• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular Interaction between Adipose Function and Metabolic Syndrome

Research Project

Project/Area Number 15081207
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyoto University

Principal Investigator

MASUZAKI Hiroaki  Kyoto University, Graduate School of Medicine, Assistant Professor (00291899)

Project Period (FY) 2003 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥38,800,000 (Direct Cost: ¥38,800,000)
Fiscal Year 2007: ¥7,400,000 (Direct Cost: ¥7,400,000)
Fiscal Year 2006: ¥7,400,000 (Direct Cost: ¥7,400,000)
Fiscal Year 2005: ¥8,000,000 (Direct Cost: ¥8,000,000)
Fiscal Year 2004: ¥8,000,000 (Direct Cost: ¥8,000,000)
Fiscal Year 2003: ¥8,000,000 (Direct Cost: ¥8,000,000)
Keywordsdyslipidemia / interal medicine / hypertension / diabetes / metabolic syndrome / translational research / therapy / adipomics / 遺伝子改変動物 / 内臓脂肪 / PPARγ / マクロファージ / 11β-HSD1 / 伸血管イベント / 炎症 / 心血管イベント / アデイポステロイド / 脂肪細胞機能 / 内臓脂肪症候群 / メタボリック症候群
Research Abstract

The prevalence of the metabolic syndrome is increasing worldwide, bringing about a parallel rise in the incidence of fatal cardiovascular events. In the ADIPOMICS project, we have focused my attention on molecular mechanism of adipose dysfunction, a central pathophysiology of the metabolic syndrome. The first branch of the study is to elucidate regulatory mechanism of intracellular glucocortiocoid reactivating enzyme, 11β-HSD1 in obese adipose tissue. Glucocorticoid plays a pivotal role in regulating adipose tissue metabolism, function and distribution, and its action on target tissue depends not only on circulating level but on intracellular concentration. Evidence has accumulated that locally-enhanced action of glucocorticoid in adipose tissue via 11β-HSD1 contributes to adipose dysfunction in obesity. In the present study, we revealed that (1) inflammatory cytokine, ceramide signaling pathway and NADPH provided by enzymes involved in pentose phosphate pathway augment the enzyme acti … More vity of 11β-HSD1 in adipose tissue, (2) elevated expression and activity of 11β-HSD1 in obese adipose tissue is reproduced in humans (approved by the ethical committee of Kyoto University, No.553, since 2004), (3) 11β-HSD1 activity is also exaggerated in infiltrated macrophages in obese adipose tissue, and thus (4) inhibition of 11β-HSD1 in obese adipose tissue may be crucial in multifaceted effects of PPARγ agonists. The second branch of the study is to explore the molecular basis of leptin resistance commonly seen in the metabolic syndrome and obesity. Little is known about a role of central melanocortin system in the control of fuel metabolism in the peripheral tissue. Skeletal muscle AMP-activated protein kinase (AMPK) is activated by leptin and serves as a master regulator of fatty acid β-oxidation, thereby improving lipotoxicity and fuel dyshomeostasis. To explore an unidentified role of central melanocortin in muscular AMPK regulation, we treated conscious mice intracerebroventricularly with melanocortin agonist (MT-II) or antagonist (SHU9119). MT-II augmented phosphorylation of AMPK and its target acetyl-CoA carboxylase (ACC) independent of caloric intake. Conversely, AMPK/ACC phosphorylation by leptin was abrogated by co-administration of SHU9119 or in KKA^y mice which centrally express endogenous melanocortin antagonist High-fat diet-induced attenuation in AMPK/ACC phosphorylation in leptin transgenic mice was not reversed by leptin, whereas markedly recovered by MT-II. Our data provide the first evidence for critical role of central melanocortin in leptin-skeletal muscle AMPK axis and highlight the system as a promising therapeutic target in leptin resistance in obesity and the metabolic syndrome. Less

Report

(6 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (85 results)

All 2007 2006 2005 2004 2003 Other

All Journal Article (51 results) (of which Peer Reviewed: 26 results) Presentation (19 results) Book (9 results) Publications (6 results)

  • [Journal Article] Augmentation of 11β-hydroxysteroid dehydrogenase type 1 in LPS-activated J774.1 macrophages -Role of 11 β-HSD1 in pro-inflammatory properties in macrophages-2007

