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Intelligent Computeraided Diagnosis Based on Normal Structure Recognition

Research Project

Project/Area Number 15070203
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionGifu University

Principal Investigator

FUJITA Hiroshi  Gifu University, Department of Intelligent Image Information, Division of Regeneration and Advanced Medical Sciences, Graduate School of Medicine, Professor (10124033)

Co-Investigator(Kenkyū-buntansha) HOSHI Hiroaki  Gifu University, School of Medicine, Department of Radiology, Professor (60128395)
HARA Takeshi  Gifu University, Derpartment of Intelligent Image Information, Division of Regeneration and Advanced Medical Sciences, Graduate School of Medicine, Associate Professor (10283285)
ZHOU Xiangrong  Gifu University, Department of Intelligent Image Information, Division of Regeneration and Advanced Medical Sciences, Graduate School of Medicine, Assistant Professor (00359738)
TSAI Du-yih  Niigata University, School of Health Sciences, Professor (50178464)
KANEMATSU Masayuki  Gifu University, School of Medicine, Department of Radiology, Associate Professor (40252134)
松原 友子  名古屋文理大学, 情報文化部, 助教授 (30279963)
福岡 大輔  岐阜工業高等専門学校, 助手 (60321436)
Project Period (FY) 2003 – 2006
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥56,000,000 (Direct Cost: ¥56,000,000)
Fiscal Year 2006: ¥14,000,000 (Direct Cost: ¥14,000,000)
Fiscal Year 2005: ¥14,000,000 (Direct Cost: ¥14,000,000)
Fiscal Year 2004: ¥14,000,000 (Direct Cost: ¥14,000,000)
Fiscal Year 2003: ¥14,000,000 (Direct Cost: ¥14,000,000)
KeywordsComputer-aided diagnosis(CAD) / Image, character, sound recognition / Medical technology / 情報システム / 画像,文章,音声等認識 / 医用画像処理 / 医用画像認識
Research Abstract

We proposed a new type of computer-aided diagnosis (CAD) system to detect abnormalities based on the understanding of the normal anatomy structures of the human body, and concentrated on the developments on recognizing the anatomy structures of the human body automatically. The following study results were obtained. (1) A database including a large number of CT patient cases with a high image-resolution was constructed. Moreover, all information including the CT images, CT scan parameters, patient information, diagnosis reports, and the experiment results were built in electronically, and could be retrieved by the computer easily. (2) An automated scheme was developed and applied to 332 cases of torso CT images. The experimental results showed that the anatomical structures (skin, fat under skin, muscle, bone, visceral fat, lungs field, trachea, mediastinum, diaphragm and liver, etc. ) in about 70% cases were recognized correctly. Moreover, the doctor also confirmed the developed schem … More e could recognize the lung lobar structures successfully and generate the excellent results automatically. (3) An attempt to construct a human body model was carried out. A method was proposed for generation of the likelihood images for internal organs (liver, mammary gland, and muscle) based on the density and the position features. We confirmed the generated likelihood images were useful for the automated segmentations of internal organs and the judgment of lesions. In addition, the volumes of the woman mammary gland regions were measured in each age stage, and those results were used to construct a normal model of the mammary gland region. The volumes of the mammary gland regions measured by the proposed scheme could be expected to be used for prediction of the incidence of the breast cancer (risk evaluation) by the comparison with the normal model. (4) The results of the normal anatomical structure recognition were also used in a CAD system for automated detections of hemorrhage regions in head and abdominal contrast-enhanced CT images for emergency medical care, and the efficiency was confirmed. Less

Report

(5 results)
  • 2007 Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (36 results)

All 2008 2006 2005 2004 Other

All Journal Article (24 results) (of which Peer Reviewed: 3 results) Presentation (2 results) Book (3 results) Remarks (1 results) Publications (6 results)

  • [Journal Article] Automated segmentation of mammary gland regions in non-contrast X-ray CT images2008

    • Author(s)
      X. Zhou, M. Han, T. Hara, H. Fujita, 他 6名
    • Journal Title

      Computerized Medical Imaging and Graphics 32

      Pages: 699-709

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 体幹部非造影X線CT画像における肝臓アトラスの自動生成法の提案とその肝臓自動抽出法への応用2008

    • Author(s)
      北川輝彦, 周 向栄, 原 武史, 藤田広志, 他 4名
    • Journal Title

      電子情報通信学会論文誌D J91-D (7)

      Pages: 1837-1850

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] X線CT画像からの人体の椎体海綿骨部における低骨密度領域の分布に関する研究2008

    • Author(s)
      林 達郎, 周 向栄, 陳 華岳, 原 武史, 藤田広志, 他3名
    • Journal Title

      生体医工学 46 (4)

      Pages: 451-457

    • NAID

      110006989900

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Automated segmentation of mammary gland regions in non-contrast X-ray CT images2008

    • Author(s)
      X. Zhou, M. Han, T. Hara, H. Fujita, et al
    • Journal Title

      Computerized Medical Imaging and Graphics 32

      Pages: 699-709

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Generation of a probabilistic liver atlas and its application to automated liver segmentation method in non-contrast X-ray torso CT images2008

    • Author(s)
      T. Kitagawa, X. Zhou, T. Hara, H. Fujita, et al
    • Journal Title

      The IEICE Transaction on Information and Systems J91-D(7)

      Pages: 1837-1850

    • NAID

      110007381104

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Investigation on the distribution of low bone-mineral-density locations at human vertebral trabecular bone from X-ray CT images2008

    • Author(s)
      T. Hayashi, X. Zhou, H. Chen, T. Hara, H. Fujita, et al
    • Journal Title

      Transactions of Japanese Society for Medical and Biological Engineering 46(4)

      Pages: 451-457

    • NAID

      110006989900

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Paper on the Medical Equipment Systems for 2006-20072006

    • Author(s)
      H. Fujita, et al
    • Journal Title

      Series of Monthly New Medical Care Data Book 432

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Automatic segmentation and recognition of anatomical lung structures from high-resolution chest CT images2006

    • Author(s)
      X.Zhou, T.Hayashi, T.Hara, H.Fujita, 他3名
    • Journal Title

      Computerized Medical Imaging and Graphics 30・5

      Pages: 299-313

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Constructing a probabilistic model for automated liver region segmentation using non-contrast X-ray torso CT images2006

    • Author(s)
      X.Zhou, T.Kitagawa, T.Hara, H.Fujita, 他5名
    • Journal Title

      Proc. of 9th International Conference for Medical Image Computing and Computer-Assisted Intervention 4191

      Pages: 856-863

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 単純X線CT画像における肝臓血管の自動抽出法の初期検討2006

    • Author(s)
      川尻 傑, 周 向栄, 張 学軍, 原 武史, 藤田広志, 他4名
    • Journal Title

      医用画像情報学会雑誌 23・5

      Pages: 141-144

    • NAID

      130000097695

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Detectability improvement of early sign of acute stroke on brain CT images using an adaptive partial smoothing filter2006

    • Author(s)
      Y.Lee, N.Takahashi, D.-Y.Tsai, H.Fujita
    • Journal Title

      Proc. of SPIE Medical Imaging 2006 6144

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Automated identification of diaphragm in non-contrast torso CT images and its application to computer-aided diagnosis systems2006

    • Author(s)
      X.Zhou, H.Ninomiya, T.Hara, H.Fujita, 他4名
    • Journal Title

      International Journal of Computer Assisted Radiology and Surgery 1

      Pages: 366-367

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 胸部骨格情報を利用した3次元体幹部マルチスライスCT画像からの胸郭の抽出2005

    • Author(s)
      周 向栄, 小林晋士, 原 武史, 他
    • Journal Title

      電子情報通信学会論文誌D-II J88-D-II・9

      Pages: 1999-2002

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Evaluation of osteoporosis in X-ray CT examination : A preliminary study for an automatic recognition algorithm for the central part of a vertebral body using abdominal X-ray CT images2005

    • Author(s)
      S.Nishihara, H.Fujita, T.Iida, et al.
    • Journal Title

      Computerized Medical Imaging and Graphics 29・4

      Pages: 259-266

    • Related Report
      2005 Annual Research Report
  • [Journal Article] アトラスに基づく体幹部マルチスライスCT画像からの胸部骨格の構造認識2005

    • Author(s)
      周 向栄, 小林晋士, 原 武史, 他
    • Journal Title

      医用画像情報学会雑誌 22・3

      Pages: 220-228

    • NAID

      130000097728

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Preliminary study for automated recognition of anatomical structure from torso CT images2005

    • Author(s)
      X.Zhou, T.Hara, H.Fujita, et al.
    • Journal Title

      Proc.of the 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference

    • Related Report
      2005 Annual Research Report
  • [Journal Article] X線CT画像における体幹部の展開と解剖学的構造の自動認識への応用2005

    • Author(s)
      神谷直希, 周 向栄, 原 武史, 他
    • Journal Title

      電子情報通信学会技術研究報告 MI2005-59

      Pages: 51-56

    • NAID

      110004018429

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 非造影体幹部X線CT像における気道の走行方向の統計的なモデルの構築2005

    • Author(s)
      林 達郎, 周 向栄, 原 武史, 他
    • Journal Title

      電子情報通信学会技術研究報告 MI2005-59

      Pages: 57-62

    • NAID

      110004018430

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Evaluation of osteoporosis in X-ray CT examination : A preliminary study for an automatic recognition algorithm for the central part of a vertebral body using abdominal X-ray CT images2005

    • Author(s)
      S.Nishihara, H.Fujita, T.Iida, et al.
    • Journal Title

      Computerized Medical Imaging and Graphics 29(in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 頭部CTA画像における脳血管領域の自動抽出の試み2004

    • Author(s)
      猪又聖美, 李 鎔範, 藤田広志, 他
    • Journal Title

      日本放射線技術学会雑誌 60・9

      Pages: 1325-1331

    • NAID

      110003461661

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Automatic segmentation of hepatic tissue and 3D volume analysis of cirrhosis in multi-detector row CT scans and MR imaging2004

    • Author(s)
      X.Zhang, W.Li, H.Fujita, et al.
    • Journal Title

      IEICE Trans.Inf.& Syst. E87-D・8

      Pages: 2138-2147

    • NAID

      110003214106

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Improvement in automated detection of pulmonary nodules on helical x-ray CT images2004

    • Author(s)
      Y.Lee, D.Y.Tsai, H.Fujita, et al.
    • Journal Title

      Proc.SPIE, Medical Imaging 2004 5370

      Pages: 824-832

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Automated recognition of human structure from torso CT images2004

    • Author(s)
      X Zhou, N Kamiya, H Fujita, et al.
    • Journal Title

      Proc.the Fourth IASTED International Conference Visualization, Imaging, and Image Processing

      Pages: 584-589

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Automated detection system for pulmonary emphysema on 3D chest CT images2004

    • Author(s)
      T.Hara, A.Yamamoto, H.Fujita, et al.
    • Journal Title

      Proc.SPIE, Medical Imaging 2004 5370

      Pages: 915-919

    • Related Report
      2004 Annual Research Report
  • [Presentation] Constructing a probabilistic model for automated liver region segmentation using non-contrast X-ray torso CT images2006

    • Author(s)
      X. Zhou, T. Kitagawa, T. Hara, H. Fujita, 他 5名
    • Organizer
      International Conference for Medical Image Computing and Computer・Assisted Intervention ・ MICCAI 2006
    • Place of Presentation
      Copenhagen, Denmark
    • Year and Date
      2006-10-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Constructing aprobabilistic model for automated liver region segmentation using non-contrast X-ray torso CT images2006

    • Author(s)
      X. Zhou, T. Kitagawa, T. Hara, H. Fujita, et al
    • Organizer
      International Conference for Medical Image Computing and Computer-Assisted Intervention - MICCAI 2006
    • Place of Presentation
      Copenhagen, Denmark.
    • Year and Date
      2006-10-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 医療機器システム白書2006〜2007, 月刊新医療データブック・シリーズ(分担)2006

    • Author(s)
      藤田広志
    • Total Pages
      432
    • Publisher
      株)エム・イー振興協会
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 医療機器システム白書2006~2007,月刊新医療データブック・シリーズ(分担)2006

    • Author(s)
      藤田広志
    • Total Pages
      432
    • Publisher
      (株)エム・イー振興協会
    • Related Report
      2006 Annual Research Report
  • [Book] 医用画像工学(第2版)2004

    • Author(s)
      岡部哲夫, 藤田広志(編著)
    • Total Pages
      332
    • Publisher
      医歯薬出版(株)
    • Related Report
      2004 Annual Research Report
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.fjt.info.gifu-u.ac.jp/publication/index.html

    • Related Report
      2007 Final Research Report Summary
  • [Publications] 西原貞光, 藤田広志, 飯田忠行, 滝川厚, 原 武史: "腹部X線CT画像を利用した骨粗鬆症のコンピュータ支援診断-計測領域の自動抽出およびCT特徴量とBMD値の比較に対する試み-"生体医工学. (in press).

    • Related Report
      2003 Annual Research Report
  • [Publications] 久山慶子, 福岡大輔, 原 武史, 小倉敏裕, 藤田広志: "複素自己回帰モデルによる凹領域認識を用いた大腸ポリープ像の自動検出"医用画像情報学会雑誌. 21・1. 137-142 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 林 達郎, 周 向栄, 原 武史, 藤田広志, 横山龍二郎, 桐生拓司, 星 博昭: "気管支情報を用いた胸部マルチスライスCT画像における肺野区間の分類"電子情報通信学会論文誌D-II. J87-D-II-1. 357-360 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 村田信之, 周 向栄, 原 武史, 藤田広志, 横山龍二郎, 桐生拓司, 星 博昭: "体幹部マルチスライスCT画像による横隔膜の自動抽出に関する研究"電子情報通信学会技術研究報告. 103(599). 109-113 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 山本 章, 原 武史, 周 向栄, 岩野信吾, 伊藤茂樹, 藤田広志, 石垣武男: "胸部X線CT像における肺気腫の病勢定量化手法"電子情報通信学会技術研究報告. 103(599). 115-120 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 岡部哲夫, 藤田広志(編著): "医用画像工学(改訂版)"医歯薬出版(株)(印刷中). 300 (2004)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2018-03-28  

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