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Molecular and cellular characteristics of brown

Research Project

Project/Area Number 15081201
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionHokkaido University

Principal Investigator

SAITO Masayuki  Hokkaido University, Professor Emeritus (80036441)

Co-Investigator(Kenkyū-buntansha) KIMURA Kazuhiro  Hokkaido University, Graduate School of Veterinary Medicine, Professor (30192561)
Project Period (FY) 2003 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥76,800,000 (Direct Cost: ¥76,800,000)
Fiscal Year 2007: ¥14,400,000 (Direct Cost: ¥14,400,000)
Fiscal Year 2006: ¥14,400,000 (Direct Cost: ¥14,400,000)
Fiscal Year 2005: ¥16,000,000 (Direct Cost: ¥16,000,000)
Fiscal Year 2004: ¥16,000,000 (Direct Cost: ¥16,000,000)
Fiscal Year 2003: ¥16,000,000 (Direct Cost: ¥16,000,000)
Keywordsbrown adipose tissue / β-adrenoceptor / leptin / UCP1 / white fat / thermogenesis / obesity / sympathetic nerve / 体脂肪 / FDG-PET / 寒冷刺激 / 脱共役蛋白質 / 褐色脂肪細胞 / 白色脂肪細胞 / UCP / エネルギー消費 / 遺伝子
Research Abstract

We have studied the role of brown adipose tissue (BAT) thermogenesis in the regulation of energy substrate metabolism and adiposity in mice and dogs, particularly focusing on the sympathetic nerve regulation of UCP1, a key molecule of BAT thermogenesis.
1. Treatment with an agonist for β3-adrenoceptor, which is present in adipocytes, increased BAT thermogenesis, lipid mobilization and whole body energy expenditure without notable effects on food intake, finally resulting in a marked reduction of white fat weight and the size of adipocytes in wild-type (WT), but not in UCP1-knockout, mice. Similar thermogenic and anti-obesity effects were also found when mice were treated with leptin, a major endogenous anorectic signal molecule.
2. The effects of β3-adrenergic stimulation were also examined in dogs. Daily treatment of obese beagle dogs with a β3-adrenoceptor agonist resulted in a marked reduction of body fat content estimated by CT, and apparent UCP1 expression in subcutaneous adipose ti … More ssue.
All these results indicate a significant role of UCP1-dependent BAT thermogenesis in the anti-obesity effect of β3-adrenoceptor agonists and leptin, and in the regulation of energy balance.
3. The thermogenesis-linked glucose utilization in BAT was studied particularly focusing on the role of UCP1. Noradrenaline (NA) increased tissue AMP levels, 5'-AMP-activated protein kinase activity, and 2-deoxyglucose (2-DG) uptake into BAT in WT mice, while these stimulatory effects of NA were much attenuated in UCP1-KO mice. Thus, the sympathetically stimulated glucose utilization in BAT is due to the serial activation of UCP1 and AMP-kinase, and thereby reflects the BAT activity in vivo.
4. Glucose utilization into adipose tissue was also examined monitoring tissue fluoro-deoxyglucose uptake by positron emission tomography in healthy adult volunteers, and found to be enhanced after cold exposure and lower in obese than lean subjects. These findings, being against a well-accepted idea that BAT is absent in adult humans, suggest a significant role of BAT in energy metabolism in man, as in the mouse and dog. Less

Report

(6 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (84 results)

All 2007 2006 2005 2004 2003 Other

All Journal Article (57 results) (of which Peer Reviewed: 22 results) Presentation (21 results) Publications (6 results)

  • [Journal Article] Brown fat UCP1 is not involved in the febrile and thermogenic responses to IL-1beta in mice.2007

    • Author(s)
      Y. Okamatsu-Ogura, N. Kitao, K. Kimura, M. Saito, M. Saito
    • Journal Title

      Am. J. Physiol. 292

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Dmbx1 is essential in agouti-related protein action.2007

    • Author(s)
      W. Fujimoto, T. Shiuchi, T. Miki, Y. Minokoshi, Y. Takahashi, A. Takeuchi, K. Kimura, M. Saito, T. Iwanaga, S. Seino
    • Journal Title

      Proc. Natl. Acad. Sci. USA 104

      Pages: 15514-15519

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The effects of obesity-associated insulin resistance on mRNA expression of peroxisome proliferator-activated receptor-gamma target genes, in dogs.2007

    • Author(s)
      C. Gayet, V. Leray, M. Saito. B. Siliart, P. Nguyen
    • Journal Title

      Br. J. Nutr. 98

      Pages: 498-503

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Day-night difference in b3-adrenoceptor agonist-induced energy expenditure : Contribution of brown fat thermogenesis and physical activity.2007

    • Author(s)
      Y. Okamatsu-Ogura, A. Uozumi, N. Kitao, K. Kimura, M. Saito
    • Journal Title

      Obes. Res. Clin. Prac. 1

      Pages: 61-67

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Uncoupling protein 1 contributes to fat-reducing effect of leptin.2007

    • Author(s)
      Y. Okamatsu-Ogura, A. Uozumi, C. Toda, K. Kimura. H. Yamashita, M. Saito
    • Journal Title

      Obes. Res. Clin. Prac. 1

      Pages: 233-241

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Plasma leptin concentration in dogs : Effects of body condition score, age, gender and breeds.2007

    • Author(s)
      K. Ishioka, K. Hosoya, H. Kitagawa, H. Shibata, T. Honjoh, K. Kimura, M. Saito
    • Journal Title

      Res. Vet. Sci. 82

      Pages: 11-15

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Beta3-adrenoceptor agonist AJ-9677 reduces body fat in obese beagles.2007

    • Author(s)
      A. Omachi, K. Ishioka, A. Uozumi, A. Kamikawa, C. Toda, K. Kimura, M. Saito
    • Journal Title

      Res. Vet. Sci. 83

      Pages: 5-11

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Brown fat UCP1 is not involved in the febrile and thermogenic responses to IL-1b in mice2007

    • Author(s)
      Okamatsu-Ogura Y, Kitao N, Kimura K, Saito M.
    • Journal Title

      Am. J. Physiol. 292

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Dmbxl is essential in agouti-related protein action2007

    • Author(s)
      Fujimoto W, Shiuchi T, Miki T, Minokoshi Y, Takahashi Y, Takeuchi A, Kimura K, Saito M., Iwanaga T, Seino S.
    • Journal Title

      Proc. Natl. Acad. Sci. USA 104

      Pages: 15514-15519

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The effects of obesity-associated insulin resistance on mRNA expression of peroxisome proliferators-activated receptor-gamma target genes in dogs.2007

    • Author(s)
      Gayet C, Leray V, Saito M, Siliart B, Nguyen P.
    • Journal Title

      Br. J. Nutr. 98

      Pages: 498-503

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Day-night difference in b3-adrenoceptor agonist-induced energy expenditure : Contribution of brown fat thermogenesis and physical activity.2007

    • Author(s)
      Okamatsu-Ogura Y, Uozumi A, Kitao N, Kimura K, Saito M.
    • Journal Title

      Obes. Res. Clin. Prac. 1

      Pages: 61-67

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Uncoupling protein 1 contributes to fat-reducing effect of leptin2007

    • Author(s)
      Okamatsu-Ogura Y, Uozumi A, Toda C, Kimura K, Yamashita H, Saito M.
    • Journal Title

      Obes. Res. Clin. Prac. 1

      Pages: 233-241

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Plasma leptin concentration in dogs : Effects of body condition score, Age, gender and breeds2007

    • Author(s)
      Ishioka K, Hosoya K, Kitagawa H, Shitaba H, Honjoh T, Kimura K, Saito M.
    • Journal Title

      Res. Vet. Sci. 82

      Pages: 11-15

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Beta3-adrenoceptor agonist AJ-9677 reduces body fat in obese beagles2007

    • Author(s)
      Omachi A, Ishioka K, Uozumi A, Kamikawa A, Toda C, Kimura K, Saito M.
    • Journal Title

      Res. Vet. Sci. 83

      Pages: 5-11

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Brown fat UCP1 is not involved in the febrile and thermogenic responses to IL-1beta in mice2007

    • Author(s)
      Y. Okamatsu-Ogura, N. Kitao, K. Kimura, M. Saito, M. saito
    • Journal Title

      Am. J. Physiol. Endocrinol. Metab. 292

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dmbxl is essential in agouti-related protein action2007

    • Author(s)
      W. Fujimoto, T. Shiuchi, T. Miki, Y. Minokoshi, Y. Takahashi, A. Takeuchi, K. Kimura, M. Saito, T. Iwanaga, S. Seino
    • Journal Title

      Proc. Natl. Acad. Sci. USA 104

      Pages: 15514-15519

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of obesity-associated insulin resistance on mRNA expression of peroxisome proliferator-activated receptor-gamma target genes, in dogs.2007

    • Author(s)
      C. Gayet, V. Leray, M. Saito, B. Siliart, P. Nguyen
    • Journal Title

      Br. J. Nutr. 98

      Pages: 498-503

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Indispensable role of mitochondrial uncoupling protein 1 (UCP1)for anti-obesity effect of b3-adrenergic stimulation.2006

    • Author(s)
      K. Inokuma, Y. Okamatsu-Ogura, A. Omachi, Y. Matsushita, K. Kimura, H. Yamashita, M. Saito
    • Journal Title

      Am. J. Physiol. 290

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Potential contribution of vasoconstriction to suppression of heat loss and homeothermic regulation in UCP1-deficient mice.2006

    • Author(s)
      Y. Wang, K. Kimura, K. Inokuma, M. Saito, Y. Kontani, Y. Kobayashi, N. Mori, H. Yamashita
    • Journal Title

      Pflug. Arch. Eur. J. Physiol. 452

      Pages: 363-369

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effects of administration of glucocorticoids and feeding status on plasma leptin concentrations in dogs.2006

    • Author(s)
      N. Nishii, M. Takasu, Y. Ohba, S. Maeda, K. Kitoh, Y. Ohtsuka, T. Honjo, M. Saito, H. Kitagawa
    • Journal Title

      Am. J. Vet. Res. 67

      Pages: 266-270

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Postprandial changes in leptin concentrations of cerebrospinal fluid in dogs during development of obesity.2006

    • Author(s)
      N. Nishii, H. Nodake, M. Takasu, O Soe, Y. Ohba, S. Maeda, Y. Ohtsuka, T. Honjo, M. Saito, H. Kitagawa
    • Journal Title

      Am. J. Vet. Res. 67

      Pages: 2006-2011

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Indispensable role of mitochondrial uncoupling protein 1 (UCP1) for anti-obesity effect of β3-adrenergic stimulation2006

    • Author(s)
      Inokuma K, Okamatsu-Ogura Y, Omachi A, Matsushita Y, Kimura K, Yamashita H, Saito M.
    • Journal Title

      Am. J. Physiol. 290

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Potential contribution of vasoconstriction to suppression of heat loss and homeothermic regulation in UCP1-deficient mice2006

    • Author(s)
      Wang Y, Kimura K, Inokuma K, Saito M, Kontani Y, Kobayashi Y, Mori N, Yamashita H.
    • Journal Title

      Pflug. Arch. Eur. J. Physiol. 452

      Pages: 363-369

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effects of administration of glucocorticoids and feeding status on plasma leptin concentrations in dogs2006

    • Author(s)
      Nishii N, Takasu M, Ohba Y, Maeda S, Kitoh K, Ohtsuka Y, Honjo T, Saito M, Kitagawa H.
    • Journal Title

      Am. J. Vet. Res. 67

      Pages: 266-270

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Postprandial changes in leptin concentrations of cerebrospinal fluid in dogs during development of obesity2006

    • Author(s)
      Nishii N, Nodake H, Takasu M, Soe O, Ohba Y, Maeda S, Ohtsuka Y, Honjo T, Saito M, Kitagawa H.
    • Journal Title

      Am. J. Vet. Res. 67

      Pages: 2006-2011

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Indispensable role of mitochondrial uncoupling protein 1 (UCP1) for anti-obesity effect of b3-adrenergic stimulation2006

    • Author(s)
      K.Inokuma, Y.Okamatsu-Ogura, A.Omachi, Y.Matsushita, K.Kimura, H.Yamashita, M.Saito
    • Journal Title

      Am. J. Physiol. Endocrinol. Metab. 290

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Potential contribution of vasoconstriction to suppression of heat loss and homeothermic regulation in UCP1-deficient mice2006

    • Author(s)
      Y.Wang, K.Kimura, K.Inokuma, M.Saito, Y.Kontani, Y.Kobayashi, N.Mori, H.Yamashita
    • Journal Title

      Pflug. Arch. Eur. J. Physiol. 452

      Pages: 363-369

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Canine adiponectin : cDNA structure, mRNA expression in adipose tissues and reduced plasma levels in obesity.2006

    • Author(s)
      K.Ishioka, A.Omachi, M.Sagawa, H.Shibata, T.Honjoh, K.Kimura, M.Saito
    • Journal Title

      Res. Vet. Sci. 80

      Pages: 127-132

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effects of administration of glucocorticoids and feeding status on plasma leptin concentrations in dogs.2006

    • Author(s)
      N.Nishii, M.Takasu, Y.Ohba, S.Maeda, K.Kitoh, Y.Ohtsuka, T.Honjo, M.Saito, H.kitagawa
    • Journal Title

      Am. J. Vet. Res. 67

      Pages: 266-270

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Postprandial changes in leptin concentrations of cerebrospinal fluid in dogs during development of obesity.2006

    • Author(s)
      N.Nishii, H.Nodake, M.Takasu, O Soe, Y.Ohba, S.Maeda, Y.Ohtsuka, T.Honjo, M.Saito, H.Kitagawa
    • Journal Title

      Am. J. Vet. Res. 67

      Pages: 2006-2011

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Uncoupling protein 1 is necessary for norepinephrine-induced glucose utilization in brown adipose tissue.2005

    • Author(s)
      K. Inokuma, Y. Ogura -Okamatsu, C. Toda, K. Kimura, H. Yamashita, M. Saito
    • Journal Title

      Diabetes 54

      Pages: 1385-1391

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] UCP1 deficiency increases susceptibility to diet-induced obesity with age.2005

    • Author(s)
      Y. Kontani, Y. Wang, K. Kimura, K. Inokuma, M. Saito, T. Suzuki-Miura, Z. Wang, Y. Sato, N. Mori, H. Yamashita
    • Journal Title

      Aging Cell 4

      Pages: 147-155

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Portal 5-hydroxytryptophan infusion enhances glucose disposal in conscious dogs.2005

    • Author(s)
      M. C. Moore, M. Shiota, K. Kimura, H. Shibata, T. Honjoh, M. Saito, C. A. Everett, M. S. Smith, A. D. Cherrington
    • Journal Title

      Am. J. Physiol. 289

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Leptin resistance extends to the coronary vasculature in prediabetic dogs and provides a protective adaptation against endothelial dysfunction.2005

    • Author(s)
      J. D. Knudson, U. D. Dincer, G. M. Dick, H. Shibata, R. Akahane, M. Saito, J. D. Tune
    • Journal Title

      Am. J. Physiol. 289

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Uncoupling protein 1 is necessary for norepinephrine-induced glucose utilization in brown adipose tissue2005

    • Author(s)
      Inokuma K, Okamatsu-Ogura Y, Toda C, Kimura K, Yamashita H, Saito M
    • Journal Title

      Diabetes 54

      Pages: 1385-1391

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] UCP1 deficiency increases susceptibility to diet-induced obesity with age.2005

    • Author(s)
      Kontani Y, Wang Y, Kimura K, Inokuma K, Saito M, Suzuki-Miura T, Wang Z, Sato Y, Mori N, Yamashita H.
    • Journal Title

      Ageing Cell 4

      Pages: 147-155

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Portal 5-hydroxytryptophan infusion enhances glucose disposal in conscious dogs2005

    • Author(s)
      Moore MC, Shiota M, Kimura K, Shibata H, Honjoh T, Saito M, Everett CA, Smith MS, Cherrington AD.
    • Journal Title

      Am. J. Physiol. 289

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Leptin resistance extends to the coronary vasculature in prediabetic dogs and provides a protective adaptation against endothelial dysfunction2005

    • Author(s)
      Knudson JD, Dincer UD, Dick GM, Shibata H, Akahane A, Saito M, Tune JD.
    • Journal Title

      Am. J. Physiol. 289

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Uncoupling protein 1 is necessary for norepinephrine-induced glucose utilization in brown adipose tissue.2005

    • Author(s)
      K.Inokuma, Y.Ogura-Kawatsu, C.Toda, K.Kimura, H.Yamashita, M.Saito
    • Journal Title

      Diabetes 54

      Pages: 1385-1391

    • Related Report
      2005 Annual Research Report
  • [Journal Article] UCP1 deficiency increases susceptibility to diet-induced obesity with age.2005

    • Author(s)
      Y.Kontani, Y.Wang, K.Kimura, K.Inokuma, M.Saito, T.Suzuki, Z.Wang, Y.Sato, N.Mori, H.Yamashita
    • Journal Title

      Aging Cell 4

      Pages: 147-155

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Portal 5-hydroxytryptophaninfusion enhances glucose disposal in conscious dogs.2005

    • Author(s)
      M.C.Moore, K.Kimura, H.Shibata, T.Honjoh, M.Saito, C.A.Everett, M.S.Smith, A.D.Cherrington
    • Journal Title

      Am.J.Physiol. 289

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Leptin resistance extends to the coronary vasculature in prediabetic dogs and provides a protective adaptation against endothelial dysfunction.2005

    • Author(s)
      J.D.Knudson, U.D.Dincer, G.M.Dick, H.Shibata, R.Akahane, M.Saito, J.D.Tune
    • Journal Title

      Am.J.Physiol. 289

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Canine adiponectin : cDNA structure, mRNA expression in adipose tissues and reduced plasma levels in obesity.2005

    • Author(s)
      K.Ishioka, A.Omachi, M.Sagawa, H.Shibata, T.Honjoh, K.Kimura, M.Saito
    • Journal Title

      Res.Vet.Sci 80

      Pages: 127-132

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effects of chronic obesity and weight loss on plasma ghrelin and leptin concentrations in dogs.2005

    • Author(s)
      I.C.Jeusette, J.Detilleux, H.Shibata, M.Saito, T.Honjoh, A.Delobel, L.Istasse, M.Diez
    • Journal Title

      Res.Vet.Sci. 79

      Pages: 169-175

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Computed tomographic assessment of body fat in beagles2005

    • Author(s)
      Ishioka K
    • Journal Title

      Vet.Raiol.Ultrasound 46(In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Diurnal variations of serum leptin in dogs : effects of fasting and re-feeding2005

    • Author(s)
      Ishioka K
    • Journal Title

      Vet.J. 169(In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Conjugated linoleic acid deteriorates insulin resistance in obese/diabetic mice in association with decreased production of adiponectin and leptin.2004

    • Author(s)
      A. Ohashi, Y. Matsushita, H. Shibata, K. Kimura, K. Miyashita, M. Saito
    • Journal Title

      J. Nutr. Sci. Vitaminol. 50

      Pages: 416-421

    • NAID

      110002704024

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Hepatocyte growth factor/scatter factor suppresses TNFa-induced E-selectin expression in human umbilical vein endothelial cells.2004

    • Author(s)
      K. Makondo, K. Kimura, T. Kitamura, D. Yamaji, B. D. Jung, H. Shibata, M Saito
    • Journal Title

      Biochim. Biophys. Acta 1644

      Pages: 9-15

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Conjugated linoleic acid deteriorates inuslin resistance in obese/diabetic mice in association with decreased production of adiponectin and leptin2004

    • Author(s)
      Ohashi A, Matsushita Y, Shibata H, Kimura K, Miyashita K, Saito M.
    • Journal Title

      J. Nutr. Sci. Vitaminol. 50

      Pages: 416-421

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Hepatocyte growth factor/scatter factor suppresses TNF-a-induced E-selectin expression in human umbilical vein endothelial cells2004

    • Author(s)
      Makondo K, Kimura K, Kitamura T, Yamaji D, Jung BD, Shibata H, Saito M.
    • Journal Title

      Biochim. Biophys. Acta 1644

      Pages: 9-15

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cloning of bovine MAIL and its mRNA expression in white blood cells of Holstein cows2004

    • Author(s)
      Yamaji D
    • Journal Title

      Vet.Immunol.Immunopath. 98

      Pages: 175-184

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Conjugated linoleic acid deteriorates insulin resistance in obese/diabetic mice in association with decreased production of adiponectin and leptin.2004

    • Author(s)
      Ohashi A
    • Journal Title

      J.Nutr.Sci.Vitaminol. 50(In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 脱共役蛋白質(UCP)によるエネルギー消費調節メカニズムとその意義2004

    • Author(s)
      猪熊健一
    • Journal Title

      現代医療 36

      Pages: 1815-1820

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Hepatocyte growth factor activates endothelial nitric oxide synthase by Ca2+ and phosphoin ositede 3-kinase/Akt-dependent phosphorylation in aortic endothelial cells.2003

    • Author(s)
      K. Makondo, K. Kimura, N. Kitamura, T. Kitamura, D. Yamaji, B. D. Jung, M. Saito
    • Journal Title

      Biochem. J. 374

      Pages: 63-69

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Proinsulin C-peptide increases nitric oxide production by enhancing mitogen-activated protein-kinase-depentent transcription of endothelial nitric oxide synthase in aortic endothelial cells of wistar rats.2003

    • Author(s)
      T. Kitamura, K. Kimura, K. Makondo, D. T. Furuya, M. Suzuki, T. Yoshida, M Saito
    • Journal Title

      Diabetologia. 46

      Pages: 1698-1705

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Hepatocyte growth factor activates endothelial nitric oxide synthase by Ca2+- and phosphoinositide 3-kinase/Akt-dependent phosphorylation in aortic endothelial cells2003

    • Author(s)
      Makondo K, Kimura K, Kitamura N, Kitamura T, Yamaji D, Jung BD, Saito M.
    • Journal Title

      Biochem. J. 374

      Pages: 63-69

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Proinsulin C-peptide increases nitric oxide production by enhancing mitogen-activated protein-kinase-dependent transcription of endothelial nitric oxide synthase in aortic endothelial cells of Wistar rats2003

    • Author(s)
      Kitamura T, Kimura K, Makondo K, Furuya DT, Suzuki M, Yoshida T, Saito M.
    • Journal Title

      Diabetologia 46

      Pages: 1698-1705

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Human brown adipose tissue evaluated by FDG-PET : activation by cold exposure.2007

    • Author(s)
      M. Saito, Y. Okamatsu-Ogura, M. Tsujisaki, T. Kaji, K. Nakada
    • Organizer
      15^<th> European Congress of Obesity
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      2007-04-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Minor role of brown fat thermogenesis in IL-1beta-induced fever.2007

    • Author(s)
      Y. Okamatsu-Ogura, N. Kitao, K. Kimura, M. Saito
    • Organizer
      15^<th> European Congress of Obesity
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      2007-04-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Human brown adipose tissue evaluated by FDG-PET : activation by cold exposure2007

    • Author(s)
      Saito M, Okamatsu-Ogura Y, Tsujisaki M, Kaji T, Nakada K.
    • Organizer
      15th European Congress of Obesity
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      2007-04-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Minor role of brown fat thermogenesis in IL-1beta-induced fever2007

    • Author(s)
      Okamatsu-Ogura Y, Kitao N, Kimura K, Saito M.
    • Organizer
      15th European Congress of Obesity
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      2007-04-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Human brown adipose tissue evaluated by FDG-PET: activation by cold exposure.2007

    • Author(s)
      M. Saito, Y. Okamatsu-Ogura, M. Tsujisaki, T. Kaji and, K. Nakada
    • Organizer
      15th European Congress of Obesity
    • Place of Presentation
      Budapest Sports Arena Budapest, Hungary
    • Year and Date
      2007-04-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] Higher thermogenic activities of β-adrenergically induced UCP1 in white adipose tissue.2006

    • Author(s)
      M. Saito. A. Omachi, Y. Okamatsu-Ogura, Y. Matasushita
    • Organizer
      10^<th> International Congress of Obesity
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2006-09-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Role of adipocytes in the regulation of morphogenic diffentiation of bovine mammary epithelial cells.2006

    • Author(s)
      D. Yamaji, K. Kimura, MM. Soliman, M. Saito
    • Organizer
      10^<th> International Congress of Obesity
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2006-09-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Minor contribution of energy exprenditure and UCP1 in the fat-reducing effect of leptin.2006

    • Author(s)
      Y. Okamatsu-Ogura, A. Uozumi, K. Kimura, M. Saito
    • Organizer
      10^<th> International Congress of Obesity
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2006-09-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Higher thermogenic activities of β-adrenergically induced UCP1 in white adipose tissue2006

    • Author(s)
      Saito M, Omachi A, Okamatsu-Ogura Y, Matsushita Y.
    • Organizer
      10th International Congress of Obesity
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2006-09-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Contributio of energy exprenditure and UCP1 in the fat-reducing effect of leptin2006

    • Author(s)
      Okamatsu-Ogura Y, Uozumi A, Kimura K, Saito M. Minor
    • Organizer
      10th International Congress of Obesity
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2006-09-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Role of adipocytes in the regulation of morphogenic differentiation of bovine mammary epithelial cells2006

    • Author(s)
      Yamaji D, Kimura K, Soliman MM, Saito M.
    • Organizer
      10th International Congress of Obesity
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2006-09-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Noradrenaline stimulates glucose uptake in brown adipose tisue through the activation of UCP1 and AMP kinase.2005

    • Author(s)
      M. Saito, K. Inokuma, C. Toda, Y. Okamatsu, K. Kimura
    • Organizer
      14^<th> European Congress of Obesity
    • Place of Presentation
      Megaron-the Athens Concert Hall, Greece
    • Year and Date
      2005-06-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Noradrenaline stimulates glucose uptake in brown adipose tisue through the activation of UCP1 and AMP kinase2005

    • Author(s)
      Saito M, Inokuma K, Toda C, Okamatsu-Ogura Y, Kimura K.
    • Organizer
      14th European Congress of Obesity
    • Place of Presentation
      Athens, Greece
    • Year and Date
      2005-06-01
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Dietary Obesity in Dogs : Plas, Adipocytokines. Uncoupling proteins, and Treatment with β3-Adrenoceptor Agonists.2004

    • Author(s)
      M. Saito, K. Ishioka, A. Omachi, N. Sasaki, K. Kimura, H. Shibata
    • Organizer
      NAASO's 2004 Annual Meeting
    • Place of Presentation
      Las Vegas, USA
    • Year and Date
      2004-11-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Dietary obesity in dogs : plasma, adipocytokines, uncoupling proteins, and treatment with β3-adrenoceptor agonists2004

    • Author(s)
      Saito M, Ishioka K, Omachi A, Sasaki N, Kimura K, Shibata H.
    • Organizer
      NAASO's 2004 Annual Meeting
    • Place of Presentation
      Las Vegas, USA.
    • Year and Date
      2004-11-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Indispensable role of UCP1 for aniti-obesity effect of BETA-3-adrenergic agonists.2004

    • Author(s)
      M. Saito, K. Inokuma. A. Omachi, Y. Matsushita, K. Kimura, H. Yamashita
    • Organizer
      13^<th> European Congress of Obesity
    • Place of Presentation
      Prague Congress Centre, Czech Republic
    • Year and Date
      2004-05-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The roles of UCP1 in glucose utilization in brown adipose tissue.2004

    • Author(s)
      K. Inokuma, K. Kimura, H. Yamashita, M. Saito
    • Organizer
      13^<th> European Congress of Obesity
    • Place of Presentation
      Prague Congress Centre, Czech Republic
    • Year and Date
      2004-05-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Indispensable role of UCP1 for aniti-obesity effect of Beta-3-adrenergic agonists2004

    • Author(s)
      Saito M. Inokuma K, Omachi A.
    • Organizer
      13^<th> European Congress of Obesity
    • Place of Presentation
      Prague Congress Centre, Czech Republic
    • Year and Date
      2004-03-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The roles of UCP1 in glucose utilization in brown adipose tissue2004

    • Author(s)
      Inokuma K, Kimura K, Yamashita H, Saito M.
    • Organizer
      13th European Congress of Obesity
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2004-03-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Production of neurotrophic factors in white adipocytes and their autocrine action.2003

    • Author(s)
      K. Kimura, I. Murashima, M. Saito
    • Organizer
      12^<th> European Congress of Obesity
    • Place of Presentation
      Helsinki, Finland
    • Year and Date
      2003-05-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Production of neurotrophic factors in white adipocytes and their autocrine action2003

    • Author(s)
      Kimura K, Murashima I, Saito M.
    • Organizer
      12th European Congress of Obesity
    • Place of Presentation
      Helsinki, Finland
    • Year and Date
      2003-03-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Publications] 木村和弘, 石岡克己 他: "犬と猫のレプチン-血中濃度の測定とその肥満評価への応用-"獣医畜産情報. 56. 43-46 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 斉藤昌之: "エネルギー消費の自律的調節と肥満に関する分子栄養学的研究"日本栄養・食糧学会誌. 56. 33-39 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kitamura H, Matsushita Y et al.: "Bacterial lipopolysaccharide-induced expression of the IkB protein MAIL in B-lymphocytes and macrophages."Arch.Histol.Cytol.. 66. 53-62 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 大橋敦子, 斉藤昌之: "共役脂肪酸の体脂肪低減効果とインスリン抵抗性・脂肪肝"肥満研究. 9. 128-135 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Haruki Shibata, Noriyasu Sasaki et al.: "Feline Leptin : Immunogenic and Biological Activities of the Recombinant Protein, and Its Measurement by ELISA."J.Vet.Med.. 65. 1207-1211 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kitamura T, Kimura K, Makondo et al.: "Proinsulin C-peptide increases nitric oxide production by enhancing mitogen-activated protein-kinase-depentent transcription of endothelial nitric oxide synthase in aortic endothelial cells of Wistar rats."Diabetologia.. 46. 1698-1705 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2018-03-28  

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