    • Author(s)
      T. Ishii, H. Masuzaki (corresponding author), et al.
    • Journal Title

      FEBS Lett. 581

      Pages: 349-354

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Bezafibrate regulates the expression and enzyme activity of 11β-hydroxysteroiddehydrogenase type 1 in murine adipose tissue and 3T3-L1 adipocytes.2007

    • Author(s)
      S. Nakano, H. Masuzaki (corresponding author), et al.
    • Journal Title

      Am. J. Physiol. (Endocrinol Metab) 292

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Central melanocortin signaling restores skeletal muscle AMP-activated protein kinase phosphoylation in mice fed a high fat diet.2007

    • Author(s)
      T. Tanaka, H. Masuzaki (corresponding author), et al.
    • Journal Title

      Cell Metabolism 5

      Pages: 395-402

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Ceramide and AMP-activated Protein Kinase are Two Novel Regulators of 11 β-Hydroxysteroid Dehydrogenase Type l Expression and Actovity in Cultured Preadipocytes2007

    • Author(s)
      N. Arai, H. Masuzaki (corresponding author), et al.
    • Journal Title

      Endocrinology 148

      Pages: 5268-5277

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Neonatal Exposure to Leptin Augments Diet-induced Obesity in Leptin-deficient ob/ob Mice2007

    • Author(s)
      S. Yura, H. Masuzaki, et al.
    • Journal Title

      Obesity (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Genetic and Pharmacological Inhibition of Rho-Associated Kinase II Enhances Adipogenesis.2007

    • Author(s)
      M. Noguchi, H. Masuzaki, et al.
    • Journal Title

      J Biol Chem 282

      Pages: 29574-29583

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Metabolic derangements in an adult patient with tetralogy of Fallot : Possible role of chronic systemic hypoxia.2007

    • Author(s)
      E. Harada, H. Masuzaki (lastauthor), et al.
    • Journal Title

      Am J Med Sci 344

      Pages: 301-304

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Augmentation of 11β-hydroxysteroid dehydrogenase type 1 in LPS-activated J774.1macrophages -Role of 11β-HSD1 in pro-inflammatory properties in macrophages-2007

    • Author(s)
      T. Ishii, H. Masuzaki (corresponding author), et al.
    • Journal Title

      FEBS Lett. 581

      Pages: 349-354

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Ceramide and AMP-activated Protein Kinase are Two Novel Regulators of 11β-Hydroxysteroid Dehydrogenase Type 1 Expression and Activity in Cultured Preadipocytes2007

    • Author(s)
      N. Arai, H. Masuzaki (corresponding author), et al.
    • Journal Title

      Endocrinology 148

      Pages: 5268-5277

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Metabolic derangements in an adult patient with tetralogy of Fallot : Possible role of chronic systemic hypoxia.2007

    • Author(s)
      E. Harada, H. Masuzaki (last author), et al.
    • Journal Title

      Am J Med Sci 334

      Pages: 301-304

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Central melanocortin signaling restores skeletal muscle AMP-activated proteinkinase phosphoylation in mice fed a high fat diet.2007

    • Author(s)
      T.Tanaka, H. Masuzaki (correspon ding author), S. Yasue, K. Ebihara, T. Shiuchi, T. Ishii, N. Arai, M. Hirata. H. Yamamoto, T. Hayashi, K. Hosoda, Y. Minokoshi, K. Nakao.
    • Journal Title

      Cell Metabolism 5

      Pages: 395-402

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ceramide and AMP-activated Protein Kinase areTwo Novel Regulators of 11β-Hydroxysteroid Dehydrogenase Type 1 Expression and Actovity in Cultured Preadipocytes2007

    • Author(s)
      N. Arai, H. Masuzaki (corresponding author), T. Tanaka, T. Ishii, S. Yasue, N. Kobayashi, T. Tomita, M. Noguchi, T. Kusakabe, H. Tanioka H. Hige, F. Miyanaga, J. Fujikura, K. Ebihara, M. Hirata, K. Hosoda, H. Sawai. Y. Minokoshi, K. Nakao
    • Journal Title

      Endocrinology 148

      Pages: 5268-5277

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bezafibrate regulates the expression and enzyme activity of 11β-hydroxysteroiddehydrogenase type 1 in murine adipose tissue and 3T3-L1 adipocytes.2007

    • Author(s)
      S. Nakano, Y. Inada, H. Masuzaki (corresponding author), T. Tanaka, S. Yasue, T. Ishii, N. Arai, K. Ebihara, K. Hosoda, K. Maruyama, Y. Yamazaki, N. Shibata, K. Nakao
    • Journal Title

      Am. J. Physiol. (Endocrinol Metab) 292

      Pages: 1213-1222

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Augmentation of 11β-hydroxysteroid dehydrogenase type 1 in LPS-activated J774.1 macrophages -Role of 11β-HSD1 in pro-inflammatory properties in macrophages-2007

    • Author(s)
      T. Ishii, H. Masuzaki (corresponding author), T. Tanaka, N. Arai, S. Yasue, N. Kobayashi, M. Noguchi, J. Fujikura, K. Ebihara, K. Hosoda, K. Nakao.
    • Journal Title

      FEBS Lett. 581

      Pages: 349-354

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolic derangements in an adult patient with tetralogy of Fallot: Possible role of chronic systemic hypoxia.2007

    • Author(s)
      E. Harada, H. Yasue, Y. Mizuno, T. Ito, S. Naritsugu, S. Yasue, H. Masuzaki (last author)
    • Journal Title

      Am J Med Sci 3

      Pages: 301-304

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy and safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophy.2007

    • Author(s)
      K. Ebihara, T. Kusakabe, M. Hirata, H. Masuzaki. F. Miyanaga, N. Kobayashi, T. Tanaka, H. Chusho, T. Miyazawa, T. Hayashi, K. Hosoda, Y. Ogawa, A.M. Depaoli, M. Fukushima, K. Nakao
    • Journal Title

      J. Clin. Endocrinol. Metab. 92

      Pages: 532-541

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumors in humans : evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion2006

    • Author(s)
      T. Tomita, H. Masuzaki (corresponding author), et al.
    • Journal Title

      Diabetologia 49

      Pages: 962-968

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Notch / Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas2006

    • Author(s)
      J. Fujikura, H. Masuzaki, et al.
    • Journal Title

      Cell Metabolism 3

      Pages: 1-7

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumors in humans : evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion2006

    • Author(s)
      T.Tomita, H.Masuzaki (corresponding author) et al.
    • Journal Title

      Diabetologia 49

      Pages: 962-968

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Notch / Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas2006

    • Author(s)
      J.Fujikura, K.Hosoda, H.Masuzaki et al.
    • Journal Title

      Cell Metabolism 3

      Pages: 1-7

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Alpha2 isoform-specific activation of 5' adenosine monophosphate -activated protein kinase by 5-aminoimidazole-4-carboxamide -1-beta-d-ribonucleoside at a physiological level activates glucose transport and increases glucose transporter 4 in mouse skeletal muscle2006

    • Author(s)
      M.Nakano, T.Hamada, H.Masuzaki et al.
    • Journal Title

      Metabolism 55

      Pages: 300-308

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Transgenic expression of mutant peroxisome proliferator-activated receptor (PPAR)γin liver precipitates fasting-induced steatosis but protects against high fat diet-induced steatosis in mice.2005

    • Author(s)
      T. Tanaka, H. Masuzaki (corresponding author), et al.
    • Journal Title

      Metabolism 54

      Pages: 1490-1498

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] CCAAT/enhancer binding protein α maintains the ability of insulin-stimulated GLUT4 translocation in 3T3-C2 fibroblastic cells.2005

    • Author(s)
      M. Fujimoto, H. Masuzaki (corresponding author), et al.
    • Journal Title

      Biochim. Biophys. Acta. (Molecular Cell Research) 1745

      Pages: 38-47

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Skeletal muscle AMPK phosphorylation parallels metabolic phenotype in leptin transgenic mice under dietary modification.2005

    • Author(s)
      T. Tanaka, H. Masuzaki (corresponding author), et al.
    • Journal Title

      Diabetes 54

      Pages: 2365-2374

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Role of Premature Leptin Surge in Obesity Resulting from Intrauterine Undernutrition.2005

    • Author(s)
      S. Yura, H. Masuzaki, et al.
    • Journal Title

      Cell Metabolism 1

      Pages: 371-378

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Rho-kinase is an Important Mediator of Insulin Action.2005

    • Author(s)
      N. Furukawa. H. Masuzaki, et al.
    • Journal Title

      Cell Metabolism 2

      Pages: 119-129

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A large amount of mRNA expression for G-protein-coupled fatty acid receptor, GPR40 in human insulinoma2005

    • Author(s)
      T. Tomita, H, Masuzaki (correspondina author), et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 338

      Pages: 1788-1790

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Transgenic expression of mutant peroxisome proliferator-activated receptor (PPAR) γ in liver precipitates fasting-induced steatosis but protects against high fat diet-induced steatosis in mice.2005

    • Author(s)
      T. Tanaka, H. Masuzaki (corresponding author), et al.
    • Journal Title

      Metabolism 54

      Pages: 1490-1498

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Rho-kinase is an Important Mediator of Insulin Action.2005

    • Author(s)
      N. Furukawa, H. Masuzaki, et al.
    • Journal Title

      Cell Metabolism 2

      Pages: 119-129

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A large amount of mRNA expression for G-protein-coupled fatty acid receptor, GPR40 in human insulinoma2005

    • Author(s)
      T. Tomita, H. Masuzaki (corresponding author), et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 338

      Pages: 1788-1790

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Transgenic expression of mutant peroxisomeproliferator-activated receptor (PPAR) γ in liver precipitates fasting-induced steatosis but protects against high fat diet-induced steatosis in mice.2005

    • Author(s)
      T.Tanaka et al.
    • Journal Title

      Metabolism 54

      Pages: 1490-1498

    • Related Report
      2005 Annual Research Report
  • [Journal Article] CCAAT/enhancer binding protein a maintains the ability of insulin-stimulated GLUT4 translocation in 3T3-C2 fibroblastic cells.2005

    • Author(s)
      M.Fujimoto et al.
    • Journal Title

      Biochim.Biophys.Acta.(Molecular Cell Research) 1745

      Pages: 38-47

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Skeletal muscle AMPK phosphorylation parallels metabolic phenotype in leptin transgenic mice under dietary modification.2005

    • Author(s)
      T.Tanaka et al.
    • Journal Title

      Diabetes 54

      Pages: 2365-2374

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Role of Premature Leptin Surge in Obesity Resulting from Intrauterine Undernutrition.2005

    • Author(s)
      S.Yura et al.
    • Journal Title

      Cell Metabolism 1

      Pages: 371-378

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Gene expression of a membrane-bound fatty acid receptor, GPR40, in pancreas and islet cell tumors in humans - Evidence for gene expression of GPR40 in pancreatic cells and its implication in insulin secretion in humans -2005

    • Author(s)
      T.Tomita et al.
    • Journal Title

      Diabetologia (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A large amount of mRNA expression for G-protein-coupled fatty acid receptor, GPR40 in human insulinoma2005

    • Author(s)
      T.Tomita et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 338

      Pages: 1788-1790

    • Related Report
      2005 Annual Research Report
  • [Journal Article] CCAAT/enhancer binding protein α maintains the ability of insulin-stimulated GLUT4 translocation in 3T3-C2 fibroblastic cells.2005

    • Author(s)
      M.Fujimoto, H.Masuzaki et al.
    • Journal Title

      Biochim.Biophys.Acta. (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11β-hydroxysteroid dehydrogenase type-1 deficient mice.2004

    • Author(s)
      N. M. Morton, H. Masuzaki, et al.
    • Journal Title

      Diabetes 53

      Pages: 931-938

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Antidiabetic and adipogenic properties of a newly-synthesized thiazolidine derivative, FPFS-410.2004

    • Author(s)
      N. Norisada, H. Masuzaki (corresponding author), et al.
    • Journal Title

      Metabolism 53

      Pages: 1532-1537

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Efficacy of long-term leptin replacement therapy for lipoatrophic diabetes in Japan.2004

    • Author(s)
      K. Ebihara, H. Masuzaki, et ai.
    • Journal Title

      N. Eng. J. Med. 351

      Pages: 615-616

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] An angiotensin II AT1 receptor antagonist, telmisartan augments glucose uptake and Glut 4 protein expression in 3T3-L1 adipocytes.2004

