• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

ニューロン-グリア相互作用に関与する機能分子の探索

Research Project

Project/Area Number 15082209
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNational Institute for Physiological Sciences (2004-2007)
Okazaki National Research Institutes (2003)

Principal Investigator

池中 一裕  National Institute for Physiological Sciences, 分子生理研究系, 教授 (00144527)

Co-Investigator(Kenkyū-buntansha) 小野 勝彦  生理学研究所, 分子生理研究係, 准教授 (30152523)
等 誠司  生理学研究所, 分子生理研究係, 准教授 (70300895)
竹林 浩秀  生理学研究所, 分子生理研究系, 助教 (60353439)
田中 謙二  生理学研究所, 分子生理研究系, 助手 (30329700)
Project Period (FY) 2003 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥60,000,000 (Direct Cost: ¥60,000,000)
Fiscal Year 2007: ¥12,000,000 (Direct Cost: ¥12,000,000)
Fiscal Year 2006: ¥12,000,000 (Direct Cost: ¥12,000,000)
Fiscal Year 2005: ¥12,000,000 (Direct Cost: ¥12,000,000)
Fiscal Year 2004: ¥12,000,000 (Direct Cost: ¥12,000,000)
Fiscal Year 2003: ¥12,000,000 (Direct Cost: ¥12,000,000)
Keywordsアストロサイト / 多様性 / ATP / グルタミン酸 / セルセンサー / 短期記憶 / 長期記憶 / アレキサンダー病 / 凝集体形成 / GFAP / カイニン酸 / けいれん / 転写因子 / 神経発生 / ドメイン構造 / 放射状グリア細胞
Research Abstract

平成19年度はアストロサイトの多様性について検討した。
アストロサイトは各種の刺激に応答して、グルタミン酸やATPを放出するが、一つのアストロサイトから両方とも放出されるのか、またそれぞれを別個に放出するアストロサイトがあるのか知られていない。われわれはバイオセンサー細胞を用いて、一つのアストロサイトから同時にグルタミン酸とATPの放出を検出する系を確立し、上記の疑問に答えた。例数はまだ多くないが、両方の物質とも放出するもの、どちらかだけしか放出しないものがあることが分かった。
また、グルタミン酸依存性ATP放出をするアストロサイトについても検討した。結果、全くATPを放出しないもの、著しく放出するもの、少ししか放出しないものなど、やはり多様性が認められた。

Report

(5 results)
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (30 results)

All 2007 2006 2005 2004 Other

All Journal Article (24 results) (of which Peer Reviewed: 1 results) Publications (6 results)

  • [Journal Article] Human cortical neurons originate from radial glia and neuron-restricted progenitors.2007

    • Author(s)
      Mo Z, Moore AR, Filipovic R, Ogawa Y, Ikenaka K, Antic SD & Zecevic N
    • Journal Title

      J Neurosci 27

      Pages: 4132-4145

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Murine model of Alexander disease : analysis of GFAP aggregate formation and its pathological significance.2007

    • Author(s)
      Tanaka KF, Takebayashi H, Ymazaki Y, Ono K, Naruse M, Iwasato T, Itohara S, Kato H, Ikenaka K
    • Journal Title

      Glia 55

      Pages: 617-631

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Regulation of filial development by cystatin C.2007

    • Author(s)
      Hasegawa A, Naruse M, Hitoshi S, Iwasaki Y, Takebayashi H, Ikenaka K
    • Journal Title

      J Neurochem 100

      Pages: 12-22

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Induced expression of cahepsins and cystatin C in a murine model of demyelination.2007

    • Author(s)
      Ma J, Tanaka KF, Yamada G, Ikenaka K
    • Journal Title

      Neurochem Res 100

      Pages: 311-320

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Direct evidence that ventral forebrain cells migrate to the cortex and contribute to the generation of cortical myelinating oligdendrosytes.2006

    • Author(s)
      Nakahira E, Kagawa T, Shimizu T, goulding MD, Ikenaka K
    • Journal Title

      Dev Biol 291

      Pages: 123-131

    • Related Report
      2006 Annual Research Report
  • [Journal Article] An animal model for late onset chronic demyelination disease caused by failed terminal differentiation of oligodendrocytes.2006

    • Author(s)
      Ma J, Matusmoto M, Tanaka KF, Takebayashi H, Ikenaka K
    • Journal Title

      Neuron Glia Biol 2

      Pages: 81-91

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Incolvement of the Olig 2 transcription factor in cholinergic neuron development of the basal forebrain.2006

    • Author(s)
      Furusho M, Ono K, Takebayashi H, Masahira N, Kagawa T, Ikeda K, Ikenaka K
    • Journal Title

      Dev Biol 293

      Pages: 348-357

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Olig2-positive progenitors in the embryonic spinal cord give rise to not only to motoneurons and oligodendrocytes, but alos to a subset of astrocytes and ependymal cells.2006

    • Author(s)
      Masahira N, Takenayashi H, Ono k, Watanabe K, Ding L, Furusho M, Ogawa Y, Nabeshima Y, Alvarez-Buylla A, Shimizu K, Ikenaka K
    • Journal Title

      Dev Biol 293

      Pages: 358-369

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Fluoro-jade : Neww fluorescent marker of ROcenthal fibers.2006

    • Author(s)
      Tanaka KF, Ochi N, Hayashi T, Ikeda E, Ikenaka K
    • Journal Title

      Neurosci Lett 407

      Pages: 127-130

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Electrophysiological abnormality precedes apparent histological demyelination in the central nercous system of mice over-expressing proteolipid protein.2006

    • Author(s)
      TanakaH, Ikenaka K, Isa T
    • Journal Title

      J Neurosci Res 84

      Pages: 1206-1216

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Induction of oligodendrocyte progenitors in dorsal forebrain by intraventricular microinjection of FGF-2.2006

    • Author(s)
      Naruse M, Nakahira e, Miyata T, Hitoshi S, Ikenaka K, Bansal R
    • Journal Title

      Dev Biol 297

      Pages: 262-273

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Dorsally derived netrin-1 provides an Inhibitory cue and elaborates the "waiting period" for primary sensory axons in the developing spinal cord2006

    • Author(s)
      Watanabe, K., Tamamaki, N., Furuta, T., Ackerman, AL., Ikenaka, K., Ono, K.
    • Journal Title

      Development 133

      Pages: 1370-1386

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Gliogenic radial glial cells show heterogeneity in the developing mouse spinal cord.2005

    • Author(s)
      Ogawa, Y., Takebayashi, H., Takahashi, M., Osumi, N., Iwasaki, Y., Ikenaka, K.
    • Journal Title

      Dev.Neurosci 27

      Pages: 364-377

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Wnt Signaling Controls the Timing of Oligodendrocyte Development in the Spinal Cord.2005

    • Author(s)
      Shimizu, T., Kagawa, T., Wada, T., Muroyama, Y., Takada, S., Ikenaka, K.
    • Journal Title

      Dev Biol. 282

      Pages: 397-410

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Improved preservation of X-gal reaction product for electron microscopy using hydroxypropyl methacrylate.2005

    • Author(s)
      Masahira, N., Ding, L., Takebayashi, H., Shimizu, K., Ikenaka, K., Ono, K.
    • Journal Title

      Neurosci.Lett. 374

      Pages: 17-20

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Isolation of cystatin C via Functional Cloning of astrocyte Differentiation Factors.2004

    • Author(s)
      Kumada, T., Hasegawa, A., Iwasaki, Y., Baba, H., Ikenaka, K.
    • Journal Title

      Dev.Neurosci. 26

      Pages: 68-76

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Sulfatide is a negative regulator of oligodendrocyte differentiation : development in sulfatide-null mice.2004

    • Author(s)
      Hirahara, Y., Bansal, R., Honke, K., Wada, Y.
    • Journal Title

      Glia 45

      Pages: 269-277

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Tetraspanin protein CD9 is a novel paranodal component regulating paranodal junctional formation.2004

    • Author(s)
      Ishibashi, T., Ding, L., Ikenaka, K., Inoue, Y., Miyado, K., Mekada, E., Baba, H.
    • Journal Title

      J.Neurosci. 24(1)

      Pages: 96-102

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Ranvier絞輪とイオンチャンネル2004

    • Author(s)
      田中久貴, 池中一裕
    • Journal Title

      CLINICAL NEUROSCIENCE Vol.22,No.7

      Pages: 770-772

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Olig2 positive progenitors in the embryonic spinal cord give rise to not only to motoneurons and oligodendrocytes, but also to a subset of astrocytes and ependymal cells.

    • Author(s)
      Masahira, N., Takebayashi, H., Ono, K., Watanabe, K., Ding, L et al.
    • Journal Title

      Dev.Biol (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Involvement of the Olig2 transcription factor in cholinergic neuron development of the basal forebrain.

    • Author(s)
      Furusho, M., Ono, K., Takebayashi, H., Masahira, N., Kagawa, T., Ikeda, K., Ikenaka, K.
    • Journal Title

      Dev Biol. (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Direct evidence that ventral forebrain cells migrate to the cortex and contribute to the generation of cortical myelinating oligdendrocytes,

    • Author(s)
      Nakahira, E., Kagawa, T., Shimizu, T., Goulding, MD, Ikenaka, K.
    • Journal Title

      Dev Biol (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] An animal model for late onset chronic demyelination disease caused by failed terminal differentiation of oligodendrocytes.

    • Author(s)
      Ma, J., Matsumoto, M., Tanaka K.F., Takebayashi H., Ikenaka K.
    • Journal Title

      Neuron Glia Biol (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Changes in N-Linked Sugar Chain Patterns Induced by Moderate-to-High Expression of the Galactosyltransferase I Gene in a Brain-derived Cell Line, CG4.

    • Author(s)
      Menon K.N., Ikeda T., Fujimoto I., Narimatsu H., Nakakita S., Hase S., Ikenaka K.
    • Journal Title

      J.Neurosci.Res.

    • Related Report
      2004 Annual Research Report
  • [Publications] Yokoo H., Nobusawa N., Takebayashi H., Ikenaka K., Isoda K., Kamiya M., Sasaki A., Hirato J., Nakazato Y.: "Anti-human Olig2 antibody as a useful immunohistochemical marker of normal oligodendrocytes and gliomas."Am J Pathology. (in press).

    • Related Report
      2003 Annual Research Report
  • [Publications] Hirahara, Y., Bansal, R., Honke, K., Ikenaka, K., Wada, Y.: "Sulfatide Is A Negative Regulator Of Oligodendrocyte Differentiation : Development In Sulfatide-Null Mice."Glia. 45. 269-277 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ishibashi T, Ding, L., Ikenaka, K., Inoue, Y., Miyado, K., Mekada, E., Baba, H: "Tetraspanin protein CD9 is a novel paranodal component regulating paranodal junctional formation."J.Neurosci.. 24(1). 96-102 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Iwasaki, Y., Hosoya, T., Takebayashi, H., Ogawa, Y., Hotta, Y., Ikenaka, K: "The potential to induce glial differentiation is conserved between Drosophila and mammalian glial cells missing (gcm) genes."Development. 130. 6027-6035 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Suzuki, R., Arata, S., Nakajo, S., Ikenaka, K., Kikuyama, S., Shioda, S: "Expression of the receptor for pituitary adenylate cyclase-activating polypeptide(PAC-R) in reactive astrocytes"Moi.Brain Res.. 115. 10-20 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Matsukawa, N., Ikenaka, K., Nanmoku, K., Yuasa, H., Hattori, M., Kawano, M., Nakazawa, H., Fujimori, O., Ueda, R., Ojika, K: "Brain malformations by retroviral vector-mediated gene transfer of hippocampal cholinergic neurostimulation peptide precursor protein into the CNS via embryonic mice ventricles"Dev.Neurosci.. 25. 349-356 (2003)

    • Related Report
      2003 Annual Research Report

URL: 

Published: 2003-04-01   Modified: 2018-03-28  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi