • Journal Title

      Cell Transplant 14

      Pages: 637-645

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Glucose transporter plasticity during memory processing.2005

    • Author(s)
      Choeiri C, Staines W, Miki T, Seino S, Messier C
    • Journal Title

      Neuroscience 130

      Pages: 591-600

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Treadmill running causes significant fiber damage in skeletal muscle of K_<ATP> channel-deficient mice.2005

    • Author(s)
      Thabet M, Miki T, Seino S, Renaud JM
    • Journal Title

      Physiol Genomics 22

      Pages: 204-212

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Role of ATP-sensitive K^+ channels in electrophysiological alterations during myocardial ischemia : a study using Kir6.2-null mice.2005

    • Author(s)
      Saito T, Sato T, Miki T, Seino S, Nakaya H
    • Journal Title

      Am J Physiol 288

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Roles of K_<ATP> channels as metabolic sensors in acute metabolic changes.2005

    • Author(s)
      Miki T, Seino S
    • Journal Title

      J Mol Cell Cardiol 38

      Pages: 917-925

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Physical and functional interaction of noc2/rab3 in exocytosis.2005

    • Author(s)
      Shibasaki T, Seino S
    • Journal Title

      Methods Enzymol 403

      Pages: 408-419

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels.2005

    • Author(s)
      Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA
    • Journal Title

      Pharmacol Rev 57

      Pages: 509-526

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis.2005

    • Author(s)
      Seino S, Shibasaki T
    • Journal Title

      Physiol Rev 85

      Pages: 1303-1342

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Sui β-saibou ni okeru cAMP compartment.2005

    • Author(s)
      Shibasaki T, Seino S
    • Journal Title

      Saishin igaku 60

      Pages: 2649-2653

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Kir6.1, Kir6.2 NC-IUPHAR subcommittee on potassium channels : Kir Group.2005

    • Author(s)
      Seino S
    • Journal Title

      The IUPHAR Compendium of Voltage-gated Ion Channels 2005. (Catterall WA, Chandy KG, and Gutman GA (eds.). IUPHAR Media)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Syoukakan no seijyou soshikizou.2005

    • Author(s)
      Iwanaga T
    • Journal Title

      Syoukaki shikkan shinryou jissen guide. (BUNKODO Co., LTD.)

      Pages: 872-882

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Tyoukan saibou kinou jikkenhou-"Kougaku kenbikyou niyoru kansatsu" oyobi denshi kenbikyou niyoru kansatsuhou.2005

    • Author(s)
      Iwanaga T
    • Journal Title

      Seibutsu kagaku jikkenhou50 Tyoukan saibou kinou jikkenhou. (Japan Scientific Societies Press)

      Pages: 7-21

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Distinct effects of glucose-dependent insulinotropic polypeptide and Glucagon-like Peptide-1 on insulin secretion and gut motility2005

    • Author(s)
      Miki T et al.
    • Journal Title

      Diabetes 54・4

      Pages: 1056-1063

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Possible role of PEPT1 in gastrointestinal hormone secretion.2005

    • Author(s)
      Matsumura K et al.
    • Journal Title

      Biochem Biophys Res Commun 336・4

      Pages: 1028-1032

    • Related Report
      2005 Annual Research Report
  • [Journal Article] K_<ATP> channel promote the differential degeneration of dopaminergic midbrain neurons2005

    • Author(s)
      Liss B et al.
    • Journal Title

      Nat Neurosci 8・12

      Pages: 1742-1751

    • Related Report
      2005 Annual Research Report
  • [Journal Article] PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis2005

    • Author(s)
      Seino S et al.
    • Journal Title

      Physiol Rev 85・4

      Pages: 1303-1342

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Physical and functional interaction of Noc2/Rab3 in exocytosis2005

    • Author(s)
      Shibasaki T et al.
    • Journal Title

      Methods in Enzymology 403

      Pages: 408-419

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Functional analysis of transcriptional repressor Otx3/Dmbx12005

    • Author(s)
      Kimura K et al.
    • Journal Title

      FEBS Letter 579・13

      Pages: 2926-2932

    • Related Report
      2005 Annual Research Report
  • [Journal Article] International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels2005

    • Author(s)
      Kubo Y et al.
    • Journal Title

      Pharmacol Rev 57・4

      Pages: 509-526

    • Related Report
      2005 Annual Research Report
  • [Journal Article] PDX-1 protein is internalized by lipid raft-dependent macropinocytosis2005

    • Author(s)
      Noguchi H et al.
    • Journal Title

      Cell Transplant 14・9

      Pages: 637-645

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells2005

    • Author(s)
      Minami K et al.
    • Journal Title

      Proc Natl Acad Sci U S A 102・42

      Pages: 15116-15121

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Treadmill running causes significant fiber damage in skeletal muscle of K_<ATP> channel-deficient mice2005

    • Author(s)
      Thabet M et al.
    • Journal Title

      Physiol Genomics 22・2

      Pages: 204-212

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Roles of K_<ATP> channels as metabolic sensors in acute metabolic changes2005

    • Author(s)
      Miki T et al.
    • Journal Title

      J Mol Cell Cardiol 38・6

      Pages: 917-925

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Direct inhibition of the interaction between α-interaction domain and β-interaction domain of voltage-dependent Ca^<2+> channels by Gem2005

    • Author(s)
      Sasaki T et al.
    • Journal Title

      J Biol Chem 280・10

      Pages: 9308-9312

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Role of ATP-sensitive K^+ channels in electrophysiological alterations during myocardial ischemia : a study using Kir6.2-null mice.2005

    • Author(s)
      Saito et al.
    • Journal Title

      Am.J.Physiol.Heart Circ.Physiol. 288

      Pages: 352-357

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Glucose transporter plasticity during memory processing.2005

    • Author(s)
      Choeiri et al.
    • Journal Title

      Neuroscience 130

      Pages: 591-600

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells2004

    • Author(s)
      Matsumoto M, et al
    • Journal Title

      Proc Natl Acad Sci USA 101

      Pages: 8313-8318

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effects of fluoroquinolones on insulin secretion and beta-cell ATP-sensitive K^+ channels2004

    • Author(s)
      Saraya A, et al.
    • Journal Title

      Eur J Pharmacol 497

      Pages: 111-117

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Interaction of ATP sensor, cAMP sensor, Ca^<2+> sensor, and voltage-dependent Ca^<2+>channel in insulin granule exocytosis2004

    • Author(s)
      Shibasaki T, et al.
    • Journal Title

      J Biol Chem 279

      Pages: 7956-7961

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Integration of ATP, cAMP, and Ca^<2+> signals in insulin granule exocytosis2004

    • Author(s)
      Shibasaki T, et al.
    • Journal Title

      Diabetes 53

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Construction of a multi一functional cDNA library specific for mouse pancreatic islets and its application to microarray2004

    • Author(s)
      Nishimura M, et al.
    • Journal Title

      DNA Res 11

      Pages: 315-323

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Prediction of the coding sequences of mouse homologues of KlAA gene : IV. The completenucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminalsequences of cDNA clones randomly sampled from size-fractionated libraries2004

    • Author(s)
      Okazaki N, et al.
    • Journal Title

      DNA Res 11

      Pages: 205-218

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Identification and characterization of Noc2 as a potential Rab3B effector protein inepithelial cells2004

    • Author(s)
      Manabe S, et al.
    • Journal Title

      Biochem Biophys Res Commun 316

      Pages: 218-225

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Diet-induced glucose intolerance in mice with decreased β-cell ATP-sensitive K^+ channels2004

    • Author(s)
      Remedi, et al.
    • Journal Title

      Diabetes 53

      Pages: 3159-3167

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Genetic disruption of Kir6.2, the pore-forming subunit of ATP-sensitive K^+ channel, predisposes to catecholamine-induced ventricular dysrhythmia2004

    • Author(s)
      Liu XK, et al.
    • Journal Title

      Diabetes 53

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] ATP-sensitive K^+ channel knockout compromises the metabolic benefit of exercise training, resulting in cardiac deficits2004

    • Author(s)
      Kane GC, et al.
    • Journal Title

      Diabetes 53

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Polymorphic variation in the CBLB gene in human type l diabetes.2004

    • Author(s)
      Kosoy R, et al.
    • Journal Title

      Genes Immun 5

      Pages: 232-235

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Gene targeting approach to clarification of ion channel function : studies of Kir6. x null mice2004

    • Author(s)
      Seino S, Miki T
    • Journal Title

      J Physiol 554

      Pages: 295-300

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Roles of ATP-sensitive K^+ channels as metabolic sensors : studies of Kir6. x null mice2004

    • Author(s)
      Minami K, et al.
    • Journal Title

      Diabetes 53

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Roles of K_<ATP> channels as metabolic sensors in acute metabolic changes2004

    • Author(s)
      Miki T, Seino S
    • Journal Title

      J Mol Cell Cardiol 38

      Pages: 917-925

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells.2004

    • Author(s)
      Matsumoto M, Miki T, Shibasaki T, Kawaguchi M, Shinozaki H, Nio J, Saraya A, Koseki H, Miyazaki M, Iwanaga T, Seino S
    • Journal Title

      Proc Natl Acad Sci USA 101

      Pages: 8313-8318

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effects of fluoroquinolones on insulin secretion and β-cell ATP-sensitive K^+ channels.2004

    • Author(s)
      Saraya A, Yokokura M, Gonoi T, Seino S
    • Journal Title

      Eur J Pharmacol 497

      Pages: 111-117

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Interaction of ATP sensor, cAMP sensor, Ca^<2+> sensor, and voltage-dependent Ca^<2+> channel in insulin granule exocytosis.2004

    • Author(s)
      Shibasaki T, Sunaga Y, Fujimoto K, Kashima Y, Seino S
    • Journal Title

      J Biol Chem 279

      Pages: 7956-7961

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Integration of ATP, cAMP, and Ca^<2+> signals in insulin granule exocytosis.2004

    • Author(s)
      Shibasaki T, Sunaga Y, Seino S
    • Journal Title

      Diabetes 53

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.2004

    • Author(s)
      Nishimura M, Yokoi N, Miki T, Horikawa Y, Yoshioka H, Takeda J, Ohara O, Seino S
    • Journal Title

      DNA Res 11

      Pages: 315-323

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Prediction of the coding sequences of mouse homologues of KIAA gene : IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.2004

    • Author(s)
      Okazaki N, R FK, Ohara R, Inamoto S, Koseki H, Hiraoka S, Saga Y, Seino S, Nishimura M, Kaisho T, Hoshino K, Kitamura H, Nagase T, Ohara O, Koga H
    • Journal Title

      DNA Res 11

      Pages: 205-218

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Identification and characterization of Noc2 as a potential Rab3B effector protein in epithelial cells.2004

    • Author(s)
      Manabe S, Nishimura N, Yamamoto Y, Kitamura H, Morimoto S, Imai M, Nagahiro S, Seino S, Sasaki T
    • Journal Title

      Biochem Biophys Res Commun 316

      Pages: 218-225

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Diet-induced glucose intolerance in mice with decreased β-cell ATP-sensitive K^+ channels.2004

    • Author(s)
      Remedi MS, Koster JC, Markova K, Seino S, Miki T, Patton BL, McDaniel ML, Nichols CG
    • Journal Title

      Diabetes 53

      Pages: 3159-3167

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Genetic disruption of Kir6.2, the pore-forming subunit of ATP-sensitive K^+ channel, predisposes to catecholamine-induced ventricular dysrhythmia.2004

    • Author(s)
      Liu XK, Yamada S, Kane GC, Alekseev AE, Hodgson DM, O'Cochlain F, Jahangir A, Miki T, Seino S, Terzic A
    • Journal Title

      Diabetes 53

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] ATP-sensitive K^+ channel knockout compromises the metabolic benefit of exercise training, resulting in cardiac deficits.2004

    • Author(s)
      Kane GC, Behfar A, Yamada S, Perez-Terzic C, O'Cochlain F, Reyes S, Dzeja PP, Miki T, Seino S, Terzic A
    • Journal Title

      Diabetes 53

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Polymorphic variation in the CBLB gene in human type 1 diabetes.2004

    • Author(s)
      Kosoy R, Yokoi N, Seino S, Concannon P
    • Journal Title

      Genes Immun 5

      Pages: 232-235

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Gene targeting approach to clarification of ion channel function : studies of Kir6.x null mice.2004

    • Author(s)
      Seino S, Miki T
    • Journal Title

      J Physiol 554

      Pages: 295-300

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Roles of ATP-sensitive K^+ channels as metabolic sensors : studies of Kir6.x null mice.2004

    • Author(s)
      Minami K, Miki T, Kadowaki T, Seino S
    • Journal Title

      Diabetes 53

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Interaction of ATP sensor, cAMP sensor, Ca^<2+> sensor, and voltage-dependent calcium channel in insulin granule exocytosis.2004

    • Author(s)
      Shibasaki et al.
    • Journal Title

      J.Biol.Chem. 279

      Pages: 7956-7961

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Noc2 is required in regulated exocytosis in endocrin and exocrine cells.2004

    • Author(s)
      Matsumoto et al.
    • Journal Title

      Proc.Natl.Acad.Sci.U.S.A. 101

      Pages: 8313-8318

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effects of fluoroquinolones on insulin secretion and β-cell ATP-sensitive K^+ channels.2004

    • Author(s)
      Saraya et al.
    • Journal Title

      Eur.J.Pharmacol. 497

      Pages: 111-117

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Integration of ATP, cAMP, and Ca^<2+> signals in insulin granule exocytosis.2004

    • Author(s)
      Shibasaki et al.
    • Journal Title

      Diabetes 53suppl.

      Pages: 59-62

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Diet-induced glucose intolerance in mice with decreased beta-cell ATP-sensitive K^+ channels.2004

    • Author(s)
      Remedi et al.
    • Journal Title

      Diabetes 53

      Pages: 3159-3167

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Genetic disruption of Kir6.2,the pore-forming subunit of ATP-sensitive K^+ channel, predisposes to catecholamine-induced ventricular dysrhythmia.2004

    • Author(s)
      Liu et al.
    • Journal Title

      Diabetes 53suppl.

      Pages: 165-168

    • Related Report
      2004 Annual Research Report
  • [Journal Article] ATP-sensitive K^+ channel knockout compromises the metabolic benefit of exercise training, resulting in cardiac deficits.2004

    • Author(s)
      Kane et al.
    • Journal Title

      Diabetes 53suppl.

      Pages: 169-175

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Construction of multi-functional cDNA library specific for normal mouse pancreatic islets and its application to microarray.2004

    • Author(s)
      Nishimura et al.
    • Journal Title

      DNA Res. 11

      Pages: 315-323

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Roles of ATP-sensitive potassium channels as metabolic sensors : Studies of Kir6.x null mice.2004

    • Author(s)
      Minami et al.
    • Journal Title

      Diabetes 53suppl.

      Pages: 176-180

    • Related Report
      2004 Annual Research Report
  • [Journal Article] ATP-sensitive K^+ channel-mediated glucose uptake is independent of IRS-1/phosphatidylinositol 3-kinase signaling2003

    • Author(s)
      Minami K, et al.
    • Journal Title

      Am J Physiol 285

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Establishment and characterization of the Komeda . diabetes-prone rat as a segregating inbred strain2003

    • Author(s)
      Yokoi N, et al.
    • Journal Title

      Exp Anim 52

      Pages: 295-301

    • NAID

      10011713364

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Rat neurological disease creeping is caused by a mutation in the reelin gene2003

    • Author(s)
      Yokoi N, et al.
    • Journal Title

      Brain Res Mol Brain Res 112

      Pages: 1-7

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cardioprotective effect of diazoxide is mediated by activation of sarcolemmal but not mitochondrial ATP-sensitive potassium channels in mice2003

    • Author(s)
      Suzuki M, et al.
    • Journal Title

      Circulation 107

      Pages: 682-685

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] KATP channels depress force by reducing action potential amplitude in mouse EDL and soleus muscle2003

    • Author(s)
      Gong B, et al.
    • Journal Title

      Am J Physiol 285

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Knockout of Kir6.2 negates ischemic preconditioning-induced protection of myocardial energetics2003

    • Author(s)
      Gumina RJ, et al.
    • Journal Title

      Am J Physiol 284

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Compendium of voltage-gated ion channels : potassium channels2003

    • Author(s)
      Gutman GA, et al.
    • Journal Title

      Pharmacol Rev 55

      Pages: 583-586

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 1型糖尿病モデルKDPラットの疾患感受性遺伝子のクローニング2003

    • Author(s)
      横井伯英, 他(依頼執筆)
    • Journal Title

      医学のあゆみ 207

      Pages: 613-617

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 全身性エリトマトーデスとシェーングレン症候群を合併した1型糖尿病の1例2003

    • Author(s)
      田中正巳, 他(依頼執筆)
    • Journal Title

      糖尿病 46

      Pages: 11-14

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 特集:臨床応用の動向と将来への展望. 膵臓を対象とした再生医療2003

    • Author(s)
      南幸太郎, 他(依頼執筆)
    • Journal Title

      日本臨床 61

      Pages: 504-508

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 膵β細胞の再生医学2003

    • Author(s)
      南幸太郎, 他(依頼執筆)
    • Journal Title

      今日の移植 16

      Pages: 125-132

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 特集:糖尿病研究の新展開 インスリン分泌の調節機構2003

    • Author(s)
      南幸太郎, 他(依頼執筆)
    • Journal Title

      生化学 75

      Pages: 1312-1323

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] ATP-sensitive K^+ channel-mediated glucose uptake is independent of IRS-1/phosphatidylinositol 3-kinase signaling.2003

    • Author(s)
      Minami K, Morita M, Saraya A, Yano H, Terauchi Y, Miki T, Kuriyama T, Kadowaki T, Seino S
    • Journal Title

      Am J Physiol 285

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Establishment and characterization of the Komeda diabetes-prone rat as a segregating inbred strain2003

    • Author(s)
      Yokoi N, Namae M, Fuse M, Wang HY, Hirata T, Seino S, Komeda K
    • Journal Title

      Exp Anim 52

      Pages: 295-301

    • NAID

      10011713364

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Rat neurological disease creeping is caused by a mutation in the reelin gene.2003

    • Author(s)
      Yokoi N, Namae M, Wang HY, Kojima K, Fuse M, Yasuda K, Serikawa T, Seino S, Komeda K
    • Journal Title

      Brain Res Mol Brain Res 112

      Pages: 1-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cardioprotective effect of diazoxide is mediated by activation of sarcolemmal but not mitochondrial ATP-sensitive potassium channels in mice.2003

    • Author(s)
      Suzuki M, Saito T, Sato T, Tamagawa M, Miki T, Seino S, Nakaya H
    • Journal Title

      Circulation 107

      Pages: 682-685

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] K_<ATP> channels depress force by reducing action potential amplitude in mouse EDL and soleus muscle.2003

    • Author(s)
      Gong B, Legault D, Miki T, Seino S, Renaud JM
    • Journal Title

      Am J Physiol 285

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Knockout of Kir6.2 negates ischemic preconditioning-induced protection of myocardial energetics2003

    • Author(s)
      Gumina RJ, Pucar D, Bast P, Hodgson DM, Kurtz CE, Dzeja PP, Miki T, Seino S, Terzic A
    • Journal Title

      Am J Physiol 284

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels : potassium channels.2003

    • Author(s)
      Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, Kuperschmidt S, Kurachi Y, Lazdunski M, Lesage F, Lester HA, McKinnon D, Nichols CG, O'Kelly I, Robbins J, Robertson GA, Rudy B, Sanguinetti M, Seino S, Stuehmer W, Tamkun MM, Vandenberg CA, Wei A, Wulff H, Wymore RS
    • Journal Title

      Pharmacol Rev 55

      Pages: 583-586

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Ichigata tounyoubyou model KDP rat no shikkan kanjyusei idenshi no cloning2003

    • Author(s)
      Yokoi N, Seino S
    • Journal Title

      Igaku no ayumi 207

      Pages: 613-617

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Systemic lupus erythematosus to Sjogren syndrome wo gappei shita ichigata tounyoubyou no ichirei.2003

    • Author(s)
      Tanaka M, Miyazaki Y, Yokoi N, Seino S
    • Journal Title

      Tounyoubyou 46

      Pages: 11-14

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Tokusyu : Rinsyou ouyou no doukou to syourai eno tenbou suizou wo taisyou tosita saisei iryou.2003

    • Author(s)
      Minami K, Okuno M, Miyawaki K, Seino S
    • Journal Title

      Nippon Rinsyou 61

      Pages: 504-508

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Sui β-saibou no saisei igaku.2003

    • Author(s)
      Minami K, Okuno M, Seino S
    • Journal Title

      Konnichi no isyoku 16

      Pages: 125-132

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Tokusyu : Tounyoubyou kenkyu no shintenkai insulin bunpitsu no tyousetsu kikou.2003

    • Author(s)
      Minami K, Shibasaki T, Miki T, Seino S
    • Journal Title

      Seikagaku 75

      Pages: 1312-1323

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Sui β-saibou niokeru glucose outousei to saibounai calcium.2003

    • Author(s)
      Minami K, Yokokura M, Seino S
    • Journal Title

      Bunshi tounyougaku no shinpo kiso kara rinsyou made-2003. (KANEHARA Co., LTD.)

      Pages: 17-22

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Involvement of Exoc31, a protein structurally related to the exocyst subunit Sec6, in insulin secretion.

    • Author(s)
      Saito T, Shibasaki T, Seino S
    • Journal Title

      Biomed Res (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] cAMPによるインスリン分泌開口分泌の制御2008

    • Author(s)
      柴崎忠雄
    • Organizer
      第42回糖尿病学の進歩
    • Place of Presentation
      高松
    • Year and Date
      2008-02-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] cAMP niyoru insulin bunpitsu no seigyo.2008

    • Author(s)
      Shibasaki T, Seino S
    • Organizer
      Advances in Diabetology 42nd Annual Post Graduate Course
    • Place of Presentation
      Takamatsu
    • Year and Date
      2008-02-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] cAMPによるインスリン開口分泌の制御2008

    • Author(s)
      柴崎忠雄, 他
    • Organizer
      第24回糖尿病学の進歩・レクチャー
    • Place of Presentation
      高松
    • Year and Date
      2008-02-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] Regulation of insulin granule dynamics.2007

    • Author(s)
      Seino S
    • Organizer
      The 33rd Autumn Congress of Korean Diabetes Association
    • Place of Presentation
      Busan, Korea
    • Year and Date
      2007-11-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of insulin granule dynamics.2007

    • Author(s)
      Seino S
    • Organizer
      The 33rd Autumn Congress of Korean Diabetes Association.
    • Place of Presentation
      Busan, Korea
    • Year and Date
      2007-11-09
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of insulin granule dynamics2007

    • Author(s)
      Seino, S
    • Organizer
      The 33rd Autumn Congress of Korean Diabetes Association
    • Place of Presentation
      Busan(Korea)
    • Year and Date
      2007-11-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] Regulation of insulin granule dynamics.2007

    • Author(s)
      Seino S
    • Organizer
      The 14th Japan-Korea Symposium on Diabetes Mellitus -Diabetes and Metabolic Syndrome in Asia
    • Place of Presentation
      京都
    • Year and Date
      2007-10-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of insulin granule dynamics.2007

    • Author(s)
      Seino S
    • Organizer
      14th Japan-Korea Symposium on Diabetes Mellitus -Diabetes and Metabolic Syndrome in Asia-.
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2007-10-05
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of insulin granule dynamics2007

    • Author(s)
      Seino, S
    • Organizer
      14th Japan-Korea Symposium on Diabetes Mellit us-
    • Place of Presentation
      京都
    • Year and Date
      2007-10-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] Regulation of insulin granule exocytosis by cAMP.2007

    • Author(s)
      Seino S
    • Organizer
      The European Association for the Study of Diabetes (EASD) Islet Study Group Symposium 2007
    • Place of Presentation
      Brussels, Belgium
    • Year and Date
      2007-09-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of insulin granule exocytosis by cAMP.2007

    • Author(s)
      Seino S
    • Organizer
      The European Association for the Study of Diabetes (EASD) Islet Study Group Symposium 2007.
    • Place of Presentation
      Brussels, Belgium
    • Year and Date
      2007-09-22
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of insulin granule exocytosis by cAMP2007

    • Author(s)
      Seino, S
    • Organizer
      EASD Islet Study Group Symposium 2007
    • Place of Presentation
      Brussels(Bclgium)
    • Year and Date
      2007-09-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] Plasticity of pancreatic cells2007

    • Author(s)
      Minami, K, et. al.
    • Organizer
      Federation of Asian and Oceanian Biochemists and Molccular Biologists(FAOBMB)
    • Place of Presentation
      Soul(Korea)
    • Year and Date
      2007-05-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] Regulation of Insulin Granule Exocytosis by cAMP2007

    • Author(s)
      Shibasaki T, et al.
    • Organizer
      第50回日本糖尿病学会年次学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2007-05-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of insulin granule exocytosis by cAMP.2007

    • Author(s)
      Shibasaki T, Takahashi H, Seino S
    • Organizer
      The 50th Annual Meeting of the Japan Diabetes Society
    • Place of Presentation
      Sendai
    • Year and Date
      2007-05-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 組織間ネットワークによるグルコース恒常性の維持機構2007

    • Author(s)
      三木隆司, 他
    • Organizer
      第50回日本糖尿病学会年次学術集会・シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2007-05-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] 膵細胞の可塑性2007

    • Author(s)
      南幸太郎, 他
    • Organizer
      第50回日本糖尿病学会年次学術集会・シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2007-05-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] cAMPによる開口分泌制御2007

    • Author(s)
      柴崎忠雄, 他
    • Organizer
      第50回日本糖尿病学会年次学術集会・シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2007-05-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] Glycobiologyにおける形態学の貢献-内在性レクチンの発現解析を中心に2007

    • Author(s)
      岩永敏彦
    • Organizer
      日本解剖学会第53回東北・北海道連合支部学術集会
    • Place of Presentation
      札幌
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Glycobiology niokeru keitaigaku no Kouken - Naizaisei lectin no hatsugen kaiseki wo tyuushin ni.2007

    • Author(s)
      Iwanaga T
    • Organizer
      The 53rd Annual Meeting of the Japanese Association of Anatomists, Tohoku and Hokkaido Branch
    • Place of Presentation
      Sapporo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Role of cAMP signaling in insulin granule exocytosis2006

    • Author(s)
      Seino S
    • Organizer
      The 6th Congress of the Federation of Asian and Oceanian Physiological Societies
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2006-10-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Role of cAMP signaling in insulin granule exocytosis.2006

    • Author(s)
      Seino S
    • Organizer
      The 6th Congress of the Federation of Asian and Oceanian Physiological Societies.
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2006-10-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regeneration of pancreatic β-cells : in vitro and in vivo models2006

    • Author(s)
      Seino S
    • Organizer
      The 10th Chinese Diabetes Society Scientific Congress
    • Place of Presentation
      Guangzhou, China
    • Year and Date
      2006-10-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regeneration of pancreatic β-cells : in vitro and in vivo models.2006

    • Author(s)
      Seino S
    • Organizer
      The 10th Chinese Diabetes Society Scientific Congress.
    • Place of Presentation
      Guangzhou, China.
    • Year and Date
      2006-10-09
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 膵β細胞障害の分子機構2006

    • Author(s)
      清野 進
    • Organizer
      第41回糖尿病学の進歩
    • Place of Presentation
      札幌
    • Year and Date
      2006-09-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 膵β細胞の研究の進歩と展望2006

    • Author(s)
      清野 進
    • Organizer
      第49回日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Year and Date
      2006-05-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Sui β-saibou no kenkyuu no shinpo to tenbou.2006

    • Author(s)
      Seino S
    • Organizer
      The 47th Annual Meeting of the Japan Diabetes Society
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-05-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 膵β細胞の機能と再生2006

    • Author(s)
      清野 進
    • Organizer
      第79回日本内分泌学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2006-05-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Sui β-saibou no kinou to saisei.2006

    • Author(s)
      Seino S
    • Organizer
      The 79th Japan Endocrine Society Meeting
    • Place of Presentation
      Kobe
    • Year and Date
      2006-05-20
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Integration of intracellular signals in insulin granule exocytosis2006

    • Author(s)
      Seino S
    • Organizer
      Nobel Minisymposium : Frontiers in Calcium Channel Research from Basics to Diseases
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2006-05-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Integration of intracellular signals in insulin granule exocytosis.2006

    • Author(s)
      Seino S
    • Organizer
      Nobel Minisymposium : Frontiers in Calcium Channel Research from Basics to Diseases.
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2006-05-05
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Beta cell signaling2005

    • Author(s)
      Seino S
    • Organizer
      The Donald F. Steiner Symposium
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2005-07-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Beta cell signaling.2005

    • Author(s)
      Seino S
    • Organizer
      The Donald F Steiner Symposium.
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2005-07-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The integration of intracellular signals in regulated exocytosis : the pancreatic β-cell model2005

    • Author(s)
      清野進
    • Organizer
      第58回日本細胞生物学会大会
    • Place of Presentation
      大宮
    • Year and Date
      2005-06-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The integration of intracellular signals in regulated exocytosis : the pancreatic β-cell model.2005

    • Author(s)
      Seino S
    • Organizer
      The 58th Annual Meeting of the Japan Society for Cell Biology
    • Place of Presentation
      Omiya
    • Year and Date
      2005-06-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular mechanism of cAMP-regulated insulin granule exocytosis.2005

    • Author(s)
      Shibasaki T, Seino S
    • Organizer
      The 82nd Annual Meeting of Physiological Society of Japan
    • Place of Presentation
      Sendai
    • Year and Date
      2005-05-20
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular Mechanism of cAMP-regulated Insulin Granule Exocytosis2005

    • Author(s)
      Shibasaki T, Seino S
    • Organizer
      第82回日本生理学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2005-05-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 糖尿病に対する再生医療の展望2005

    • Author(s)
      清野進
    • Organizer
      第48回日本糖尿病協会総会及び年次集会
    • Place of Presentation
      神戸
    • Year and Date
      2005-05-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Tounyoubyou ni taisuru saisei iryou no tenbou2005

    • Author(s)
      Seino S
    • Organizer
      The 48th Annual Meeting of the Japan Diabetes Association
    • Place of Presentation
      Kobe
    • Year and Date
      2005-05-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 膵β細胞研究の新展開2005

    • Author(s)
      清野 進
    • Organizer
      第71回日本糖尿病学会中部地方会
    • Place of Presentation
      岐阜
    • Year and Date
      2005-03-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Sui β-saibou no shintenkai.2005

    • Author(s)
      Seino S
    • Organizer
      The 71st Annual Meeting of the Japan Diabetes Society, Chubu Branch
    • Place of Presentation
      Gifu
    • Year and Date
      2005-03-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 膵β細胞研究と糖尿病.2005

    • Author(s)
      清野進
    • Organizer
      第11回日本糖尿病眼学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2005-03-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Sui β-saibou kenkyu to tounyoubyou2005

    • Author(s)
      Seino S
    • Organizer
      The 11th Annual Meeting of the Japanese Society of Ophthalmic Diabetology
    • Place of Presentation
      Nagoya
    • Year and Date
      2005-03-05
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 糖尿病モデル動物による膵β細胞機能解析.2005

    • Author(s)
      清野進
    • Organizer
      第19回日本糖尿病動物研究会年次学術集会
    • Place of Presentation
      京都
    • Year and Date
      2005-02-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Tounyoubyou model doubutsu niyoru sui β-saibou kinou kaiseki2005

    • Author(s)
      Seino S
    • Organizer
      The 19th Japan Association of Animal Diabetes Research
    • Place of Presentation
      Kyoto
    • Year and Date
      2005-02-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 膵β細胞の生物学2005

    • Author(s)
      清野 進
    • Organizer
      第17回高遠・分子細胞生物学シンポジウム
    • Place of Presentation
      長野
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 分泌細胞研究の新しい試み: Rab蛋白標的分子Noc2遺伝子欠損が内分泌細胞と外分泌細胞に及ぼす影響2005

    • Author(s)
      岩永敏彦, 他
    • Organizer
      第110回日本解剖学会総会
    • Place of Presentation
      富山
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Sui β-saibou no seibutsugaku2005

    • Author(s)
      Seino S
    • Organizer
      The 17th Takato Molecular Cellular Biology Symposium
    • Place of Presentation
      Nagano
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Bunpitsu saibou kenkyuu no atarashii kokoromi : Rab tanpakushitu hyouteki bunshi Noc2 idensi kesson ga naibunpitsu saibou to gaibunpitsu saibou ni oyobosu eikyou.2005

    • Author(s)
      Iwanaga T, Teramae H, Nio J
    • Organizer
      The 110th Annual Meeting of the Japanese Association of Anatomists
    • Place of Presentation
      Toyama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mechahisms of insulin secretion2004

    • Author(s)
      Seino S
    • Organizer
      Pioneers in Physiological Research and Challenges for 21^<st>Century Physiologists, Special Symposium
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2004-10-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ATP-sensitive (K_<ATP>)channel as the molecular target of sulfonylurea : its physiology and pathophysiologv2004

    • Author(s)
      Seino S
    • Organizer
      The Research Symposium of Korean Diabetes Association, special Seminar
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2004-10-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ATP-sensitive (K_<ATP>) channel as the molecular target of sulfonylurea : its physiology and pathophysiology.2004

    • Author(s)
      Seino S
    • Organizer
      The Research Symposium of Korean Diabetes Association, Special Seminar
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2004-10-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mechanisms of insulin secretion.2004

    • Author(s)
      Seino S
    • Organizer
      Pioneers in Physiological Research and Challenges for 21st Century Physiologists, Special Symposium.
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2004-10-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 膵β細胞の生物学 - インスリン分泌システムの形成機構2004

    • Author(s)
      清野進
    • Organizer
      文部科学省特定領域研究-アディポミクス、脂肪細胞の機能世界と破綻病態の解明公開シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2004-10-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Sui β-saibou no seibutsugaku - insulin bunpitsu system no keisei kikou.2004

    • Author(s)
      Seino S
    • Organizer
      Adipomics, Open symposium, Grant-in-Aid for Scientific Research on Priority Areas from the Ministry of Education, Culture, Sports, Science, and Technology
    • Place of Presentation
      Osaka
    • Year and Date
      2004-10-01
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Integration of intracellular signals in insulin granule exocytosis2004

    • Author(s)
      Seino S
    • Organizer
      Diabetes Endocrinology Research Center, University of Washington, Special Symposium : Cellular Aspects of Insulin Secretion and Insulin Action
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2004-09-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Integration of intracellular signals in insulin granule exocytosis.2004

    • Author(s)
      Seino S
    • Organizer
      Diabetes Endocrinology Research Center, University of Washington, Special Symposium : Cellular Aspects of Insulin Secretion and Insulin Action
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2004-09-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Integration of stimulus-secretion coupling in insulin granule exocytosis2004

    • Author(s)
      Seino S
    • Organizer
      The 81st Annual Meeting of the Physiological Society of Japan, Second Korea-Japan Joint Symposium : Endocrine and Exocrine Secretion
    • Place of Presentation
      札幌
    • Year and Date
      2004-06-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Integration of stimulus-secretion coupling in insulin granule exocytosis.2004

    • Author(s)
      Seino S
    • Organizer
      Second Korea-Japan Joint Symposium : Endocrine and Exocrine Secretion.
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2004-06-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] インスリン分泌の分子構造2004

    • Author(s)
      清野進
    • Organizer
      第47回日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Year and Date
      2004-05-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Insulin bunpitsu no kouzou.2004

    • Author(s)
      Seino S
    • Organizer
      The 47th Annual Meeting of the Japan Diabetes Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2004-05-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The biology of K_<ATP> channels : Emphasis on Kir2004

    • Author(s)
      Seino S
    • Organizer
      The 5th International group on insulin secretion Symposium
    • Place of Presentation
      St. Jean-Cap-Ferrat, France
    • Year and Date
      2004-03-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The biology of K_<ATP> channels : Emphasis on Kir.2004

    • Author(s)
      Seino S
    • Organizer
      The 5th Servier-IGIS Symposium.
    • Place of Presentation
      St. Jean-Cap-Ferrat, France.
    • Year and Date
      2004-03-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Evolution of Type II Diabetes and Obesity Marketplace to the year 20202004

    • Author(s)
      清野進
    • Organizer
      Key Opinion Leader Advisory Board
    • Place of Presentation
      東京
    • Year and Date
      2004-02-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Evolution of Type II Diabetes and Obesity Marketplace to the year 2020.2004

    • Author(s)
      Seino S
    • Organizer
      Key Opinion Leader Advisory Board.
    • Place of Presentation
      Tokyo
    • Year and Date
      2004-02-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Integration of ATP, cAMP and Calcium Signaling in Insulin Secretion2004

    • Author(s)
      Seino S
    • Organizer
      International Symposium on Pathogenesis of Diabetes Mellitus
    • Place of Presentation
      神戸
    • Year and Date
      2004-01-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Integration of ATP, cAMP and calcium signaling in insulin secretion.2004

    • Author(s)
      Seino S
    • Organizer
      International Symposium on Pathogenesis of Diabetes Mellitus.
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2004-01-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Integration of stimulus-secretion coupling in insulin granule exocytosis2004

    • Author(s)
      清野進
    • Organizer
      第81回日本生理学会大会 Second Korea-Japan Joint Symposium : Endocrine and Exocrine Secretion
    • Place of Presentation
      札幌
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] インスリン分泌システムの形成とその破綻2004

    • Author(s)
      清野進
    • Organizer
      第22回内分泌・代謝学サマーセミナー
    • Place of Presentation
      淡路
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Integration of stimulus-secretion coupling in insulin granule exocytosis.2004

    • Author(s)
      Seino S
    • Organizer
      The 81st Annual Meeting of the Physiological Society of Japan, Second Korea-Japan Joint Symposium : Endocrine and Exocrine Secretion
    • Place of Presentation
      Sapporo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Insulin bunpitsu system no keisei to sono hatan2004

    • Author(s)
      Seino S
    • Organizer
      The 22nd JES Summer Seminar on Endocrinology and Metabolism
    • Place of Presentation
      Awaji
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Positional cloning of the autoimmune type 1 diabetes gene in the KDP rat2003

    • Author(s)
      Yokoi N, Seino S
    • Organizer
      Cold Spring Harbor Laboratory Winter Biotechnology Conference on Rat Genomics and Models
    • Place of Presentation
      Cold spring Harbor, USA
    • Year and Date
      2003-12-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Positional cloning of the autoimmune type 1 diabetes gene in the KDP rat.2003

    • Author(s)
      Yokoi N, Seino S
    • Organizer
      Cold Spring Harbor Laboratory Winter Biotechnology Conference on Rat Genomics and Models.
    • Place of Presentation
      Cold Spring Harbor, USA
    • Year and Date
      2003-12-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Involvement of Piccolo/cAMP-GEFII/Rim2 Complex in cAMP-dependent Insulin Secretion2003

    • Author(s)
      Shibasaki T, et al.
    • Organizer
      第76回日本生化学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2003-10-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Involvement of Piccolo/cAMP-GEFII/Rim2. Complex in cAMP-dependent Insulin Secretion.2003

    • Author(s)
      Shibasaki T, Fujimoto K, Yokoi N, Seino S
    • Organizer
      The 76th Annual Meeting of Japanese Biochemical Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2003-10-16
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Classical and novel effectors2003

    • Author(s)
      Seino S
    • Organizer
      The18th International Diabetes Federation Congress, Symposium : Normal β-cell stimulus-secretion coupling
    • Place of Presentation
      Paris, France
    • Year and Date
      2003-08-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Classical and novel effectors.2003

    • Author(s)
      Seino S
    • Organizer
      The 18th International Diabetes Federation Congress, Symposium : Normal β-cell stimulus-secretion coupling.
    • Place of Presentation
      Paris, France
    • Year and Date
      2003-08-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 1型糖尿病モデルKDPラットにおける感受性遺伝子のポジショナルクローニング2003

    • Author(s)
      横井伯英, 他
    • Organizer
      第46回日本糖尿病学会年次学術集会
    • Place of Presentation
      富山
    • Year and Date
      2003-05-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Ichigata tounyoubyou model KDP rat ni okeru kanjyusei idenshi no positional cloning.2003

    • Author(s)
      Yokoi N, Seino S
    • Organizer
      The 46th Annual Meeting of the Japan Diabetes Society
    • Place of Presentation
      Toyama
    • Year and Date
      2003-05-23
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] SU剤の標的分子K_<ATP>チャネル-新しい展開-2003

    • Author(s)
      清野 進
    • Organizer
      第46回日本糖尿病学会年次学術集会
    • Place of Presentation
      富山
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 形態学から見た消化管における内分泌・外分泌の特殊性と普遍性 : すべては消化管から始まった2003

    • Author(s)
      岩永敏彦
    • Organizer
      第7回小児分子内分泌研究会
    • Place of Presentation
      富良野
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] SU zai no hyouteki bunshi K_<ATP> channel -atarashii tenkai-.2003

    • Author(s)
      Seino S
    • Organizer
      The 46th Annual Meeting of the Japan Diabetes Society
    • Place of Presentation
      Toyama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] keitaigaku kara mita syoukakan ni okeru naibunpitsu gaibunpitsu no tokusyusei to huhensei subeteha syoukakan kara hajimmata.2003

    • Author(s)
      Iwanaga T
    • Organizer
      Society for pedeatric molecular endocrinology.
    • Place of Presentation
      Furano
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Sui β-saibou shougai no bunshi kikou

    • Author(s)
      Seino S
    • Organizer
      Advances in Diabetology 41st Annual Post Graduate Course
    • Place of Presentation
      sapporo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] PKA-independent mechanism of cAMP in insulin secretion. Pancreatic Beta Cell in Health and Disease. Seino S and Bell GI (eds.)2008

    • Author(s)
      Seino S, et al. (分担執筆)
    • Publisher
      springer
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 自然発症1型糖尿病動物の原因遺伝子. 糖尿病学基礎と臨床(編集 : 門脇孝、石橋俊、佐倉宏、戸邉一之、野田光彦)2007

    • Author(s)
      横井伯英, 他(分担執筆)
    • Publisher
      西村書店
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 膵腺房細胞の分化転換によるインスリン分泌細胞の作出. 糖尿病学2007(編集 : 岡芳知、谷澤幸生)2007

    • Author(s)
      南幸太郎, 他(分担執筆)
    • Publisher
      診断と治療社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 膵腺房細胞の分化転換によるβ細胞再生の可能性. 分子糖尿病学の進歩 基礎から臨床まで-2007(監修 : 矢崎義雄、編集 : 清野 進、渥美義仁、門脇 孝、春日雅人)2007

    • Author(s)
      南幸太郎, 他(分担執筆)
    • Publisher
      金原出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Pancreatic beta cell in health and disease 編者名:Seomo, S and Bell, G(PKA-independent mcchanism of cAMP in insulin secretion)2007

    • Author(s)
      Seino, S, et. al. (分担執筆)
    • Publisher
      Springer
    • Related Report
      2007 Annual Research Report
  • [Book] cAMPコンパートメントとインスリン分泌. 分子糖尿病学の進歩 基礎から臨床まで-2006(監修: 矢崎義雄、編集: 清野 進、渥美義仁、門脇 孝、春日雅人)2006

    • Author(s)
      柴崎忠雄, 他(分担執筆)
    • Publisher
      金原出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Kir6.1, Kir6.2 NC-IUPHAR subcommittee on potassium channels: Kir Group. The IUPHAR Compendium of Voltage-gated Ion Channels 2005. Catterall WA, Chandy KG, and Gutman GA(eds. )2005

    • Author(s)
      Seino S (分担執筆)
    • Publisher
      IUPHAR Media
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 消化管の正常組織像 消化器疾患診療実践ガイド(編集 : 千葉 勉、井廻道夫)2005

    • Author(s)
      岩永敏彦(分担執筆)
    • Publisher
      文光堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 腸管細胞形態観察法-「光学顕微鏡による観察」および「電子顕微鏡による観察法」. 生物化学実験法50 腸管細胞機能実験法(編集 : 上野川修一、清水 誠、八村敏志、戸塚 護)2005

    • Author(s)
      岩永敏彦(分担執筆)
    • Publisher
      学会出版センター
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 膵β細胞におけるグルコース応答性と細胞内カルシウム. 分子糖尿病学の進歩 基礎から臨床まで-2003 (監修 : 矢崎義雄、編集 : 清野 進、渥美義仁、門脇 孝、春日雅人)2003

    • Author(s)
      南幸太郎, 他(分担執筆)
    • Publisher
      金原出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Patent(Industrial Property Rights)] Noc2ノックアウトマウス2004

    • Inventor(s)
      清野進, 三木隆司, 岩永俊彦, 松本正成
    • Industrial Property Rights Holder
      京都大学, 日本ケミカルリサーチ
    • Industrial Property Number
      2004-110374
    • Filing Date
      2004-04-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Patent(Industrial Property Rights)] インスリン分泌細胞の誘導2004

    • Inventor(s)
      清野 進, 南幸太郎, 奥野正顕, 宮脇一真
    • Industrial Property Rights Holder
      京都大学, 日本ケミカルリサーチ
    • Industrial Property Number
      2004-165367
    • Filing Date
      2004-06-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 遺伝子改変動物の新規用途2004

    • Inventor(s)
      清野 進, 三木隆司, 尾山和信
    • Industrial Property Rights Holder
      神戸大学, 武田薬品工業株式会社
    • Industrial Property Number
      2004-313063
    • Filing Date
      2004-10-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 遺伝子改変動物の新規用途2004

    • Inventor(s)
      清野 進
    • Industrial Property Rights Holder
      神戸大学
    • Industrial Property Number
      2004-313063
    • Filing Date
      2004-10-27
    • Related Report
      2004 Annual Research Report
  • [Publications] Suzuki, et al.: "Cardioprotective effect of diazoxide is mediated by activation of sarcolemmal but not mitochondrial ATP-sensitive potassium channels in mice"Circulation. 107. 682-685 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Gunima, et al.: "Knockout of Kir6.2 negates ischemia preconditioning-induced protection of myocardial energetics"Am.J.Physiol.Heart Circ.Physiol.. 284. 2106-2113 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Gong, et al.: "KATP channels depress force by reducing action potential amplitude in mouse EDL and soleus muscle"Am.J.Physiol.Cell Physiol.. 285. 1464-1474 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Minami, et al.: "ATP sensitive K+ channe-mediated glucose uptake is independent of IRS-1/phosphatidylinositol 3-kinase signaling"Am.J.Physiol.Endocrinol.Metab.. 285. 1289-1296 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Seino, et al.: "Gene targeting approach to clarification ion channel function : studies of Kir6.x null mice"J.Physiol.. 554. 295-300 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kosoy, et al.: "Polymorphic variation in the CBLB gene in human type 1 diabetes"Genes and Immunity. (In press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 南 幸太郎ら: "分子糖尿病学の進歩 基礎から応用まで"膵β細胞におけるグルコース応答性と細胞内カルシウム. 199 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2018-03-28  

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