    • Author(s)
      M. Fujimoto, H. Masuzaki (corresponding author), et al.
    • Journal Title

      FEBS Lett. 576

      Pages: 492-497

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Efficacy of long-term leptin replacement therapy for lipoatrophic diabetes in Japan.2004

    • Author(s)
      K. Ebihara, H. Masuzaki, et al.
    • Journal Title

      N. Eng. J. Med. 351

      Pages: 615-616

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11β-hydroxysteroid dehydrogenase type-1 deficient mice.2004

    • Author(s)
      N.M.Morton, H.Masuzaki et al.
    • Journal Title

      Diabetes 53

      Pages: 931-938

    • Related Report
      2004 Annual Research Report
  • [Journal Article] An angiotensin II AT1 receptor antagonist, telmisartan augments glucose uptake and Glut 4 protein expression in 3T3-L1 adipocytes.2004

    • Author(s)
      M.Fujimoto, H.Masuzaki et al.
    • Journal Title

      FEBS Lett. 576

      Pages: 492-497

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Antidiabetic and adipogenic properties of a newly-synthesized thiazolidine derivative, EPFS-410.2004

    • Author(s)
      N.Norisada, H.Masuzaki et al.
    • Journal Title

      Metabolism 53

      Pages: 1532-1537

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Efficacy of long-term leptin replacement therapy for lipoatrophic diabetes in Japan.2004

    • Author(s)
      K.Ebihara, H.Masuzaki et al.
    • Journal Title

      N.Eng.J. Med 351

      Pages: 615-616

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Association of Ob-R gene polymorphism and insulin resistance in Japanese men.2004

    • Author(s)
      A.Yasuno, H.Masuzaki et al.
    • Journal Title

      Metabolism 53

      Pages: 650-654

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice.2003

    • Author(s)
      H. Masuzaki (senior author), H. Yamamoto, et al.
    • Journal Title

      J. Clin. Invest. 112

      Pages: 83-90

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Efficacy and safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophy.

    • Author(s)
      K.Ebihara, T.Kusakabe, H.Masuzaki et al.
    • Journal Title

      J.Clin.Endocrinol.Metab. (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Augmentation of 11β-hydroxysteroid dehydrogenase type 1 in LPS-activated J774.1 macrophages - Role of 11β-HSD1 in pro- inflammatory properties in macrophages -

    • Author(s)
      T.Ishii, H.Masuzaki (corresponding author) et al.
    • Journal Title

      FEBS Lett. (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Bezafibrate regulates the expression and enzyme activity of 11β-hydroxysteroid dehydrogenase type 1 in murine adipose tissue and 3T3-L1 adipocytes.

    • Author(s)
      S.Nakano, Y.Inada, H.Masuzaki (corresponding author) et al.
    • Journal Title

      Am.J.Physiol. (Endocrinol Metab) (in press)

    • Related Report
      2006 Annual Research Report
  • [Presentation] 脂肪細胞分子とメタボリックシンドローム:創薬の展望2007

    • Author(s)
      益崎 裕章、泰江 慎太郎、石井 崇子、田中 智洋、岡田 定規、藤倉 純二、野口 倫生、海老原 健、平田 雅一、細田 公則、中尾 一和
    • Organizer
      第44回 日本糖尿病学会 近畿地方会 シンポジウム:アデイポサイエンスからメタボリックシンドロームを探る
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2007-11-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] 脂肪組織、視床下部、骨格筋の臓器間、細胞間ネットワークと肥満制御2007

    • Author(s)
      益崎 裕章
    • Organizer
      第28回 日本肥満学会 シンポジウム3:臓器・細胞間クロストークによるエネルギー代謝制御
    • Place of Presentation
      都市センターホテル(東京)
    • Year and Date
      2007-10-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] 脂肪組織の機能異常を基盤とする病態解明へのアプローチ2007

    • Author(s)
      益崎 裕章、泰江 慎太郎、田中 智洋、石井 崇子、荒井 直樹、海老原 健、細田 公則、中尾 一和
    • Organizer
      第80回 日本内分泌学会 学術総会 クリニカルアワーメタボリックシンドローム
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2007-06-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] 脂肪組織の機能異常と11β-HSD1の役割2007

    • Author(s)
      益崎 裕章、泰江 慎太郎、田中 智洋、石井 崇子、荒井 直樹、藤倉 純二、野口 倫生、海老原 健、平田 雅一、細田 公則、中尾 一和
    • Organizer
      第50回 日本糖尿病学会 年次学術集会 指定シンポジウム:脂肪細胞とアデイポサイトカイン
    • Place of Presentation
      ホテルメトロポリタン(仙台)
    • Year and Date
      2007-05-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] メタボリックシンドロームの病態解明から食育を考える(教育講演)2007

    • Author(s)
      益崎 裕章
    • Organizer
      第110回 日本小児科学会 年次学術集会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2007-04-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] Dysregulation of intracellular glucocorticoid reactivating enzyme, 11β-HSD1 in adipocytes and macrophages : -Promising drug target of the metabolic syndrome -2007

    • Author(s)
      H. Masuzaki
    • Organizer
      2007 Asia Oceania Association for the study of Obesity“Lipid Metabolism, Obesity and Inflammation Hot Topics"
    • Place of Presentation
      ソウル(韓国)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Role of Membrane-Bound Fatty Acid Receptor in Glucose Homeostasis2006

    • Author(s)
      H. Masuzaki
    • Organizer
      REGREP 06 : GPCR International Symposim
    • Place of Presentation
      箱根
    • Year and Date
      2006-09-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Adipocyte Dysfunction as a Key for the Metabolic Syndrome2006

    • Author(s)
      H. Masuzaki
    • Organizer
      第20回国際生化学会・国際分子生物学会学術集会(20^<th> IUBMB International Congress of Biochemistry and Molecular Biology and 11^<th> FAOBMB Congress)
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Role of 11β-HSD1 in the Metabolic Syndrome2006

    • Author(s)
      H. Masuzaki
    • Organizer
      第10回国際肥満学会議 : ICO
    • Place of Presentation
      シドニー(オーストラリア)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Role of Intracellular Glucocorticoid Reactivating Enzyme in Dysfunction of Adipose Tissue and Metabolic Syndrome2006

    • Author(s)
      H. Masuzaki
    • Organizer
      The 21st Scientific Meeting of International Society of Hypertension (ISH) Metabolic Syndrome and Hypertension :
    • Place of Presentation
      福岡
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Adipocyte Dysfunction as a Key for the Metabolic Syndrome2006

    • Author(s)
      H. Masuzaki
    • Organizer
      20^<th> IUBMB International Congress of Biochemistry and Molecular Biology and 11^<th> FAOBMB Congress
    • Place of Presentation
      Kyoto, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Fat cell-derived hormones and adipocyte function Exciting drug targets for the metabolic syndrome -2004

    • Author(s)
      H. Masuzaki
    • Organizer
      77th Annual Meeting of the Japan Endocrine Society International Symposium
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Leptin Treatment on Various Types of Diabetes Mellitus2004

    • Author(s)
      H. Masuzaki
    • Organizer
      第12回国際内分泌学会ICE Symposium : Management of Diabetes -Novel Therapies-
    • Place of Presentation
      リスボン(ポルトガル)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Fat cell-derived hormones and adipocyte function Exciting drug targets for the metabolic syndrome -2004

    • Author(s)
      H. Masuzaki
    • Organizer
      77th Annual Meeting of the Japan Endocrine Society International Symposium
    • Place of Presentation
      Kyoto, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Leptin Treatment on Various Types of Diabetes Mellitus

    • Author(s)
      H. Masuzaki
    • Organizer
      12Th Intrnational Congress of Endocrinology Symposium : Management of Diabetes - Novel Therapies -
    • Place of Presentation
      Lisbon, Portugal
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Role of 11β-HSD1 in the Metabolic Syndrome

    • Author(s)
      H. Masuzaki
    • Organizer
      10^<th> Intrnational Congress on Obesity September 3-8 Sydney, Australia REGREP 06 : GPCR International Symposium
    • Place of Presentation
      Sydney, Australia
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Role of Membrane-Bound Fatty Acid Receptor in Glucose Homeostasis

    • Author(s)
      H. Masuzaki
    • Organizer
      REGREP 06 : GPCR International Symposium
    • Place of Presentation
      Hakone, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Role of Intracellular Glucocorticoid Reactivating Enzyme in Dysfunction of Adipose Tissue and Metabolic Syndrome

