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Downsizing studies on chemical experiments for minimization of environmental loads

Research Project

Project/Area Number 15069207
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionTokyo Metropolitan University

Principal Investigator

KORENAGA Takashi  Tokyo Metropolitan University, Faculty of Urban Liberal Arts, Professor, 理学研究科, 教授 (30124788)

Co-Investigator(Kenkyū-buntansha) OWARI Masanori  The University of Tokyo, Environmental Science Ceter, Professor, 環境安全研究センター, 教授 (70160950)
TAKEUCHI Toyohide  Gufu University, Faculty of Engineering, Professor, 工学部, 教授 (40135322)
UCHIYAMA Kazumi  Tokyo Metropolitan University, Faculty of Urban Environmental Sciences, Assoc.Professor, 工学研究科, 助教授 (40151899)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥9,200,000 (Direct Cost: ¥9,200,000)
Fiscal Year 2005: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2004: ¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 2003: ¥2,800,000 (Direct Cost: ¥2,800,000)
Keywordschemical experiment / experimental education / downsizing / glass apparatus / environmental load / exposure risk / microchip / micro reactor / 環境分析 / マイクロ化学リアクター / 環境科学 / 環境安全学 / 環境負荷低減 / 実験設備 / 環境教育
Research Abstract

Academic educational activities for decresing experimental wastes on chemical experiments in university laboratories were proper as the title of this program or the scientific research of priority area project, considering the present situations of the environmental, health and safety waste management issues. It was concluded that the research activities would give their suggestion about the new term to the project, considering "downsizing on chemical experiments" to be the key word of the research activities of the important academic research program.
Microcolumns were integrated into the micro HPLC systems to reduce hazardous organic solvents. A microchip device for monitoring of the trace gas in the air was developed. The micro device has been developed and optimized in order to measure for atmospheric nitrogen dioxide (NO_2) with high sensitivity. The detection limit was approximately 1 ppb in wind tunnel. The trace gas measurement microchip was composed of two polymethylmethacrylat … More e plates and polytetrafluoroethylene filter as absorbing area. Microchannel was fabricated by injection molding. Under optimized conditions, the microchip-device was tested measurement of NO_2. Comparison with the date generated by the conventional instrument indicated with agreements. Development of a micro reactor for organic synthesis was also carried out in this program. We developed a device for simultaneous determination of benz[a]pyrene (BaP) and benzo[k]fluoranthene (BkF) in diesel exhaust particles and clean-up microchip for pretreatment. About more than 90% of recovery of BaP and BkF in diesel exhaust particle solutions was attained by the clean-up microchip. Combining the clean-up microchip and detection device, detection time could be shortened less than one tenth compared with the conventional method. PAHs in diesel exhaust particle (DEP) were trapped into silica gel beads, which were packed into the microchip, and extracted into chloroform. Pre-treatment system with a microchip reactor was developed for eluting PAHs from DEP. These chemical experimental results with micro scale tools obtained were the same as ordinary bulk scale methods. Less

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (45 results)

All 2006 2005 2004 2003 2002 Other

All Journal Article (30 results) Book (4 results) Patent(Industrial Property Rights) (4 results) Publications (7 results)

  • [Journal Article] On-line precolumn enrichment of bisphenol A using boronate column in microcolumn liquid chromatography2006

    • Author(s)
      L.W.Lim, T.Takeuchi
    • Journal Title

      J.Chromatogr.A 1106

      Pages: 139-145

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Development and Optimization of a Lab-on-a-Chip Device for the measurement of Trace Nitrogen Dioxide Gas in the Atmosphere.2006

    • Author(s)
      Y.Takabayashi, M.Uemoto, K.Aoki, T.Odake, T.Korenaga
    • Journal Title

      Analyst 131

      Pages: 573-578

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Integration of cleanup process : pretreatment of poly cyclic aromatic hydro-carbons from diesel exhaust particles on silica gel beads in a microchannel.2006

    • Author(s)
      H.Masaki, J.Hoshi, S.Amano, Y.Sasaki, T.Korenaga
    • Journal Title

      Analytical Science 22

      Pages: 345-348

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Quantitative extraction using flowing nano-liter droplet in microfluidic2006

    • Author(s)
      M.Kumemura, T.Korenaga
    • Journal Title

      Analytica Chimica Acta 558

      Pages: 75-79

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A novel method to identify illegal diesel fuel, II : the use of 〔1-D〕 n-Alkane with stable hydrogen isotope analysis2006

    • Author(s)
      Y.Suzuki, T.Korenaga, Y.Chikaraishi
    • Journal Title

      Chemistry Letters 35

      Pages: 532-533

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Environment, Safety, and Health2006

    • Author(s)
      T.Korenaga (Editor)
    • Journal Title

      Sankyo Shuppan, Tokyo

      Pages: 1-227

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Quantitative extraction using flowing nano-liter droplet in microfluidic system2006

    • Author(s)
      M.Kumemura, T.Korenaga
    • Journal Title

      Analytica Chimica Acta 558

      Pages: 75-79

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Laser-induced fluorescence microscopic system using an optical parametric oscillator for tunable detection in microchip analysis2005

    • Author(s)
      M.Kumemura, T.Odake, T.Korenaga
    • Journal Title

      Anal.Bioanal.Chem. 382

      Pages: 992-995

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Development of a micro dual beam fluorometric detector specific for microchip analysis of benzo[a]pyrene and benzo[k]fluoranthene in diesel exhaust particulate samples2005

    • Author(s)
      H.Masaki, H.Susaki, T.Korenaga
    • Journal Title

      Analyst 130

      Pages: 1253-1257

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Fabrication of an integrated PDMS microchip incorporating and LED-induced fluorescence device2005

    • Author(s)
      K.Miyaki, Y.Guo, T.Shimosaka, T.Nakagama, H.Nakajima, K.Uchiyama
    • Journal Title

      Anal.Bioanal.Chem. 382

      Pages: 810-816

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] マイクロチャネルを用いる酵素免疫測定法によるヒト唾液中イムノグロブリンAの迅速定量2005

    • Author(s)
      中嶋秀, 増田裕紀, 吉野智美, 中釜達朗, 下坂琢哉, 荒井健介, 吉村吉博, 内山一美
    • Journal Title

      分析化学 54(9)

      Pages: 817-823

    • NAID

      110002910488

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Laser-induced fluorescence microscopic system using an optical parametric oscillator for tunable detection in microchip analysis.2005

    • Author(s)
      M.Kumemura, T.Odake, T.Korenaga
    • Journal Title

      Anal.Bioanal.Chem. 382

      Pages: 992-995

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] On-line determination of trace sulfur dioxide in air by integrated microchip coupled with fluorescence detection2005

    • Author(s)
      W.Chang, Y.Ono, M.Kumemura, T.Korenaga
    • Journal Title

      Talanta 67

      Pages: 636-650

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Development of a micro dual beam fluorometric detector specific for micro- chip analysis of benzo[a]pyrene and benzo[k]fluoranthene in diesel exhaust particulate samples2005

    • Author(s)
      H.Masaki, H.Susaki, T.Korenaga
    • Journal Title

      Analyst 130

      Pages: 1253-1257

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Rapid determination of Immunoglobulin A in human saliva by enzyme- Linked immunosorbent assay on a micro channel chip.2005

    • Author(s)
      H.Nakajima, H.Masuda, S.Ishino, T.Nakagama, T.Shimosaka, K.Arai, Y.Yoshimura, K.Uchiyama
    • Journal Title

      Analytical Chemistry 54

      Pages: 817-823

    • NAID

      110002910488

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] An integrated microfluidic device in polyester for electrophoretic analysis of amino acids.2005

    • Author(s)
      Y.Guo, K.Uchiyama, T.Nakagama, T.Shimosaka, T.Hobo
    • Journal Title

      Electrophoresis 26

      Pages: 1843-1848

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 環境汚染物のリアルタイムナノ計測2005

    • Author(s)
      伊永 隆史
    • Journal Title

      ぶんせき 10

      Pages: 551-557

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 大学における有機合成化学実験に対応したセパラブル・タイプのガラス製マイクロスケール実験用器具の開発2004

    • Author(s)
      金 朋央, 東條洋介, 坂本哲夫, 尾張真則
    • Journal Title

      化学と教育 52(3)

      Pages: 172-173

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Fnbrication of an integrated PDMS microchip incorporating and LED- Induced fluorescence device.2004

    • Author(s)
      K.Miyaki, Y.Guo, T.Shimosaka, T.Nakagama, H.Nakajima, K.Uchiyama
    • Journal Title

      Anal.Bioanal.Chem. 382

      Pages: 2005-2005

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Development of a separable-type of micro-scale glassware optimized for microscale chemical experiments in university laboratories.2004

    • Author(s)
      B.Kim, Y.Tojo, T.Sakamoto, M.Owari
    • Journal Title

      Chemical Education 52

      Pages: 172-173

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Separation of benzene and deuterated benzenes by reversed-phase and recycle liquid chromatography using monolithic capillary columns2004

    • Author(s)
      L.W.Lim, H.Uzu, T.Takeuchi
    • Journal Title

      J.Sep.Sci. 27

      Pages: 1339-1344

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Determination of iodide in seawater and edible salt by microcolumn liquid chromatography with poly (ethylene glycol) stationary phase.2004

    • Author(s)
      L.Rong, T.Takeuchi
    • Journal Title

      J.Chromatogr.A 1042

      Pages: 131-135

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Droplets Formation from Microfluidic Device for Sampling and Measurement of Atmospheric Nitrogen Dioxide2004

    • Author(s)
      M.Kumemura, T.Korenaga
    • Journal Title

      Analyst 192・2

      Pages: 105-106

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 学術研究が産学連携ニーズから始まり社会還元の出口へ向かうとき2004

    • Author(s)
      伊永 隆史
    • Journal Title

      学術月報 57・1

      Pages: 44-48

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 小型可搬式飛行時間型質量分析計の試作と天然物・環境汚染物資測定2004

    • Author(s)
      伊永隆史, 伊藤正善, 城丸春夫
    • Journal Title

      バイオインダストリー 21(11)

      Pages: 44-52

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Synthesis and glycosidase inhibitory activity of some N-substituted 5a-carba-β-fuco-and-β-galactopyranosylamines, and selected derivatives2004

    • Author(s)
      Masayoshi Itoh, Takashi Korenaga, Seiichiro Ogawa, Shigeo Fujiedada
    • Journal Title

      Bioorganic & Medicainal Chemistry 12

      Pages: 6569-6579

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Convenient synthesis of (+)-valiolamine and (-)-1-epi-valiolamine from (-)-vibo-quercitol2004

    • Author(s)
      T.Korenaga et al.
    • Journal Title

      Organic and Biomolecular Chemistry 2

      Pages: 1-7

    • Related Report
      2004 Annual Research Report
  • [Journal Article] On-line precolumn enrichment of bisphenol A using boronate column in microcolumn liquid chromatography.2002

    • Author(s)
      L.W.Lim, T.Takeuchi
    • Journal Title

      J.Chromatogr.A 1106

      Pages: 2006-2006

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Rapid determination of bromide in seawater samples by capillary ion chromatography using monolithic silica columns modified with cetyltrimethylammonium ion

    • Author(s)
      A.Suzuki, L.W.Lim, T.Hiroi, T.Takeuchi
    • Journal Title

      Talanta (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Application of a monolithic silica capillary adsorbent for the preconcentration of airborne trichloroethylene and tetrachloroethylene

    • Author(s)
      W.Chang, T.Korenaga
    • Journal Title

      Anal.Bional.Chem. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 環境・安全・衛生-大学のアピール2006

    • Author(s)
      伊永隆史編
    • Total Pages
      227
    • Publisher
      三共出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 環境・安全・衛生-大学のアピール2006

    • Author(s)
      伊永 隆史
    • Total Pages
      227
    • Publisher
      三共出版
    • Related Report
      2005 Annual Research Report
  • [Book] マイクロ化学チップの技術と応用2004

    • Author(s)
      伊永 隆史
    • Related Report
      2004 Annual Research Report
  • [Book] 4 分析化学2004

    • Author(s)
      伊永隆史, 久米村百子
    • Publisher
      朝倉書店
    • Related Report
      2004 Annual Research Report
  • [Patent(Industrial Property Rights)] チップ、および微量分析法2005

    • Inventor(s)
      成澤 紀久也, 石井 隆弘, 篠田 正紀, 伊永 隆史, 正木 浩幸
    • Industrial Property Number
      2005-152797
    • Filing Date
      2005-05-25
    • Related Report
      2005 Annual Research Report
  • [Patent(Industrial Property Rights)] ガラス接合構造、ガラス接合構造を有する物品、およびガラス接合方法2005

    • Inventor(s)
      正木 浩幸, 伊永 隆史, 藤田 洋行, 岡田 英司, 最上 克一
    • Industrial Property Number
      2005-249757
    • Filing Date
      2005-09-02
    • Related Report
      2005 Annual Research Report
  • [Patent(Industrial Property Rights)] 試料導入マイクロデバイス2004

    • Inventor(s)
      内山 一美外3名
    • Filing Date
      2004-12-24
    • Acquisition Date
      2005-11-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] マイクロリアクター及び分析方法2003

    • Inventor(s)
      伊永 隆史外3名
    • Filing Date
      2003-07-11
    • Acquisition Date
      2005-02-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Publications] 伊永 隆史: "学術研究が産学連携ニーズから始まり社会還元の出口へ向かうとき"学術月報. 57・1. 44-48 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 伊永 隆史: "マイクロTAS接続に適したマイクロ質量分析装置の開発"日本農芸化学会誌. 77・9. 876-879 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] M.Kumemura, T.Korenaga: "Droplets Formation from Microfluidic Device for Sampling and Measurement of Atmospheric Nitrogen Dioxide"Analyst. (印刷中).

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Korenaga et al.: "Convenient Synthesis and Evaluation of Glycosidase Inhibitory Activity of α- and β- Galactose- Type Valienamines, and Some N- Alkyl Derivatives"Biomedical Chromatography. (印刷中).

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Korenaga et al.: "Convenient synthesis of (+)- valiolamine and (-)- 1- epi- valiolamine from (-)- vibo- quercitol"Organic and Biomolecular Chemistry. 2. 1-7 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] M.Helaleh, S.Ngudiwaluyo, T.Korenaga, K.Tanaka: "Development of Passive Sampler Technique for Ozone Monitoring. Estimation of Indoor and Outdoor Ozone Concentration"Talanta. 58. 649-659 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] 伊永 隆史: "マイクロ化学プロセスに適したマイクロ質量分析システム ナノバイオテクノロジーの最前線"シーエムシー出版. 439 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2018-03-28  

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