    • Author(s)
      H. Masuzaki
    • Organizer
      The 21st Scientific Meeting of International Society of Hypertension (ISH) Metabolic Syndrome and Hypertension
    • Place of Presentation
      Fukuoka, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Dysregulation of intracellular glucocorticoid reactivating enzyme, 11(β-HSD1 in adipocytes and macrophages : - Promising drug target of the metabolic syndrome -

    • Author(s)
      H. Masuzaki
    • Organizer
      2007 Asia Oceania Association for the Study of Obesity “Lipid Metabolism, Obesity and Inflammation Hot Topics"
    • Place of Presentation
      Seoul, korea
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 日本医師会雑誌 -メタボリックシンドロームup to date-2007

    • Author(s)
      益崎 裕章、泰江 慎太郎、中尾 一和
    • Publisher
      (日本医師会)
    • Related Report
      2007 Annual Research Report
  • [Book] Adiposcience2007

    • Author(s)
      益崎 裕章、石井 崇子、中尾 一和
    • Publisher
      フジメディカル出版
    • Related Report
      2007 Annual Research Report
  • [Book] 医学のあゆみ2007

    • Author(s)
      益崎 裕章、中尾 一和
    • Publisher
      医歯薬出版
    • Related Report
      2007 Annual Research Report
  • [Book] Adiposcience2007

    • Author(s)
      益崎 裕章、田中 智洋、中尾 一和
    • Publisher
      フジメディカル出版
    • Related Report
      2007 Annual Research Report
  • [Book] 実験医学(臨時増刊号:メタボリックシンドローム:解明が進む分子メカニズムと治療・創薬への応用)2007

    • Author(s)
      益崎 裕章、田中 智洋、中尾 一和
    • Publisher
      羊土社
    • Related Report
      2007 Annual Research Report
  • [Book] Life Style Medicine2007

    • Author(s)
      益崎 裕章、泰江 慎太郎、中尾 一和
    • Publisher
      先端医学社
    • Related Report
      2007 Annual Research Report
  • [Book] Adiposcience2007

    • Author(s)
      益崎 裕章、泰江 慎太郎、中尾 一和
    • Publisher
      フジメディカル出版
    • Related Report
      2007 Annual Research Report
  • [Book] 日本小児科学会雑誌2007

    • Author(s)
      益崎 裕章、田中 智洋、石井 崇子、泰江 慎太郎、中尾 一和
    • Publisher
      日本小児科学会
    • Related Report
      2007 Annual Research Report
  • [Book] 最新医学2007

    • Author(s)
      益崎 裕章、石井 崇子、泰江 慎太郎、田中 智洋、中尾 一和
    • Publisher
      最新医学社
    • Related Report
      2007 Annual Research Report
  • [Publications] H.Masuzaki, J.S.Flier et al.: "Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice."J.Clin.Invest.. 112. 83-90 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] H.Masuzaki, J.S.Flier.: "Tissue-specific glucocorticoid reactivating enzyme, 11β-hydroxy steroid dehydrogenase type 1(11β-HSD1). - A promising drug target for the treatment of the Metabolic Syndrome -"Curr.Drug Targets Immune Endocrinol.Metab.Disord.. 3. 249-256 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] A.Takahashi-Yasuno, H.Masuzaki (corresponding author) et al.: "Leptin receptor (Ob-R) Arg223Gln polymorphism is associated with serum cholesterol elevation and impairment of cholesterol lowering effect by simvastatin in Japanese men."Diabetes Res.Clin.Pract.. 62. 169-175 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] H.Shinyama, H.Masuzaki et al.: "Regulation of melanocortin-4 receptor signaling : Agonist-mediated desensitization and internalization."Endocrinology. 144. 1301-1314 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] N.M.Morton, H.Masuzaki, et al.: "Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11β-hydroxysteroid dehydrogenase type-1 deficient mice."Diabetes. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 益崎 裕章, 中尾 一和: "Annual Review 内分泌代謝"中外医学社. 6 (2004)

    • Related Report
      2003 Annual Research Report

URL: 

Published: 2003-04-01   Modified: 2018-03-28  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi